百晓学者学者目录

张荧荧

副教授、助理教授，厦门大学

精选作品

期刊论文

2026

Mapping the holonomic signaling network that drives pathological changes in endotoxic shock

Teng Teng, Xinhe Gao, Peipei Zhang, Ye-Hsuan Sun, Yi-Fei Liu, Rui Zhao, Yilong Fu, Yi-Yuan Liu, Zhizhong Lin, Yingying Zhang, Jia-Huai Han

Cellular & Molecular Immunology

DOI

2026

Arginine Di-methylation of RIP3 safeguards necroptosis for intestinal homeostasis.

Pan Zhao, Han-Long Dan, Ya-Zhou Wang, Xin Chen, Xiang-Ling Jiang, Yao Shen, Danfeng Feng, Jiajia Wang, Zhiwei Yang, Jia-Sheng Zhao, Yingying Zhang, Meng-Ying Wei, Jian-Yong Zheng, Wen Liu, Jian Zhang

Cell Death and Differentiation

DOI

2026

Z-RNA-ZBP1 axis drives Tau-mediated neurodegeneration

Wei Liu, Song-Ang Wu, Bo-Xin Zhang, Shuanghui Guo, Lang Li, Wen-Jing Sun, Xu-Shen Xiong, Jiu-Hong Nan, Jianfeng Wu, Linghui Zeng, Pi-Long Li, Zhi-Yu Cai, Huan-Feng Ye, Shuo Zhang, Sheng Nie, Baizhou Li, Dan Wu, Pu Cheng, Xu-Chen Qi, Dong Fang, Wei Chen, Yingying Zhang, Qiang Chen, Zhang-Hua Yang, Jiahuai J. Han, Wei Mo

bioRxiv

DOI

2026

Tau aggregates cause reactivation of transposable DNA elements, leading to Z-RNA–ZBP1-mediated neuronal death

Wei Liu, Songfang Wu, Bo-Xin Zhang, Shuanghui Guo, Lang Li, Wen-Jing Sun, Xu-Shen Xiong, Jiu-Hong Nan, Jianfeng Wu, Ling-Hui Zeng, Pi-Long Li, Zhi-Yu Cai, Huan-Feng Ye, Shuo Zhang, Shengfu Nie, Baizhou Li, Dan Wu, Pu-Wei Cheng, Xuchen Qi, Dong Fang, Wei Chen, Yingying Zhang, Qiang Chen, Zhang-Hua Yang, Jia-Huai Han, Wei Mo

Nature Neuroscience

DOI

2025

[Review] Optimal dose of oxytocin to improve social impairments and repetitive behaviors in autism spectrum disorders: meta-analysis and dose-response meta-analysis of randomized controlled trials

Yingying Zhang, Xiaolu Zhang, Linghong Huang

Frontiers In Psychiatry，Vol. 15

DOI

2025

RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal necroptosis in TNF-treated mice.

Tao Han, Chenchen Ruan, H. Lin, Yu-Xia Zhang, Lang Li, Ye-Hsuan Sun, Chuan-Qi Zhong, Xin Chen, Kai Huang, Yating Cao, Zu-Sen Fan, Hong-Bing Zhang, Jia-Huai Han, Yingying Zhang

Journal of Experimental Medicine

DOI

2025

RIOK2 kinase regulates the translocation of the FADD–RIPK1–Caspase-8 complex to the ER and the cleavage of Gasdermin D to drive pyroptosis

Ming-Tong Ma, Fei Wang, Pengfei Cui, Yingying Zhang, Hanyu Ma, Yifan He, Yuan-Na Cheng, Jingping Huang, Jing-Xiang Wang, Xiang-Yang Wu, Hua Yang, Rui-Juan Zheng, Hao-Wen Ma, Qian Cai, Lin Wang, Bao-Xue Ge

Nature Communications

DOI

2024

A GSDMD agonist boosts specific antitumor immunity

Yingying Zhang, Jia-Huai Han

Cell Research

DOI

2024

Residue Y362 is crucial for FLIPL to impart catalytic activity to pro-caspase-8 to suppress necroptosis.

Mao Hong, Xiu-Rong Wu, Peng He, Rangxin Peng, Lang Li, Suqin Wu, Jian-Bang Zhao, A. Han, Yingying Zhang, Jia-Huai Han, Zhang-Hua Yang

Cell Reports

DOI

2024

Author Correction: RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

Zhen-Tao Yang, Yan Wang, Yingying Zhang, Xia-Di He, Chuan-Qi Zhong, H. Ni, Xin Chen, Yao-Ji Liang, Jianfeng Wu, Shiming Zhao, Da-Wang Zhou, Jiahuai Han

Nature Cell Biology

DOI

2023

Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death

Xinhe Gao, Teng Teng, Yi-Fei Liu, Tingting Ai, Rui Zhao, Yilong Fu, Pei-Pei Zhang, Jiahuai Han, Yingying Zhang

Protein & Cell

DOI

2022

Molecular genetic associations between a prominent serotonin transporter gene polymorphism (5-HTTLPR/rs25531) and individual differences in tendencies toward autistic traits and generalized internet use disorder in China and Germany

YingYing Zhang, Shuxia Yao, Helena Schmitt, Benjamin Becker, Keith M. Kendrick, Christian Montag

