崔忠凯｜南方医科大学｜学者主页

2026

A cell-free lipid sterosomal therapeutic enables bone regeneration via USP18-mediated noncanonical S1P signaling

Wen-hao YE, Jie Zhou, Junxiang Qiu, Zhengbo Liu, Ruolin He, Sixu Chen, Jing Wen, Binyang Feng, Beibei Lyu, Zhen Yinming Wang, Zhong‐Kai Cui

Bioactive Materials

DOI

2026

NUDT2 and a proteome-wide causal map of plasma proteins in osteoporosis

Zhen Wang, Sixu Chen, Junjie Luo, Zhengbo Liu, Jing Wen, Binyang Feng, Wen-hao YE, Jian-Chao Ma, Zhenyue Chen, Zhen Li, Zhenwen Yang, Junxiang Qiu, Zhong‐Kai Cui

Journal of Advanced Research

DOI

2026

Stable acid-responsive two-component lipid vesicles for redox regulation-enabled ferroptosis-driven immunotherapy of hepatocellular carcinoma

Chengyuan Cai, Jing Wen, Xiao Wang, Zike Liao, Jinmei Cheng, Jiaxin Li, Jisheng Xiao, Zhong‐Kai Cui, Xiaopin Duan

Chemical Engineering Journal

DOI

2025

Author Correction: Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12

Chuangxin Lin, Liangliang Liu, Chun Zeng, Zhong‐Kai Cui, Yuhui Chen, Pinling Lai, Hong Wang, Yan Xia Shao, Haiyan Zhang, Rongkai Zhang, Chang Ming Zhao, Hang Fang, Daozhang Cai, Xiaochun Bai

Bone Research

DOI

2025

Author Correction: Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors

Wei Xia, Jing Xie, Zhiqing Cai, Xuhua Liu, Jing Wen, Zhong‐Kai Cui, Run Zhao, Xiaomei Zhou, Jiahui Chen, Xinru Mao, Zhengtao Gu, Zhimin Zou, Zhipeng Zou, Yue Zhang, Ming Fei Zhao, Maegele Mac, Qiancheng Song, Xiaochun Bai

Nature Communications

DOI

2025

Retraction Note: β2AR-HIF-1α-CXCL12 signaling of osteoblasts activated by isoproterenol promotes migration and invasion of prostate cancer cells

Zhibin Huang, Guihuan Li, Zhishuai Zhang, Ruonan Gu, Wenyang Wang, Xiaoju Lai, Zhong‐Kai Cui, Fangyin Zeng, Shiyuan Xu, Fan Deng

BMC Cancer

DOI

2024

抑制Hmga2促进小鼠脂肪间充质干细胞成骨分化并加速骨缺损修复

柯志勇，黄子城，何若琳，张倩，陈思旭，崔忠凯，丁晶

《南方医科大学学报》

2024

A facile and smart strategy to enhance bone regeneration with efficient vitamin D3 delivery through sterosome technology

Shuxi Ye, Jing Wen, Wen-Hao Ye, Zhen Li, Xiaomeng Huang, Sixu Chen, Jian-Chao Ma, Yaohong Wu, Rongchun Chen, Zhong‐Kai Cui

Journal of Controlled Release

DOI

2024

Polymerizable rotaxane of cucurbituril protecting dopamine based adhesive hydrogels

Yunpeng Gao, Xin Tian, Xueru Xiong, Yushi Wang, Wen Huang, Xuetao Shi, Yong‐Guang Jia, Zhong‐Kai Cui

International Journal of Biological Macromolecules

DOI

2024

Repurposing propofol for breast cancer therapy through promoting apoptosis and arresting cell cycle

Peng Sun, Hanqing Huang, Jian-Chao Ma, Binyang Feng, Yiqing Zhang, Genggeng Qin, Weian Zeng, Zhong‐Kai Cui

Oncology Reports

DOI

2024

[Hmga2 knockdown enhances osteogenic differentiation of adipose-derived mesenchymal stem cells and accelerates bone defect healing in mice].

