邓国亮｜信阳师范大学｜学者主页

2025

Targeting MAPK14 by Lobeline Upregulates Slurp1‐Mediated Inhibition of Alternative Activation of TAM and Retards Colorectal Cancer Growth

Mingxia Zhao, Li-Sha Zhou, Qin-Chang Zhang, Meijing Wang, Yue Dong, Yue Wang, Rui-Xue Pei, Enguang He, Yanyan Liang, Yu-Jun Shen, Guoliang Deng, Hong-Qi Chen, Dongdong Sun, Yu-Xian Shen, Yang Sun, Hai-Bo Cheng

Advancement of science

DOI

2025

Harnessing FDA-approved dipyridamole to inhibit NLRP3 inflammasome and improve outcomes of acute lung injury in sepsis.

Xiuhui Chen, Yutong Zheng, Xiao-Feng Zhang, Anran Zheng, Junjun Huang, Guoliang Deng, Xuna Wu, Yuying Peng, Xiao-Ling Zhang, Renshan Chen, Qing Xiao, Weijun Ye

Toxicology and Applied Pharmacology

DOI

2024

Erratum: Author correction to "SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade" [Acta Pharm Sin B 9 (2019) 304-315].

Mingxia Zhao, Wen-Jie Guo, Yuanyuan Wu, Chenxi Yang, L. Zhong, Guoliang Deng, Yu-Yu Zhu, Wen Liu, Yanhong Gu, Yin Lu, Ling-Dong Kong, Xiangbao Meng, Qiang Xu, Yang Sun

Acta Pharmaceutica Sinica B

DOI

2024

Erratum: Author correction to "Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice" [Acta Pharm Sin B 11 (2021) 1200-1212].

Yu-Yu Zhu, Ning Wan, Xinni Shan, Guoliang Deng, Qiang Xu, Hui Ye, Yang Sun

Acta Pharmaceutica Sinica B

DOI

2024

Targeting the NLRP3 inflammasome in psoriasis

Xiuhui Chen, Guoliang Deng, Kaifeng Chen, Yanhong Chen, Weijun Ye, Ping Sun

International Journal of Dermatology

DOI

2023

Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer

Xiao-Fan Sun, Li-Sha Zhou, Yi Wang, Guoliang Deng, Xinran Cao, Bo-Wen Ke, Xiaoqi Wu, Yan-Hong Gu, Hai-Bo Cheng, Qiang Xu, Qian-Ming Du, Hong-Qi Chen, Yang Sun

Journal of Pharmaceutical Analysis

DOI

2022

Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation

Guoliang Deng, Li-Sha Zhou, Binglin Wang, Xiao-Fan Sun, Qin-Chang Zhang, Hong-Qi Chen, Ning Wan, Hui Ye, Xiaoqi Wu, Dongdong Sun, Yang Sun, Hai-Bo Cheng

Journal for ImmunoTherapy of Cancer

DOI

2022

Re-Du-Ning injection ameliorates radiation-induced pneumonitis and fibrosis by inhibiting AIM2 inflammasome and epithelial-mesenchymal transition.

Chenxi Yang, Chenglin Song, Yi Wang, Wen-Cheng Zhou, W. Zheng, Hang Zhou, Guoliang Deng, Haibo Li, Wei Xiao, Zhongqi Yang, Ling-Dong Kong, Hui-Ming Ge, Ya-kun Song, Yang Sun

Phytomedicine

DOI

2021

CXCR6 is required for antitumor efficacy of intratumoral CD8+ T cell

Binglin Wang, Yi Wang, Xiao-Fan Sun, Guoliang Deng, Wei Huang, Xing-Xin Wu, Yang-Hong Gu, Z. Tian, Zhi-Min Fan, Qiang Xu, Hong-Qi Chen, Yang Sun

Journal for ImmunoTherapy of Cancer

DOI

2021

Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation.

