尤琳雅｜复旦大学｜学者主页

2026

基于DeepSeek-R1模型的PBL教学模式构建与应用

刘禺汐，徐晓菲，王铭洁，向萌，杨达伟，尤琳雅，刘琼

《基础医学与临床》

2026

项目小组合作学习和虚拟仿真在大脑发育教学中的结合

尤琳雅，陈彦熙，刘琼

《解剖学杂志》

2026

人工智能应用于阿尔茨海默病神经病理特征识别

张书铨，陆辉，姜民，庞圣如，李文生，刘颖，刘琼，尤琳雅

《解剖学报》

2026

组织胚胎学神经组织实验教学多模态模式的构建与实践

尤琳雅，陈彦熙，刘琼

《解剖学杂志》

2026

Erratum to: Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

Weiwei Xian, Mohammad Asad, Shuai Wu, Zhixin Bai, Fengjiao Li, Junfeng Lu, Gaoyu Zu, Erin Brintnell, Hong Chen, Ying Mao, Guomin Zhou, Bo Liao, Jinsong Wu, Edwin Wang, Linya You

MedScience

DOI

2026

Astrocytes as central integrators of neural circuit function: Mechanisms and dysregulation in neuropsychiatric disorders

Xinyu Liu, Xin Zhou, Ruotong Meng, Yanxi Chen, You Chen, Blake Highet, Maurice A. Curtis, Bernhard Hirt, Shunying Yu, Jin Zhou, Linya You

Clinical and Translational Discovery

DOI

2026

Transcriptomics and functional genomics implicate WNT3 in hemispheric lateralization of speech production

Zixian Wang, Yanxi Chen, Yongqi Feng, Gaoyu Zu, Wenxu Wang, Limiao Liang, Xinyu Liu, Yuhang Mei, Jiaxuan Yang, Tian Wang, Mengqi Liu, Linxi Jiang, Russell G. Snell, Blake Highet, Maurice A. Curtis, Liang Chen, Shi‐Bin Li, Jinsong Wu, Menghan Zhang, Wensheng Li, Gong‐Hong Wei, Linya You

iScience

DOI

2025

SpatialE identifies spatial enrichment of Alzheimer's Disease and Amyotrophic Lateral Sclerosis genes in human brain

Jingyan Guo, Linya You, Yan Chen, Ming Zhang

Alzheimer s & Dementia

DOI

2025

Molecular architecture of language‐related cortical areas revealed by integrative proteomic and connectome analyses

Jinsong Wu, Zixian Wang, Fengjiao Li, Shuolei Bu, Lianglong Sun, Zheng Chen, Zhixin Bai, Luhao Yang, Fangyuan Gong, Jiali Chen, Yien Huang, Wanjing Li, Guoquan Yan, Weiwei Xian, Jiaxuan Yang, Shuai Wu, Kemin Zhu, Wenke Fan, Qiong Liu, Guomin Zhou, Gong‐Hong Wei, Wensheng Li, Jing Yan, Jingliang Cheng, Russell G. Snell, Maurice A. Curtis, Tianye Jia, Binke Yuan, Yong He A, Weijiang Zhang, Linya You

Clinical and Translational Medicine

DOI

2025

Deep learning analyses of splicing variants identify the link of PCP4 with amyotrophic lateral sclerosis

Tang Xuelin, Yan Chen, Yongfei Ren, Wanli Yang, Wendi Yu, Yu Zhou, Jingyan Guo, Jiali Hu, Xi Chen, Yuqi Gu, Chuyi Wang, Yi Dong, Hong Seuk Yang, Christine Sato, Ji He, Dongsheng Fan, Linya You, Lorne H. Zinman, Ekaterina A. Rogaeva, Yelin Chen, Ming Zhang

Brain

DOI

2024

正常和帕金森病患者基底神经节的转录差异分析

俎高钰，李凤娇，咸伟伟，郭旸洋，赵百成，李文生，尤琳雅

《解剖学报》

2024

Single nuclei RNA-seq reveals a medium spiny neuron glutamate excitotoxicity signature prior to the onset of neuronal death in an ovine Huntington’s disease model

Andrew Jiang, Linya You, Renée R. Handley, Victoria Hawkins, Suzanne J. Reid, Jessie C. Jacobsen, Stefano Patassini, Skye R. Rudiger, Clive J. McLaughlan, Jennifer M. Kelly, Paul John Verma, Christopher Simon Bawden, James F. Gusella, Marcy E. MacDonald, Henry John Waldvogel, Richard L. M. Faull, Klaus Lehnert, Russell G. Snell

