钟伊南｜中国药科大学｜学者主页

2026

Uniform sub-10 nm crosslinked polymeric nanoparticles loaded with berberine for oral diabetes treatment

Xiang Zhou, Fuwei Han, Yu-Hong Ma, Yinan Zhong, De-Chun Huang, Hong-Liang Qian

Chemical Engineering Journal

2026

Ultrasmall zwitterion-micelles coupled with anti-checkpoint antibody for overcoming glioma barriers to eliminate stem cells and amplify immunotherapy.

Ke Wang, Yi Wang, Dongyu Zhang, Bing-Bing Zhao, Shineng Chen, Yinan Zhong, De-Chun Huang, Hong-Liang Qian, Hao Xie, Wei Chen

Journal of Controlled Release

DOI

2026

Transdermal delivery of small zwitterionic amorphous solid dispersion to increase solubility and penetrate the stratum corneum for psoriasis therapy

Xiang Zhou, Jiahui Ma, Lanlan Wang, Dongyu Zhang, Dongyue Ding, Rui Xu, Ke Wang, Junlong Qi, Yinan Zhong, Dechun Huang, Wei Chen

Chemical Engineering Journal

DOI

2025

Small-sized twin-nanoparticles normalize tumor vasculature to enhance tumor accumulation and penetration for potent eradication of cancer stem-like cells

Changshun Zhao, Wei Wang, Zheng-Wei Huang, Yuqing Wan, Rui Xu, Jun-Mei Zhang, Bing-Bing Zhao, Ke Wang, Suchen Wen, Yinan Zhong, De-Chun Huang, Wei Chen

Acta Pharmaceutica Sinica B

DOI

2025

Dual STING activation and CD47/SIRPα blockade via chitooligosaccharide-based nanoparticles to amplify antitumor immunity.

Shaohui Xu, Jiahan Shao, Zhi-Jun Miao, Heng Wang, Huaxing Dai, Bo Tian, Run Shi, Yinan Zhong, Chao Wang

Journal of Controlled Release

DOI

2025

Targeted delivery of polymeric NO-donor micelles to hepatic stellate cells for restoration of liver function and inhibition of hepatic fibrosis.

Rui Yang, Lifen Yang, Ni Zhang, Yuqing Wan, Shineng Chen, Yiqing Xiao, Xiaoping Liang, Shangjie Yang, Yinan Zhong, De-Chun Huang, Wei Chen, Bing-Bing Zhao

Journal of Controlled Release

DOI

2025

On‐Demand ER Stress Modulation in Tumor Cells and TAMs via an Adaptively Transformable Nanoplatform Enhances Photodynamic Immunotherapy

Bing-Bing Zhao, Xiaoyu Chen, Shaohui Xu, Yanran Xing, Jiahan Shao, Yiqing Xiao, Junlong Qi, Hong-Liang Qian, De-Chun Huang, Wei Chen, Yinan Zhong

Advances in Materials

DOI

2025

Oral delivery of ultra-small zwitterionic nanoparticles to overcome mucus and epithelial barriers for macrophage modulation and colitis therapy.

Changshun Zhao, Suchen Wen, Rui Xu, Ke Wang, Yinan Zhong, De-Chun Huang, Bing-Bing Zhao, Wei Chen

Acta Biomaterialia

DOI

2025

Enterosoluble microcapsules embedded with tripeptide-modified zwitterionic nanosystems to overcome intestinal barriers for intact exocytosis and hepatic-targeted gradual insulin delivery

Yuhong Ma, Bing-Bing Zhao, Umm E. Hani, Yu-Kun Ma, Caihua Li, Li-Cheng Li, Jing-Xian Han, Yinan Zhong, De-Chun Huang, Wei Chen, Hong-Liang Qian

Chemical Engineering Journal

DOI

2025

Sequentially unlockable prodrug nanoparticles enable spatiotemporal coordination of chemotherapy and tumor microenvironment regulation for metastasis prevention in breast cancer.

Zheng Wang, Rui Yang, William Lee Davis, Yanran Xing, Yiwen Fu, Bo Wang, Wanhong Li, Hong-Liang Qian, Li-Qing Gao, De-Chun Huang, Yinan Zhong, Wei Chen

Biomaterials Science

DOI

2025

Rational Design of Zwitterionic Nanosystems to Overcome Biological Barriers for Drug Delivery by Various Administration Routes.

