杨光保｜苏州大学｜学者主页

2026

Injectable hydrogel-mediated spermidine delivery triggers tumor pyroptosis via oxidative metabolism for enhanced cancer therapy.

Zheng Deng, Xirui Wu, Tian-Hao Huang, Huiyuan Chen, Zhu-Chao Wu, Li Liu, Yuqian Liu, Chun-Jie Wang, Zijian Xiong, Zhuang Liu, Guangbao Yang

Biomaterials

DOI

2026

Hierarchically Chiral Silver Nanoclusters Mediated Enantioselective Glutathione Depletion and Intracellular Self-Assembly for Enhanced Anticancer Therapy.

Xuejuan Wang, Xirui Wu, Yue Zhao, Xiang-Yang Zhang, Jianfeng Zhao, Miao-Long Li, Guangbao Yang, Guo-Feng Liu

Angewandte Chemie

DOI

2026

Modulation of intrabone distribution of anionic polypeptide nanocarriers through hydrophobic modification for the treatment of acute myeloid leukemia.

Wanying Wang, Jing Zhao, Yuqian Liu, Xiaoxiong Jin, Xing-Liang Liu, Guangbao Yang, Jianglong Xia, Ziyuan Song

Acta Biomaterialia

DOI

2025

Intracellular Disulfide Stress Induced Actin Dysfunction for Enhancing Radiotherapy Sensitivity and Eliciting Antitumor Immunity.

Yang Liu, Cai Zhang, Zheng Deng, Jiadong Wang, Xianglong Sun, Xirui Wu, Yifan Zhang, Guangbao Yang, Yan-Li Zhao

ACS Nano

DOI

2025

Self-Assembled arachidonic acid Nanomicelles for Radiation-Induced ferroptosis to enhance tumor Radioimmunotherapy

Jiadong Wang, Yueyue Jing, Li Liu, Peng-Fei Xing, Zheng Deng, Yifan Zhang, Xirui Wu, Bin Hu, Cai Zhang, Xianglong Sun, Yuqian Liu, Jiawei Liu, Junjun Zhang, Guangbao Yang

Chemical Engineering Journal

DOI

2025

Hollow spiky MnOx nanocarriers amplify radiotherapy-induced pyroptosis for eliciting antitumor immunity

Yifan Zhang, Yuqian Liu, Bin Hu, Xianglong Sun, Jiadong Wang, Zheng Deng, Xirui Wu, Cai Zhang, Yueyue Jing, Junjun Zhang, Rongrui Liang, Guangbao Yang

Journal of Nanobiotechnology

DOI

2025

Biomimetic Chiral Recognition of Biothiols by Enantiomeric Nanoclusters in Plasma

Xuejuan Wang, Xiang-Yang Zhang, Yue Zhao, Xirui Wu, Guangbao Yang, Yan-Li Zhao, Guo-Feng Liu

Advances in Materials

DOI

2024

Bacteria-based biohybrids for remodeling adenosine-mediated immunosuppression to boost radiotherapy-triggered antitumor immune response.

Xirui Wu, Junjun Zhang, Zheng Deng, Xianglong Sun, Yifan Zhang, Cai Zhang, Jiadong Wang, Xinke Yu, Guangbao Yang

Biomaterials

DOI

2024

Immunomodulatory metal-based biomaterials for cancer immunotherapy.

Kangzhi Yuan, Cai Zhang, Xin-bo Pan, Bin Hu, Junjun Zhang, Guangbao Yang

Journal of Controlled Release

DOI

2024

FeS-based cascade bioreactors driven by Shewanella oneidensis MR-1 for efficient chemodynamic therapy with augmented antitumor immunity

Min Xi, Zheng Deng, Cai Zhang, Xirui Wu, Lin Zhang, Yifan Zhang, Xianglong Sun, Jin-Hua Zhou, Guangbao Yang

Nano Today

DOI

2024

Petaloid Metal-Organic Frameworks for Resiquimod Delivery To Potentiate Antitumor Immunity.

Cai Zhang, Zheng Deng, Xianglong Sun, Kangzhi Yuan, Jiadong Wang, Xirui Wu, Yifan Zhang, Kai Yang, Junjun Zhang, Guangbao Yang

ACS Applied Materials and Interfaces

DOI

2023

Design strategies for enhancing antitumor efficacy through tumor microenvironment exploitation using albumin-based nanosystems: A review.