Z Ke, Z Huang, Renliang He, Q Zhang, S Chen, Zhong‐Kai Cui, J Ding

PubMed

DOI

2023

Choosing the right animal model for osteomyelitis research: Considerations and challenges

Shen Huang, Jing Wen, Yiqing Zhang, Xiaochun Bai, Zhong‐Kai Cui

Journal of Orthopaedic Translation

DOI

2023

Main-Chain Cationic Bile Acid Polymers Mimicking Facially Amphiphilic Antimicrobial Peptides

Caihong Lin, Zunwei Ma, Yunpeng Gao, Mengqi Le, Zhifeng Shi, Dawei Qi, Jian-Chao Ma, Zhong‐Kai Cui, Lin Wang, Yong‐Guang Jia

ACS Applied Materials & Interfaces

DOI

2023

Intrinsic antibacterial and osteoinductive sterosomes promote infected bone healing

Yiqing Zhang, Jie Zhou, Jiao-Lan Wu, Jian-Chao Ma, Hui Wang, Jing Wen, Shen Huang, Min Lee, Xiaochun Bai, Zhong‐Kai Cui

Journal of Controlled Release

DOI

2023

Exosome Release Delays Senescence by Disposing of Obsolete Biomolecules

Wenchong Zou, Mingqiang Lai, Yuanjun Jiang, Linlin Mao, Zhou Wu, Sheng Zhang, Pinglin Lai, Bin Guo, Tiantian Wei, Chengtao Nie, Lei Zheng, Jiahuan Zhang, Xuefei Gao, Xiaoyang Zhao, Laixin Xia, Zhipeng Zou, Anling Liu, Shiming Liu, Zhong‐Kai Cui, Xiaochun Bai

Advanced Science

DOI

2023

Exploring the translational potential of PLGA nanoparticles for intra-articular rapamycin delivery in osteoarthritis therapy

Jian-Chao Ma, Tingting Luo, Binyang Feng, Zicheng Huang, Yiqing Zhang, Hanqing Huang, Yang Xiao, Jing Wen, Xiaochun Bai, Zhong‐Kai Cui

Journal of Nanobiotechnology

DOI

2023

Inhalable GSH-Triggered Nanoparticles to Treat Commensal Bacterial Infection in In Situ Lung Tumors

Zunwei Ma, Huaiming Wang, Zhifeng Shi, Fengying Yan, Qingtao Li, Junjian Chen, Zhong‐Kai Cui, Yunjiao Zhang, Xin Jin, Yong‐Guang Jia, Lin Wang

ACS Nano

DOI

2022

hUC-MSC-mediated recovery of subacute spinal cord injury through enhancing the pivotal subunits β3 and γ2 of the GABAA receptor

Tingting Cao, Huan Chen, Weiping Huang, Sisi Xu, Peilin Liu, Weiwei Zou, Mao Pang, Ying Xu, Xiaochun Bai, Bin Liu, Limin Rong, Zhong‐Kai Cui, Mangmang Li

Theranostics

DOI

2022

Evaluation of the transdentinal capability of the intrinsic antibacterial cetylpyridinium chloride/cholesterol sterosomes in vitro and in vivo

Xiaojun Yang, Chaoning Zhan, Tianjiao Cheng, Minchun Huang, Weiwen Ge, Yiqing Zhang, Ting Chen, Yanli Lu, Zhong‐Kai Cui, Jin Lin Hou

International Endodontic Journal

DOI

2022

Polydatin activates the Nrf2/HO-1 signaling pathway to protect cisplatin-induced hearing loss in guinea pigs

Dafei Li, Haiyan Zhao, Piao Xu, Qiongping Lin, Tingting Zhao, Chubing Li, Zhong‐Kai Cui, Guangyong Tian

Frontiers in Pharmacology

DOI

2022

Local delivery of a CXCR3 antagonist decreases the progression of bone resorption induced by LPS injection in a murine model

Soma Lari, Sarah Hiyari, Davi Neto de Araújo Silva, Beatriz de Brito Bezerra, Makiko Ishii, Sepehr Monajemzadeh, Zhong‐Kai Cui, Sotirios Tetradis, Min Lee, Flavia Q M Pirih

Clinical Oral Investigations

DOI

2022

Upper Critical Solution Temperature Polyvalent Scaffolds Aggregate and Exterminate Bacteria (Small 11/2022)

Kai‐Feng Chen, Yiqing Zhang, Jiawei Lin, Junyou Chen, Caihong Lin, Meng Gao, Yunhua Chen, Sa Liu, Lin Wang, Zhong‐Kai Cui, Yong‐Guang Jia

Small

DOI

2022

Upper Critical Solution Temperature Polyvalent Scaffolds Aggregate and Exterminate Bacteria

Kai‐Feng Chen, Yiqing Zhang, Jiawei Lin, Junyou Chen, Caihong Lin, Meng Gao, Yunhua Chen, Sa Liu, Lin Wang, Zhong‐Kai Cui, Yong‐Guang Jia