Jia-Hui Ma, Dong Ding, Rui Xu, Shuxian Ma, Yinan Zhong, Wei Liu, Li-Qing Gao, Wei Chen

Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology

DOI

2025

Super-small zwitterionic nitric oxide-donor micelles efficiently scavenge ROS and alleviate inflammation for combined ischemic stroke therapy.

Ke Wang, Yuli Ao, Yiqing Xiao, Yi Wang, Xiaoping Liang, Min Zhao, Dongyu Zhang, Yinan Zhong, Hong-Liang Qian, Bing-Bing Zhao, Wei Chen

Acta Biomaterialia

DOI

2025

Macrophage-camouflaged nano-gasholder mediates a differentiated delivery of nitric oxide for blocking cancer-bone crosstalk and bone metastases

Jun-Mei Zhang, Bing-Bing Zhao, Jing-qi Li, Yiqing Xiao, Yanran Xing, Yecheng Tang, Xin Liu, Xuan Zhang, De-Chun Huang, Wei Chen, Yinan Zhong

Chemical Engineering Journal

DOI

2025

Triphenylphosphine-Chitosan Functionalized MoS2 Nanosheets Delivering Elesclomol-Cu(II) Complex for Enhanced Cuproptosis-Mediated Cancer Therapy.

Shaohui Xu, Ze Chen, Yifei Huang, Yinan Zhong, Wei Chen

Biomacromolecules

DOI

2024

Thiolated polyglycerol sulfate as potential mucolytic for muco-obstructive lung diseases.

J. Arenhoevel, A. Kuppe, A. Addante, Ling-Fang Wei, Nico Boback, C. Butnarasu, Yinan Zhong, C. Wong, S. Y. Graeber, Julia Duerr, M. Gradzielski, Daniel Lauster, M. Mall, Rainer Haag

Biomaterials Science

DOI

2024

ROS-responsive core-shell nano-inhibitor impedes pyruvate metabolism for reinforced photodynamic therapy and interrupted pre-metastatic niche formation.

Mengtong Lv, Bing-Bing Zhao, Jun-Mei Zhang, Guizhi Miao, Siming Wei, Yecheng Tang, Xin Liu, Hong-Liang Qian, De-Chun Huang, Wei Chen, Yinan Zhong

Acta Biomaterialia

DOI

2024

Photothermal-controlled no-releasing Nanogels reverse epithelial-mesenchymal transition and restore immune surveillance against cancer metastasis.

Jun-Mei Zhang, Guizhi Miao, My Hanh Ta, Bing-Bing Zhao, Wei Wang, Yanran Xing, Hong-Liang Qian, De-Chun Huang, Wei Chen, Yinan Zhong

Journal of Controlled Release

DOI

2024

Bioresponsive Nanoparticles Boost Starvation Therapy and Prevent Premetastatic Niche Formation for Pulmonary Metastasis Treatment.

Yanran Xing, Yuanyuan Zhang, Jing-qi Li, Yecheng Tang, Jun-Mei Zhang, Rui Yang, Hui Tang, Hong-Liang Qian, De-Chun Huang, Wei Chen, Yinan Zhong

ACS Applied Materials and Interfaces

DOI

2024

Oral delivery of berberine by liver-targeted zwitterionic nanoparticles to overcome multi-intestinal barriers and extend insulin treatment duration

Yuhong Ma, Caihua Li, Fuwei Han, Yunzhu Liu, Umm E. Hani, Yinan Zhong, De-Chun Huang, Wei Chen, Hong-Liang Qian

Chemical Engineering Journal

DOI

2024

Ursodeoxycholic Acid‐Decorated Zwitterionic Nanoparticles for Orally Liver‐Targeted Close‐Looped Insulin Delivery

Yuhong Ma, Wei Wang, Caihua Li, Fuwei Han, Mujiao He, Yinan Zhong, De-Chun Huang, Wei Chen, Hong-Liang Qian

Advanced Healthcare Materials

DOI

2023

PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy.

Yuhong Ma, Wei Wang, Mujiao He, Yunzhu Liu, Caihua Li, Yinan Zhong, Quan-Min Bu, De-Chun Huang, Hong-Liang Qian, Wei Chen

Biomaterials Science

DOI

2023

Super-small zwitterionic micelles enable the improvement of blood-brain barrier crossing for efficient orthotopic glioblastoma combinational therapy.

