关岚｜中南大学｜学者主页

2026

根皮素通过激活PPARγ/PGC-1α信号通路减轻镉诱导的小鼠心脏损伤

谢欢欢，关岚，谢青，骆检兰，曾方明，曾明

《中国病理生理杂志》

2026

SiO2 dust induces the transformation of lung fibroblasts to myofibroblasts by activating the S1P-RhoA-YAP signaling pathway

Hualing Zhang, Fangcai Huang, Lan Guan, Ming Zeng

Toxicology in Vitro

DOI

2025

[Review] The association between cadmium exposure and the risk of early liver disease: A systematic review and meta-analysis

Hualing Zhang, Yue Jing, Lan Guan, Jianlan Luo, Ming Zeng

Regulatory Toxicology And Pharmacology，Vol. 163

DOI

2025

镉暴露与心血管疾病关联的meta分析

谢欢欢，关岚，曾明，骆检兰

《环境与职业医学》

2024

PAT exposure caused human hepatocytes apoptosis and induced mice subacute liver injury by activating oxidative stress and the ERS-associated PERK pathway.

Hualing Zhang, Meng Tang, Qin Liu, Die Wu, Bing Sun, Jingbang Dong, Lan Guan, Jianlan Luo, Ming Zeng

Science of the Total Environment

DOI

2023

PI3K/Akt/mTOR通路介导巨噬细胞自噬影响矽尘致肺成纤维细胞表型转化

杜悦，黄芳财，关岚，曾明

《中南大学学报(医学版)》

2023

MiR-30a inhibits silica dust-induced epithelial-mesenchymal transition by targeting Snail

Fangcai Huang, Yupei Li, Lan Guan, Yuming Hu, Ming Zeng

Toxicology in Vitro

DOI

2023

Role of PI3K/Akt/mTOR pathway-mediated macrophage autophagy in affecting the phenotype transformation of lung fibroblasts induced by silica dust exposure.

Yue Du, Fangcai Huang, Lan Guan, Ming Zeng

PubMed

DOI

2023

SiO2 dust induces inflammation and pulmonary fibrosis in rat lungs through activation of ASMase /ceramide pathway

Fangcai Huang, Yue Du, Xiang‐fei Zhang, Lan Guan, Xinmin Liu, Ming Zeng

Journal of Applied Toxicology

DOI

2022

PM2.5混悬液对3种癌细胞侵袭和迁移能力的影响

李柏茹，秦双建，蔡颖，李闰冰，关岚，肖芳，曾明，徐新云

《癌变·畸变·突变》

2022

基于问题导向的毒理学基础实验教学模式探讨

郭蓉，曾明，关岚，叶淑姿，唐思璇，肖芳

《实验室研究与探索》

DOI

2022

Combined intervention with N-acetylcysteine and desipramine alleviated silicosis development by regulating the Nrf2/HO-1 and ASMase/ceramide signaling pathways

Meng Tang, Zhihui Yang, Jing Liu, Xiangfei Zhang, Lan Guan, Xinming Liu, Ming Zeng

Ecotoxicology and Environmental Safety

DOI

2022

Chlorpyrifos residue level and ADHD among children aged 1–6 years in rural China: A cross-sectional study

Wenjuan Zhou, Yuanying Deng, Chen Zhang, Hongmei Dai, Lan Guan, Xiangwen Luo, Wei He, Jing Tian, Lingling Zhao

Frontiers in Pediatrics

DOI

2021

PM2.5对HK-2细胞氧化损伤和凋亡的影响

李柏茹，秦双建，关岚，李闰冰，蔡颖，蒲桔宁，曾明，肖芳，徐新云

《癌变·畸变·突变》

2021

SiO2 stimulates macrophage stress to induce the transformation of lung fibroblasts into myofibroblasts and its relationship with the sphingomyelin metabolic pathway

Jing Liu, Lan Guan, Er‐Jin Wang, Edward Howard Schuchman, Xingxuan He, Ming Zeng

Journal of Applied Toxicology

DOI

2020

丹参提取物对铅中毒小鼠肾氧化应激的保护作用

曹春芽，龚明，仇成凤，王安，关岚，刘新民

《中成药》

2019

Knowledge and behavior regarding pesticide use: a survey among caregivers of children aged 1–6 years from rural China

Yuanying Deng, Hongmei Dai, Ming Zeng, Lan Guan, Xiangwen Luo, Chen Zhang, Jing Tian, Jie Zhang, Ying Li, Qiong Xi, Mengwen Zhao, Mei L. Jiang, Lingling Zhao

Environmental Science and Pollution Research

DOI

2018

二氧化硫对脓毒症致急性肺损伤大鼠炎症反应的抑制作用

关岚，刘志伟，黄冬梅，赵斌

《北京医学》

DOI

2018

雪峰虫草超微粉Ⅰ段生殖毒性试验研究

肖志勇，刘新民，关岚，李海钢，王安

《湖南师范大学学报(医学版)》

2018

The role of IP3R-SOCCs in Cr( vi )-induced cytosolic Ca2+ overload and apoptosis in L-02 hepatocytes

