百晓学者学者目录

徐进宜

副教授、教授、研究员、讲师，中国药科大学

精选作品

期刊论文

2026

Design, Synthesis and Biological Evaluation of Novel Bioorthogonal Prodrugs Derived from Microtubule Polymerization Inhibitors

Tiandong Zheng, Fengze Sun, Yunteng Guo, Zhichao Guo, Yihan Wang, Yechen Mao, Junjin Tan, Jichao Chen, Jinyi Xu, Zheying Zhu, Jie Liu

European Journal of Medicinal Chemistry

DOI

2026

Development of High-Efficiency Mitochondrial Protease Targeting Chimeras (MtPTACs) for Targeted Degradation of POLRMT and Beyond

Cong Chen, Lihua Liu, Xinnan Li, Yuning Shi, Jieya Zhou, Lijuan Huang, Liyue Zeng, Dazhi Feng, Yunyue Wang, Xinyang Nie, Quanyi Huang, Yifei Wu, Shaokang Pang, Jinyi Xu, Shengtao Xu, Hong Yao

JACS Au

DOI

2026

From Structure to Selectivity: Integrating CADD and AIDD in Rational Medicinal Chemistry Strategies for DYRK1A Inhibitor Discovery

Minghui Yu, Shuangtian Tang, Lijuan Huang, Yunyue Wang, Jinyi Xu, Huajian Zhu, Hong Yao

Journal of Medicinal Chemistry

DOI

2026

Discovery of Novel HPK1 Inhibitors via Chemistry-Based Direct-to-Bioassay Screening and SAR Optimization

Yiping Duan, Chen He, Zhichao Guo, Kai Sun, Tiandong Zheng, Yang Lu, Baixue Zhang, Wenyi Zhong, Yansong Ren, Jie Liu, Shengtao Xu, Jinyi Xu

Journal of Medicinal Chemistry

DOI

2026

Discovery of novel and potent 2-aminopyrazine-based HPK1 inhibitors enhancing T-cell immunity against cancer

Zhichao Guo, Yiping Duan, Baixue Zhang, Kai Sun, Tiandong Zheng, Lanlan Chen, Chen He, Jiajie Feng, Yang Lu, Geting Xiong, Shengtao Xu, Jie Liu, Zheying Zhu, Jinyi Xu

European Journal of Medicinal Chemistry

DOI

2026

Discovery of Novel Snail Inhibitors Derived from Omeprazole for Antiatherosclerotic Therapy: A Structure-Based Approach

Zhaolan Zeng, Yang Lu, Mengsha Fang, Xiaopeng Guo, Wenyi Zhong, Geting Xiong, Yu Wang, Fengze Sun, Jinyi Xu, Zhaoqiu Wu, Rong Fu, Jie Liu

Journal of Medicinal Chemistry

DOI

2025

药学类新生研讨课教学思路探索与实践

徐盛涛，姚鸿，朱华健，罗姗姗，徐进宜

《药学教育》

DOI

2025

小分子疏水标签蛋白降解剂的研究进展

霍子瑞，裴捷雨，詹芳怡，谢绍文，徐进宜，徐盛涛

《中国药科大学学报》

2025

Bioorthogonal Chemistry: An Emerging Strategy for Targeted Protein Degradation

Pijun Zhou, Junda Li, Jinyi Xu, Yansong Ren, Shengtao Xu

Chemistry - A European Journal

DOI

2025

Discovery of Novel Bifunctional Agents as Potent TRK Inhibitors and Degraders against xDFG Mutation Resistance

Jian Zheng Song, Jingjie Zhu, Wenjian Zhu, Jinwei Feng, Jiarong Fan, Yi Mei, Qiren Shi, Yuzhuo Yang, Zhijie Feng, Peng George Wang, Tianduanyi Wang, Shengtao Xu, Jinyi Xu, Huajian Zhu

Journal of Medicinal Chemistry

DOI

2025

Construction of Small‐Molecule Deubiquitinase‐Targeting Chimeras to Reactivate and Stabilize Mutant p53 Y220C in Vitro and in Vivo

Chen He, Junda Li, Chenxi Cui, Jia Xie, Jiajie Feng, Baixue Zhang, Xingting Huang, Rui Ma, Lufeng Zheng, Jinyi Xu, Hong Yao, Shengtao Xu

Angewandte Chemie

DOI

2025

Modulating G6PD/PGD to overcome FSP1/DHODH‐mediated ferroptosis defence: A novel oridonin derivative suppresses liver cancer

Chenhui Ma, Li Han, Hong Yao, Wenxuan Zhao, Feihong Chen, Xiuyuan Wu, Guoqi Li, Ruimin Huang, Cheng Heng Pang, Zheying Zhu, Jinyi Xu, Guoyu Pan

British Journal of Pharmacology

DOI

2025

Development of Adamantane-based hydrophobic tags targeting anaplastic lymphoma kinase with enhanced antitumor activities

Jingjie Zhu, Fangyi Zhan, Jia Xie, Tonghao Fang, Yuan Sun, Feiyan Zhan, Tian Xiang Gao, J. Y. Liu, Jiajie Feng, Pijun Zhou, Huajian Zhu, Hong Yao, Zheying Zhu, Shengtao Xu, Jinyi Xu, Shengtao Xu

Bioorganic Chemistry

DOI

2025

Overcoming E3 Ligase-Mediated Resistance: Development of Novel Hydrophobic Tagging-Based Degraders Targeting ALK Protein

Shaowen Xie, Jingjie Zhu, Fangyi Zhan, Dazhi Feng, Chen He, Lihua Liu, Jia Xie, J. Y. Liu, Ming Zhong, Xingting Zhang, Jinyi Xu, Hong Yao, Shengtao Xu

