张晓坤｜厦门大学｜学者主页

2025

RXRα modulates hepatic stellate cell activation and liver fibrosis by targeting CaMKKβ–AMPKα axis

Lijun Cai, Meimei Yin, Shuangzhou Peng, Lin Fen, Liangliang Lai, Xindao Zhang, Xindao Zhang, Lei Xie, Chuanying Wang, Huiying Zhou, Yunfeng Zhan, Gulimiran Alitongbieke, Baohuan Lian, Zhibin Su, Tenghui Liu, Yuqi Zhou, Zongxi Li, Xiaohui Chen, Qi Zhao, Ting Deng, Lulu Chen, Jingwei Su, Luoyan Sheng, Ying Su, Ling-Juan Zhang, Fu-Quan Jiang, Xiao-kun Zhang, Xiao-kun Zhang

Acta Pharmaceutica Sinica B

精选作品

期刊论文

RXRα modulates hepatic stellate cell activation and liver fibrosis by targeting CaMKKβ–AMPKα axis

Dual Sentiment-aware Networks for Adverse Drug Reactions Detection

Endocytic activation and exosomal secretion of matriptase stimulate the second wave of EGF signaling to promote skin and breast cancer invasion

Unveiling the Mechanisms of Apoptosis Induction by Deep‐Sea‐Derived Polyketide‐Terpenoid Hybrids from Penicillium allii‐sativi : A Focus on Mitochondrial and mTOR Pathways

SEDGCN: Sentiment Enhanced Dual Graph Convolutional Networks for Detecting Adverse Drug Reactions

KESDT: knowledge enhanced shallow and deep Transformer for detecting adverse drug reactions

Precise delivery of celastrol by PEGylated aptamer dendrimer nanoconjugates for enormous therapeutic effect via superior intratumor penetration over antibody counterparts

Phase separation of Nur77 mediates XS561-induced apoptosis by promoting the formation of Nur77/Bcl-2 condensates

Nuclear receptor RXRα binds the precursor of miR-103 to inhibit its maturation

Acid-Responsive Macroporous Silica Nanoparticles for Bcl-2-Functional-Converting Peptide Release and Synergism with Celastrol for Enhanced Therapy against Resistant Cancer

Nur77 Serves as a Potential Prognostic Biomarker That Correlates with Immune Infiltration and May Act as a Good Target for Prostate adenocarcinoma

Perceived individual fairness with a molecular representation for medicine recommendations

The anti-inflammatory effect of Pien Tze Huang in non-alcoholic fatty liver disease

Disruption of the glucagon receptor increases glucagon expression beyond α-cell hyperplasia in zebrafish

SAR study of oxidative DIMs analogs targeting the Nur77-mediated apoptotic pathway of cancer cells

Design, synthesis and biological evaluation of acyl hydrazones-based derivatives as RXRα-targeted anti-mitotic agents

Malayoside, a cardenolide glycoside extracted from Antiaris toxicaria Lesch, induces apoptosis in human non-small lung cancer cells via MAPK-Nur77 signaling pathway

Design, synthesis, and biological evaluation of novel sulindac derivatives as partial agonists of PPARγ with potential anti-diabetic efficacy

Merbromin is a mixed-type inhibitor of 3-chyomotrypsin like protease of SARS-CoV-2

Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates

Protocol to identify centrosome-associated transcription factors during mitosis in mammalian cell lines

Impact of macroporous silica nanoparticles at sub-50nm on bio-behaviors and biosafety in drug-resistant cancer models

Penipyrols C–G and methyl-penipyrol A, α-pyrone polyketides from the mangrove derived fungus Penicillium sp. HDN-11-131

Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis

Optimization of novel oxidative DIMs as Nur77 modulators of the Nur77-Bcl-2 apoptotic pathway

The Roles of GSK-3β in Regulation of Retinoid Signaling and Sorafenib Treatment Response in Hepatocellular Carcinoma

Centrosomal Localization of RXRα Promotes PLK1 Activation and Mitotic Progression and Constitutes a Tumor Vulnerability

Norlichexanthone purified from plant endophyte prevents postmenopausal osteoporosis by targeting ER to inhibit RANKL signaling

Rosiglitazone binds to RXRα to induce RXRα tetramerization and NB4 cell differentiation