Human Molecular Genetics

DOI

2024

Spatial enrichment and genomic analyses reveal the link of NOMO1 with amyotrophic lateral sclerosis

Jingyan Guo, Linya You, Yu Zhou, Jiali Hu, Jiahao Li, Wanli Yang, Tang Xuelin, Yi‐Min Sun, Yuqi Gu, Yi Dong, Xi Chen, Christine Sato, Lorne H. Zinman, Ekaterina A. Rogaeva, Jian Wang, Yan Chen, Ming Zhang

Brain

DOI

2024

Regional- and cell type-specific changes of the human brain during aging

Yanxi Chen, Gaoyu Zu, Bill Ling Feng Zhang, Zhixin Bai, Qiong Liu, Wensheng Li, Linya You

Human Brain

DOI

2023

Forebrain excitatory neuron-specific loss of Brpf1 attenuates excitatory synaptic transmission and impairs spatial and fear memory

Baicheng Zhao, Hang Zhang, Ying Liu, Gaoyu Zu, Yuxiao Zhang, Jiayi Hu, Shuai Liu, Linya You

Neural Regeneration Research

DOI

2023

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

Weiwei Xian, Mohammad Asad, Shuai Wu, Zhixin Bai, Fengjiao Li, Junfeng Lu, Gaoyu Zu, Erin Brintnell, Hong Chen, Ying Qing Mao, Guomin Zhou, Bo Liao, Jinsong Wu, Edwin Wang, Linya You

Frontiers of Medicine

DOI

2023

INCREASED DIFFERENTIAL GENE EXPRESSION AND NETWORK OF DOPAMINE NEURONS IN SCHIZOPHRENIA BASAL GANGLIA BY SPLIT-SEQ

Fengjiao Li, Peilong Li, Ying Zhu, Linya You

IBRO Neuroscience Reports

DOI

2023

HIPPOCAMPUS-SPECIFIC LOSS BRPF1 MURINE MODEL EXHIBITS ATTENUATED EXCITATORY SYNAPTIC TRANSMISSION AND IMPAIRED SPATIAL AND FEAR MEMORY

Baicheng Zhao, Hang Zhang, Ying Liu, Linya You

IBRO Neuroscience Reports

DOI

2022

Delineation of complex gene expression patterns in single cell RNA-seq data with ICARUS v2.0

Andrew Jiang, Linya You, Russell G. Snell, Klaus Lehnert

NAR Genomics and Bioinformatics

DOI

2022

Elevated ETV6 Expression in Glioma Promotes an Aggressive In Vitro Phenotype Associated with Shorter Patient Survival

Zhang Xiong, Shuai Wu, Feng-jiao Li, Chen Luo, Qiu-yan Jin, Ian David Connolly, Melanie Hayden Gephart, Linya You

Genes

DOI

2022

BRPF1-KAT6A/KAT6B Complex: Molecular Structure, Biological Function and Human Disease

Gaoyu Zu, Ying Liu, Jingli Cao, Baicheng Zhao, Hang Zhang, Linya You

Cancers

DOI

2022

Microglia Heterogeneity: A Single-cell Concerto

Leilei Wang, Haoran Wu, Shanshan Zhang, Dingxian He, Yi Chen, Jingxin Xue, Linya You, Qiong Liu, Wensheng Li

Human Brain

DOI

2022

ICARUS, an interactive web server for single cell RNA-seq analysis

Andrew Jiang, Klaus Lehnert, Linya You, Russell G. Snell

Nucleic Acids Research

DOI

2021

上海脑库脑组织样本的质量控制分析

李凤娇，咸伟伟，卜硕蕾，曹静丽，吴劲松，李文生，尤琳雅

《解剖学报》

DOI

2021

Deficiency of Intellectual Disability-Related Gene Brpf1 Attenuated Hippocampal Excitatory Synaptic Transmission and Impaired Spatial Learning and Memory Ability

Weiwei Xian, Jingli Cao, Xiang-Shan Yuan, Guoxiang Wang, Qiuyan Jin, Hang Zhang, Guomin Zhou, Linya You

Frontiers in Cell and Developmental Biology

DOI

2021

Deficiency of intellectual disability-related gene Brpf1 reduced inhibitory neurotransmission in MGE-derived GABAergic interneurons

Jingli Cao, Weiwei Xian, Maierdan Palihati, Yu Zhu, Guoxiang Wang, Yunli Xie, Guomin Zhou, Linya You

G3 Genes Genomes Genetics

DOI

2019

Analysis of cell diversity in human and mouse basal ganglia by single-cell RNA sequencing