Journal of Medicinal Chemistry

DOI

2025

The latest advances with natural products in drug discovery and opportunities for the future: a 2025 update

Shaowen Xie, Fangyi Zhan, Jingjie Zhu, Shengtao Xu, Jinyi Xu

Expert Opinion on Drug Discovery

DOI

2025

Novel agents derived from natural product β-elemene: A second round of design and synthesis to enhance antitumor properties

Zhouyan Liu, Tong Li, Chenglei Gu, Cheng Chen, Cheng Chen, Ziwei Tang, Yanyan Feng, Chen Zhou, Jinyi Xu, Jichao Chen

Bioorganic & Medicinal Chemistry

DOI

2025

Rational design of the linkers in targeting chimeras

Yiping Duan, Michelle Y. Cai, Jinyi Xu, Quanyin Hu

Chemical Science

DOI

2025

Selectively triggered: ROS-activated Michael acceptor prodrug strategy to enhance tumor targeting efficacy

Dazhi Feng, Xinnan Li, Junkai Liu, Xiao Shao, Lihua Liu, Yuning Shi, Yunyue Wang, Minghui Yu, Shuangtian Tang, Li Deng, Yongjie Zhang, Shaowen Xie, Jinyi Xu, Shengtao Xu, Hong Yao

Chemical Science

DOI

2024

In Vivo Self‐Assembly of PROTACs by Bioorthogonal Chemistry for Precision Cancer Therapy

Shaowen Xie, Jingjie Zhu, Yihan Peng, Fangyi Zhan, Feiyan Zhan, Chen He, Dazhi Feng, Jia Qing Xie, Jingyu Liu, Huajian Zhu, Hong Yao, Jinyi Xu, Zhigui Su, Shengtao Xu

Angewandte Chemie

DOI

2024

An updated review of small-molecule HPK1 kinase inhibitors (2016-present)

Yiping Duan, Zhichao Guo, Wenyi Zhong, Jichao Chen, Shengtao Xu, Jie Liu, Jinyi Xu

Future Medicinal Chemistry

DOI

2024

Palladium-Mediated Bioorthogonal System for Prodrug Activation of N-Benzylbenzamide-Containing Tubulin Polymerization Inhibitors for the Treatment of Solid Tumors

Jinlong Li, Tong Zhang, Di Wu, Chen He, Haoxiang Weng, Tiandong Zheng, Jie Liu, Hong Yao, Jichao Chen, Yansong Ren, Zheying Zhu, Jinyi Xu, Shengtao Xu

Journal of Medicinal Chemistry

DOI

2024

Identification of 6-Fluorine-Substituted Coumarin Analogues as POLRMT Inhibitors with High Potency and Safety for Treatment of Pancreatic Cancer

Shengnan Zhou, Xiaotong Ze, Dazhi Feng, Lihua Liu, Yuning Shi, Minghui Yu, Lijuan Huang, Yunyue Wang, Hanlu Men, Jianbing Wu, Zhenwei Yuan, Mengze Zhou, Jinyi Xu, Xinnan Li, Hong Yao

Journal of Medicinal Chemistry

DOI

2024

Advances in SHP2 tunnel allosteric inhibitors and bifunctional molecules

Zhichao Guo, Yiping Duan, Kai Sun, Tiandong Zheng, Jie Liu, Shengtao Xu, Jinyi Xu

European Journal of Medicinal Chemistry

DOI

2024

Hit-to-Lead Optimization of the Natural Product Oridonin as Novel NLRP3 Inflammasome Inhibitors with Potent Anti-Inflammation Activity

Chen He, Junkai Liu, Junda Li, Hongyu Wu, Chenyang Jiao, Xiaotong Ze, Shengtao Xu, Zheying Zhu, Wenjie Guo, Jinyi Xu, Hong Yao

Journal of Medicinal Chemistry

DOI

2024

Iodine-Promoted Reductive Sulfenylation Using Ketones as Hydride Donors

Yiping Duan, Zhichao Guo, Tiandong Zheng, Lu Yang, Jinyi Xu, Jie Liu, Fulai Yang

The Journal of Organic Chemistry

DOI

2023

Recent advances of vacuolar protein-sorting 34 inhibitors targeting autophagy

Long Chen, Tian Gao, Pijun Zhou, Wenxuan Xia, Hong Yao, Shengtao Xu, Jinyi Xu

Bioorganic Chemistry

DOI

2023

Design, Synthesis and Biological Evaluation of Novel Indanones Derivatives As Potent Acetylcholinesterase/Monoamine Oxidase B Inhibitors

Zhaoxin Hu, Shengnan Zhou, Junda Li, Xinnan Li, Yang Zhou, Zheying Zhu, Jinyi Xu, Jie Liu

Future Medicinal Chemistry

DOI

2023

Small-Molecule Hydrophobic Tagging: A Promising Strategy of Druglike Technology for Targeted Protein Degradation

Shaowen Xie, Jingjie Zhu, Junda Li, Feiyan Zhan, Hong Yao, Jinyi Xu, Shengtao Xu

Journal of Medicinal Chemistry

DOI

2023

Controlled release of MT-1207 using a novel gastroretentive bilayer system comprised of hydrophilic and hydrophobic polymers

Napoleon-Nikolaos Vrettos, Peng Wang, Yuhan Wang, Clive J. Roberts, Jinyi Xu, Hong Yao, Zheying Zhu

Pharmaceutical Development and Technology

DOI

2023

Advances of bioorthogonal coupling reactions in drug development

Feiyan Zhan, Jingjie Zhu, Shaowen Xie, Jinyi Xu, Shengtao Xu

European Journal of Medicinal Chemistry

DOI

2023

Design, Synthesis, and Biological Evaluation of Novel Hybrids Containing Dihydrochalcone as Tyrosinase Inhibitors to Treat Skin Hyperpigmentation

