杨清湖｜延安大学｜学者主页

2026

乳酸代谢紊乱介导星形胶质细胞溶酶体功能障碍的分子机制研究

王改霞，马欢，白占涛，刘霞，杨清湖

《延安大学学报(医学科学版)》

2025

亨廷顿舞蹈症中星形胶质细胞转录异质性分析

陈贝宁，杨清湖，袁增强，郭兴

《南京医科大学学报(自然科学版)》

2025

混合谱系激酶域样假激酶参与小鼠高原脑水肿的初步研究

孟欣宇，孟瀚，毛竹青，王砚锦，谈妍辰，王亚周，崔毅，杨清湖

《空军军医大学学报》

DOI

2025

Microglial Rack1 Deficiency Alleviates Alzheimer's Disease Pathology through Enhancing IGF1‐Mediated Astrocytic Phagocytosis

Jingdan Zhang, Jingdan Zhang, Yanling He, Pin Yang, Hengchang Zhang, Yueyang Tong, Lingling Jiang, Zehan Li, Meichen Yan, Xiaoheng Li, Qinghu Yang, Jing Hui Yang, Zengqiang Yuan, Jiyan Zhang, Jiyan Zhang, Jinbo Cheng

Advanced Science

DOI

2025

Cathepsin B deficiency disrupts cortical development via PEG3, leading to depression-like behavior

Zhen Xie, Qinghu Yang, Fei Lan, Wei Kong, Shuxuan Zhao, Jinyi Sun, Yan Yan, Zhenzhen Quan, Zhan‐Tao Bai, Hong Qing, Jian Mao, Junjun Ni

Communications Biology

DOI

2025

Hippocampal Neurogenesis in Alzheimer’s Disease: Multimodal Therapeutics and the Neurogenic Impairment Index Framework

Li Ma, Qian Wei, Ming Jiang, Yanyan Wu, Xia Liu, Qinghu Yang, Zhan‐Tao Bai, Liang Yang

International Journal of Molecular Sciences

DOI

2025

Decoding extracellular matrix–lysosome cross-talk and its implications for neurodegenerative diseases

Qinghu Yang, Huan Ma, Liang Yang, Ming Jiang, Xia Liu, Zhan‐Tao Bai

Science Signaling

DOI

2024

抗痛蝎多肽的分离与筛选

王玉，张晓婷，姜鸣，吴艳艳，杨亮，杨清湖，刘霞，白占涛

《延安大学学报(自然科学版)》

2024

Extracellular Matrix Remodeling Alleviates Memory Deficits in Alzheimer's Disease by Enhancing the Astrocytic Autophagy‐Lysosome Pathway

Qinghu Yang, Chengxiang Yan, Yahan Sun, Zhen Xie, Liang Yang, Ming Jiang, Junjun Ni, Beining Chen, Sen Xu, Zhaoyue Yuan, Zhaoyue Yuan, Yanyan Wu, Xia Liu, Zengqiang Yuan, Zengqiang Yuan, Zhan‐Tao Bai

Advanced Science

DOI

2024

Establishment of a two-hit mouse model of environmental factor induced autism spectrum disorder

Weian Zheng, Mengmeng Wang, Yi Cui, Qing Xu, Yujiang Chen, Panpan Xian, Qinghu Yang, Shengxi Wu, Yazhou Wang

Heliyon

DOI

2023

胞外基质和神经干细胞参与抑郁症发生的作用机制

杨亮，周艳，杨清湖，姜鸣，雒雪婷，刘霞，白占涛

《延安大学学报(自然科学版)》

2023

外侧缰核在疼痛与负性情绪中的作用及其机制

杨新江，李海涛，王菲，解柔刚，罗层，杨清湖

《神经解剖学杂志》

2023

肠道运动疾病与情绪异常共病发生的TRP通道机制

何法，刘畅，吴艳艳，刘霞，姜鸣，杨清湖，杨亮，白占涛

《生命科学》

2023

Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways

Zhen Xie, Mengyuan Zhao, Chengxiang Yan, Wei Kong, Fei Lan, Narengaowa, Shuxuan Zhao, Qinghu Yang, Zhan‐Tao Bai, Hong Qing, Junjun Ni

Cell Death and Disease

DOI

2023

Dual Behavior Regulation: Tether‐Free Deep‐Brain Stimulation by Photothermal and Upconversion Hybrid Nanoparticles