Ke Wang, Bing-Bing Zhao, Yuli Ao, Jinyu Zhu, Changshun Zhao, Wei Wang, Yan Zou, De-Chun Huang, Yinan Zhong, Wei Chen, Hong-Liang Qian

Journal of Controlled Release

DOI

2023

Two-in-One Polymeric NO-Donor Prodrugs Mediate Precision and Synergistic Prostate Cancer Treatment

Bing Zhao, Yuqing Wan, Xiang Yang Zhou, Junmei Zhang, Jiaxin Chen, Jiachen Yang, Yunzhu Liu, Wei Chen, Yinan Zhong, Hongliang Qian

ACS Applied Materials & Interfaces

DOI

2023

Reversibly “double locked” hydroxycamptothecin prodrug nanoparticles for targeted chemotherapy of lung cancer

Junmei Zhang, Bo Wang, Hui Wang, Zheng Wang, Pan Zhang, Xin Huang, Hongliang Qian, Dechun Huang, Wei Chen, Yinan Zhong

Acta Biomaterialia

DOI

2022

Recent advances on next generation of polyzwitterion-based nano-vectors for targeted drug delivery

Hongliang Qian, Ke Wang, Mengtong Lv, Changshun Zhao, Hui Wang, Suchen Wen, Dechun Huang, Wei Chen, Yinan Zhong

Journal of Controlled Release

DOI

2022

Macromolecular NO‐Donor Micelles for Targeted and Augmented Chemotherapy against Prostate Cancer

Jiaxin Chen, Bing Zhao, Junhui Zou, Jiachen Yang, Lifen Yang, Junmei Zhang, Wei Chen, Dechun Huang, Yinan Zhong

Advanced Healthcare Materials

DOI

2022

Dual tumor- and subcellular-targeted photodynamic therapy using glucose-functionalized MoS2 nanoflakes for multidrug-resistant tumor ablation

Shaohui Xu, Pan Zhang, Isabelle Heing‐Becker, Junmei Zhang, Peng Tang, Raju Bej, Sumati Bhatia, Yinan Zhong, Rainer Haag

Biomaterials

DOI

2022

Black Phosphorus-Synergic Nitric Oxide Nanogasholder Spatiotemporally Regulates Tumor Microenvironments for Self-Amplifying Immunotherapy

Xin Huang, Yinan Zhong, Yanfei Li, Xiang Yang Zhou, Lifen Yang, Bing Zhao, Jingjing Zhou, Haishi Qiao, Dechun Huang, Hongliang Qian, Wei Chen

ACS Applied Materials & Interfaces

DOI

2022

Up-converted nano-gasholder with precise nitric oxide release remodels immunosuppressive microenvironment and potentiates tumor immunotherapy

Yanfei Li, Hongliang Qian, Xin Huang, Xiang Yang Zhou, Bing Zhao, Lifen Yang, Jiaxin Chen, Haishi Qiao, Dechun Huang, Yinan Zhong, Wei Chen

Nano Today

DOI

2021

Cascade-Responsive Hierarchical Nanosystems for Multisite Specific Drug Exposure and Boosted Chemoimmunotherapy

Junmei Zhang, Yuanyuan Zhang, Bing Zhao, Mengtong Lv, Enping Chen, Changshun Zhao, Linyang Jiang, Hongliang Qian, Dechun Huang, Yinan Zhong, Wei Chen

ACS Applied Materials & Interfaces

DOI

2021

Mitochondrial Targeting and pH-Responsive Nanogels for Co-Delivery of Lonidamine and Paclitaxel to Conquer Drug Resistance

Enping Chen, Ting Wang, Junmei Zhang, Xiang Yang Zhou, Yafan Niu, Fu Liu, Yinan Zhong, Dechun Huang, Wei Chen

Frontiers in Bioengineering and Biotechnology

DOI

2021

Inherently nitric oxide containing polymersomes remotely regulated by NIR for improving multi-modal therapy on drug resistant cancer

Zhihong Liu, Yinan Zhong, Xiang Yang Zhou, Xin Huang, Jingjing Zhou, Dechun Huang, Yanfei Li, Zhixiang Wang, Bin Dong, Haishi Qiao, Wei Chen

Biomaterials

DOI

2021

Thermoresponsive Hydrogels as Microniches for Growth and Controlled Release of Induced Pluripotent Stem Cells

Wanjun Liang, Sumati Bhatia, Felix Reisbeck, Yinan Zhong, Abhishek Kumar Singh, Wenzhong Li, Rainer Haag