Songtao Xue, Zhiwei Li, Xiaotong Ze, Xiuyuan Wu, Chen He, Shuai Wen, Maria Marlow, Jian Chen, David J. Scurr, Zheying Zhu, Jinyi Xu, Shengtao Xu

Journal of Medicinal Chemistry

DOI

2023

Discovery of Norbornene as a Novel Hydrophobic Tag Applied in Protein Degradation

Shaowen Xie, Feiyan Zhan, Jingjie Zhu, Yuan Sun, Huajian Zhu, Jie Liu, Jian Chen, Zheying Zhu, Dong‐Hua Yang, Zhe‐Sheng Chen, Hong Yao, Jinyi Xu, Shengtao Xu

Angewandte Chemie

DOI

2023

Design, synthesis and biological evaluation of novel dihydroquinolin-4(1H)-one derivatives as novel tubulin polymerization inhibitors

Yuchen Tan, Han Hu, Wenjian Zhu, Wenjian Zhu, Tao Wang, Tian Xiang Gao, Hongqi Wang, Jian Chen, Shengtao Xu, Jinyi Xu, Shengtao Xu, Huajian Zhu

European Journal of Medicinal Chemistry

DOI

2022

Development of p-Tau Differentiated Cell Model of Alzheimer’s Disease to Screen Novel Acetylcholinesterase Inhibitors

Giuseppe Uras, Xinuo Li, Alessia Manca, Antonella Pantaleo, Marco Bo, Jinyi Xu, Stephanie Allen, Zheying Zhu

International Journal of Molecular Sciences

DOI

2021

作用于AT2受体化合物的研究进展

张艳春，张祖志，徐进宜，王丹慧，徐梅月

《药学学报》

DOI

2021

High‐throughput tandem‐microwell assay for ammonia repositions FDA‐Approved drugs to inhibit Helicobacter pylori urease

Fan Liu, Jing Quan Yu, Yan‐Xia Zhang, Fangzheng Li, Qi Liu, Yueyang Zhou, Shengshuo Huang, Houqin Fang, Zhu‐Ping Xiao, Lujian Liao, Jinyi Xu, Xin‐Yan Wu, Fang Wu

The FASEB Journal

DOI

2021

A Practical Synthetic Route to Artepillin C and Drupanin

Xue‐Zheng Zhao, Lu Wang, Xiaoya Li, Qingqing Zhang, Wei Li, Aijun Lin, Jinyi Xu, Xiao‐Ming Wu, Weijia Xie

Asian Journal of Organic Chemistry

DOI

2021

In vitro and in vivo evaluation of a sustained-release once-a-day formulation of the novel antihypertensive drug MT-1207

Napoleon-Nikolaos Vrettos, Peng Wang, Yan Zhou, Clive J. Roberts, Jinyi Xu, Hong Yao, Zheying Zhu

Pharmaceutical Development and Technology

DOI

2020

Direct Transformation of Alkylarenes into N‐(Pyridine‐2‐yl)amides by C(sp3)–C(sp3) Bond Cleavage

Haipin Zhou, Yanpeng Liu, Hai‐Dong Xia, Jinyi Xu, Tingfang Wang, Shengtao Xu

European Journal of Organic Chemistry

DOI

2020

Identification of a Potent Oridonin Analogue for Treatment of Triple-Negative Breast Cancer

Hong Yao, Shaowen Xie, Xiaoqian Ma, Junkai Liu, Hongyu Wu, Aijun Lin, Hequan Yao, Dahong Li, Shengtao Xu, Dong‐Hua Yang, Zhe‐Sheng Chen, Jinyi Xu

Journal of Medicinal Chemistry

DOI

2020

Organocatalytic 1,5-trifluoromethylthio-sulfonylation of vinylcyclopropane mediated by visible light in the water phase

Junkai Liu, Hong Yao, Xinnan Li, Hongyu Wu, Aijun Lin, Hequan Yao, Jinyi Xu, Shengtao Xu

Organic Chemistry Frontiers

DOI

2019

3,6-脱水己糖构建方法的研究进展

王洪，卢路，黄宇豪，徐进宜，谢唯佳，吴晓明

《药学进展》

2019

Practical Route to Neokotalanol and Its Natural Analogues: Sulfonium Sugars with Antidiabetic Activities

Yuhao Huang, Yunlong Gao, Weigang He, Zihao Wang, Wei Li, Aijun Lin, Jinyi Xu, Genzoh Tanabe, Osamu Muraoka, Xiaoming Wu, Weijia Xie

Angewandte Chemie

DOI

2019

Chemodivergent synthesis of N -(pyridin-2-yl)amides and 3-bromoimidazo[1,2- a ]pyridines from α-bromoketones and 2-aminopyridines

Yanpeng Liu, Lixue Lu, Haipin Zhou, Feijie Xu, Cong Ma, Zhangjian Huang, Jinyi Xu, Shengtao Xu

RSC Advances

DOI

2018

异香豆素类仙鹤草内酯的研究进展

李运之，饶雪敏，徐进宜，谢唯佳，吴晓明

《药学进展》

2018

天然环酯肽Hikiamides A-C的全合成

傅东林，饶雪敏，徐进宜，谢唯佳，吴晓明

《中国药科大学学报》

2018

Development of Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Signaling Pathway

Tianyu Wang, Xiaoxing Wu, Changying Guo, Kuojun Zhang, Jinyi Xu, Zheng Li, Sheng Jiang