Small

DOI

2021

Paracrine Effects of Recombinant Human Adiponectin Promote Bone Regeneration

Yanping Gong, Yang Wang, Yiqing Zhang, Liangchen Wang, Lijuan Wan, Yuan Zu, Chunlin Li, Xin Wang, Zhong‐Kai Cui

Frontiers in Cell and Developmental Biology

DOI

2021

Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors

Nature Communications

DOI

2021

Synergistic effect of the anti-PD-1 antibody with blood stable and reduction sensitive curcumin micelles on colon cancer

Feirong Gong, Jian-Chao Ma, Jianguo Jia, Fa-Zhan Li, Jiao-Lan Wu, Shanfeng Wang, Xin Teng, Zhong‐Kai Cui

Drug Delivery

DOI

2020

Drug-interactive mPEG- b -PLA-Phe(Boc) micelles enhance the tolerance and anti-tumor efficacy of docetaxel

Feirong Gong, Rongrong Wang, Zhengquan Zhu, Jiayao Duan, Xin Teng, Zhong‐Kai Cui

Drug Delivery

DOI

2019

RETRACTED ARTICLE: β2AR-HIF-1α-CXCL12 signaling of osteoblasts activated by isoproterenol promotes migration and invasion of prostate cancer cells

Zhibin Huang, Guihuan Li, Zhishuai Zhang, Ruonan Gu, Wenyang Wang, Xiaoju Lai, Zhong‐Kai Cui, Fangyin Zeng, Shiyuan Xu, Fan Deng

BMC Cancer

DOI

2019

ETS2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting JUNB transcription

Fang Yao, Xiaojing Wang, Zhong‐Kai Cui, Haibing Lan, Xiaolan Ai, Qiancheng Song, Zhenguo Chen, Jun Yang, Bingyi Wu, Xiaochun Bai

Laboratory Investigation

DOI

2019

Correction to: Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12

C. X. Lin, Liangliang Liu, Chun Zeng, Zhong‐Kai Cui, Yuhui Chen, Pinling Lai, Hong Wang, Yan Xia Shao, Haiyan Zhang, Rongkai Zhang, Chang Zhao, Hang Fang, Daozhang Cai, Xiaochun Bai

Bone Research

DOI

2019

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Zhong‐Kai Cui, Soyon Kim, Jessalyn J. Baljon, Benjamin M. Wu, Tara L Aghaloo, Min Lee

Nature Communications

DOI

2019

Wnt1 inhibits vascular smooth muscle cell calcification by promoting ANKH expression

Beidong Chen, Yang Zhao, Duanyang Han, Ban Zhao, Yonghui Mao, Zhong‐Kai Cui, Yun-Chin Chu, Lu Feng, Sen Yin, Cun‐Yu Wang, Xian Wang, Ming‐Jiang Xu, Gexin Zhao

Journal of Molecular and Cellular Cardiology

DOI

2019

Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice

Wen Liu, Zhenyu Wang, Jun Yang, Yongkui Wang, Kai Li, Bin Huang, Bo Yan, Ting Wang, Mangmang Li, Zhipeng Zou, Jian Yang, Guozhi Xiao, Zhong‐Kai Cui, Anling Liu, Xiaochun Bai

Open Biology

DOI

2019

Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12

Chuangxin Lin, Liangliang Liu, Chun Zeng, Zhong‐Kai Cui, Yuhui Chen, Pinling Lai, Hong Wang, Yan Xia Shao, Haiyan Zhang, Rongkai Zhang, Chang Ming Zhao, Hang Fang, Daozhang Cai, Xiaochun Bai

Bone Research

DOI

2019

N‐(3‐methoxybenzyl)‐(9Z,12Z,15Z)‐octadecatrienamide promotes bone formation via the canonical Wnt/β‐catenin signaling pathway

Ting Wang, Chunhan Sun, Haobo Zhong, Yan Gong, Zhong‐Kai Cui, Jing Xie, Yan‐peng Wang, Chuang Liang, He‐he Cao, Xiaorui Chen, Zhipeng Zou, Shengfa Li, Xiaochun Bai

Phytotherapy Research

DOI

2018

Exosome Release Is Regulated by mTORC1

Wenchong Zou, Mingqiang Lai, Yue Zhang, Lei Zheng, Zhe Xing, Ting Li, Zhipeng Zou, Qiancheng Song, Xiaoyang Zhao, Laixin Xia, Jian Yang, Anling Liu, Han Zhang, Zhong‐Kai Cui, Yu Jiang, Xiaochun Bai

Advanced Science

DOI

2018

Chitosan–Lysozyme Conjugates for Enzyme-Triggered Hydrogel Degradation in Tissue Engineering Applications