Qi Liang, Yujing Zhang, Ming Zeng, Lan Guan, Yuanyuan Xiao, Fang Xiao

Toxicology Research

DOI

2015

3%苦参碱水剂致突变作用研究

谢贵元，关岚，刘新民，王安

《湖南师范大学学报(医学版)》

2014

酸性鞘磷脂酶在二氧化硅致小鼠胚肺成纤维细胞纤维化体外模型中的作用

金丰，蒋盛威，曾明，何兴轩，Edward H SCHUCHMAN，王安，罗磊，王傅，肖芳，关岚，刘新民，钟才高

《中国药理学与毒理学杂志》

2014

草甘膦对GC-1小鼠精原细胞的毒性作用及N-乙酰半胱氨酸的干预效应

曾明，黄婷，易吉平，钟才高，关岚，王安，刘新民

《生态毒理学报》

2014

10%浏阳霉素乳剂对肝细胞线粒体损伤效应的研究

刘新民，钟才高，曾明，关岚，谢颖，肖芳

《卫生研究》

2013

Time-order effects of vitamin C on hexavalent chromium-induced mitochondrial damage and DNA-protein crosslinks in cultured rat peripheral blood lymphocytes

Fang Xiao, DONGFANG CHEN, Lei Luo, Xiali Zhong, Ying Xie, Lianhong Zou, Ming Zeng, Lan Guan, Caigao Zhong

Molecular Medicine Reports

DOI

2013

Reactive Oxygen Species Play a Central Role in Hexavalent Chromium-Induced Apoptosis in Hep3B Cells without the Functional Roles of p53 and Caspase-3

Ming Zeng, Fang Xiao, Xiali Zhong, Feng Jin, Lan Guan, An Wang, Xinmin Liu, Caigao Zhong

Cellular Physiology and Biochemistry

DOI

2012

hOGG1基因在Cr(Ⅵ)诱导线粒体DNA氧化损伤中的作用

李鹏，钟才高，王安，关岚，肖芳，邹悦，杨渊

《卫生研究》

2012

赤霉素对雌性大鼠早期生长发育及胰岛素样生长因子表达水平的影响

关岚，张喆，钟才高，刘新民，王安，曾明

《卫生研究》

2012

Hexavalent chromium induces energy metabolism disturbance and p53-dependent cell cycle arrest via reactive oxygen species in L-02 hepatocytes

Fang Xiao, Xiaotao Feng, Ming Zeng, Lan Guan, Qingqing Hu, Caigao Zhong

Molecular and Cellular Biochemistry

DOI

2012

[Effects of gibberellins on early development and IGF-1 expression in female rats].

Lan Guan, Zhe Zhang, 钟才高, Xinmin Liu, An Wang, Ming Zeng

PubMed

2012

WITHDRAWN: Hexavalent chromium induces premature senescence through reactive oxygen species-mediated p53 pathway in L-02 hepatocytes

Fang Xiao, Qingqing Hu, Ming Zeng, Lan Guan, Xinmin Liu, Yang Yuan, Caigao Zhong

Biochemical and Biophysical Research Communications

DOI

2012

Cr(VI) induces the decrease of ATP level and the increase of apoptosis rate mediated by ROS or VDAC1 in L-02 hepatocytes

Yang Yuan, Zen Ming, Gonghua Hu, Guan Lan, Dai Lu, Li Peng, Jing Feng, Caigao Zhong

Environmental Toxicology and Pharmacology

DOI

2010

环境卷烟烟雾对大鼠血脂水平及脂代谢酶的影响

曾明，黄婷，关岚

《环境与健康杂志》

2010

赤霉素对大鼠肝细胞线粒体呼吸功能的影响

邓媛媛，钟才高，关岚，陈晶，肖芳

《卫生研究》

2010

甲醛对雌性大鼠卵巢储备功能的影响

彭国庆，钟才高，张琼，关岚，余剑英，肖芳

《癌变·畸变·突变》

2008

香烟烟雾水溶性提取物对肝细胞线粒体的损伤

王黎明，钟才高，张洪霞，关岚

《毒理学杂志》

2006

杀螟丹对小鼠精子的毒性作用

武红叶，曾明，关岚，陈东方，廖春华，钟才高

《毒理学杂志》

2006

维生素C对Cr(Ⅵ)诱导大鼠淋巴细胞DNA-蛋白质交联的时序效应

陈东方，钟才高，安飞云，关岚，刘新民，潘新亮

《毒理学杂志》

2005

硒在Cr(Ⅵ)诱导肝细胞氧化应激中的作用

钟才高，曹赫，张洪霞，关岚

《毒理学杂志》

2005

乐果对小鼠骨骼肌细胞毒性作用及凋亡的诱导

曾明，路嘉宏，张才云，武红叶，安飞云，关岚

《中国公共卫生》

精选作品

期刊论文

根皮素通过激活PPARγ/PGC-1α信号通路减轻镉诱导的小鼠心脏损伤

SiO2 dust induces the transformation of lung fibroblasts to myofibroblasts by activating the S1P-RhoA-YAP signaling pathway

