袁子文｜甘肃农业大学｜学者主页

2026

正交试验结合G1-熵权法优选补中益气散水提物的制备工艺

娄源博，纪鹏，马倩，严建鹏，赵年寿，张勇，华永丽，袁子文，魏彦明

《甘肃农业大学学报》

2026

油当归水提物治疗小鼠便秘效果评价及对肠道相关指标的影响

赵梦璐，周轲，纪鹏，武凡琳，周海，赵志珍，魏彦明，袁子文，华永丽

《动物医学进展》

DOI

2026

Mechanism of liquiritin from Codonopsis pilosula-Glycyrrhiza uralensis extract in alleviating piglet weaning stress via binding to alpha-1-microglobulin/bikunin precursor by machine learning and molecular dynamics simulation

Yanzi Cai, Lidong Jiang, Sanhang Yang, Fengyu Zhang, Yongli Hua, Peng Ji, Ziwen Yuan, Yanming Wei

International Journal of Biological Macromolecules

DOI

2026

ShenQiGan Extract Mitigates Intestinal Oxidative Stress in Weaned Piglets Through Bile Acid Metabolism Regulation and Gut Microbiota Remodeling via the Nrf2/Keap1 Pathway

Rongxia Guo, Chenghui Jiang, Xitong Yin, Chun Niu, Baoxia Chen, Ziwen Yuan, Hongjuan Wang, Yanming Wei, Yongli Hua

Antioxidants

DOI

2025

桔梗-甘草配伍对脂多糖诱导小鼠急性肺损伤的保护作用

白彤，纪鹏，张文飞，杨昊赤，赵年寿，魏彦明，王秀琴，华永丽，袁子文

《动物医学进展》

DOI

2025

黄芩泻白散中8种活性成分的高效液相色谱法测定

张文飞，纪鹏，董嘉琪，买占海，韩罗霞，何磊，华永丽，袁子文，王秀琴，魏彦明

《动物医学进展》

DOI

2025

仔猪腹泻大肠杆菌的分离鉴定及黄连解毒汤对其致病性的影响

张丰裕，蔡燕子，史艳，纪鹏，华永丽，袁子文，魏彦明

《农业生物技术学报》

2025

Characteristics of Coassembling Nanoparticles Based on Oleanolic Acid and Glycyrrhetinic Acid/Caffeic Acid Phenethyl Ester

Juanjuan Qin, Dongshuai Shen, Min Cheol Yang, Ziwen Yuan, Xin Chen

ACS Applied Nano Materials

DOI

2025

Shaoyao decoction promotes ISCs proliferation by activating Wnt/β-catenin and YAP1/TAZ signaling to enhance epithelial regeneration in damp-heat colitis

Rong Li Yang, Luoxia Han, Yahui Zhang, Jiaqi Dong, Qian Ma, Yongli Hua, Peng Ji, Wanling Yao, Ziwen Yuan, Yanming Wei

Journal of Ethnopharmacology

DOI

2025

ShenQiGan Extract Repairs Intestinal Barrier in Weaning-Stressed Piglets by Modulating Inflammatory Factors, Immunoglobulins, and Short-Chain Fatty Acids

Rongxia Guo, Chenghui Jiang, Yanlong Niu, Chun Niu, Baoxia Chen, Ziwen Yuan, Yongli Hua, Yanming Wei

Animals

DOI

2024

基于系统药理学的柴胡防治非酒精性脂肪肝作用机制研究

祝亚梅，史艳，蔡燕子，魏彦明，王桂荣，袁子文

《甘肃农业大学学报》

2024

The impact of Codonopsis Pilosulae and Astragalus Membranaceus extract on growth performance, immunity function, antioxidant capacity and intestinal development of weaned piglets

Rongxia Guo, Hao Zhang, Chenghui Jiang, Chun Niu, Baoxia Chen, Ziwen Yuan, Yanming Wei, Yongli Hua