Journal of Medicinal Chemistry

DOI

2018

First Total Syntheses of Amorfrutin C and pseudo‐Amorfrutin A

Qi Miao, Yunzhi Li, Jinyi Xu, Aijun Lin, Genzoh Tanabe, Osamu Muraoka, Xiaoming Wu, Weijia Xie

European Journal of Organic Chemistry

DOI

2018

Cobalt-catalyzed carbon–sulfur/selenium bond formation: synthesis of benzo[ b ]thio/selenophene-fused imidazo[1,2- a ]pyridines

Tianyu Wang, Jichao Chen, Jia Wang, Shengtao Xu, Aijun Lin, Hequan Yao, Sheng Jiang, Jinyi Xu

Organic & Biomolecular Chemistry

DOI

2017

冬凌草甲素抗肿瘤作用机制及其结构改造研究进展

胡梅，徐盛涛，徐进宜

《药学与临床研究》

2017

五环三萜羽扇豆烷型天然产物抗肿瘤活性研究进展

王艺玮，徐盛涛，徐进宜

《药学与临床研究》

2017

吴茱萸碱类衍生物的生物活性研究进展

裘杨溢，徐盛涛，徐进宜

《药学与临床研究》

2017

氮杂环卡宾催化有机反应的研究进展

王翱，肖永龙，周宇，徐进宜，柳红

《有机化学》

2017

龙脷叶中天然产物sauropunol A-D的全合成

王子豪，王诚倩，徐进宜，吴晓明，谢唯佳

《中国药科大学学报》

2017

Design, synthesis, biological evaluation, and docking study of 4‐isochromanone hybrids bearing N‐benzyl pyridinium moiety as dual binding site acetylcholinesterase inhibitors (part II )

Jia Wang, Chaolei Wang, Zheng Qiu Wu, Xinnan Li, Shengtao Xu, Jie Liu, Qinying Lan, Zheying Zhu, Jinyi Xu

Chemical Biology & Drug Design

DOI

2017

Metal-free C5-selective halogenation of quinolines under aqueous conditions

Jichao Chen, Tianyu Wang, Tianyu Wang, Yanpeng Liu, Tong Wang, Tong Wang, Aijun Lin, Hequan Yao, Jinyi Xu

Organic Chemistry Frontiers

DOI

2016

有机硒化合物及其生物学活性的研究进展

李方正，吴方，徐进宜

《药学与临床研究》

2016

Copper-catalyzed C5-selective thio/selenocyanation of 8-aminoquinolines

Jichao Chen, Tianyu Wang, Tianyu Wang, Tong Wang, Tong Wang, Aijun Lin, Hequan Yao, Jinyi Xu

Organic Chemistry Frontiers

DOI

2016

The Construction of Anhydro Monosaccharides

Weijia Xie, Aijun Lin, Jinyi Xu, Xiaoming Wu

Asian Journal of Organic Chemistry

DOI

2016

Multiple Roles of the Pyrimidyl Group in the Rhodium‐Catalyzed Regioselective Synthesis and Functionalization of Indole‐3‐carboxylic Acid Esters

Hui Jiang, Shang Gao, Jinyi Xu, Xiaoming Wu, Aijun Lin, Hequan Yao

Advanced Synthesis & Catalysis

DOI

2016

Total synthesis, structural elucidation and anti-inflammatory activity evaluation of 2-deoxy-3,6-anhydro hexofuranoside derivatives isolated from Sauropus rostratus

Chenxi Zhang, Chengcheng Wang, Zihao Wang, Genzoh Tanabe, Osamu Muraoka, Aijun Lin, Jinyi Xu, Xiaoming Wu, Liang Li Wu, Weijia Xie

Organic & Biomolecular Chemistry

DOI

2015

具有NO供体的N-苯基-1H-吡咯羧酸结构化合物的设计,合成及抗高血压活性研究

张艳春，姚和权，周金培，吴晓明，徐进宜

《中国药学杂志》

2015

3-烃基-1(3H)-异苯并硒吩酮的合成及其抗血小板聚集和抗氧化活性

方建根，王旭亮，凌菁菁，尹伟，徐进宜，季晖，张奕华

《中国药科大学学报》

2015

Rh( iii )-catalyzed redox-neutral annulation of azo and diazo compounds: one-step access to cinnolines

Peng Sun, Youzhi Wu, Yue Huang, Xiaoming Wu, Jinyi Xu, Hequan Yao, Aijun Lin

Organic Chemistry Frontiers

DOI

2015

Synthesis of Heterocycle‐fused Pyridine N‐Oxides from Oximes and Diazo Compounds via RhIII‐Catalyzed CH Activation and Annulation

Peng Sun, Youzhi Wu, Tie Yang, Xiaoming Wu, Jinyi Xu, Aijun Lin, Hequan Yao

Advanced Synthesis & Catalysis

DOI

2015

Synthesis and Biological Evaluation of Oxygen‐containing Heterocyclic Ring‐fused 23‐Hydroxybetulinic Acid Derivatives as Antitumor Agents

Hengyuan Zhang, Fangzheng Li, Peiqing Zhu, Jie Liu, Hequan Yao, Jieyun Jiang, Wen‐Cai Ye, Xiaoming Wu, Jinyi Xu

Chemical Biology & Drug Design

DOI

2015

Synthesis and Biological Evaluation of Strictosamide Derivatives with Improved Antiviral and Antiproliferative Activities

Zan Li, Zhaoliang Li, Yun‐Wei Lin, Zhaoqing Meng, Gang Ding, Liang Cao, Na Li, Wenjun Liu, Wei Xiao, Xiaoming Wu, Jinyi Xu

Chemical Biology & Drug Design

DOI

2015

Synthesis of spiro[2.5]octa-4,7-dien-6-one with consecutive quaternary centers via 1,6-conjugate addition induced dearomatization of para -quinone methides