Fengjiao Li, Mohammad Imam Hasan Bin Asad, Xiang-Shan Yuan, Weiwei Xian, Qiong Liu, Wensheng Li, Guomin Zhou, Edwin Wang, Linya You

IBRO Reports

DOI

2019

Single-cell profiling of tumors more accurately classifies glioma molecular subtypes

Weiwei Xian, Mohammad Imam Hasan Bin Asad, Shuai Wu, Fengjiao Li, Junfeng Lu, Hong Chen, Ying Qing Mao, Liangfu Zhou, Guomin Zhou, Jinsong Wu, Edwin Wang, Linya You

IBRO Reports

DOI

2019

of fetal

Lin-Ya You, Lin Li, J. Zou, Kezhi Yan, Jad I. Belle, A. Nijnik, Edwin Wang, Xiang-Jiao Yang

2016

BRPF1 is essential for development of fetal hematopoietic stem cells.

Lin-Ya You, Lin Li, Jinfeng Zou, Kezhi Yan, Jad I. Belle, A. Nijnik, E. Wang, Xiang-Jiao Yang

Journal of Clinical Investigation

DOI

2016

Mice lacking α-tubulin acetyltransferase 1 are viable but display α-tubulin acetylation deficiency and dentate gyrus distortion.

Go-woon Kim, Lin Li, Mohammad Ghorbani, Lin-Ya You, Xiang-Jiao Yang

Journal of Biological Chemistry

DOI

2015

Brpf1 loss compromises neural stem cells and neuronal precursors.

Lin-Ya You, Kezhi Yan, Jin-Feng Zhou, Hong Zhao, R. Nicholas, Park Morag, W. Edwin, Xiang-Jiao Yang

DOI

2015

Deficiency of the Chromatin Regulator Brpf1 Causes Abnormal Brain Development*

Lin-Ya You, Jinfeng Zou, Hong Zhao, N. Bertos, Morag Park, E. Wang, Xiang-Jiao Yang

Journal of Biological Chemistry

DOI

2015

The Lysine Acetyltransferase Activator Brpf1 Governs Dentate Gyrus Development through Neural Stem Cells and Progenitors

Lin-Ya You, Kezhi Yan, Jin-Feng Zhou, Hong Zhao, N. Bertos, Morag Park, E. Wang, Xiang-Jiao Yang

PLoS Genetics

DOI

2015

Brpf1 loss impairs dentate gyrus development, dendritic tree formation and neuronal proliferation.

Lin-Ya You, Kezhi Yan, Jin-Feng Zhou, Hong Zhao, R. Nicholas, Park Morag, W. Edwin, Xiang-Jiao Yang

DOI

2015

Deregulated Gfap expression in the mutant hippocampus.

Lin-Ya You, Kezhi Yan, Jin-Feng Zhou, Hong Zhao, R. Nicholas, Park Morag, W. Edwin, Xiang-Jiao Yang

DOI

2015

Brpf1 expression during forebrain development.

Lin-Ya You, Kezhi Yan, Jin-Feng Zhou, Hong Zhao, R. Nicholas, Park Morag, W. Edwin, Xiang-Jiao Yang

DOI

2015

Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.

Jianyun Nie, Chao Xu, Jing Jin, J. A. Aka, W. Tempel, Vivian Nguyen, Lin-Ya You, Ryan Weist, J. Min, T. Pawson, Xiang-Jiao Yang

Structure

DOI

2015

Analysis of neuronal migration in the hippocampus by BrdU labeling.

Lin-Ya You, Kezhi Yan, Jin-Feng Zhou, Hong Zhao, R. Nicholas, Park Morag, W. Edwin, Xiang-Jiao Yang

DOI

2015

Forebrain-specific Brpf1 loss causes hypoplasia of the dentate gyrus.

Lin-Ya You, Kezhi Yan, Jin-Feng Zhou, Hong Zhao, R. Nicholas, Park Morag, W. Edwin, Xiang-Jiao Yang

DOI

2015

Defective Tbr2+ and NeuroD1+ neuronal precursors in the mutant hippocampus.

Lin-Ya You, Kezhi Yan, Jin-Feng Zhou, Hong Zhao, R. Nicholas, Park Morag, W. Edwin, Xiang-Jiao Yang

DOI

2015

The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival*

Kezhi Yan, Lin-Ya You, C. Degerny, Mohammad Ghorbani, Xin Liu, Lulu Chen, Lin Li, D. Miao, Xiang-Jiao Yang

Journal of Biological Chemistry

DOI

2015

The Chromatin Regulator Brpf1 Regulates Embryo Development and Cell Proliferation*

Lin-Ya You, Kezhi Yan, Jinfeng Zou, Hong Zhao, N. Bertos, Morag Park, E. Wang, Xiang-Jiao Yang

Journal of Biological Chemistry

DOI

2015

Brpf1 loss deregulates gene expression important for hippocampus development.