Frontiers in Veterinary Science

DOI

2024

Exploring the Potential Role of Sophora alopecuroides L. in Inflammation of Bovine Mammary Epithelial Cells Induced by Lipoteichoic Acid Based on Network Pharmacology and Experimental Validation

Ziwen Yuan, Fang Li, Wenfei Zhang, Yanming Wei, Yongli Hua

Combinatorial Chemistry & High Throughput Screening

DOI

2024

Pulsatilla decoction alleviates DSS-induced UC by activating FXR-ASBT pathways to ameliorate disordered bile acids homeostasis

Ying Xiao, Ya‐qian Jia, Wenjuan Liu, Chun Niu, Zhanhai Mai, Jiaqi Dong, Xiao-song Zhang, Ziwen Yuan, Peng Ji, Yanming Wei, Yongli Hua

Frontiers in Pharmacology

DOI

2024

Screening of polysaccharides from the differently processed products of Angelica sinensis with the best liver protection effect on chicken and the intervention mechanism study based on tandem mass tag proteomics and multiple reaction monitoring approach

Chen‐chen Li, Peng Ji, Jian He, Y.S. Peng, Fanlin Wu, Yongli Hua, Wanling Yao, Ziwen Yuan, Yanming Wei

Biomedical Chromatography

DOI

2024

Shaoyao decoction improves damp-heat colitis by activating the AHR/IL-22/STAT3 pathway through tryptophan metabolism driven by gut microbiota

Yahui Zhang, Luoxia Han, Jiaqi Dong, Ziwen Yuan, Wanling Yao, Peng Ji, Yongli Hua, Yanming Wei

Journal of Ethnopharmacology

DOI

2024

Mechanisms predictive of Tibetan Medicine Sophora moorcroftiana alkaloids for treatment of lung cancer based on the network pharmacology and molecular docking

Peng Ji, Nianshou Zhao, Fanlin Wu, Yanming Wei, Ci-Dan Laba, Cuomu Wujin, Yongli Hua, Ziwen Yuan, Wanling Yao

BMC Complementary Medicine and Therapies

DOI

2023

砂生槐子生物碱对LPS诱导的小鼠急性肺炎的保护作用研究

徐誉彰，武振帅，纪鹏，魏彦明，张文飞，武凡琳，张晓松，任建明，李琛琛，华永丽，姚万玲，袁子文

《动物医学进展》

2023

白头翁汤对C57BL/6小鼠粪便中短链脂肪酸含量的影响

陈宝霞，白珊泽，任建明，周轲，魏彦明，纪鹏，姚万玲，袁子文，华永丽

《中国兽医杂志》

2023

酪蛋白胶束乳液凝胶性质及其在大黄素负载中的应用

瓦文强，秦娟娟，杨敏，魏彦明，袁子文，纪鹏，甄晨波

《食品与发酵工业》

DOI

2023

基于文献和系统药理学的黄连解毒汤治疗溃疡性结肠炎药效物质基础及其作用机制研究

史艳，祝亚梅，蔡燕子，华永丽，纪鹏，魏彦明，袁子文

《中国野生植物资源》

2023

鹳榆止泻颗粒剂的成型工艺优化与质量标准研究

胥晨，纪鹏，马挺，武振帅，张晓松，华永丽，姚万玲，袁子文，王东升，魏彦明

《动物医学进展》

2023

基于高通量测序研究黄芩-连翘配伍对LPS诱导的急性肺炎小鼠肠道菌群的影响

武振帅，徐誉彰，李宏雅，武凡琳，李琛琛，华永丽，姚万玲，袁子文，纪鹏，魏彦明

《动物医学进展》

2023

多指标综合评分法结合正交试验优化黄芪-当归水提物制备工艺

刘文娟，肖莹，买占海，张晓松，周轲，姚万玲，纪鹏，华永丽，袁子文，魏彦明

《动物医学进展》

2023

白头翁汤对溃疡性结肠炎小鼠的作用及对炎性细胞因子的影响

胡肖丽，华永丽，纪鹏，姚万玲，袁子文，魏彦明

《中成药》

2023

基于网络药理学探究党参-甘草提取物增强断奶仔猪免疫功能的作用机制

蔡燕子，袁子文，张兴平，张丰裕，祝亚梅，史艳，姜立冬，华永丽，魏彦明

《中国畜牧兽医》

2023

Exploration of the Potential Mechanism of Yujin Powder Treating Dampness-heat Diarrhea by Integrating UPLC-MS/MS and Network Pharmacology Prediction

