刘北东｜浙江农林大学｜学者主页

2026

Label-Free Target Discovery Strategy for Natural Active Products

Shang Lei, Yujia Chen, Xiu-Ling Cao, Xuejiao Jin, Beidong Liu

Biomolecules

DOI

2026

Trr1 (thioredoxin reductase 1) modulates ERphagy in aging via liquid-liquid phase separation.

Yuan Gao, Jing-Yi Zhao, Xiangdong Hu, Per Sunnerhagen, Bei-Dong Liu

Autophagy

DOI

2025

Stress granule formation is regulated by signaling machinery involving Sch9/Ypk1, sphingolipids, and Ubi4

Lihua Chen, Yuan Gao, Xin-Xin Hao, Xiao-Xue Yang, Michelle Lindström, Sha Jiang, Xiu-Ling Cao, Hui-Sheng Liu, T. Nyström, Per Sunnerhagen, Bei-Dong Liu

Theranostics

DOI

2025

Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

Xiuling Cao, Xiang Wu, Lei Zhao, Ju Zheng, Xuejiao Jin, Xinxin Hao, Joris Winderickx, Shenkui Liu, Lihua Chen, Beidong Liu

eLife

DOI

2024

Unveiling the Longevity Potential of Natural Phytochemicals: A Comprehensive Review of Active Ingredients in Dietary Plants and Herbs

Yu Wang, Xiu-Ling Cao, Jin Ma, Shen-Kui Liu, Xuejiao Jin, Beidong Liu

Journal of Agricultural and Food Chemistry

DOI

2023

The yeast guanine nucleotide exchange factor Sec7 is a bottleneck in spatial protein quality control and detoxifies neurological disease proteins

Roja Babazadeh, K. Schneider, Arthur Fischbach, Xin-Xin Hao, Bei-Dong Liu, T. Nystrom

Scientific Reports

DOI

2023

Metabolomics in aging research: aging markers from organs

Weicheng Fang, Shuxin Chen, Xuejiao Jin, Shen-Kui Liu, Xiu-Ling Cao, Bei-Dong Liu

Frontiers in Cell and Developmental Biology

DOI

2023

Calmodulin regulates protease versus co-chaperone activity of a metacaspase.

Anna Maria Eisele-Bürger, F. Eisele, Sandra Malmgren Hill, Xin-Xin Hao, K. Schneider, Rahmi Imamoglu, D. Balchin, Bei-Dong Liu, F. Hartl, P. Bozhkov, T. Nyström

Cell Reports

DOI

2023

The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae

R. Josefson, Navinder Kumar, Xin-Xin Hao, Bei-Dong Liu, T. Nyström

Scientific Reports

DOI

2023

Targeting Protein Aggregates with Natural Products: An Optional Strategy for Neurodegenerative Diseases

Lingzhi Xiang, Yanan Wang, Shen-Kui Liu, Bei-Dong Liu, Xuejiao Jin, Xiu-Ling Cao

International Journal of Molecular Sciences

DOI

2022

Lsm7 phase-separated condensates trigger stress granule formation

Michelle Lindström, Lihua Chen, Shan Jiang, Dan Zhang, Yuan Gao, Ju Zheng, Xin-Xin Hao, Xiao-Xue Yang, Arpitha Kabbinale, Johannes Thoma, L. C. Metzger, De-Yuan Y. Zhang, Xuefeng Zhu, Hui-Sheng Liu, C. Gustafsson, B. Burmann, J. Winderickx, P. Sunnerhagen, Bei-Dong Liu

Nature Communications

DOI

2022

The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator

Xiangdong Hu, Xuejiao Jin, Xiu-Ling Cao, Bei-Dong Liu

International Journal of Molecular Sciences

DOI

2022

Effects of pH alterations on stress- and aging-induced protein phase separation

Xuejiao Jin, Min Zhou, Shuxin Chen, Dan-Qi Li, Xiu-Ling Cao, Bei-Dong Liu

Cellular and Molecular Life Sciences

DOI

2021

Genome-Wide Imaging-Based Phenomic Screening Using Yeast (Saccharomyces cerevisiae) Strain Collections.