舒林酸衍生物K-80003与MEK抑制剂考比替尼联合用药对乳腺癌的效果研究

Macroporous organosilicon nanocomposites co-deliver Bcl2-converting peptide and chemotherapeutic agent for synergistic treatment against multidrug resistant cancer

SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway

Cancer-targeted and intracellular delivery of Bcl-2-converting peptide with functional macroporous silica nanoparticles for biosafe treatment

Enhanced cancer therapy of celastrol in vitro and in vivo by smart dendrimers delivery with specificity and biosafety

Sulindac‐derived retinoid X receptor‐α modulator attenuates atherosclerotic plaque progression and destabilization in ApoE−/− mice

Oncogenic potential of truncated RXRα during colitis-associated colorectal tumorigenesis by promoting IL-6-STAT3 signaling

BI1071, a Novel Nur77 Modulator, Induces Apoptosis of Cancer Cells by Activating the Nur77-Bcl-2 Apoptotic Pathway

Discovery of atorvastatin as a tetramer stabilizer of nuclear receptor RXRα through structure-based virtual screening

Cancer therapeutics based on BCL-2 functional conversion

视黄醇X受体小分子配体衍生物对宫颈癌细胞周期及细胞凋亡的影响

雷公藤红素通过靶向核受体Nur77促进损伤线粒体自噬而抑制炎症反应

Design, synthesis and biological evaluation of tetrazole-containing RXRα ligands as anticancer agents

Dendrimer-like mesoporous silica nanospheres with suitable surface functionality to combat the multidrug resistance

Retinoid X Receptor Alpha Nitro-ligand Z-10 and Its Optimized Derivative Z-36 Reduce β-Amyloid Plaques in Alzheimer’s Disease Mouse Model

Macroporous silica nanoparticles for delivering Bcl2-function converting peptide to treat multidrug resistant-cancer cells

Celastrol binds to its target protein via specific noncovalent interactions and reversible covalent bonds

Modulation of the Nur77-Bcl-2 apoptotic pathway by p38α MAPK

AlCl3·6H2O-Catalyzed Friedel-Crafts Alkylation of Indoles by the para-Quinone Methide Moiety of Celastrol

Moving nuclear receptor Nur77 to damaged mitochondria for clearance by mitophagy

Targeting to the non-genomic activity of retinoic acid receptor-gamma by acacetin in hepatocellular carcinoma

TRC4, an improved triptolide derivative, specifically targets to truncated form of retinoid X receptor-alpha in cancer cells

Virtual screening and experimental validation identify novel modulators of nuclear receptor RXRα from Drugbank database

Binding characterization, synthesis and biological evaluation of RXRα antagonists targeting the coactivator binding site

Targeting truncated RXRα for cancer therapy

NUR77 exerts a protective effect against inflammatory bowel disease by negatively regulating the TRAF6 / TLR–IL‐1R signalling axis

Dioxasampsones A and B, Two Polycyclic Polyprenylated Acylphloroglucinols with Unusual Epoxy-Ring-Fused Skeleton from Hypericum sampsonii

Norsampsones A–D, Four New Decarbonyl Polycyclic Polyprenylated Acylphloroglucinols from Hypericum sampsonii

Identification of a New RXR? Antagonist Targeting the Coregulator-Binding Site

和厚朴酚调控P38信号通路诱导人宫颈癌Hela细胞凋亡的实验研究

Fatty acids as natural specific inhibitors of the proto-oncogenic protein Shp2

Exfoliazone通过诱导细胞凋亡抑制HepG2细胞体外增殖

Regulation of Nur77 expression by β‐catenin and its mitogenic effect in colon cancer cells

Bioactive Xanthones from the Stems of Cratoxylum formosum ssp. pruniflorum

大黄素诱导癌细胞凋亡和抑制视黄醇X受体的转录激活功能

动脉粥样硬化药物治疗的新靶点——核受体Nur77和类视黄醇X受体

全反式视黄酸对癌细胞凋亡的诱导

预印本

Malayoside induces excessive mitophagy and mitochondrial apoptosis in Human Non-Small Cell Lung Cancer through SIN3A-Nur77 signal pathway

10-4-4, A Cardiac Glycoside Block Growth in Cancer Cells via Nuclear Receptor Nur77 Mediated Na+/K+- ATPase Endocytosis