Lidong Jiang, Wangdong Zhang, Baoshan Wang, Yan-zi Cai, Xue Zhi. Qin, Wenbo Zhao, Peng Ji, Ziwen Yuan, Yanming Wei, Wanling Yao

Combinatorial Chemistry & High Throughput Screening

DOI

2023

Highly stable emulsion gels with micellar casein based on the jamming transition, for bioactive molecule delivery

Juanjuan Qin, Ziwen Yuan, Jing An, Yan Shi, Jie Zheng, Min Cheol Yang

Food Hydrocolloids

DOI

2022

黄芩-连翘配伍对脂多糖诱导小鼠急性肺炎模型的保护作用

武振帅，纪鹏，魏彦明，徐誉彰，张晓松，武凡琳，任建明，李琛琛，华永丽，姚万玲，袁子文

《中国实验动物学报》

2022

加味玉屏风及其多糖对小鼠免疫功能的影响

李宏雅，纪鹏，魏彦明，买占海，张晓松，周轲，武凡琳，赵年寿，华永丽，姚万玲，袁子文

《动物医学进展》

2022

Regulation of Yujin Powder alcoholic extracts on ILC3s-TD IgA-colonic mucosal flora axis of DSS-induced ulcerative colitis

Yanqiao Wen, Wangdong Zhang, Rong Yang, Lidong Jiang, Xiaosong Zhang, Baoshan Wang, Yongli Hua, Peng Ji, Ziwen Yuan, Yanming Wei, Wanling Yao

Frontiers in Microbiology

DOI

2022

Pulsatilla decoction improves DSS-induced colitis via modulation of fecal-bacteria-related short-chain fatty acids and intestinal barrier integrity

Chun Niu, Xiao-li Hu, Ziwen Yuan, Ying Xiao, Peng Ji, Yanming Wei, Yongli Hua

Journal of Ethnopharmacology

DOI

2022

[Integrated strategy for mechanism of Baitouweng Decoction in treating dampness-heat diarrhea based on urine metabolomics coupled with network pharmacology].

Yongli Hua, Qi Ma, Xiaosong Zhang, Peng Ji, Ziwen Yuan, Yanming Wei

PubMed

DOI

2021

砂生槐子生物碱超声辅助醇提工艺优化

赵年寿，拉巴次旦，纪鹏，武凡琳，魏彦明，吴金措姆，马兴斌，华永丽，姚万玲，袁子文

《动物医学进展》

DOI

2021

黄连及黄连须、黄连茎叶体外抗氧化活性的谱效关系研究

彭晓婷，杨丽宏，袁子文，李航，华永丽，魏彦明

《中兽医医药杂志》

DOI

2021

苦豆子总碱对溃疡性结肠炎小鼠结肠及肝组织中FXR、TGR5、CYP7A1蛋白表达的影响

肖莹，华永丽，贾娅倩，董嘉琪，李芳，魏彦明，袁子文，纪鹏

《天然产物研究与开发》

DOI

2021

Sheng Mai San ameliorated heat stress-induced liver injury via regulating energy metabolism and AMPK/Drp1-dependent autophagy process

Xiaosong Zhang, Ya‐qian Jia, Ziwen Yuan, Yanqiao Wen, Yahui Zhang, Jianmin Ren, Peng Ji, Wanling Yao, Yongli Hua, Yanming Wei

Phytomedicine

DOI

2021

A new method providing complementary explanation of the blood‐enriching function and mechanism of unprocessed Angelica sinensis and its four kinds of processed products based on tissue‐integrated metabolomics and confirmatory analysis