Kuo Gai, Xinxin Fang, Xuanyi Li, Jinyi Xu, Xiaoming Wu, Aijun Lin, Hequan Yao

Chemical Communications

DOI

2015

Rh( iii )-catalyzed cyclization reaction of azoles with alkynes: efficient synthesis of azole-fused-pyridines

Xuebing Chen, Youzhi Wu, Jinyi Xu, Hequan Yao, Aijun Lin, Yue Huang

Organic & Biomolecular Chemistry

DOI

2014

23-羟基白桦酸衍生物抗肿瘤作用的三维定量构效关系及分子对接模式探索研究

张婷婷，毕毅，陈蒙蒙，张晓晨，徐进宜，吴晓明

《中国药学杂志》

2014

茚并异喹啉酮类拓扑异构酶1抑制剂的研究进展

丛蔚，吴晓明，徐进宜

《药学与临床研究》

2014

H2S气体分子及相关药物研究进展

杨雪，刘洁，吴晓明，徐进宜

《药学与临床研究》

2014

吡咯并菲啶酮构建方法学研究进展

丛蔚，徐进宜，姚和权

《有机化学》

2014

β-榄香烯对RAW264.7巨噬细胞源性泡沫细胞作用的研究

段文丽，白仁仁，钟颖，徐进宜，尚靖

《现代生物医学进展》

2014

Palladium-catalyzed oxidative cross-coupling of azole-4-carboxylates with indoles: an approach to the synthesis of pimprinine

Haipin Zhou, Kuo Gai, Aijun Lin, Jinyi Xu, Xiaoming Wu, Hequan Yao

Organic & Biomolecular Chemistry

DOI

2014

Synthesis and Biological Evaluations of Novel Nitric Oxide-donating Derivatives of [1,2,4]triazol-5(4H)-one with N-phenylpyrrolyl-2-tetrazole Moiety as Anti-hypertension Candidates

Yanchun Zhang, Jichao Chen, Jinyi Xu, Jinpei Zhou, Xiaoming Wu

Letters in Drug Design & Discovery

DOI

2014

Design, Synthesis and Pharmacological Evaluation of Novel NO ‐Releasing Benzimidazole Hybrids as Potential Antihypertensive Candidate

Yanchun Zhang, Jinyi Xu, Yunman Li, Hequan Yao, Xiaoming Wu

Chemical Biology & Drug Design

DOI

2014

Solvent-Controlled Switchable C–H Alkenylation of 4-Aryl-1 H -pyrrole-3-carboxylates: Application to the Total Synthesis of (±)-Rhazinilam

Youla Su, Haipin Zhou, Jiaxuan Chen, Jinyi Xu, Xiaoming Wu, Aijun Lin, Hequan Yao

Organic Letters

DOI

2014

Novel 3‐Substituted Ocotillol‐Type Triterpenoid Derivatives as Antibacterial Candidates

Yi Bi, Cong Ma, Hengyuan Zhang, Zhiwen Zhou, Jian Xiang Yang, Zhenlei Zhang, Qingguo Meng, Peter John Lewis, Jinyi Xu

Chemical Biology & Drug Design

DOI

2014

A Mannich/cyclization cascade process for the asymmetric synthesis of spirocyclic thioimidazolidineoxindoles

Hao Cai, Yu Zhou, Dong Zhang, Jinyi Xu, Hong Shu Liu

Chemical Communications

DOI

2014

Design, synthesis and biological evaluation of hydrogen sulfide releasing derivatives of 3-n-butylphthalide as potential antiplatelet and antithrombotic agents

Xiaoli Wang, Linna Wang, Xiao Sheng, Zhangjian Huang, Tingting Li, Ming Zhang, Jinyi Xu, Hui Ji, Jian Yin, Yihua Zhang

Organic & Biomolecular Chemistry

DOI

2014

First total synthesis of antihypertensive natural products S-(+)-XJP and R-(−)-XJP

Chaolei Wang, Guoxiang Wei, Xue Yang, Hequan Yao, Jieyun Jiang, Jie Liu, Mingqin Shen, Xiaoming Wu, Jinyi Xu

Organic & Biomolecular Chemistry

DOI

2013

白桦酸衍生物抗HIV活性的研究进展

李赞，徐进宜，谢唯佳，吴晓明

《药学进展》

2013

环氧合酶-2抑制剂类抗肿瘤药物研究进展

黄晓静，姚和权，吴晓明，徐进宜

《药学与临床研究》

2013

天然活性产物异色满-4-酮肟醚类衍生物的合成及其β-肾上腺素受体阻断活性(英文)

白仁仁，徐盛涛，刘洁，洪文，汤依群，吴晓明，谢唯佳，姚和权，徐进宜

Chinese Journal of Natural Medicines

2013

异长春花苷内酰胺经酸催化形成喜果苷的研究(英文)

孟兆青，刘文君，李赞，林蕴薇，李孟璇，安士影，丁岗，王振中，萧伟，徐进宜

Chinese Journal of Natural Medicines

2013

氨基甲酸酯-异山梨醇-丁苯酞开环物三联体的合成及抗血小板聚集活性

杨春昱，黄张建，凌菁菁，季晖，赖宜生，徐进宜，彭司勋，张奕华

《中国药科大学学报》

2013

Transformation of strictosamide to vincoside lactam by acid catalysis

Zhaoqing Meng, Wenjun Liu, Zan Li, Yun‐Wei Lin, Meng-Xuan LI, Shi-Ying AN, Gang Ding, Zhenzhong Wang, Wei Xiao, Jinyi Xu