Advanced Functional Materials

DOI

2021

Toolbox of Biodegradable Dendritic (Poly glycerol sulfate)–SS-poly(ester) Micelles for Cancer Treatment: Stability, Drug Release, and Tumor Targeting

Daniel Braatz, Mathias Dimde, Guoxin Ma, Yinan Zhong, Michael Tully, Carsten Grötzinger, Yuanyuan Zhang, Alexandros Mavroskoufis, Michael Schirner, Zhiyuan Zhong, Matthias Ballauff, Rainer Haag

Biomacromolecules

DOI

2021

Multi-functional polymeric micelles for chemotherapy-based combined cancer therapy

Raut Bholakant, Bin Dong, Xiang Yang Zhou, Xin Huang, Changshun Zhao, Dechun Huang, Yinan Zhong, Hongliang Qian, Wei Chen, Jan Feijén

Journal of Materials Chemistry B

DOI

2021

Synthesis of zwitterionic chimeric polymersomes for efficient protein loading and intracellular delivery

Bing Zhao, Yuting Yan, Junmei Zhang, Enping Chen, Ke Wang, Changshun Zhao, Yinan Zhong, Dechun Huang, Zhiqin Cui, Dawei Deng, Congying Gu, Wei Chen

Polymer Chemistry

DOI

2020

Tumor Microenvironment‐Activatable Nanoenzymes for Mechanical Remodeling of Extracellular Matrix and Enhanced Tumor Chemotherapy

Yinan Zhong, Jianguang Zhang, Junmei Zhang, Yong Xia Hou, Enping Chen, Dechun Huang, Wei Chen, Rainer Haag

Advanced Functional Materials

DOI

2020

Recent Advances of Polycationic siRNA Vectors for Cancer Therapy

Raut Bholakant, Hongliang Qian, Junmei Zhang, Xin Huang, Dechun Huang, Jan Feijén, Yinan Zhong, Wei Chen

Biomacromolecules

DOI

2020

CD44-targeted vesicles encapsulating granzyme B as artificial killer cells for potent inhibition of human multiple myeloma in mice

Yinan Zhong, Fenghua Meng, Wen Zhang, Bin Li, Jan C. M. van Hest, Zhiyuan Zhong

Journal of Controlled Release

DOI

2020

Tumor localization of oncolytic adenovirus assisted by pH-degradable microgels with JQ1-mediated boosting replication and PD-L1 suppression for enhanced cancer therapy

Haishi Qiao, Xingmei Chen, Qiming Wang, Junmei Zhang, Dechun Huang, Enping Chen, Hongliang Qian, Yinan Zhong, Qi Tang, Wei Chen

Biomaterials Science

DOI

2015

刺激响应性聚合物纳米药物用于高效靶向肿瘤治疗

钟伊南

《苏州大学》

2015

负载阿霉素的透明质酸修饰还原敏感纳米粒子对乳腺癌细胞株MDA-MB231的靶向杀伤及生物学意义

周春艳，钟伊南，刘文婷，王雪峰，钟志远，谢芳

《中国现代医药杂志》

精选作品

期刊论文

Uniform sub-10 nm crosslinked polymeric nanoparticles loaded with berberine for oral diabetes treatment

Ultrasmall zwitterion-micelles coupled with anti-checkpoint antibody for overcoming glioma barriers to eliminate stem cells and amplify immunotherapy.

Transdermal delivery of small zwitterionic amorphous solid dispersion to increase solubility and penetrate the stratum corneum for psoriasis therapy

Small-sized twin-nanoparticles normalize tumor vasculature to enhance tumor accumulation and penetration for potent eradication of cancer stem-like cells

Dual STING activation and CD47/SIRPα blockade via chitooligosaccharide-based nanoparticles to amplify antitumor immunity.

Targeted delivery of polymeric NO-donor micelles to hepatic stellate cells for restoration of liver function and inhibition of hepatic fibrosis.

On‐Demand ER Stress Modulation in Tumor Cells and TAMs via an Adaptively Transformable Nanoplatform Enhances Photodynamic Immunotherapy

Oral delivery of ultra-small zwitterionic nanoparticles to overcome mucus and epithelial barriers for macrophage modulation and colitis therapy.

Enterosoluble microcapsules embedded with tripeptide-modified zwitterionic nanosystems to overcome intestinal barriers for intact exocytosis and hepatic-targeted gradual insulin delivery

Sequentially unlockable prodrug nanoparticles enable spatiotemporal coordination of chemotherapy and tumor microenvironment regulation for metastasis prevention in breast cancer.