Feiyi Sun, Hanchen Shen, Qinghu Yang, Zhaoyue Yuan, Yuyang Chen, Weihua Guo, Yu Wang, Liang Yang, Zhan‐Tao Bai, Qingqing Liu, Ming Jiang, Jacky W. Y. Lam, Jianwei Sun, Ruquan Ye, Ryan T. K. Kwok, Ben Zhong Tang

Advanced Materials

DOI

2023

Mirror image pain mediated by D2 receptor regulation of astrocytic Cx43 phosphorylation and channel opening

Qinghu Yang, Ming Jiang, Sen Xu, Liang Yang, Pan Yang, Yutian Song, Hongni Zhu, Yu Wang, Yahan Sun, Chengxiang Yan, Zhaoyue Yuan, Xia Liu, Zhan‐Tao Bai

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI

2022

以科研为导向的研究生培养模式下的“神经生物学”教学改革

谢真，杨亮，杨清湖

《科学咨询》

2022

社交互动的杏仁核神经回路研究进展：从微回路到输入输出回路

徐森，孙雅涵，吕清波，张明双，刘霞，白占涛，杨清湖

《神经解剖学杂志》

2022

靶向KCNQ的蝎多肽药物设计与研究进展

刘艳，杨清湖，杨亮，岳杰，刘霞，白占涛，姜鸣

《生命的化学》

2022

The Dual Nature of Microglia in Alzheimer’s Disease: A Microglia-Neuron Crosstalk Perspective

Zhen Xie, Jie Meng, Zhou Wu, Hiroshi Nakanishi, Yoshinori Hayashi, Wei Kong, Fei Lan, Narengaowa, Qinghu Yang, Hong Qing, Junjun Ni

The Neuroscientist

DOI

2022

Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer’s disease

Zhen Xie, Jie Meng, Wei Kong, Zhou Wu, Fei Lan, Narengaowa, Yoshinori Hayashi, Qinghu Yang, Zhan‐Tao Bai, Hiroshi Nakanishi, Hong Qing, Junjun Ni

Aging Cell

DOI

2021

焦虑神经环路的TRPV1表达与调控

赵雅丽，杨清湖，杨亮，何法，刘霞，白占涛

《延安大学学报(自然科学版)》

DOI

2021

动物多肽与钠通道选择性互作的微基序空间等电点

白占涛，张晓婷，杨清湖，李盼欣，雷祎凡，刘霞，姜鸣

《延安大学学报(自然科学版)》

DOI

2021

神经发育疾病相关Tenascin C表达的分子调控通路

苏琦，姜鸣，杨清湖，杨亮，何建秧，刘霞，白占涛

《延安大学学报(自然科学版)》

DOI

2021

自闭基因Fmr1和MeCP2与GABA神经微环路调控

刘雪红，姜鸣，杨清湖，王立欢，刘霞，白占涛

《延安大学学报(医学科学版)》

DOI

2021

Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice

Qinghu Yang, Da Feng Song, Zhen Xie, Guiqiong He, Juan Zhao, Zhe Wang, Zhifang Dong, Heao Zhang, Liang Yang, Ming Jiang, Yili Wu, Qing Shi, Junjie Li, Jun Yang, Zhan‐Tao Bai, Zhenzhen Quan, Hong Qing

Progress in Neurobiology

DOI

2021

Neural Circuits for Social Interactions: From Microcircuits to Input-Output Circuits

Sen Xu, Ming Jiang, Xia Liu, Yahan Sun, Liang Yang, Qinghu Yang, Zhan‐Tao Bai

Frontiers in Neural Circuits

DOI

2021

Role of the Extracellular Matrix in Alzheimer’s Disease

Yahan Sun, Sen Xu, Ming Jiang, Xia Liu, Liang Yang, Zhan‐Tao Bai, Qinghu Yang

Frontiers in Aging Neuroscience

DOI

2020

The lateralization of left hippocampal CA3 during the retrieval of spatial working memory

Da Song, De-Heng Wang, Qinghu Yang, Tianyi Yan, Zhe Wang, Yan Yan, Juan Zhao, Zhen Xie, Yuchen Liu, Zun-Ji Ke, T. J. Qazi, Yanhui Li, Yili Wu, Qing Shi, Yi-Ran Lang, He-Ao Zhang, Tao Huang, Chunjian Wang, Zhen-Zhen Quan, H. Qing