Lin-Ya You, Kezhi Yan, Jin-Feng Zhou, Hong Zhao, R. Nicholas, Park Morag, W. Edwin, Xiang-Jiao Yang

DOI

2015

Correction: The Lysine Acetyltransferase Activator Brpf1 Governs Dentate Gyrus Development through Neural Stem Cells and Progenitors

Lin-Ya You, Kezhi Yan, Jinfeng Zou, Hong Zhao, N. Bertos, Morag Park, E. Wang, Xiang-Jiao Yang

PLoS Genetics

DOI

2015

Cell cycle properties and progenitor number in the mutant dentate gyrus.

Lin-Ya You, Kezhi Yan, Jin-Feng Zhou, Hong Zhao, R. Nicholas, Park Morag, W. Edwin, Xiang-Jiao Yang

DOI

2014

Expression atlas of the multivalent epigenetic regulator Brpf1 and its requirement for survival of mouse embryos

Lin-Ya You, Lulu Chen, J. Penney, D. Miao, Xiang-Jiao Yang

Epigenetics

DOI

2013

The Tumor Suppressor Kinase LKB1 Activates the Downstream Kinases SIK2 and SIK3 to Stimulate Nuclear Export of Class IIa Histone Deacetylases*

Donald R. Walkinshaw, Ryan Weist, Go-woon Kim, Lin-Ya You, Lin Xiao, Jianyun Nie, Cathy S. Li, S. Zhao, Ming-Hong Xu, Xiang-Jiao Yang

Journal of Biological Chemistry

DOI

2013

Mice Lacking α-Tubulin Acetyltransferase 1 Are Viable but Display α-Tubulin Acetylation Deficiency and Dentate Gyrus Distortion*

Go-woon Kim, Lin Li, M. Gorbani, Lin-Ya You, Xiang-Jiao Yang

Journal of Biological Chemistry

DOI

2013

Sumoylation of Krüppel-like Factor 4 Inhibits Pluripotency Induction but Promotes Adipocyte Differentiation*

Soroush Tahmasebi, Mohammad Ghorbani, P. Savage, Kezhi Yan, Goran Gocevski, Lin Xiao, Lin-Ya You, Xiang-Jiao Yang

Journal of Biological Chemistry

DOI

2012

Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock

Chao Xu, Jing Jin, C. Bian, R. Lam, Ruijun Tian, Ryan Weist, Lin-Ya You, Jianyun Nie, A. Bochkarev, W. Tempel, C. S. Tan, G. Wasney, M. Vedadi, G. Gish, C. Arrowsmith, T. Pawson, Xiang-Jiao Yang, J. Min

Science Signaling

DOI

2012

Lysine acetylation: enzymes, bromodomains and links to different diseases.

Lin-Ya You, Jianyun Nie, Weijian Sun, Zhi-qiang Zheng, Xiang-Jiao Yang

Essays in Biochemistry

DOI

精选作品

期刊论文

基于DeepSeek-R1模型的PBL教学模式构建与应用

项目小组合作学习和虚拟仿真在大脑发育教学中的结合

人工智能应用于阿尔茨海默病神经病理特征识别

组织胚胎学神经组织实验教学多模态模式的构建与实践

Erratum to: Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

Astrocytes as central integrators of neural circuit function: Mechanisms and dysregulation in neuropsychiatric disorders

Transcriptomics and functional genomics implicate WNT3 in hemispheric lateralization of speech production

SpatialE identifies spatial enrichment of Alzheimer's Disease and Amyotrophic Lateral Sclerosis genes in human brain

Molecular architecture of language‐related cortical areas revealed by integrative proteomic and connectome analyses

Deep learning analyses of splicing variants identify the link of PCP4 with amyotrophic lateral sclerosis

正常和帕金森病患者基底神经节的转录差异分析

Single nuclei RNA-seq reveals a medium spiny neuron glutamate excitotoxicity signature prior to the onset of neuronal death in an ovine Huntington’s disease model

Spatial enrichment and genomic analyses reveal the link of NOMO1 with amyotrophic lateral sclerosis