Soyon Kim, Zhong‐Kai Cui, Bonhye Koo, Jiwen Zheng, Tara L Aghaloo, Min Lee

ACS Applied Materials & Interfaces

DOI

2018

TSC1 deletion in fibroblasts alleviates lipopolysaccharide-induced acute kidney injury

Junhui Shen, Zhong‐Kai Cui, Fang Yao, Kai Li, Yue Zhang, Zhenguo Chen, Yüxia Zhou, Song Xu, Yuwei Zhang, Wenqing Jiang, Hanbin Zhang, Kaifen Tan, Anling Liu, Xiaochun Bai

Clinical Science

DOI

2018

Bone and plasma citrate is reduced in osteoporosis

Hongdong Chen, Yeyang Wang, Huaiqian Dai, Xinggui Tian, Zhong‐Kai Cui, Zhenguo Chen, Le Hu, Qiancheng Song, Anling Liu, Zhiyong Zhang, Guozhi Xiao, Jian Yu Yang, Yu Jiang, Xiaochun Bai

Bone

DOI

2017

Design and Characterization of a Therapeutic Non-Phospholipid Liposomal Nanocarrier with Osteoinductive Characteristics to Promote Bone Formation

Zhong-Kai Cui, Soyon Kim, Jessalyn J. Baljon, Mahmoudreza Doroudgar, M. Lafleur, Benjamin M. Wu, T. Aghaloo, Min Lee

ACS Nano

DOI

2014

Impact of interfacial cholesterol-anchored polyethylene glycol on sterol-rich non-phospholipid liposomes.

Zhong-Kai Cui, K. Edwards, Alejandro Nieto Orellana, G. Bastiat, J. Benoit, M. Lafleur

Journal of Colloid and Interface Science

DOI

2014

Lamellar self-assemblies of single-chain amphiphiles and sterols and their derived liposomes: distinct compositions and distinct properties.

Zhong-Kai Cui, M. Lafleur

Colloids and Surfaces B: Biointerfaces

DOI

2014

Formation, stability, and pH sensitivity of free-floating, giant unilamellar vesicles using palmitic acid-cholesterol mixtures.

Nicolas Cottenye, G. Carbajal, Zhong-Kai Cui, P. Ducharme, J. Mauzeroll, M. Lafleur

Soft Matter

DOI

2014

Nonphospholipid fluid liposomes with switchable photocontrolled release.

Zhong-Kai Cui, Thida Phoeung, Pierre-Antoine Rousseau, G. Rydzek, Qian Zhang, C. Bazuin, M. Lafleur

Langmuir

DOI

2013

Novel non phospholipid liposomes with high sterol content : development and characterization

Zhong-Kai Cui

2013

Non-phospholipid liposomes with high sterol content display a very limited permeability

C. Gustavo, Zhong-Kai Cui, L. Michel

DOI

2013

Interactions between non-phospholipid liposomes containing cetylpyridinium chloride and biofilms of Streptococcus mutans: modulation of the adhesion and of the biodistribution

Nicolas Cottenye, Zhong-Kai Cui, K. Wilkinson, J. Barbeau, M. Lafleur

Biofouling (Print)

DOI

2012

Formation of pH-sensitive cationic liposomes from a binary mixture of monoalkylated primary amine and cholesterol.

Zhong-Kai Cui, Anne Bouisse, Nicolas Cottenye, M. Lafleur

Langmuir

DOI

2010

Influence of the nature of the sterol on the behavior of palmitic acid/sterol mixtures and their derived liposomes.

Zhong-Kai Cui, G. Bastiat, Chester Jin, A. Keyvanloo, M. Lafleur

Biochimica et Biophysica Acta

DOI

2010

Formation of fluid lamellar phase and large unilamellar vesicles with octadecyl methyl sulfoxide/cholesterol mixtures.

Zhong-Kai Cui, G. Bastiat, M. Lafleur

Langmuir

DOI

精选作品

期刊论文

A cell-free lipid sterosomal therapeutic enables bone regeneration via USP18-mediated noncanonical S1P signaling

NUDT2 and a proteome-wide causal map of plasma proteins in osteoporosis

Stable acid-responsive two-component lipid vesicles for redox regulation-enabled ferroptosis-driven immunotherapy of hepatocellular carcinoma

Author Correction: Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12

Author Correction: Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors

Retraction Note: β2AR-HIF-1α-CXCL12 signaling of osteoblasts activated by isoproterenol promotes migration and invasion of prostate cancer cells

抑制Hmga2促进小鼠脂肪间充质干细胞成骨分化并加速骨缺损修复

A facile and smart strategy to enhance bone regeneration with efficient vitamin D3 delivery through sterosome technology

Polymerizable rotaxane of cucurbituril protecting dopamine based adhesive hydrogels

Repurposing propofol for breast cancer therapy through promoting apoptosis and arresting cell cycle

[Hmga2 knockdown enhances osteogenic differentiation of adipose-derived mesenchymal stem cells and accelerates bone defect healing in mice].

