洪尚宇｜复旦大学｜学者主页

2026

Hepatic Nnmt Deficiency Alleviates Thiamethoxam-Induced Hepatic Steatosis Via AMPK Activation

Yilian Liu, Zixuan Meng, Siting Fan, Xin Wang, Shangyu Hong

Phenomics

DOI

2026

An In Vivo Phenotypic Screen Identifies Sclerostin as a Regulator of the Development of Non-Alcoholic Steatohepatitis in Mice

Guangxing Lu, Shangyu Hong, Lei Sun, Xiaohui Wu, Jin Li

Phenomics

DOI

2026

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

Zhonghan Sun, Chang He, Xiaonan Ma, Ping Wu, Tianlei Wang, Jiaying Yuan, Yanni Pu, Xiaofeng Zhou, Zhendong Mei, Huiling Song, Yetong Wang, Haiyan Yue, Yuanqing Fu, Ju‐Sheng Zheng, An Pan, Da Chen, Shangyu Hong, Xiong‐Fei Pan, Yan Zheng

iMeta

DOI

2026

Hepatic-IL-22RA1 is indispensable for IL-22-induced in vitro expansion of primary mouse hepatocytes

Xiaonan Ma, Xin Wang, Haili Tian, Yuxuan Huang, Shangyu Hong

Journal of Hepatology

DOI

2026

Multi-kingdom profiling reveals altered gut phage-bacteria-metabolite interactions in MASLD

Xiaofeng Zhou, D X Zhou, Yanni Pu, Hanseul Kim, Zhonghan Sun, Wenhao Qi, Jiadong Jin, Wanqin Zhang, Mingfeng Xia, Chengyan Wang, Shangyu Hong, Long H. Nguyen, Na Jiao, Y J Zheng, Taotao Liu

Nature Communications

DOI

2026

Queuine tRNA ribosyltransferase 1 deficiency ameliorates hepatic steatosis and atherosclerosis possibly via modulating lipogenesis

Runda Wu, Shuning Zhang, Wanxin Wang, Zheng Dong, Wei Gao, Yongduan Teng, Yuxiang Dai, Shangyu Hong, Kang Yao, Junbo Ge

Genes & Diseases

DOI

2025

母鼠生酮饮食干预对子代糖脂代谢的影响

滕永端，李潇，洪尚宇，孙璘

《复旦学报(自然科学版)》

DOI

2025

Abstract 4354717: Specific Microbial Metabolite Enhances the Anti-Atherosclerotic Efficacy of Colchicine by Improving Bioavailability

Wanxin Wang, Xiao Li, Kang Yao, Shangyu Hong, Junbo Ge

Circulation

DOI

2025

NNMT/1-MNA protects against hepatic ischemia-reperfusion injury through the AKT/FOXO1/ANGPT2/JNK axis

Bing Yin, Baolin Qian, Hongjun Yu, Shanjia Ke, Zihao Li, Yongliang Hua, Shounan Lu, Chaoqun Wang, Mengxin Li, Sixun Guo, Zhongyu Li, Yongzhi Zhou, Zhanzhi Meng, Xinglong Li, Yanan Xu, Zhigang Feng, Miaoyu Bai, Yao Fu, Wei Tang, Shangyu Hong, Yong Ma

Nature Communications

DOI

2025

The Role of Gut Microbiota and Arginine Metabolism in Blood Lipid Regulation During Low-Carb Diet Intervention

Mengmeng Kong, Xiao Li, Xi-Chen Cui, Yan Zheng, Shangyu Hong

Current Developments in Nutrition

DOI

2024

Gut Microbiota Modulates Fgf21 Expression and Metabolic Phenotypes Induced by Ketogenic Diet

Xinyi Wei, Yanyan Lu, Shangyu Hong

Nutrients

DOI

2024

Abstract Tu105: Inhibition of Queuine tRNA-Ribosyltransferase 1 Ameliorates Heaptic Lipogenesis and Atherosclerosis

Runda Wu, shuning zhang, Yuanji ma, Wei Gao, Jianquan Liao, Xinyu Weng, Yongduan Teng, Lei Zhang, Lili Xu, Ya Su, Wanxin Wang, Yuxiang Dai, Shangyu Hong, Kang Yao, Junbo Ge