Peng Ji, Chen‐chen Li, Yanming Wei, Yongli Hua, Wanling Yao, Fanlin Wu, Xiao‐song Zhang, Ziwen Yuan, Nianshou Zhao, Yahui Zhang, Yanqiao Wen

Biomedical Chromatography

DOI

2021

Baitouweng Tang ameliorates DSS-induced ulcerative colitis through the regulation of the gut microbiota and bile acids via pathways involving FXR and TGR5

Yongli Hua, Ya‐qian Jia, Xiaosong Zhang, Ziwen Yuan, Peng Ji, Junjie Hu, Yanming Wei

Biomedicine & Pharmacotherapy

DOI

2020

头孢噻呋钠联合脂多糖致雏鸡肝损伤模型的建立

刘胜利，纪鹏，魏彦明，何建，李琛琛，华永丽，姚万玲，张晓松，袁子文

《动物医学进展》

DOI

2020

当归多糖对头孢噻呋钠联合LPS致鸡肝损伤的防治效果

李琛琛，何建，纪鹏，魏彦明，刘胜利，袁子文，张晓松，文艳巧，张亚辉，华永丽，姚万玲

《动物医学进展》

2020

Mechanism of Huang-lian-Jie-du decoction and its effective fraction in alleviating acute ulcerative colitis in mice: Regulating arachidonic acid metabolism and glycerophospholipid metabolism

Ziwen Yuan, Lihong Yang, Xiaosong Zhang, Peng Ji, Yongli Hua, Yanming Wei

Journal of Ethnopharmacology

DOI

2020

Total alkaloids of Sophora alopecuroides L. ameliorated murine colitis by regulating bile acid metabolism and gut microbiota

Ya‐qian Jia, Ziwen Yuan, Xiao-song Zhang, Jiaqi Dong, Xue-nan Liu, Xiao‐ting Peng, Wanling Yao, Peng Ji, Yanming Wei, Yongli Hua

Journal of Ethnopharmacology

DOI

2020

Screening study of blood-supplementing active components in water decoction of Angelica sinensis processed with yellow rice wine based on response surface methodology

Peng Ji, Chenchen Li, Yanming Wei, Fanlin Wu, Shengli Liu, Yongli Hua, Wanling Yao, Xiaosong Zhang, Ziwen Yuan, Yanqiao Wen

Pharmaceutical Biology

DOI

2019

Therapeutic effect of n-butanol fraction of Huang-lian-Jie-du Decoction on ulcerative colitis and its regulation on intestinal flora in colitis mice

Ziwen Yuan, Lihong Yang, Xiaosong Zhang, Peng Ji, Yanming Wei

Biomedicine & Pharmacotherapy

DOI

2019

Huang-Lian-Jie-Du Decoction Ameliorates Acute Ulcerative Colitis in Mice via Regulating NF-κB and Nrf2 Signaling Pathways and Enhancing Intestinal Barrier Function

Ziwen Yuan, Lihong Yang, Xiaosong Zhang, Peng Ji, Yongli Hua, Yanming Wei

Frontiers in Pharmacology

DOI

2019

A novel approach based on metabolomics coupled with network pharmacology to explain the effect mechanisms of Danggui Buxue Tang in anaemia

Yongli Hua, Qi Ma, Ziwen Yuan, Xiaosong Zhang, Wanling Yao, Peng Ji, Junjie Hu, Yanming Wei

Chinese Journal of Natural Medicines

DOI

2018

当归干预血瘀证大鼠血浆代谢组学研究

袁子文，钟立甲，纪鹏，华永丽，姚万玲，马琪，张晓松，文艳巧，魏彦明

《天然产物研究与开发》

2018

苦豆草治疗大肠湿热证大鼠血清代谢组学研究

张晓松，马琪，文艳巧，张亚辉，何建，尹博，姚万玲，袁子文，纪鹏，华永丽，魏彦明

《药学学报》

2018

Metabolomics study on promoting blood circulation and ameliorating blood stasis: Investigating the mechanism of Angelica sinensis and its processed products