Chinese Journal of Natural Medicines

DOI

2012

新型羟基脲化合物Ⅲ5的镇痛抗炎作用

蒋斯怡，王秋娟，郭青龙，徐进宜，江波，黄晓静

《中国生化药物杂志》

2012

NO供体型呋咱类1-位氧代冬凌草甲素衍生物的合成及抗增殖活性(英文)

李达翃，王磊，蔡浩，蒋博文，张奕华，孙益军，徐进宜

Chinese Journal of Natural Medicines

2012

Structural elucidation of impurities in 5-n-butyl-4-{4-[2-(1H-tetrazole-5-yl)-1H-pyrrol-1-yl]phenylmethyl}-2,4-dihydro-2-(2,6-dichlorophenyl)-3H-1,2,4-triazol-3-one (Ib), a novel nonpeptide angiotensin AT1 receptor antagonist

Ting Gao, Yaxuan Liu, Yibing Ji, Xiaoming Wu, Jinyi Xu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2011

选择性AT2受体激动剂的构效关系研究进展

刘琴，徐进宜，姚和权，吴晓明

《药学进展》

2011

植物来源的抗肿瘤药物研究进展

王超磊，孙炳峰，姚和权，吴晓明，徐进宜

《药学进展》

2011

14-O-取代冬凌草甲素衍生物的合成及抗肿瘤活性(英文)

王磊，冉倩，李达翃，姚和权，张奕华，袁胜涛，张陆勇，沈明勤，徐进宜

Chinese Journal of Natural Medicines

2011

Copper(II)-catalyzed oxidation of 4-carboxythiazolines and 4-carboxyoxazolines to 4-carboxythiazoles and 4-carboxyoxazoles

Yiyun Wang, Ziyuan Li, Yue Huang, Changhua Tang, Xiaoming Wu, Jinyi Xu, Hequan Yao

Tetrahedron

DOI

2011

Synthetic Routes and Biological Evaluation of Largazole and Its Analogues as Potent Histone Deacetylase Inhibitors

Shang Li, Hequan Yao, Jinyi Xu, Sheng Jiang

Molecules

DOI

2011

Cell-Permeable Iminocoumarine-Based Fluorescent Dyes for Mitochondria

Diliang Guo, Tao Chen, Deju Ye, Jinyi Xu, Hualiang Jiang, Kaixian Chen, Hui Wang, Hong Shu Liu

Organic Letters

DOI

2011

Synthesis and Anti-tumor Activity of 14-O-Derivatives of Natural Oridonin

Lei Wang, Qian Ran, Dahong Li, Hequan Yao, Yihua Zhang, Shengtao Yuan, Luyong Zhang, Mingqin Shen, Jinyi Xu

Chinese Journal of Natural Medicines

DOI

2011

Oxidation of 1-benzyldihydroisoquinolines or 1-benzyltetrahydroisoquinolines with dioxygen to 1-benzoylisoquinolines

Haifeng Gan, Yunyu Lu, Yue Huang, Lijun Ni, Jinyi Xu, Hequan Yao, Xiaoming Wu

Tetrahedron Letters

DOI

2011

Environmental-benign oxidation of 2-oxazolines to oxazoles by dioxygen as the sole oxidant

Yue Huang, Lijun Ni, Haifeng Gan, Yu He, Jinyi Xu, Xiaoming Wu, Hequan Yao

Tetrahedron

DOI

2010

酮内酯类抗生素的结构修饰研究进展

李赞，徐进宜，顾觉奋

《今日药学》

2010

HIV整合酶抑制剂的研究进展

郭涤亮，刘冠男，周宇，李建，徐进宜，蒋华良，陈凯先，柳红

《有机化学》

2010

大黄素的高效提取及其NMR结构探索研究

陈东军，王磊，祖晓冬，王超磊，徐进宜

《南京中医药大学学报》

2010

Concise approach to the core of englerin A via an organocatalytic [4+3] cycloaddition reaction

Bingfeng Sun, Chaolei Wang, Rui Ding, Jinyi Xu, Guo‐Qiang Lin

Tetrahedron Letters

DOI

2010

Design, Synthesis, and Biological Evaluation of 1,5‐Diaryl‐1,2,4‐triazole Derivatives as Selective Cyclooxygenase‐2 Inhibitors

Bo Jiang, Yi Zeng, Meng-jie Li, Jinyi Xu, Yong‐Na Zhang, Qiujuan Wang, Ni‐Yue Sun, Tao Lu, Xiaoming Wu

Archiv der Pharmazie

DOI

2010

Synthesis of 3‐Benzoyl Acrylates/Acrylamides via Dehydrogenation of 3‐Benzoyl Propionates/Propionamides Using IBX/p‐TsOH

Ziyuan Li, Yiyun Wang, Changhua Tang, Jinyi Xu, Xiaoming Wu, Hequan Yao

Chinese Journal of Chemistry

DOI

2010

ChemInform Abstract: Oxidation of 4‐Carboxylate Thiazolines to 4‐Carboxylate Thiazoles by Molecular Oxygen.