Circulation Research

DOI

2024

Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption

Xiao Li, Jie Yang, Xiaofeng Zhou, Chen Dai, Mengmeng Kong, Linshan Xie, Chenglin Liu, Yilian Liu, Dandan Li, Xiaonan Ma, Yuxiang Dai, Yan Sun, Zhijie Jian, Xiaohuan Guo, Xu Lin, Yixue Li, Liang Sun, Xin Liu, Jin Li, Huiru Tang, Yan Zheng, Shangyu Hong

Nature Metabolism

DOI

2024

Exerkines: Benign adaptation for exercise and benefits for non-alcoholic fatty liver disease

Yang Chen, Yan Zhang, Xingsheng Jin, Shangyu Hong, Haili Tian

Biochemical and Biophysical Research Communications

DOI

2024

Living Conditions Alter Ketogenic Diet-induced Metabolic Consequences in Mice through Modulating Gut Microbiota

Jie Yang, Xiao Li, Chen Dai, Yongduan Teng, Linshan Xie, Haili Tian, Shangyu Hong

Phenomics

DOI

2023

内质网应激通过不依赖脂质从头合成的通路诱导非酒精性脂肪肝病

钟王磊，戴晨，洪尚宇

《复旦学报(自然科学版)》

2023

生酮饮食通过肠道微生物依赖的机制诱导肠道ROS升高

杨洁，戴晨，洪尚宇

《工业微生物》

2023

Diets, Gut Microbiota and Metabolites

Yilian Liu, Wanglei Zhong, Xiao Li, Feng Shen, Xiaonan Ma, Qi Yang, Shangyu Hong, Yan Sun

Phenomics

DOI

2023

BCAA insufficiency leads to premature ovarian insufficiency via ceramide‐induced elevation of ROS

Xiao Guo, Yuemeng Zhu, Lu Guo, Yiwen Qi, Xiaocheng Liu, Jinhui Wang, Jiangtao Zhang, Linlin Cui, Yueyang Shi, Qichu Wang, Cenxi Liu, Guangxing Lu, Yilian Liu, Tao Li, Shangyu Hong, Yingying Qin, Xuelian Xiong, Hao Wu, Lin Huang, He Huang, Chao Gu, Bin Li, Jin Li

EMBO Molecular Medicine

DOI

2022

The Storage Conditions of High-Fat Diet Are the Key Factors for Diet-Induced Obesity and Liver Damage

Chuanyou Yi, Dandan Li, Xiao Guo, Jinhui Wang, Cenxi Liu, Guangxing Lu, Yan Sun, He Huang, Shangyu Hong, Jin Li

Nutrients

DOI

2022

Hepatocyte-specific depletion of Nnmt protects mice from non-alcoholic steatohepatitis

Dandan Li, Chuanyou Yi, He Huang, Jin Li, Shangyu Hong

Journal of Hepatology

DOI

2021

An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation

Tamara Casteels, Yufeng Zhang, Thomas Frogne, Caterina Sturtzel, Charles-Hugues Lardeau, Ilke Sen, Xiaocheng Liu, Shangyu Hong, Florian M. Pauler, Thomas Penz, Marlene Brandstetter, Charlotte Barbieux, Ekaterine Berishvili, Thomas Heuser, Christoph Bock, Christian G. Riedel, Dirk Meyer, Martin Distel, Jacob Hecksher‐Sørensen, Jin Li, Stefan Kubicek

Molecular Metabolism

DOI

2020

Cavin1 Deficiency Causes Disorder of Hepatic Glycogen Metabolism and Neonatal Death by Impacting Fenestrations in Liver Sinusoidal Endothelial Cells

Zhuang Wei, Jigang Lei, Feng Shen, Yuxiang Dai, Yan Sun, Yilian Liu, Yan Dai, Zhijie Jian, Shilong Wang, Zhengjun Chen, Kan Liao, Shangyu Hong

Advanced Science

DOI

2020

Depot-specific regulation of NAD+/SIRTs metabolism identified in adipose tissue of mice in response to high-fat diet feeding or calorie restriction