Ziwen Yuan, Lijia Zhong, Yongli Hua, Peng Ji, Wanling Yao, Qi Ma, Xiaosong Zhang, Yanqiao Wen, Lihong Yang, Yanming Wei

Biomedical Chromatography

DOI

2018

Urinary metabolomics study the mechanism of Taohong Siwu Decoction intervention in acute blood stasis model rats based on liquid chromatography coupled to quadrupole time-of-flight mass spectrometry

Xiaosong Zhang, Pengling Li, Yongli Hua, Peng Ji, Wanling Yao, Qi Ma, Ziwen Yuan, Yanqiao Wen, Chaoxue Yang, Yanming Wei

Journal of Chromatography B

DOI

2017

A novel approach using metabolomics coupled with hematological and biochemical parameters to explain the enriching-blood effect and mechanism of unprocessed Angelica sinensis and its 4 kinds of processed products

Peng Ji, Yanming Wei, Yongli Hua, Xiaosong Zhang, Wanling Yao, Qi Ma, Ziwen Yuan, Yanqiao Wen, Chaoxue Yang

Journal of Ethnopharmacology

DOI

精选作品

期刊论文

正交试验结合G1-熵权法优选补中益气散水提物的制备工艺

油当归水提物治疗小鼠便秘效果评价及对肠道相关指标的影响

Mechanism of liquiritin from Codonopsis pilosula-Glycyrrhiza uralensis extract in alleviating piglet weaning stress via binding to alpha-1-microglobulin/bikunin precursor by machine learning and molecular dynamics simulation

ShenQiGan Extract Mitigates Intestinal Oxidative Stress in Weaned Piglets Through Bile Acid Metabolism Regulation and Gut Microbiota Remodeling via the Nrf2/Keap1 Pathway

桔梗-甘草配伍对脂多糖诱导小鼠急性肺损伤的保护作用

黄芩泻白散中8种活性成分的高效液相色谱法测定

仔猪腹泻大肠杆菌的分离鉴定及黄连解毒汤对其致病性的影响

Characteristics of Coassembling Nanoparticles Based on Oleanolic Acid and Glycyrrhetinic Acid/Caffeic Acid Phenethyl Ester

Shaoyao decoction promotes ISCs proliferation by activating Wnt/β-catenin and YAP1/TAZ signaling to enhance epithelial regeneration in damp-heat colitis

ShenQiGan Extract Repairs Intestinal Barrier in Weaning-Stressed Piglets by Modulating Inflammatory Factors, Immunoglobulins, and Short-Chain Fatty Acids

基于系统药理学的柴胡防治非酒精性脂肪肝作用机制研究

The impact of Codonopsis Pilosulae and Astragalus Membranaceus extract on growth performance, immunity function, antioxidant capacity and intestinal development of weaned piglets

Exploring the Potential Role of Sophora alopecuroides L. in Inflammation of Bovine Mammary Epithelial Cells Induced by Lipoteichoic Acid Based on Network Pharmacology and Experimental Validation

Pulsatilla decoction alleviates DSS-induced UC by activating FXR-ASBT pathways to ameliorate disordered bile acids homeostasis

Screening of polysaccharides from the differently processed products of Angelica sinensis with the best liver protection effect on chicken and the intervention mechanism study based on tandem mass tag proteomics and multiple reaction monitoring approach

Shaoyao decoction improves damp-heat colitis by activating the AHR/IL-22/STAT3 pathway through tryptophan metabolism driven by gut microbiota

Mechanisms predictive of Tibetan Medicine Sophora moorcroftiana alkaloids for treatment of lung cancer based on the network pharmacology and molecular docking