Yue Huang, Haifeng Gan, Shang Li, Jinyi Xu, Xiaoming Wu, Hequan Yao

ChemInform

DOI

2010

Oxidation of 4-carboxylate thiazolines to 4-carboxylate thiazoles by molecular oxygen

Yue Huang, Haifeng Gan, Shang Li, Jinyi Xu, Xiaoming Wu, Hequan Yao

Tetrahedron Letters

DOI

2009

Raltegravir的合成工艺研究(英文)

郭涤亮，刘冠男，李建，周宇，徐进宜，蒋华良，柳红

《中国药科大学学报》

2009

新型三唑类化合物Ⅱ3的抗炎作用及其机制

张永娜，颜天华，王秋娟，郭青龙，徐进宜，吴晓明

《中国药科大学学报》

2009

毛细管气相色谱法测定新药Ⅰb原料中9种残留溶剂

季一兵，张瑜，徐进宜，吴晓明

《中国新药杂志》

2009

新型三唑类化合物Ⅱ3的镇痛作用及对环氧酶活性的影响

张永娜，颜天华，王秋娟，江波，徐进宜，吴晓明

《中国药科大学学报》

2008

环氧合酶-2和5-脂氧化酶双重抑制剂的研究进展

江波，徐进宜，吴晓明，华维一

《中国现代应用药学》

2008

新型AT1受体拮抗剂化合物Ib对血管紧张素Ⅱ诱导的血管平滑肌细胞增殖的抑制作用

王玉，王秋娟，徐进宜，吴晓明，季晖

《中国药科大学学报》

2008

1,5-二芳基取代-1,2,4-三唑类衍生物的合成、抗炎活性及其构效关系研究

徐进宜，曾翼，江波，付立志，朱林荣，张晓栋，吴晓明，华维一，王秋娟，贾莹，杨丰

《中国药物化学杂志》

2008

Efficient Iron-Catalyzed N-Arylation of Aryl Halides with Amines

Diliang Guo, He Huang, Jinyi Xu, Hualiang Jiang, Hong Liu

Organic Letters

DOI

2008

Simultaneous determination of multiple angiotensin type 1 receptor antagonists and its application to high-throughput pharmacokinetic study: Cassette dosing versus cassette analysis

Xiaoyan Zhu, Jianguo Sun, Haiping Hao, Guangji Wang, Xiaoling Hu, Hua Lv, Shenghua Gu, Xiaoming Wu, Jinyi Xu

International Journal of Mass Spectrometry

DOI

2007

冬凌草甲素的研究进展

冉倩，徐进宜，吴晓明，华维一

《药学与临床研究》

2007

抗肿瘤天然药物的研究概况

杨静怡，徐进宜，吴晓明，华维一

《中国现代应用药学》

2007

23-羟基白桦脂酸的30位羟基衍生物的合成及其抗肿瘤活性

毕毅，徐进宜，吴晓明，叶文才，袁胜涛，张陆勇

《中国药科大学学报》

2007

新型AT1受体拮抗剂Ⅰb对血管紧张素Ⅱ的拮抗作用

王玉，王秋娟，吴锦慧，徐进宜，吴晓明

《中国药科大学学报》

2007

γ-氨基丁酸受体及相关药物研究进展

付立志，徐进宜，吴晓明，华维一，王其华

《中国医疗前沿》

2007

新型AT1受体拮抗剂Ⅰb对异丙肾上腺素诱发大鼠心肌肥厚的作用

张静，王秋娟，徐进宜，吴晓明

《中国药科大学学报》

2007

[Ca2+]i and PKC-α are involved in the inhibitory effects of Ib, a novel nonpeptide AngiotensinII subtype AT1 receptor antagonist, on AngiotensinII-induced vascular contraction in vitro

Yu Wang, Wei Wang, Qiujuan Wang, Jinhui Wu, Jinyi Xu, Jinhui Wu

Biochemical and Biophysical Research Communications

DOI

2007

Determination of 5-n-Butyl-4-{4-[2-(1H-tetrazole-5-yl)-1H-pyrrol-1-yl]phenylmethyl}-2,4-dihydro-2-(2,6-dichloridephenyl)-3H-1,2,4-triazol-3-one, a New Angiotensin Type 1 Receptor Antagonist in Rat Plasma by LC-ESI-MS: Application to Pharmacokinetic Studies

Bei Yan, Guangji Wang, Jianguo Sun, Fen-zhi Sun, Xiaoyu Li, Xiao-ming Wu, Jinyi Xu, Yuanting Zheng, Hua Lv

Chromatographia

DOI

2007

Identification of the major metabolites of 5‐n‐butyl‐4‐{4‐[2‐(1H‐tetrazole‐5‐yl)‐1H‐pyrrol‐1‐yl]phenylmethyl}‐2,4‐dihydro‐2‐(2,6‐dichloridephenyl)‐3H‐1,2,4‐triazol‐3‐one, a new angiotensin type 1 receptor antagonist, in rat bile by HPLC–diode array detection–MS and HPLC‐MS/MS

Bei Yan, Guangji Wang, Jianguo Sun, Xiaoyu Li, Yuanting Zheng, Hua Ai, Hua Lv, Xiaoming Wu, Jinyi Xu

Biomedical Chromatography

DOI

2006

白桦酸类化合物抗肿瘤活性的研究进展

徐萍，周金培，徐进宜，吴晓明

《药学前沿》

2006

新型血管紧张素Ⅱ受体和内皮素受体双重拮抗剂研究进展

魏臻，徐进宜，吴晓明，华维一

《药学进展》

2006

选择性环氧合酶-2抑制剂的研究现状及进展

曾翼，徐进宜，吴晓明，华维一

《中国新药杂志》

2006

4-取代-3-烷基-4,5-二氢-1-(3-氯-4-氟苯基)-1,2,4-三唑-5-酮的合成及生物活性

徐进宜，贺乾辉，魏臻，曾翼，华维一，吴晓明，王秋娟，胡松，张静

《有机化学》

2006

新型AT1受体拮抗剂Ⅰb对L-甲状腺素诱发大鼠心肌肥厚的作用

张静，王秋娟，徐进宜，吴晓明

《中国药科大学学报》

2006

药物化学

徐进宜

《化学工业出版社》

2006

Synthesis and cytotoxic activity of 17-carboxylic acid modified 23-hydroxy betulinic acid ester derivatives