Brain And Behavior，Vol. 120, No. 100

DOI

2022

Rethinking sepsis after a two-year battle with COVID-19

Yingying Zhang, Jiahuai Han

Cellular & Molecular Immunology

DOI

2022

Immunostaining of phospho-RIPK3 in L929 cells, murine yolk sacs, ceca, and small intestines

Lang Li, Kai Huang, Chenchen Ruan, Jiahuai Han, Yingying Zhang

STAR Protocols

DOI

2021

A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5

Yingying Zhang, Kai Huang, Yu-Xia Zhang, Tao Han, Lang Li, Chenchen Ruan, Ye-Hsuan Sun, Wen-Ke Shi, Wei Han, Su-qin Wu, Jing Song, Jun Liu, Jia-Huai Han

PLoS Biology

DOI

2019

Efficient engulfment of necroptotic and pyroptotic cells by nonprofessional and professional phagocytes

Jiongcong Lu, Wen-Ke Shi, Bo Liang, Chang’an Chen, Rui Wu, Huaipeng Lin, Yingying Zhang, Jia-Huai Han

Cell Discovery

DOI

2018

RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

Zhen-Tao Yang, Yan Wang, Yingying Zhang, Xia-Di He, Chuan-Qi Zhong, H. Ni, Xin Chen, Yao-Ji Liang, Jian-Feng Wu, Shimin Zhao, Da-Wang Zhou, Jia-Huai Han

Nature Cell Biology

DOI

2018

RIP3 is an upregulator of aerobic metabolism and the enhanced respiration by necrosomal RIP3 feeds back on necrosome to promote necroptosis

Xing-Feng Qiu, Yingying Zhang, Jia-Huai Han

Cell Death and Differentiation

DOI

2017

Plasma membrane changes during programmed cell deaths

Yingying Zhang, Xin Chen, C. Gueydan, Jia-Huai Han

Cell Research

DOI

2017

The RIP3-RIP1-NF-κB signaling axis is dispensable for necroptotic cells to elicit cross-priming of CD8+ T cells

Junming Ren, X. Jia, Yi-Hao Zhao, Wen-Ke Shi, Jiongcong Lu, Yingying Zhang, Jian-Feng Wu, Bo Liang, Rui Wu, G. Fu, Jia-Huai Han

Cellular &Molecular Immunology

DOI

2017

RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome

Yingying Zhang, Sheng Sean Su, Shubo Zhao, Zhen-Tao Yang, Chuan-Qi Zhong, Xin Chen, Qixu Cai, Zhang-Hua Yang, De-Li Huang, Rui Wu, Jia-Huai Han

Nature Communications

DOI

2016

Electrophysiologist shows a cation channel function of MLKL

Yingying Zhang, Jia-Huai Han

Cell Research

DOI

2016

ElectrophysiologistはのMLKLのカチオンチャンネル機能を示す【Powered by NICT】

Yingying Zhang, Jia-Huai Han

2016

The MLKL Channel in Necroptosis Is an Octamer Formed by Tetramers in a Dyadic Process

De-Li Huang, Xinru Zheng, Zi-An Wang, Xin Chen, Wan-ting He, Yingying Zhang, Jin-Gen Xu, Hang Zhao, Wen-Ke Shi, X. Wang, Yong-Qun Zhu, Jia-Huai Han

Molecular and Cellular Biology

DOI

2014

Distinct roles of RIP1–RIP3 hetero- and RIP3–RIP3 homo-interaction in mediating necroptosis

Xiao-Nan Wu, Zhang-Hua Yang, X. Wang, Yingying Zhang, Huilin Wan, Y. Song, Xin Chen, J. Shao, Jiahuai Han

Cell Death and Differentiation

DOI

2013

Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis

Jian-Feng Wu, Zhe Huang, Junming Ren, Zhirong Zhang, Peng He, Yang-Xin Li, Jian-Hui Ma, Wanze Chen, Yingying Zhang, Xiaojuan Zhou, Zhen-Tao Yang, Su-qin Wu, Lan-Fen Chen, Jia-Huai Han

Cell Research

DOI

2013

Diverse Sequence Determinants Control Human and Mouse Receptor Interacting Protein 3 (RIP3) and Mixed Lineage Kinase domain-Like (MLKL) Interaction in Necroptotic Signaling*

Wanze Chen, Zhenru Zhou, Li-Sheng Li, Chuan-Qi Zhong, Xinru Zheng, Xiu-Rong Wu, Yingying Zhang, Huanran Ma, De-Li Huang, Wen-Juan Li, Zong-Ping Xia, Jia-Huai Han

Journal of Biological Chemistry

DOI

2012

Investigation of Receptor interacting protein (RIP3)-dependent Protein Phosphorylation by Quantitative Phosphoproteomics*

Xiu-Rong Wu, Li-Li Tian, Jie Li, Yingying Zhang, Victor Han, Yuan-Yue Li, Xiao-Zheng Xu, Han-Jie Li, Xi Chen, Jinan Chen, Wenhai Jin, Yong-Ming Xie, Jia-Huai Han, Chuan-Qi Zhong

Molecular & Cellular Proteomics

DOI

数据集

2022

LncRNA LINC00649 promotes the growth and metastasis of triple-negative breast cancer by maintaining the stability of HIF-1α through the NF90/NF45 complex

Jianhua Zhang, Du, Chuang, Linfeng Zhang, Yan Wang, Yingying Zhang, Jingruo Li

Figshare

DOI

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