Cai Zhang, Kai Yang, Guangbao Yang

International Journal of Biological Macromolecules

DOI

2023

X‐ray‐Induced Release of Nitric Oxide from Hafnium‐Based Nanoradiosensitizers for Enhanced Radio‐Immunotherapy

Nanhui Liu, Junjie Zhu, Wenjun Zhu, Linfu Chen, Maoyi Li, Jingjing Shen, Muchao Chen, Yumin Wu, Feng Pan, Zheng Deng, Yi Liu, Guangbao Yang, Zhuang Liu, Qian Chen, Yang Yang

Advanced Materials

DOI

2023

Biomineralized MnO2 Nanoplatforms Mediated Delivery of Immune Checkpoint Inhibitors with STING Pathway Activation to Potentiate Cancer Radio-Immunotherapy

Zheng Deng, Min Xi, Cai Zhang, Xirui Wu, Quguang Li, Chunjie Wang, Huapan Fang, Guanting Sun, Yifan Zhang, Guangbao Yang, Zhuang Liu

ACS Nano

DOI

2022

Biogenic platinum nanoparticles on bacterial fragments for enhanced radiotherapy to boost antitumor immunity

Zheng Deng, Jiawei Liu, Min Xi, Chunjie Wang, Huapan Fang, Xirui Wu, Cai Zhang, Guanting Sun, Yifan Zhang, Lin Shen, Minjiang Chen, Jiansong Ji, Zhuang Liu, Guangbao Yang

Nano Today

DOI

2022

Light‐Triggered Hypoxia‐Responsive Nanoscale Metal‐Organic Frameworks for Highly Efficient Antitumor Treatment

Guangbao Yang, Anivind Kaur Bindra, Soo Zeng Fiona Phua, Jiawei Liu, Hongwei Wu, Dongdong Wang, Cheng Qian, Guofeng Liu, Yanli Zhao

Advanced Optical Materials

DOI

2021

Multifunctional MnO 2 nanoparticles for tumor microenvironment modulation and cancer therapy

Guangbao Yang, Jiansong Ji, Zhuang Liu

Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology

DOI

2020

pH-Sensitive Biomaterials for Drug Delivery

Shijie Zhuo, Feng Zhang, Junyu Yu, Xican Zhang, Guangbao Yang, Xiaowen Liu

Molecules

DOI

2018

Light-responsive, singlet oxygen-triggered on-demand drug release from photosensitizer-doped mesoporous silica nanorods for cancer combination therapy

Guangbao Yang, Zhuang Liu

Nanomedicine Nanotechnology Biology and Medicine

DOI

2018

Smart Nanoreactors for pH-Responsive Tumor Homing, Mitochondria-Targeting, and Enhanced Photodynamic-Immunotherapy of Cancer

Guangbao Yang, Ligeng Xu, Jun Xu, Rui Zhang, Guosheng Song, Yu Chao, Liangzhu Feng, Fengxuan Han, Ziliang Dong, Bin Li, Zhuang Liu

Nano Letters

DOI

2017

功能介孔氧化硅纳米结构在肿瘤诊疗中的应用

杨光保

《苏州大学》

2017

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

Guangbao Yang, Ligeng Xu, Yu Chao, Jun Xu, Xiaoqi Sun, Yifan Wu, Rui Peng, Zhuang Liu

Nature Communications

DOI

2017

Light-controlled drug release from singlet-oxygen sensitive nanoscale coordination polymers enabling cancer combination therapy

Jingjing Liu, Guangbao Yang, Wenwen Zhu, Ziliang Dong, Yu Pu Yang, Yu Chao, Zhuang Liu

Biomaterials

DOI

2017

Manganese Dioxide Coated WS2@Fe3O4/sSiO2 Nanocomposites for pH‐Responsive MR Imaging and Oxygen‐Elevated Synergetic Therapy

Guangbao Yang, Rui Zhang, Chao Liang, He Zhao, Xuan Yi, Sida Shen, Kai Yang, Liang Cheng, Zhuang Liu

Small

DOI

2016

All‐in‐One Theranostic Nanoplatform Based on Hollow TaOx for Chelator‐Free Labeling Imaging, Drug Delivery, and Synergistically Enhanced Radiotherapy

Guosheng Song, Yu Chao, Yuyan Chen, Chao Liang, Xuan Yi, Guangbao Yang, Kai Yang, Liang Cheng, Qiao Zhang, Zhuang Liu