Yanpin Gu, Yong-Cheng Zhu, Guoliang Deng, Songjun Liu, Yang Sun, W-F Lv

International Immunopharmacology

DOI

2020

中药活性分子环黄芪醇增强抗肿瘤免疫的初步机制研究

邓国亮

《南京大学》

2020

Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice

Yu-Yu Zhu, Ning Wan, Xinni Shan, Guoliang Deng, Qiang Xu, Hui Ye, Yang Sun

Acta Pharmaceutica Sinica B

DOI

2020

Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels

Wen Liu, Ye Yin, Meijing Wang, Ting Fan, Yu-Yu Zhu, Lihong Shen, Shuang Peng, Jian Gao, Guoliang Deng, Xiangbao Meng, Ling-Dong Kong, Gen-Sheng Feng, Wen-Jie Guo, Qiang Xu, Yang Sun

Journal of Biological Chemistry

DOI

2019

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis

Jian Gao, Shuang Peng, Xinni Shan, Guoliang Deng, Lihong Shen, Jian Sun, Chun-Hong Jiang, Xiaoling Yang, Z. Chang, Xin-Chen Sun, F. Feng, Ling-Dong Kong, Yan-Hong Gu, Wen-Jie Guo, Qiang Xu, Yang Sun

Cell Death and Disease

DOI

2019

Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice.

Guoliang Deng, Wen-Jun Chen, Peng Wang, Tianying Zhan, Wei Zheng, Zhengbing Gu, Xiao-Mei Wang, Xiaoyun Ji, Yang Sun

International Immunopharmacology

DOI

2019

Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis

Mingxia Zhao, Lihong Shen, Zi-Jun Ouyang, Manru Li, Guoliang Deng, Chenxi Yang, Wei Zheng, Ling-Dong Kong, Xue-Feng Wu, Xue-Feng Wu, Wen-Jie Guo, Ye Yin, Qiang Xu, Yang Sun

Journal of Molecular Cell Biology

DOI

2018

SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade

Mingxia Zhao, Wen-Jie Guo, Yuanyuan Wu, Chenxi Yang, L. Zhong, Guoliang Deng, Yu-Yu Zhu, Wen Liu, Yan-Hong Gu, Yin Lu, Ling-Dong Kong, Xiangbao Meng, Qiang Xu, Yang Sun

Acta Pharmaceutica Sinica B

DOI

邓国亮

精选作品

期刊论文

Targeting MAPK14 by Lobeline Upregulates Slurp1‐Mediated Inhibition of Alternative Activation of TAM and Retards Colorectal Cancer Growth

Harnessing FDA-approved dipyridamole to inhibit NLRP3 inflammasome and improve outcomes of acute lung injury in sepsis.

Erratum: Author correction to "SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade" [Acta Pharm Sin B 9 (2019) 304-315].

Erratum: Author correction to "Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice" [Acta Pharm Sin B 11 (2021) 1200-1212].

Targeting the NLRP3 inflammasome in psoriasis

Single-cell analyses reveal cannabidiol rewires tumor microenvironment via inhibiting alternative activation of macrophage and synergizes with anti-PD-1 in colon cancer

Targeting cathepsin B by cycloastragenol enhances antitumor immunity of CD8 T cells via inhibiting MHC-I degradation

Re-Du-Ning injection ameliorates radiation-induced pneumonitis and fibrosis by inhibiting AIM2 inflammasome and epithelial-mesenchymal transition.

CXCR6 is required for antitumor efficacy of intratumoral CD8+ T cell

Curcumin analogue AI-44 alleviates MSU-induced gouty arthritis in mice via inhibiting cathepsin B-mediated NLRP3 inflammasome activation.

中药活性分子环黄芪醇增强抗肿瘤免疫的初步机制研究

Celastrol targets adenylyl cyclase-associated protein 1 to reduce macrophages-mediated inflammation and ameliorates high fat diet-induced metabolic syndrome in mice

Disrupting phosphatase SHP2 in macrophages protects mice from high-fat diet-induced hepatic steatosis and insulin resistance by elevating IL-18 levels

Inhibition of AIM2 inflammasome-mediated pyroptosis by Andrographolide contributes to amelioration of radiation-induced lung inflammation and fibrosis

Inhibition of NLRP3 inflammasome-mediated pyroptosis in macrophage by cycloastragenol contributes to amelioration of imiquimod-induced psoriasis-like skin inflammation in mice.

Loss of hnRNP A1 in murine skeletal muscle exacerbates high-fat diet-induced onset of insulin resistance and hepatic steatosis

SHP2 inhibition triggers anti-tumor immunity and synergizes with PD-1 blockade

研究方向