Nature Communications

DOI

2019

Pterostilbene, an active component of the dragon's blood extract, acts as an antidepressant in adult rats

Liang Yang, Yuanyuan Ran, Zhenzhen Quan, Ran Wang, Qinghu Yang, Qiutian Jia, Heao Zhang, Yanhui Li, Yiheng Peng, JianHua Liang, Hui Wang, Hiroshi Nakanishi, Yulin Deng, Hong Qing

Psychopharmacology，Vol. 2360, No. 4

DOI

2019

Optogenetic manipulation of astrocytes from synapses to neuronal networks: A potential therapeutic strategy for neurodegenerative diseases

Zhen Xie, Qinghu Yang, Da Feng Song, Zhenzhen Quan, Hong Qing

Glia

DOI

2019

Developmental phenotypes of extracellular matrix modulating the expression of sodium channels in rat dorsal root ganglion neurons

Yanyan Wu, Lei Xi, Xiang-Xiang Chen, Xu-Ri Zhang, Rui Gao, Ruo-Song Ai, Qinghu Yang, A.I. Ruo-Song, Cheng-Hui Cao, Xia Liu, Zhan‐Tao Bai

Toxicon

DOI

2019

Modulation of Cx 43 phosphorylation underlying mirror image pain induced by a scorpion peptide

Qinghu Yang, Lei Xi, Xu-Ri Zhang, Rui Gao, Ruo-Song Ai, Cheng-Hui Cao, Sui‐Bin Ma, Yanyan Wu, Xiang-Xiang Chen, Zhan‐Tao Bai

Toxicon

DOI

2019

Activation of D2-Cx43 signaling pathways in mirror image pain induced by a scorpion peptide

Lei Xi, Cheng-Hui Cao, Rui Gao, Xu-Ri Zhang, Qinghu Yang, Sui‐Bin Ma, Yanyan Wu, Xiang-Xiang Chen, Qi Wang, A.I. Ruo-Song, Huan Guo, Danyang Li, Xia Liu, Zhan‐Tao Bai

Toxicon

DOI

2019

Extracellular chondroitin sulfate proteoglycans and sodium channel beta subunits modulating mirror image pain induced by a scorpion peptide

Lei Xi, Xiang-Xiang Chen, Yanyan Wu, Qinghu Yang, Jia Li, Cheng-Hui Cao, Ruo-Song Ai, Xu-Ri Zhang, Rui Gao, Xia Liu, Zhan‐Tao Bai

Toxicon

DOI

2018

Manipulation of hippocampal CA3 firing via luminopsins modulates spatial and episodic short-term memory, especially working memory, but not long-term memory

Da Song, Qinghu Yang, Yiran Lang, Zhaosen Wen, Zhen Xie, Da Zheng, Tianyi Yan, Yujun Deng, Hiroshi Nakanishi, Zhenzhen Quan, Hong Qing

Neurobiology Of Learning And Memory，Vol. 155

DOI

2017

[Review] Neural changes in Alzheimer's disease from circuit to molecule: Perspective of optogenetics

Qinghu Yang, Da Song, Hong Qing

Neuroscience And Biobehavioral Reviews，Vol. 79

DOI

2017

Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution

Zhenzhen Sun, Yujie Xie, Yin-Tong Chen, Qinghu Yang, Zhen-Zhen Quan, R. Dai, H. Qing

Molecular Neurobiology

DOI

2016

蝎毒素多肽致/抗痛的靶离子通道机制

刘霞，袁琛皓，杨清湖，白占涛

《生命科学》

2015

脊髓5-HT2A受体在疼痛中的作用与机制

王江博，杨清湖，孙志宏，白占涛

《延安大学学报(自然科学版)》

2015

硫酸软骨蛋白聚糖调控神经损伤修复机制

赵小霞，杨清湖，刘霞，白占涛

《延安大学学报(医学科学版)》

2015

脊髓多巴胺D2受体对疼痛的调控

宋雨田，杨清湖，刘霞，白占涛

《延安大学学报(医学科学版)》

2015

抗痛蝎毒素多肽的重组表达研究

冉秋行，刘霞，杨清湖，白占涛

《延安大学学报(自然科学版)》

2015

缝隙连接蛋白磷酸化介导镜像痛敏的时空表达研究

杨清湖

《延安大学》

2014

外周神经胶质细胞缝隙连接的表达与功能调控

杨清湖，白占涛

《生命科学研究》

精选作品

期刊论文

乳酸代谢紊乱介导星形胶质细胞溶酶体功能障碍的分子机制研究

亨廷顿舞蹈症中星形胶质细胞转录异质性分析

混合谱系激酶域样假激酶参与小鼠高原脑水肿的初步研究

Microglial Rack1 Deficiency Alleviates Alzheimer's Disease Pathology through Enhancing IGF1‐Mediated Astrocytic Phagocytosis