Advanced Functional Materials

DOI

2016

Light‐Responsive, Singlet‐Oxygen‐Triggered On‐Demand Drug Release from Photosensitizer‐Doped Mesoporous Silica Nanorods for Cancer Combination Therapy

Guangbao Yang, Xiaoqi Sun, Jingjing Liu, Liangzhu Feng, Zhuang Liu

Advanced Functional Materials

DOI

2016

Near-infrared-light responsive nanoscale drug delivery systems for cancer treatment

Guangbao Yang, Jingjing Liu, Yifan Wu, Liangzhu Feng, Zhuang Liu

Coordination Chemistry Reviews

DOI

2016

Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy

Hua Gong, Yu Chao, Jian Xiang, Xiao Han, Guosheng Song, Liangzhu Feng, Jingjing Liu, Guangbao Yang, Qian Chen, Zhuang Liu

Nano Letters

DOI

2016

Mesoporous silica-coated WS2@Fe3O4 nanosheets as a multifunctional theranostic nanocarrier for combination therapy of cancer

Guangbao Yang, Hua Gong, Teng Liu, Xiaoqi Sun, Liang Cheng, Zhuang Liu

Nanomedicine Nanotechnology Biology and Medicine

DOI

2016

Photosensitizer cross-linked nano-micelle platform for multimodal imaging guided synergistic photothermal/photodynamic therapy

Xiaodong Liu, Guangbao Yang, Lifen Zhang, Zhuang Liu, Zhenping Cheng, Xiulin Zhu

Nanoscale

DOI

2015

Two-dimensional magnetic WS2@Fe3O4 nanocomposite with mesoporous silica coating for drug delivery and imaging-guided therapy of cancer

Guangbao Yang, Hua Gong, Teng Liu, Xiaoqi Sun, Liang Cheng, Zhuang Liu

Biomaterials

DOI

2015

Magnetic nanomaterials with near-infrared pH-activatable fluorescence via iron-catalyzed AGET ATRP for tumor acidic microenvironment imaging

Xiaodong Liu, Qian Chen, Guangbao Yang, Lifen Zhang, Zhuang Liu, Zhenping Cheng, Xiulin Zhu

Journal of Materials Chemistry B

DOI

2014

FeS nanoplates as a multifunctional nano-theranostic for magnetic resonance imaging guided photothermal therapy

Kai Yang, Guangbao Yang, Lei Chen, Liang Cheng, Lu Wang, Cuicui Ge, Zhuang Liu

Biomaterials

DOI

2014

Multifunctional Theranostic Red Blood Cells For Magnetic‐Field‐Enhanced in vivo Combination Therapy of Cancer

Chao Wang, Xiaoqi Sun, Liang Cheng, Shengnan Yin, Guangbao Yang, Yonggang Li, Zhuang Liu

Advanced Materials

DOI

2014

Mesoporous silica nanorods intrinsically doped with photosensitizers as a multifunctional drug carrier for combination therapy of cancer

Guangbao Yang, Hua Gong, Xiaoxin Qian, Pengli Tan, Zhiwei Li, Teng Liu, Jingjing Liu, Youyong Li, Zhuang Liu

Nano Research

DOI

2014

Near-infrared light triggered photodynamic therapy in combination with gene therapy using upconversion nanoparticles for effective cancer cell killing

Xin Wang, Kai Liu, Guangbao Yang, Liang Cheng, Lu He, Yumeng Liu, Yonggang Li, Liang Guo, Zhuang Liu

Nanoscale

DOI

2013

Iron Oxide @ Polypyrrole Nanoparticles as a Multifunctional Drug Carrier for Remotely Controlled Cancer Therapy with Synergistic Antitumor Effect

Chao Wang, Huan Xu, Chao Liang, Yumeng Liu, Zhiwei Li, Guangbao Yang, Liang Cheng, Yonggang Li, Zhuang Liu

ACS Nano

DOI

精选作品

期刊论文

Injectable hydrogel-mediated spermidine delivery triggers tumor pyroptosis via oxidative metabolism for enhanced cancer therapy.

Hierarchically Chiral Silver Nanoclusters Mediated Enantioselective Glutathione Depletion and Intracellular Self-Assembly for Enhanced Anticancer Therapy.

Modulation of intrabone distribution of anionic polypeptide nanocarriers through hydrophobic modification for the treatment of acute myeloid leukemia.

