冷历歌｜厦门大学｜学者主页

2026

Amygdala astrocyte senescence drives stress-induced anxiety and hyperglycemia.

Aojie He, Yu-Fei Zhu, Chensi Liang, Shang-Meng Huang, Ziqi Yuan, Shangchen Yang, Yaoyi Chen, Can Dan, Aiyu Lei, Huifang Li, Lige Leng, Jie Zhang

Cell Metabolism

DOI

2026

Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice

Chensi Liang, Yu-Lan Zhou, Kai Zhuang, Shuzhong Wang, Li Zhong, Can Dan, Aiyu Lei, Huifang Li, Jie Zhang, Lige Leng

Nature Neuroscience

DOI

2026

Metabolites released from apoptotic cells in central nervous system orchestrates the pathological process of Alzheimer disease through improving autophagy

F. Xiao, Xiao-Mei Tan, Aojie He, Yulan Zhou, Kaicheng Xu, Ziqi Yuan, Yu-Fei Zhu, Chensi Liang, Can Dan, Jie Zhang, Lige Leng

Autophagy

DOI

2025

A neural substrate of comorbid depressive symptoms in alcohol use

Zhenlei Chen, Shangchen Yang, Lige Leng, Jinjun Ding, Ziqi Yuan, Kai Zhuang, Dan Can, Tingting Zou, Ya Wang, Huifang Li, Ti-Fei Yuan, Jie Zhang

Molecular Psychiatry，Vol. 300, No. 100

DOI

2025

CDK3 induces neuronal death and brain atrophy in Alzheimer’s disease

Kai Zhuang, Liu Zi, Xiao Su, Chen Hu, Xin-Rui Li, Shuzhong Wang, Yujun Xia, Bo Wu, Yuemin Su, Shaokun Chen, Hao-Jie Li, Silv Wang, Meng-Dan Wang, Jieyin Li, Wenting Xie, Yanbing Chen, Lige Leng, Hui-Fang Li, Li Zhong, Jiechao Zhou, Yan Liu, Qingsong Liu, Karl Herrup, Jie Zhang

Nature Aging

DOI

2025

Mannose Promotes β‐Amyloid Pathology by Regulating BACE1 Glycosylation in Alzheimer's Disease

Chensi Liang, Ziqi Yuan, Shangchen Yang, Yu-Fei Zhu, Zhenlei Chen, Can Dan, Aiyu Lei, Huifang Li, Lige Leng, Jie Zhang

Advancement of science

DOI

2024

Multi-omics analysis reveals GAPDH posttranscriptional regulation of IFN-γ and PHGDH as a metabolic checkpoint of microglia polarization

Shangchen Yang, Ziqi Yuan, Yufei Zhu, Chensi Liang, Zhenlei Chen, Jie Zhang, Lige Leng

Brain Behavior And Immunity，Vol. 117

DOI

2024

Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity

Na Wang, Lujian Cai, Xinyu Pei, Zhihao Lin, Li-Hong Huang, Chensi Liang, Min Wei, Lin Shao, Tiantian Guo, F. Huang, Hong Luo, Hong-Hua Zheng, Xiao-Fen Chen, Lige Leng, Yun-Wu Zhang, Xin Wang, Jie Zhang, Kai Guo, Zhan-Xiang Wang, Hong-Sheng Zhang, Ying-Jun Zhao, Huaxi Xu

iScience

DOI

2024

Menin Deficiency Induces Autism‐Like Behaviors by Regulating Foxg1 Transcription and Participates in Foxg1‐Related Encephalopathy

Kai Zhuang, Lige Leng, Xiao Su, Shuzhong Wang, Yuemin Su, Yanbing Chen, Ziqi Yuan, Liu Zi, Jieyin Li, Wenting Xie, Sihan Yan, Yujun Xia, Han Wang, Huifang Li, Zhen-Yi Chen, Ti-Fei Yuan, Jie Zhang

Advancement of science

DOI

2023

Microglial metabolic reconfiguration provides a new strategy for the treatment of Alzheimer’s disease

Lige Leng, J Zhang

Neural Regeneration Research

DOI

2023

Menin Reduces Parvalbumin Expression and is Required for the Anti‐Depressant Function of Ketamine

Lige Leng, Kai Zhuang, Huizhong Lin, Jinjun Ding, Shangchen Yang, Ziqi Yuan, Changquan Huang, Guimiao Chen, Zhenlei Chen, Meng-Dan Wang, Han Wang, Hao Sun, Huifang Li, Helena Chang, Zhen-Yi Chen, Qi Xu, Ti-Fei Yuan, Jie Zhang

Advancement of science

DOI

2023

Hypothalamic Menin regulates systemic aging and cognitive decline

Lige Leng, Zi-Qi Yuan, Xiao Su, Zhenlei Chen, Shangchen Yang, Meiqin Chen, Kai Zhuang, Huizhong Lin, Haoyue Sun, Huifang Li, Maoqiang Xue, Jun Xu, Jingqi Yan, Zhenyi Chen, Ti-Fei Yuan, J Zhang

PLoS Biology

DOI

2022

Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance

Lige Leng, Zi-Qi Yuan, Ruiyuan Pan, Xiao Su, Han Wang, Jin Xue, Kai Zhuang, Ju Gao, Zhenlei Chen, Huizhong Lin, Wenting Xie, Huifang Li, Zhenyi Chen, Keke Ren, Xiao Zhang, Wenting Wang, Zi-Dan Jin, Shengxi Wu, Xing-Long Wang, Zeng-Qiang Yuan, Huaxi Xu, Hei-Man Chow, Jie Zhang

Nature Metabolism

DOI

2022

Author Correction: Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance

Nature Metabolism

DOI

2022

CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer's disease.