Xiu-Ling Cao, Xuejiao Jin, Bei-Dong Liu

Methods in molecular biology

DOI

2021

An Hsp90 co-chaperone links protein folding and degradation and is part of a conserved protein quality control.

F. Eisele, Anna Maria Eisele-Bürger, Xin-Xin Hao, L. Berglund, J. Höög, Bei-Dong Liu, T. Nyström

Cell Reports

DOI

2021

Editorial: The Dynamics of Stress Granules

Subhash Mehto, Bei-Dong Liu, Ronggui Hu, S. Chauhan

Frontiers in Cell and Developmental Biology

DOI

2021

Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and toxicity

Stefanie Andersson, A. Romero, J. I. Rodrigues, Sansan Hua, Xin-Xin Hao, Therese Jacobson, V. Karl, N. Becker, A. Ashouri, S. Rauch, T. Nyström, Bei-Dong Liu, Markus J. Tamás

Journal of Cell Science

DOI

2021

Functional Roles of Poly(ADP-Ribose) in Stress Granule Formation and Dynamics

Xuejiao Jin, Xiu-Ling Cao, Shen-Kui Liu, Bei-Dong Liu

Frontiers in Cell and Developmental Biology

DOI

2021

Isolation of Aged Yeast Cells Using Biotin-Streptavidin Affinity Purification.

Xuejiao Jin, Xiu-Ling Cao, Bei-Dong Liu

Methods in molecular biology

DOI

2020

The involvement of stress granules in aging and aging‐associated diseases

Xiu-Ling Cao, Xuejiao Jin, Bei-Dong Liu

Aging Cell

DOI

2020

Protein phase separation and its role in tumorigenesis

Shan Jiang, J. Fagman, Changyan Chen, S. Alberti, Bei-Dong Liu

eLife

DOI

2019

Syntaxin 5 Is Required for the Formation and Clearance of Protein Inclusions during Proteostatic Stress.

Roja Babazadeh, Doryaneh Ahmadpour, Song Jia, Xin-Xin Hao, P. Widlund, K. Schneider, F. Eisele, L. D. Edo, G. Smits, Bei-Dong Liu, T. Nystrom

Cell Reports

DOI

2018

Yeast as a Model to Unravel Mechanisms Behind FUS Toxicity in Amyotrophic Lateral Sclerosis

Michelle Lindström, Bei-Dong Liu

Frontiers in Molecular Neuroscience

DOI

2018

A Mitochondria-Associated Oxidative Stress Perspective on Huntington’s Disease

Ju Zheng, J. Winderickx, V. Franssens, Bei-Dong Liu

Frontiers in Molecular Neuroscience

DOI

2017

Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1.

Ju Zheng, Jun-Sheng Yang, Young-Jun Choe, Xin-Xin Hao, Xiu-Ling Cao, Qian Zhao, Yue-Jie Zhang, V. Franssens, F. Hartl, T. Nyström, J. Winderickx, Bei-Dong Liu

Biochemical and Biophysical Research Communications - BBRC

DOI

2017

Yeast buddies helping to unravel the complexity of neurodegenerative disorders.

Gernot Fruhmann, David Seynnaeve, Ju Zheng, Karen Ven, Sofie Molenberghs, T. Wilms, Bei-Dong Liu, J. Winderickx, V. Franssens

Mechanisms of Ageing and Development

DOI

2017

Differential effects of soluble and aggregating polyQ proteins on cytotoxicity and type-1 myosin-dependent endocytosis in yeast

L. Berglund, Xin-Xin Hao, Bei-Dong Liu, J. Grantham, T. Nyström

Scientific Reports

DOI

2017

Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases

Lihua Chen, Bei-Dong Liu

Oxidative Medicine and Cellular Longevity

DOI

2016

Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins.