Cathepsin B deficiency disrupts cortical development via PEG3, leading to depression-like behavior

Hippocampal Neurogenesis in Alzheimer’s Disease: Multimodal Therapeutics and the Neurogenic Impairment Index Framework

Decoding extracellular matrix–lysosome cross-talk and its implications for neurodegenerative diseases

抗痛蝎多肽的分离与筛选

Extracellular Matrix Remodeling Alleviates Memory Deficits in Alzheimer's Disease by Enhancing the Astrocytic Autophagy‐Lysosome Pathway

Establishment of a two-hit mouse model of environmental factor induced autism spectrum disorder

胞外基质和神经干细胞参与抑郁症发生的作用机制

外侧缰核在疼痛与负性情绪中的作用及其机制

肠道运动疾病与情绪异常共病发生的TRP通道机制

Cathepsin B in programmed cell death machinery: mechanisms of execution and regulatory pathways

Dual Behavior Regulation: Tether‐Free Deep‐Brain Stimulation by Photothermal and Upconversion Hybrid Nanoparticles

Mirror image pain mediated by D2 receptor regulation of astrocytic Cx43 phosphorylation and channel opening

以科研为导向的研究生培养模式下的“神经生物学”教学改革

社交互动的杏仁核神经回路研究进展：从微回路到输入输出回路

靶向KCNQ的蝎多肽药物设计与研究进展

The Dual Nature of Microglia in Alzheimer’s Disease: A Microglia-Neuron Crosstalk Perspective

Microglial cathepsin E plays a role in neuroinflammation and amyloid β production in Alzheimer’s disease

焦虑神经环路的TRPV1表达与调控

动物多肽与钠通道选择性互作的微基序空间等电点

神经发育疾病相关Tenascin C表达的分子调控通路

自闭基因Fmr1和MeCP2与GABA神经微环路调控

Optogenetic stimulation of CA3 pyramidal neurons restores synaptic deficits to improve spatial short-term memory in APP/PS1 mice

Neural Circuits for Social Interactions: From Microcircuits to Input-Output Circuits

Role of the Extracellular Matrix in Alzheimer’s Disease

The lateralization of left hippocampal CA3 during the retrieval of spatial working memory

Pterostilbene, an active component of the dragon's blood extract, acts as an antidepressant in adult rats

Optogenetic manipulation of astrocytes from synapses to neuronal networks: A potential therapeutic strategy for neurodegenerative diseases

Developmental phenotypes of extracellular matrix modulating the expression of sodium channels in rat dorsal root ganglion neurons

Modulation of Cx 43 phosphorylation underlying mirror image pain induced by a scorpion peptide

Activation of D2-Cx43 signaling pathways in mirror image pain induced by a scorpion peptide

Extracellular chondroitin sulfate proteoglycans and sodium channel beta subunits modulating mirror image pain induced by a scorpion peptide

Manipulation of hippocampal CA3 firing via luminopsins modulates spatial and episodic short-term memory, especially working memory, but not long-term memory

[Review] Neural changes in Alzheimer's disease from circuit to molecule: Perspective of optogenetics

Rab21, a Novel PS1 Interactor, Regulates γ-Secretase Activity via PS1 Subcellular Distribution

蝎毒素多肽致/抗痛的靶离子通道机制

脊髓5-HT2A受体在疼痛中的作用与机制

硫酸软骨蛋白聚糖调控神经损伤修复机制

脊髓多巴胺D2受体对疼痛的调控

抗痛蝎毒素多肽的重组表达研究

缝隙连接蛋白磷酸化介导镜像痛敏的时空表达研究

外周神经胶质细胞缝隙连接的表达与功能调控

会议论文

蝎毒多肽类钠通道调制剂的分离纯化与功能研究

尿酸盐结晶与Tenascins在炎性痛发生中的Na～+通道调控机制

研究方向