Wenting Xie, Dong Guo, Jieyin Li, Lei Yue, Qi Kang, Guimiao Chen, Tingwen Zhou, Han Wang, Kai Zhuang, Lige Leng, Huifang Li, Zhenyi Chen, Weiwei Gao, Jie Zhang

Cell Death and Differentiation

DOI

2022

Brain Energy Metabolism: Astrocytes in Neurodegenerative Diseases

Zhenlei Chen, Zi-Qi Yuan, Shangchen Yang, Yu-Fei Zhu, Maoqiang Xue, Jie Zhang, Lige Leng

CNS Neuroscience & Therapeutics

DOI

2020

Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover

Jiechao Zhou, Hei-Man Chow, Yan Liu, Di Wu, Meng Shi, Jieyin Li, Lei Wen, Yuehong Gao, Guimiao Chen, Kai Zhuang, Hui Lin, Guanyun Zhang, Wenting Xie, Huifang Li, Lige Leng, Mengdan Wang, Naizhen Zheng, Hao Sun, Yingjun Zhao, Yunwu Zhang, Maoqiang Xue, Timothy Y. Huang, Guojun Bu, Huaxi Xu, Zengqiang Yuan, Karl Herrup, Jie Zhang

Biological Psychiatry，Vol. 87, No. 8

DOI

2018

Neuron-specific menin deletion leads to synaptic dysfunction and cognitive impairment by modulating p35 expression

Kai Zhuang, Changquan Huang, Lige Leng, Hong-Hua Zheng, Yue Gao, Guimiao Chen, Zhilin Ji, Haoyue Sun, Yu Hu, Di Wu, Meng Shi, Huifang Li, Yingjun Zhao, Yun-Wu Zhang, Maoqiang Xue, Guo-Jun Bu, Timothy Y. Huang, Huaxi Xu, Jie Zhang

Cell Reports

DOI

2018

Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation.

Lige Leng, Kai Zhuang, Ze-Yue Liu, Changquan Huang, Yue Gao, Guimiao Chen, Huizhong Lin, Yu Hu, Di Wu, Meng Shi, Wenting Xie, Haoyue Sun, Zhi-Cheng Shao, Huifang Li, Kun-Kun Zhang, W. Mo, Timothy Y. Huang, Maoqiang Xue, Zeng-Qiang Yuan, Xia Zhang, Guo-Jun Bu, Huaxi Xu, Qi Xu, Jie Zhang

Neuron

DOI

冷历歌

精选作品

期刊论文

Amygdala astrocyte senescence drives stress-induced anxiety and hyperglycemia.

Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice

Metabolites released from apoptotic cells in central nervous system orchestrates the pathological process of Alzheimer disease through improving autophagy

A neural substrate of comorbid depressive symptoms in alcohol use

CDK3 induces neuronal death and brain atrophy in Alzheimer’s disease

Mannose Promotes β‐Amyloid Pathology by Regulating BACE1 Glycosylation in Alzheimer's Disease

Multi-omics analysis reveals GAPDH posttranscriptional regulation of IFN-γ and PHGDH as a metabolic checkpoint of microglia polarization

Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity

Menin Deficiency Induces Autism‐Like Behaviors by Regulating Foxg1 Transcription and Participates in Foxg1‐Related Encephalopathy

Microglial metabolic reconfiguration provides a new strategy for the treatment of Alzheimer’s disease

Menin Reduces Parvalbumin Expression and is Required for the Anti‐Depressant Function of Ketamine

Hypothalamic Menin regulates systemic aging and cognitive decline

Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance

Author Correction: Microglial hexokinase 2 deficiency increases ATP generation through lipid metabolism leading to β-amyloid clearance

CEND1 deficiency induces mitochondrial dysfunction and cognitive impairment in Alzheimer's disease.

Brain Energy Metabolism: Astrocytes in Neurodegenerative Diseases

Cyclin-Dependent Kinase 5-Dependent BAG3 Degradation Modulates Synaptic Protein Turnover

Neuron-specific menin deletion leads to synaptic dysfunction and cognitive impairment by modulating p35 expression

Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation.

会议论文

己糖激酶2调节创伤后应激障碍中星形胶质细胞-神经元丝氨酸穿梭和机体葡萄糖代谢

预印本

Urine N-Glycoproteomics Diagnostic Biomarkers Discovery of Preclinical Stage, Mci Stage and Dementia Stage of Alzheimer's Disease

研究方向