Sarah Hanzén, Katarina Vielfort, Jun-Sheng Yang, Friederike Roger, Veronica Andersson, Sara Zamarbide-Forés, Rebecca Andersson, Lisa Malm, G. Palais, B. Biteau, Bei-Dong Liu, M. Toledano, Mikael Molin, T. Nyström

Cell

DOI

2016

A genome-wide imaging-based screening to identify genes involved in synphilin-1 inclusion formation in Saccharomyces cerevisiae

Lei Zhao, Qian Yang, Ju Zheng, Xuefeng Zhu, Xin-Xin Hao, Jia Song, Tom Lebacq, V. Franssens, J. Winderickx, T. Nystrom, Bei-Dong Liu

Scientific Reports

DOI

2016

Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions

S. M. Hill, Xin-Xin Hao, Johan Grönvall, Stephanie Spikings-Nordby, P. Widlund, T. Amen, Anna Jörhov, R. Josefson, Daniel Kaganovich, Bei-Dong Liu, T. Nyström

Cell Reports

DOI

2016

Author response: Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex

Jun-Sheng Yang, Xin-Xin Hao, Xiu-Ling Cao, Bei-Dong Liu, T. Nyström

DOI

2016

Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex

Jun-Sheng Yang, Xin-Xin Hao, Xiu-Ling Cao, Bei-Dong Liu, T. Nyström

eLife

DOI

2016

The RQC machinery is involved in managing mutant huntintin protein nuclear localization

Ju Zheng, T. Nyström, Jun-Sheng Yang, Xin-Xin Hao, V. Franssens, J. Winderickx, Bei-Dong Liu

2015

Mediator tail subunits can form amyloid-like aggregates in vivo and affect stress response in yeast

Xuefeng Zhu, Lihua Chen, Jonas O. P. Carlsten, Qian Liu, Jun-Sheng Yang, Bei-Dong Liu, C. Gustafsson

Nucleic Acids Research

DOI

2014

Life-span extension by a metacaspase in the yeast Saccharomyces cerevisiae

S. M. Hill, Xin-Xin Hao, Bei-Dong Liu, T. Nyström

Science

DOI

2014

Essential Genetic Interactors of SIR2 Required for Spatial Sequestration and Asymmetrical Inheritance of Protein Aggregates

Jia Song, Qian Yang, Jun-Sheng Yang, L. Larsson, Xin-Xin Hao, Xuefeng Zhu, Sandra Malmgren-Hill, M. Cvijovic, J. Fernandez-Rodriguez, J. Grantham, C. Gustafsson, Bei-Dong Liu, T. Nyström

PLoS Genetics

DOI

2014

The mystery of aging and rejuvenation - a budding topic.

T. Nyström, Bei-Dong Liu

Current Opinion in Microbiology

DOI

2014

The Yin and Yang of a metacaspase

Bei-Dong Liu

Cell Cycle

DOI

2014

Protein quality control in time and space - links to cellular aging.

T. Nyström, Bei-Dong Liu

FEMS Yeast Research

DOI

2014

Stress Granule-Defective Mutants Deregulate Stress Responsive Transcripts

Xiaoxu Yang, Yi Shen, E. Garre, Xin-Xin Hao, Daniel Krumlinde, M. Cvijovic, Christina E. Arens, T. Nyström, Bei-Dong Liu, Per Sunnerhagen

PLoS Genetics

DOI

2013

Enhancing protein disaggregation restores proteasome activity in aged cells

Veronica Andersson, Sarah Hanzén, Bei-Dong Liu, Mikael Molin, T. Nyström

Aging

DOI

2011

Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing.

Antonio Caballero, A. Ugidos, Bei-Dong Liu, David Öling, Kristian Kvint, Xin-Xin Hao, Cora A Mignat, L. Nachin, Mikael Molin, T. Nyström

Molecules and Cells

DOI

2011

Mediator Influences Telomeric Silencing and Cellular Life Span

Xuefeng Zhu, Bei-Dong Liu, Jonas O. P. Carlsten, Jenny Béve, T. Nyström, L. Myers, C. Gustafsson

Molecular and Cellular Biology

DOI

2010

The polarisome is required for segregation and retrograde transport of protein aggregates.