Intracellular Disulfide Stress Induced Actin Dysfunction for Enhancing Radiotherapy Sensitivity and Eliciting Antitumor Immunity.

Self-Assembled arachidonic acid Nanomicelles for Radiation-Induced ferroptosis to enhance tumor Radioimmunotherapy

Hollow spiky MnOx nanocarriers amplify radiotherapy-induced pyroptosis for eliciting antitumor immunity

Biomimetic Chiral Recognition of Biothiols by Enantiomeric Nanoclusters in Plasma

Bacteria-based biohybrids for remodeling adenosine-mediated immunosuppression to boost radiotherapy-triggered antitumor immune response.

Immunomodulatory metal-based biomaterials for cancer immunotherapy.

FeS-based cascade bioreactors driven by Shewanella oneidensis MR-1 for efficient chemodynamic therapy with augmented antitumor immunity

Petaloid Metal-Organic Frameworks for Resiquimod Delivery To Potentiate Antitumor Immunity.

Design strategies for enhancing antitumor efficacy through tumor microenvironment exploitation using albumin-based nanosystems: A review.

X‐ray‐Induced Release of Nitric Oxide from Hafnium‐Based Nanoradiosensitizers for Enhanced Radio‐Immunotherapy

Biomineralized MnO2 Nanoplatforms Mediated Delivery of Immune Checkpoint Inhibitors with STING Pathway Activation to Potentiate Cancer Radio-Immunotherapy

Biogenic platinum nanoparticles on bacterial fragments for enhanced radiotherapy to boost antitumor immunity

Light‐Triggered Hypoxia‐Responsive Nanoscale Metal‐Organic Frameworks for Highly Efficient Antitumor Treatment

Multifunctional MnO 2 nanoparticles for tumor microenvironment modulation and cancer therapy

pH-Sensitive Biomaterials for Drug Delivery

Light-responsive, singlet oxygen-triggered on-demand drug release from photosensitizer-doped mesoporous silica nanorods for cancer combination therapy

Smart Nanoreactors for pH-Responsive Tumor Homing, Mitochondria-Targeting, and Enhanced Photodynamic-Immunotherapy of Cancer

功能介孔氧化硅纳米结构在肿瘤诊疗中的应用

Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

Light-controlled drug release from singlet-oxygen sensitive nanoscale coordination polymers enabling cancer combination therapy

Manganese Dioxide Coated WS2@Fe3O4/sSiO2 Nanocomposites for pH‐Responsive MR Imaging and Oxygen‐Elevated Synergetic Therapy

All‐in‐One Theranostic Nanoplatform Based on Hollow TaOx for Chelator‐Free Labeling Imaging, Drug Delivery, and Synergistically Enhanced Radiotherapy

Light‐Responsive, Singlet‐Oxygen‐Triggered On‐Demand Drug Release from Photosensitizer‐Doped Mesoporous Silica Nanorods for Cancer Combination Therapy

Near-infrared-light responsive nanoscale drug delivery systems for cancer treatment

Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy

Mesoporous silica-coated WS2@Fe3O4 nanosheets as a multifunctional theranostic nanocarrier for combination therapy of cancer

Photosensitizer cross-linked nano-micelle platform for multimodal imaging guided synergistic photothermal/photodynamic therapy

Two-dimensional magnetic WS2@Fe3O4 nanocomposite with mesoporous silica coating for drug delivery and imaging-guided therapy of cancer

Magnetic nanomaterials with near-infrared pH-activatable fluorescence via iron-catalyzed AGET ATRP for tumor acidic microenvironment imaging

FeS nanoplates as a multifunctional nano-theranostic for magnetic resonance imaging guided photothermal therapy

Multifunctional Theranostic Red Blood Cells For Magnetic‐Field‐Enhanced in vivo Combination Therapy of Cancer

Mesoporous silica nanorods intrinsically doped with photosensitizers as a multifunctional drug carrier for combination therapy of cancer

Near-infrared light triggered photodynamic therapy in combination with gene therapy using upconversion nanoparticles for effective cancer cell killing

Iron Oxide @ Polypyrrole Nanoparticles as a Multifunctional Drug Carrier for Remotely Controlled Cancer Therapy with Synergistic Antitumor Effect

会议论文

光敏分子掺杂的多孔硅纳米棒用于光响应的,单线态氧诱导的药物可控释放

内在掺杂光敏剂的介孔二氧化硅纳米棒作为多功能药物载体用于癌症的联合治疗

研究方向