Yi Bi, Jinyi Xu, Xiaoming Wu, Wen‐Cai Ye, Shengtao Yuan, Luyong Zhang

Bioorganic & Medicinal Chemistry Letters

DOI

2005

抗艾滋病药物的研究进展

毕毅，徐进宜，吴晓明

《中国现代应用药学》

2005

药物化学课程群的改革与建设

徐进宜，尤启冬，姚其正

《药学教育》

2005

二芳基取代-1,2,4-三唑类化合物的合成及其抗炎活性研究

徐进宜，姚和权，曾翼，华维一，吴晓明，王秋娟，胡松，吴雪丰，岳攀

《高等学校化学学报》

2005

4,5-二氢-1,2,4-三唑-5-酮类化合物的设计 合成及生物活性

徐进宜，魏臻，曾翼，华维一，吴晓明，王秋娟，张静

《中国药物与临床》

2005

N-苯基-1H-吡咯取代的双苯并咪唑类衍生物的合成及其AT1受体拮抗活性研究

徐进宜，张立，魏臻，华维一，吴晓明，王秋娟，张静

《中国药科大学学报》

2005

白桦酸类化合物的研究进展

毕毅，徐进宜，吴晓明

《中国新药杂志》

2005

非肽类血管紧张素ⅡAT1受体拮抗剂的定量构效关系研究

徐进宜，吉念宁，华维一，吴晓明

《中国药科大学学报》

2004

芳香化酶抑制剂来曲唑的研究进展

祝鸿，徐进宜，吴晓明

《海峡药学》

2004

甲氨蝶呤与一氧化氮供体或一氧化氮合酶抑制剂组合物的合成

姚其正，张志祥，PFLEIDERER，Wolfgang，郑国海，徐进宜，唐锋，华维一

《化学学报》

2004

2,6-二氟苯甲醛的合成

汪嵘，徐进宜，王亚楼

《江苏化工》

2003

治疗充血性心力衰竭药物进展

贺乾辉，周金培，徐进宜，吴晓明

《药物流行病学杂志》

2001

4′-甲基-N-叔丁基-1′,2-联苯磺酰胺的合成

李能刚，徐进宜，吴晓明

《中国医药工业杂志》

2001

血管紧张素受体AT1/AT2均衡拮抗剂的研究现状

张立，徐进宜，吴晓明

《药学进展》

2000

非甾体抗炎药的研究与开发

姚和权，徐进宜，吴晓明

《药学进展》

2000

血管紧张素转化酶和中性肽链内切酶的双重抑制剂

李能刚，徐进宜，吴晓明

《药学进展》

1999

1-芳基-3-烷基-1,4-二氢-4-取代-5H-1,2,4-三唑啉酮-5衍生物的合成及生物活性

徐进宜，周宇昕，吴晓明，唐康，王秋娟

《中国药科大学学报》

1999

高香草酸的合成

王亚楼，徐进宜，文国清

《中国药科大学学报》

1998

浅谈药物化学课程的教学

徐进宜

《药学教育》

1998

新型降压药洛沙坦的合成

徐进宜，赵胜宝，吴晓明，华维一

《中国药物化学杂志》

1998

咪唑啉、噁唑啉类化合物的合成及其降压活性研究

徐进宜，王亚楼，傅继华，郑悟华，张华

《中国药科大学学报》

1997

药化专业药化实验改革的进一步探索

李志裕，徐进宜，尤启冬，王华

《药学教育》

1997

药物化学课程建设的几点体会

尤启冬，李志裕，徐进宜，毕小玲，王华

《药学教育》

1997

3,4-二甲氧基芳烷胺类衍生物的合成及生物活性

徐进宜，夏霖，倪沛洲，傅纪华

《中国药科大学学报》

1996

齐多夫定和拉米夫定联用治疗艾滋病

徐进宜

《药学进展》

1995

左旋羟丙哌嗪

徐进宜

《药学进展》

1992

苯乙胺类化合物的合成及心血管活性

徐进宜，夏霖，倪沛洲

《中国药科大学学报》

1992

3,4-二甲氧基苯乙胺类衍生物构效关系研究

夏霖，韦苞洋，蔡惠民，徐进宜，倪沛洲

《中国药科大学学报》

1992

N-取代甘氨酰美西律的合成及其心血管活性的研究

倪沛洲，徐进宜，唐伟方，贾丽莎，夏霖，柳红

《中国药科大学学报》

1989

促渗剂Azone对几种药物透皮速率的影响

沈子龙，徐进宜，蔺胜照，郭素珍

《中国药理学通报》

会议论文

2012

Construction of some libraries of novel diterpenoid analogues:design,synthesis and biological evaluation

李达翃，蔡浩，裴玲玲，徐盛涛，王磊，徐进宜

《2012长三角药物化学研讨会论文集》

2012

Design,synthesis and biological evaluation of novel ocotillol-type ginsenoside derivatives

周志文，张恒源，毕毅，吴晓明，徐进宜

《2012长三角药物化学研讨会论文集》

2012

Design,synthesis and antihypertensive evaluation of novel nitric oxide-releasing isochroman-4-one hybrids

白仁仁，杨雪，徐进宜，吴晓明

《2012长三角药物化学研讨会》

2012

硫化氢供体型丁苯酞衍生物的设计、合成及其抗脑缺血活性研究

王晓丽，徐进宜，张奕华

《2012长三角药物化学研讨会》

2011

Synthesis and biological activity of substituted biphenyl sulfonamides as non-peptide angiotensin AT2 receptor agonists

刘琴，白仁仁，姜坤桃，吴晓明，徐进宜

《2011年全国药物化学学术会议——药物的源头创新》

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