Xiaojing Wei, Ru Jia, Guan Wang, Shangyu Hong, Lin Song, Bo Sun, Ke Chen, Nan Wang, Qiqi Wang, Xiao Min Luo, Jianqun Yan

The Journal of Nutritional Biochemistry

DOI

2019

Hypoxic Training in Obese Mice Improves Metabolic Disorder

Ru Wang, Shanshan Guo, Haili Tian, Yiru Huang, Qin Yang, Kewei Zhao, Chia‐Hua Kuo, Shangyu Hong, Peijie Chen, Tiemin Liu

Frontiers in Endocrinology

DOI

2018

Nicotinamide N -Methyltransferase Interacts with Enzymes of the Methionine Cycle and Regulates Methyl Donor Metabolism

Shangyu Hong, Bo Zhai, Pavlos Pissios

Biochemistry

DOI

洪尚宇

精选作品

期刊论文

Hepatic Nnmt Deficiency Alleviates Thiamethoxam-Induced Hepatic Steatosis Via AMPK Activation

An In Vivo Phenotypic Screen Identifies Sclerostin as a Regulator of the Development of Non-Alcoholic Steatohepatitis in Mice

A gut microbiome‐lipid axis in early pregnancy is associated with metabolic dysregulation and diabetes risk

Hepatic-IL-22RA1 is indispensable for IL-22-induced in vitro expansion of primary mouse hepatocytes

Multi-kingdom profiling reveals altered gut phage-bacteria-metabolite interactions in MASLD

Queuine tRNA ribosyltransferase 1 deficiency ameliorates hepatic steatosis and atherosclerosis possibly via modulating lipogenesis

母鼠生酮饮食干预对子代糖脂代谢的影响

Abstract 4354717: Specific Microbial Metabolite Enhances the Anti-Atherosclerotic Efficacy of Colchicine by Improving Bioavailability

NNMT/1-MNA protects against hepatic ischemia-reperfusion injury through the AKT/FOXO1/ANGPT2/JNK axis

The Role of Gut Microbiota and Arginine Metabolism in Blood Lipid Regulation During Low-Carb Diet Intervention

Gut Microbiota Modulates Fgf21 Expression and Metabolic Phenotypes Induced by Ketogenic Diet

Abstract Tu105: Inhibition of Queuine tRNA-Ribosyltransferase 1 Ameliorates Heaptic Lipogenesis and Atherosclerosis

Ketogenic diet-induced bile acids protect against obesity through reduced calorie absorption

Exerkines: Benign adaptation for exercise and benefits for non-alcoholic fatty liver disease

Living Conditions Alter Ketogenic Diet-induced Metabolic Consequences in Mice through Modulating Gut Microbiota

内质网应激通过不依赖脂质从头合成的通路诱导非酒精性脂肪肝病

生酮饮食通过肠道微生物依赖的机制诱导肠道ROS升高

Diets, Gut Microbiota and Metabolites

BCAA insufficiency leads to premature ovarian insufficiency via ceramide‐induced elevation of ROS

The Storage Conditions of High-Fat Diet Are the Key Factors for Diet-Induced Obesity and Liver Damage

Hepatocyte-specific depletion of Nnmt protects mice from non-alcoholic steatohepatitis

An inhibitor-mediated beta-cell dedifferentiation model reveals distinct roles for FoxO1 in glucagon repression and insulin maturation

Cavin1 Deficiency Causes Disorder of Hepatic Glycogen Metabolism and Neonatal Death by Impacting Fenestrations in Liver Sinusoidal Endothelial Cells

Depot-specific regulation of NAD+/SIRTs metabolism identified in adipose tissue of mice in response to high-fat diet feeding or calorie restriction

Hypoxic Training in Obese Mice Improves Metabolic Disorder

Nicotinamide N -Methyltransferase Interacts with Enzymes of the Methionine Cycle and Regulates Methyl Donor Metabolism

会议论文

肝脏特异性敲除Nnmt减缓非酒精性脂肪炎的进展

NNMT Regulates Methyl Donor Content and Differentiation of 3T3-L1 Cells

研究方向