Regional- and cell type-specific changes of the human brain during aging

Forebrain excitatory neuron-specific loss of Brpf1 attenuates excitatory synaptic transmission and impairs spatial and fear memory

Distinct immune escape and microenvironment between RG-like and pri-OPC-like glioma revealed by single-cell RNA-seq analysis

INCREASED DIFFERENTIAL GENE EXPRESSION AND NETWORK OF DOPAMINE NEURONS IN SCHIZOPHRENIA BASAL GANGLIA BY SPLIT-SEQ

HIPPOCAMPUS-SPECIFIC LOSS BRPF1 MURINE MODEL EXHIBITS ATTENUATED EXCITATORY SYNAPTIC TRANSMISSION AND IMPAIRED SPATIAL AND FEAR MEMORY

Delineation of complex gene expression patterns in single cell RNA-seq data with ICARUS v2.0

Elevated ETV6 Expression in Glioma Promotes an Aggressive In Vitro Phenotype Associated with Shorter Patient Survival

BRPF1-KAT6A/KAT6B Complex: Molecular Structure, Biological Function and Human Disease

Microglia Heterogeneity: A Single-cell Concerto

ICARUS, an interactive web server for single cell RNA-seq analysis

上海脑库脑组织样本的质量控制分析

Deficiency of Intellectual Disability-Related Gene Brpf1 Attenuated Hippocampal Excitatory Synaptic Transmission and Impaired Spatial Learning and Memory Ability

Deficiency of intellectual disability-related gene Brpf1 reduced inhibitory neurotransmission in MGE-derived GABAergic interneurons

Analysis of cell diversity in human and mouse basal ganglia by single-cell RNA sequencing

Single-cell profiling of tumors more accurately classifies glioma molecular subtypes

of fetal

BRPF1 is essential for development of fetal hematopoietic stem cells.

Mice lacking α-tubulin acetyltransferase 1 are viable but display α-tubulin acetylation deficiency and dentate gyrus distortion.

Brpf1 loss compromises neural stem cells and neuronal precursors.

Deficiency of the Chromatin Regulator Brpf1 Causes Abnormal Brain Development*

The Lysine Acetyltransferase Activator Brpf1 Governs Dentate Gyrus Development through Neural Stem Cells and Progenitors

Brpf1 loss impairs dentate gyrus development, dendritic tree formation and neuronal proliferation.

Deregulated Gfap expression in the mutant hippocampus.

Brpf1 expression during forebrain development.

Ankyrin repeats of ANKRA2 recognize a PxLPxL motif on the 3M syndrome protein CCDC8.

Analysis of neuronal migration in the hippocampus by BrdU labeling.

Forebrain-specific Brpf1 loss causes hypoplasia of the dentate gyrus.

Defective Tbr2+ and NeuroD1+ neuronal precursors in the mutant hippocampus.

The Chromatin Regulator BRPF3 Preferentially Activates the HBO1 Acetyltransferase but Is Dispensable for Mouse Development and Survival*

The Chromatin Regulator Brpf1 Regulates Embryo Development and Cell Proliferation*

Brpf1 loss deregulates gene expression important for hippocampus development.

Correction: The Lysine Acetyltransferase Activator Brpf1 Governs Dentate Gyrus Development through Neural Stem Cells and Progenitors

Cell cycle properties and progenitor number in the mutant dentate gyrus.

Expression atlas of the multivalent epigenetic regulator Brpf1 and its requirement for survival of mouse embryos

The Tumor Suppressor Kinase LKB1 Activates the Downstream Kinases SIK2 and SIK3 to Stimulate Nuclear Export of Class IIa Histone Deacetylases*

Mice Lacking α-Tubulin Acetyltransferase 1 Are Viable but Display α-Tubulin Acetylation Deficiency and Dentate Gyrus Distortion*

Sumoylation of Krüppel-like Factor 4 Inhibits Pluripotency Induction but Promotes Adipocyte Differentiation*

Sequence-Specific Recognition of a PxLPxI/L Motif by an Ankyrin Repeat Tumbler Lock

Lysine acetylation: enzymes, bromodomains and links to different diseases.

会议论文

PDE1A Downregulation Disrupts Oligodendrocyte Myelination and Promotes Neuropsychiatric-like Behaviors in a Rodent Model

Transcriptomic and functional genomic insights reveal WNT3 as a critical modulator of human speech processing

Brpf1 regulates the function of MGE-derived GABAergic interneurons

上海脑库-全脑库建设现状及未来规划

预印本

Evidence for glutamate excitotoxicity that occurs before the onset of striatal cell loss and motor symptoms in an ovine Huntington’s Disease model