Choosing the right animal model for osteomyelitis research: Considerations and challenges

Main-Chain Cationic Bile Acid Polymers Mimicking Facially Amphiphilic Antimicrobial Peptides

Intrinsic antibacterial and osteoinductive sterosomes promote infected bone healing

Exosome Release Delays Senescence by Disposing of Obsolete Biomolecules

Exploring the translational potential of PLGA nanoparticles for intra-articular rapamycin delivery in osteoarthritis therapy

Inhalable GSH-Triggered Nanoparticles to Treat Commensal Bacterial Infection in In Situ Lung Tumors

hUC-MSC-mediated recovery of subacute spinal cord injury through enhancing the pivotal subunits β3 and γ2 of the GABAA receptor

Evaluation of the transdentinal capability of the intrinsic antibacterial cetylpyridinium chloride/cholesterol sterosomes in vitro and in vivo

Polydatin activates the Nrf2/HO-1 signaling pathway to protect cisplatin-induced hearing loss in guinea pigs

Local delivery of a CXCR3 antagonist decreases the progression of bone resorption induced by LPS injection in a murine model

Upper Critical Solution Temperature Polyvalent Scaffolds Aggregate and Exterminate Bacteria (Small 11/2022)

Upper Critical Solution Temperature Polyvalent Scaffolds Aggregate and Exterminate Bacteria

Paracrine Effects of Recombinant Human Adiponectin Promote Bone Regeneration

Damaged brain accelerates bone healing by releasing small extracellular vesicles that target osteoprogenitors

Synergistic effect of the anti-PD-1 antibody with blood stable and reduction sensitive curcumin micelles on colon cancer

Drug-interactive mPEG- b -PLA-Phe(Boc) micelles enhance the tolerance and anti-tumor efficacy of docetaxel

RETRACTED ARTICLE: β2AR-HIF-1α-CXCL12 signaling of osteoblasts activated by isoproterenol promotes migration and invasion of prostate cancer cells

ETS2 promotes epithelial-to-mesenchymal transition in renal fibrosis by targeting JUNB transcription

Correction to: Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12

Microporous methacrylated glycol chitosan-montmorillonite nanocomposite hydrogel for bone tissue engineering

Wnt1 inhibits vascular smooth muscle cell calcification by promoting ANKH expression

Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice

Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12

N‐(3‐methoxybenzyl)‐(9Z,12Z,15Z)‐octadecatrienamide promotes bone formation via the canonical Wnt/β‐catenin signaling pathway

Exosome Release Is Regulated by mTORC1

Chitosan–Lysozyme Conjugates for Enzyme-Triggered Hydrogel Degradation in Tissue Engineering Applications

TSC1 deletion in fibroblasts alleviates lipopolysaccharide-induced acute kidney injury

Bone and plasma citrate is reduced in osteoporosis

Design and Characterization of a Therapeutic Non-Phospholipid Liposomal Nanocarrier with Osteoinductive Characteristics to Promote Bone Formation

Impact of interfacial cholesterol-anchored polyethylene glycol on sterol-rich non-phospholipid liposomes.

Lamellar self-assemblies of single-chain amphiphiles and sterols and their derived liposomes: distinct compositions and distinct properties.

Formation, stability, and pH sensitivity of free-floating, giant unilamellar vesicles using palmitic acid-cholesterol mixtures.

Nonphospholipid fluid liposomes with switchable photocontrolled release.

Novel non phospholipid liposomes with high sterol content : development and characterization

Non-phospholipid liposomes with high sterol content display a very limited permeability

Interactions between non-phospholipid liposomes containing cetylpyridinium chloride and biofilms of Streptococcus mutans: modulation of the adhesion and of the biodistribution

Formation of pH-sensitive cationic liposomes from a binary mixture of monoalkylated primary amine and cholesterol.

Influence of the nature of the sterol on the behavior of palmitic acid/sterol mixtures and their derived liposomes.

Formation of fluid lamellar phase and large unilamellar vesicles with octadecyl methyl sulfoxide/cholesterol mixtures.

预印本

ELF5 promotes non-small cell lung cancer cell proliferation through regulating the expression of APC2

研究方向