Bei-Dong Liu, L. Larsson, Antonio Caballero, Xin-Xin Hao, David Oling, J. Grantham, T. Nyström

Cell

DOI

精选作品

期刊论文

Label-Free Target Discovery Strategy for Natural Active Products

Trr1 (thioredoxin reductase 1) modulates ERphagy in aging via liquid-liquid phase separation.

Stress granule formation is regulated by signaling machinery involving Sch9/Ypk1, sphingolipids, and Ubi4

Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

Unveiling the Longevity Potential of Natural Phytochemicals: A Comprehensive Review of Active Ingredients in Dietary Plants and Herbs

The yeast guanine nucleotide exchange factor Sec7 is a bottleneck in spatial protein quality control and detoxifies neurological disease proteins

Metabolomics in aging research: aging markers from organs

Calmodulin regulates protease versus co-chaperone activity of a metacaspase.

The GET pathway is a major bottleneck for maintaining proteostasis in Saccharomyces cerevisiae

Targeting Protein Aggregates with Natural Products: An Optional Strategy for Neurodegenerative Diseases

Lsm7 phase-separated condensates trigger stress granule formation

The Anaphase-Promoting Complex/Cyclosome Is a Cellular Ageing Regulator

Effects of pH alterations on stress- and aging-induced protein phase separation

Genome-Wide Imaging-Based Phenomic Screening Using Yeast (Saccharomyces cerevisiae) Strain Collections.

An Hsp90 co-chaperone links protein folding and degradation and is part of a conserved protein quality control.

Editorial: The Dynamics of Stress Granules

Genome-wide imaging screen uncovers molecular determinants of arsenite-induced protein aggregation and toxicity

Functional Roles of Poly(ADP-Ribose) in Stress Granule Formation and Dynamics

Isolation of Aged Yeast Cells Using Biotin-Streptavidin Affinity Purification.

The involvement of stress granules in aging and aging‐associated diseases

Protein phase separation and its role in tumorigenesis

Syntaxin 5 Is Required for the Formation and Clearance of Protein Inclusions during Proteostatic Stress.

Yeast as a Model to Unravel Mechanisms Behind FUS Toxicity in Amyotrophic Lateral Sclerosis

A Mitochondria-Associated Oxidative Stress Perspective on Huntington’s Disease

Role of the ribosomal quality control machinery in nucleocytoplasmic translocation of polyQ-expanded huntingtin exon-1.

Yeast buddies helping to unravel the complexity of neurodegenerative disorders.

Differential effects of soluble and aggregating polyQ proteins on cytotoxicity and type-1 myosin-dependent endocytosis in yeast

Relationships between Stress Granules, Oxidative Stress, and Neurodegenerative Diseases

Lifespan Control by Redox-Dependent Recruitment of Chaperones to Misfolded Proteins.

A genome-wide imaging-based screening to identify genes involved in synphilin-1 inclusion formation in Saccharomyces cerevisiae

Asymmetric Inheritance of Aggregated Proteins and Age Reset in Yeast Are Regulated by Vac17-Dependent Vacuolar Functions

Author response: Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex

Spatial sequestration and detoxification of Huntingtin by the ribosome quality control complex

The RQC machinery is involved in managing mutant huntintin protein nuclear localization

Mediator tail subunits can form amyloid-like aggregates in vivo and affect stress response in yeast

Life-span extension by a metacaspase in the yeast Saccharomyces cerevisiae

Essential Genetic Interactors of SIR2 Required for Spatial Sequestration and Asymmetrical Inheritance of Protein Aggregates

The mystery of aging and rejuvenation - a budding topic.

The Yin and Yang of a metacaspase

Protein quality control in time and space - links to cellular aging.

Stress Granule-Defective Mutants Deregulate Stress Responsive Transcripts

Enhancing protein disaggregation restores proteasome activity in aged cells

Absence of mitochondrial translation control proteins extends life span by activating sirtuin-dependent silencing.

Mediator Influences Telomeric Silencing and Cellular Life Span

The polarisome is required for segregation and retrograde transport of protein aggregates.

研究方向