Rational Design of Zwitterionic Nanosystems to Overcome Biological Barriers for Drug Delivery by Various Administration Routes.

Super-small zwitterionic nitric oxide-donor micelles efficiently scavenge ROS and alleviate inflammation for combined ischemic stroke therapy.

Macrophage-camouflaged nano-gasholder mediates a differentiated delivery of nitric oxide for blocking cancer-bone crosstalk and bone metastases

Triphenylphosphine-Chitosan Functionalized MoS2 Nanosheets Delivering Elesclomol-Cu(II) Complex for Enhanced Cuproptosis-Mediated Cancer Therapy.

Thiolated polyglycerol sulfate as potential mucolytic for muco-obstructive lung diseases.

ROS-responsive core-shell nano-inhibitor impedes pyruvate metabolism for reinforced photodynamic therapy and interrupted pre-metastatic niche formation.

Photothermal-controlled no-releasing Nanogels reverse epithelial-mesenchymal transition and restore immune surveillance against cancer metastasis.

Bioresponsive Nanoparticles Boost Starvation Therapy and Prevent Premetastatic Niche Formation for Pulmonary Metastasis Treatment.

Oral delivery of berberine by liver-targeted zwitterionic nanoparticles to overcome multi-intestinal barriers and extend insulin treatment duration

Ursodeoxycholic Acid‐Decorated Zwitterionic Nanoparticles for Orally Liver‐Targeted Close‐Looped Insulin Delivery

PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy.

Super-small zwitterionic micelles enable the improvement of blood-brain barrier crossing for efficient orthotopic glioblastoma combinational therapy.

Two-in-One Polymeric NO-Donor Prodrugs Mediate Precision and Synergistic Prostate Cancer Treatment

Reversibly “double locked” hydroxycamptothecin prodrug nanoparticles for targeted chemotherapy of lung cancer

Recent advances on next generation of polyzwitterion-based nano-vectors for targeted drug delivery

Macromolecular NO‐Donor Micelles for Targeted and Augmented Chemotherapy against Prostate Cancer

Dual tumor- and subcellular-targeted photodynamic therapy using glucose-functionalized MoS2 nanoflakes for multidrug-resistant tumor ablation

Black Phosphorus-Synergic Nitric Oxide Nanogasholder Spatiotemporally Regulates Tumor Microenvironments for Self-Amplifying Immunotherapy

Up-converted nano-gasholder with precise nitric oxide release remodels immunosuppressive microenvironment and potentiates tumor immunotherapy

Cascade-Responsive Hierarchical Nanosystems for Multisite Specific Drug Exposure and Boosted Chemoimmunotherapy

Mitochondrial Targeting and pH-Responsive Nanogels for Co-Delivery of Lonidamine and Paclitaxel to Conquer Drug Resistance

Inherently nitric oxide containing polymersomes remotely regulated by NIR for improving multi-modal therapy on drug resistant cancer

Thermoresponsive Hydrogels as Microniches for Growth and Controlled Release of Induced Pluripotent Stem Cells

Toolbox of Biodegradable Dendritic (Poly glycerol sulfate)–SS-poly(ester) Micelles for Cancer Treatment: Stability, Drug Release, and Tumor Targeting

Multi-functional polymeric micelles for chemotherapy-based combined cancer therapy

Synthesis of zwitterionic chimeric polymersomes for efficient protein loading and intracellular delivery

Tumor Microenvironment‐Activatable Nanoenzymes for Mechanical Remodeling of Extracellular Matrix and Enhanced Tumor Chemotherapy

Recent Advances of Polycationic siRNA Vectors for Cancer Therapy

CD44-targeted vesicles encapsulating granzyme B as artificial killer cells for potent inhibition of human multiple myeloma in mice

Tumor localization of oncolytic adenovirus assisted by pH-degradable microgels with JQ1-mediated boosting replication and PD-L1 suppression for enhanced cancer therapy

刺激响应性聚合物纳米药物用于高效靶向肿瘤治疗

负载阿霉素的透明质酸修饰还原敏感纳米粒子对乳腺癌细胞株MDA-MB231的靶向杀伤及生物学意义

会议论文

透明质酸修饰还原敏感纳米粒子负载的阿霉素对乳腺癌细胞株MDA-MB231的靶向杀伤及意义

双硫交联可降解纳米粒用于肿瘤的高效主动靶向治疗

研究方向