砂生槐子生物碱对LPS诱导的小鼠急性肺炎的保护作用研究

白头翁汤对C57BL/6小鼠粪便中短链脂肪酸含量的影响

酪蛋白胶束乳液凝胶性质及其在大黄素负载中的应用

基于文献和系统药理学的黄连解毒汤治疗溃疡性结肠炎药效物质基础及其作用机制研究

鹳榆止泻颗粒剂的成型工艺优化与质量标准研究

基于高通量测序研究黄芩-连翘配伍对LPS诱导的急性肺炎小鼠肠道菌群的影响

多指标综合评分法结合正交试验优化黄芪-当归水提物制备工艺

白头翁汤对溃疡性结肠炎小鼠的作用及对炎性细胞因子的影响

基于网络药理学探究党参-甘草提取物增强断奶仔猪免疫功能的作用机制

Exploration of the Potential Mechanism of Yujin Powder Treating Dampness-heat Diarrhea by Integrating UPLC-MS/MS and Network Pharmacology Prediction

Highly stable emulsion gels with micellar casein based on the jamming transition, for bioactive molecule delivery

黄芩-连翘配伍对脂多糖诱导小鼠急性肺炎模型的保护作用

加味玉屏风及其多糖对小鼠免疫功能的影响

Regulation of Yujin Powder alcoholic extracts on ILC3s-TD IgA-colonic mucosal flora axis of DSS-induced ulcerative colitis

Pulsatilla decoction improves DSS-induced colitis via modulation of fecal-bacteria-related short-chain fatty acids and intestinal barrier integrity

[Integrated strategy for mechanism of Baitouweng Decoction in treating dampness-heat diarrhea based on urine metabolomics coupled with network pharmacology].

砂生槐子生物碱超声辅助醇提工艺优化

黄连及黄连须、黄连茎叶体外抗氧化活性的谱效关系研究

苦豆子总碱对溃疡性结肠炎小鼠结肠及肝组织中FXR、TGR5、CYP7A1蛋白表达的影响

Sheng Mai San ameliorated heat stress-induced liver injury via regulating energy metabolism and AMPK/Drp1-dependent autophagy process

A new method providing complementary explanation of the blood‐enriching function and mechanism of unprocessed Angelica sinensis and its four kinds of processed products based on tissue‐integrated metabolomics and confirmatory analysis

Baitouweng Tang ameliorates DSS-induced ulcerative colitis through the regulation of the gut microbiota and bile acids via pathways involving FXR and TGR5

头孢噻呋钠联合脂多糖致雏鸡肝损伤模型的建立

当归多糖对头孢噻呋钠联合LPS致鸡肝损伤的防治效果

Mechanism of Huang-lian-Jie-du decoction and its effective fraction in alleviating acute ulcerative colitis in mice: Regulating arachidonic acid metabolism and glycerophospholipid metabolism

Total alkaloids of Sophora alopecuroides L. ameliorated murine colitis by regulating bile acid metabolism and gut microbiota

Screening study of blood-supplementing active components in water decoction of Angelica sinensis processed with yellow rice wine based on response surface methodology

Therapeutic effect of n-butanol fraction of Huang-lian-Jie-du Decoction on ulcerative colitis and its regulation on intestinal flora in colitis mice

Huang-Lian-Jie-Du Decoction Ameliorates Acute Ulcerative Colitis in Mice via Regulating NF-κB and Nrf2 Signaling Pathways and Enhancing Intestinal Barrier Function

A novel approach based on metabolomics coupled with network pharmacology to explain the effect mechanisms of Danggui Buxue Tang in anaemia

当归干预血瘀证大鼠血浆代谢组学研究

苦豆草治疗大肠湿热证大鼠血清代谢组学研究

Metabolomics study on promoting blood circulation and ameliorating blood stasis: Investigating the mechanism of Angelica sinensis and its processed products

Urinary metabolomics study the mechanism of Taohong Siwu Decoction intervention in acute blood stasis model rats based on liquid chromatography coupled to quadrupole time-of-flight mass spectrometry

A novel approach using metabolomics coupled with hematological and biochemical parameters to explain the enriching-blood effect and mechanism of unprocessed Angelica sinensis and its 4 kinds of processed products

研究方向