[Review] The association between cadmium exposure and the risk of early liver disease: A systematic review and meta-analysis

镉暴露与心血管疾病关联的meta分析

PAT exposure caused human hepatocytes apoptosis and induced mice subacute liver injury by activating oxidative stress and the ERS-associated PERK pathway.

PI3K/Akt/mTOR通路介导巨噬细胞自噬影响矽尘致肺成纤维细胞表型转化

MiR-30a inhibits silica dust-induced epithelial-mesenchymal transition by targeting Snail

Role of PI3K/Akt/mTOR pathway-mediated macrophage autophagy in affecting the phenotype transformation of lung fibroblasts induced by silica dust exposure.

SiO2 dust induces inflammation and pulmonary fibrosis in rat lungs through activation of ASMase /ceramide pathway

PM2.5混悬液对3种癌细胞侵袭和迁移能力的影响

基于问题导向的毒理学基础实验教学模式探讨

Combined intervention with N-acetylcysteine and desipramine alleviated silicosis development by regulating the Nrf2/HO-1 and ASMase/ceramide signaling pathways

Chlorpyrifos residue level and ADHD among children aged 1–6 years in rural China: A cross-sectional study

PM2.5对HK-2细胞氧化损伤和凋亡的影响

SiO2 stimulates macrophage stress to induce the transformation of lung fibroblasts into myofibroblasts and its relationship with the sphingomyelin metabolic pathway

丹参提取物对铅中毒小鼠肾氧化应激的保护作用

Knowledge and behavior regarding pesticide use: a survey among caregivers of children aged 1–6 years from rural China

二氧化硫对脓毒症致急性肺损伤大鼠炎症反应的抑制作用

雪峰虫草超微粉Ⅰ段生殖毒性试验研究

The role of IP3R-SOCCs in Cr( vi )-induced cytosolic Ca2+ overload and apoptosis in L-02 hepatocytes

3%苦参碱水剂致突变作用研究

酸性鞘磷脂酶在二氧化硅致小鼠胚肺成纤维细胞纤维化体外模型中的作用

草甘膦对GC-1小鼠精原细胞的毒性作用及N-乙酰半胱氨酸的干预效应

10%浏阳霉素乳剂对肝细胞线粒体损伤效应的研究

Time-order effects of vitamin C on hexavalent chromium-induced mitochondrial damage and DNA-protein crosslinks in cultured rat peripheral blood lymphocytes

Reactive Oxygen Species Play a Central Role in Hexavalent Chromium-Induced Apoptosis in Hep3B Cells without the Functional Roles of p53 and Caspase-3

hOGG1基因在Cr(Ⅵ)诱导线粒体DNA氧化损伤中的作用

赤霉素对雌性大鼠早期生长发育及胰岛素样生长因子表达水平的影响

Hexavalent chromium induces energy metabolism disturbance and p53-dependent cell cycle arrest via reactive oxygen species in L-02 hepatocytes

[Effects of gibberellins on early development and IGF-1 expression in female rats].

WITHDRAWN: Hexavalent chromium induces premature senescence through reactive oxygen species-mediated p53 pathway in L-02 hepatocytes

Cr(VI) induces the decrease of ATP level and the increase of apoptosis rate mediated by ROS or VDAC1 in L-02 hepatocytes

环境卷烟烟雾对大鼠血脂水平及脂代谢酶的影响

赤霉素对大鼠肝细胞线粒体呼吸功能的影响

甲醛对雌性大鼠卵巢储备功能的影响

香烟烟雾水溶性提取物对肝细胞线粒体的损伤

杀螟丹对小鼠精子的毒性作用

维生素C对Cr(Ⅵ)诱导大鼠淋巴细胞DNA-蛋白质交联的时序效应

硒在Cr(Ⅵ)诱导肝细胞氧化应激中的作用

乐果对小鼠骨骼肌细胞毒性作用及凋亡的诱导

会议论文

SiO 2 致NIH3T3细胞纤维化与ASMase/Cer信号通路的关系及rAC的干预效应

尘肺患者鞘磷脂类信号通路物质的表达及相关性研究

ROS依赖性p53活化在Cr(Ⅵ)诱导的肝细胞早衰中的作用研究

预印本

Puerarin Alleviates Acetaminophen-Induced Subacute Liver Injury in Mice by Activating the Pi3k/Akt Signaling Pathway

研究方向