许戈阳｜暨南大学｜学者主页

2026

温度敏感性离子通道TRPM3在糖脂代谢中的多面性作用

吴少鸿，许戈阳

《中国病理生理杂志》

2026

L-cell-specific Abca1 deficiency impairs glucose homeostasis through defective GLP-1 production in mice

Lu-Yang Gao, Yubi Lin, Qian-Qian Ye, Yu-Hang Zhao, Wen-Xin He, Shi-Jie Lv, Ke Yang, Jia Chen, Zhen Zhang, Xin-Xin Xiang, Ge-Yang Xu

Acta Pharmaceutica Sinica B

DOI

2026

The TRPM family: key players and mechanisms in energy metabolism.

Mengxue Han, Ge-Yang Xu

Cell Calcium

DOI

2026

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Hui Chen, Qimeng Wang, Ke Yang, Qing-Hai Lian, Xu-Yun Peng, Zhi-Yong Gong, Xin-Yi Zhao, Yong Wu, Tian Tao, Siqi Xu, Yifan Chen, Xiaoyan Tang, Jing-Hui Guo, Ge-Yang Xu, Qi Zhang

Advancement of science

DOI

2025

Intestinal L-cell mechanoreception regulates hepatic lipid metabolism through GLP-1

Lu-Yang Gao, Ke Yang, Ya-Wen Zhao, Jin-Shan Zhang, Shao-Hua Jiang, Ru-Jiao Zhang, Wenxin He, Yu-Hang Zhao, Qian-Qian Ye, Ge-Yang Xu

Science Advances

DOI

2025

Regulation of Ghrelin Production and Food Intake by Gastric Adenylyl Cyclase Type 8

Shaohong Wu, Handan Deng, Rui-Li Yu, Quan Yu, Wei Li, Ya-Wen Zhao, Ke Yang, Lu-Yang Gao, Ge-Yang Xu

Journal of Cellular Physiology

DOI

2025

Adcy8 deficiency contributes to impaired lipolysis and an increased prevalence of obesity in mice.

Mengxue Han, Qing Shu, Rui-Li Yu, Shaohong Wu, Handan Deng, Yang Liu, Quan Yu, Wei Li, Lu-Yang Gao, Ya-Wen Zhao, Ge-Yang Xu

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

DOI

2025

Hepatocyte Piezo1 regulates glycogen metabolism via the FGF21-STAT3 pathway

Tian Tao, Ke Yang, Zhenming Li, Mengyuan Zhang, Zhejiao Zhang, Jing-Hui Guo, Hui Chen, Ge-Yang Xu

Cellular and Molecular Life Sciences

DOI

2024

Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake

Ya-Wen Zhao, Yang Liu, Tian Tao, Jin-Shan Zhang, Wenying Guo, Handan Deng, Mengxue Han, Haocong Mo, Xiao-Han Tong, Song Lin, Jie Yang, Hening Zhai, Qimeng Wang, Zhengfang Hu, Wei-Zhen Zhang, Hui Chen, Geyang Xu

Nature Metabolism

DOI

2024

Mechanical regulation of lipid and sugar absorption by Piezo1 in enterocytes

Tian Tao, Qing Shu, Ya-Wen Zhao, Wenying Guo, Jinting Wang, Yuhao Shi, Shi-Qi Jia, Hening Zhai, Hui Chen, Cunchuan Wang, Ge-Yang Xu

Acta Pharmaceutica Sinica B

DOI

2024

Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

Yanling Huang, Haocong Mo, Jie Yang, Luyang Gao, Tian Tao, Qing Shu, Wenying Guo, Yawen Zhao, Jingya Lyu, Qimeng Wang, Jinghui Guo, Hening Zhai, Linyan Zhu, Hui Chen, Geyang Xu

eLife

DOI

2024

Mechano-sensor Piezo1 inhibits glucagon production in pancreatic α-cells.

Wenying Guo, Lu-Yang Gao, Haocong Mo, Handan Deng, Ya-Wen Zhao, Ge-Yang Xu

Biochimica et Biophysica Acta - Molecular Basis of Disease

DOI

2024

Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice

Jin-Shan Zhang, Ya-Wen Zhao, Shaohong Wu, Mengxue Han, Lu-Yang Gao, Ke Yang, Hui Chen, Cun-Chuan Wang, Ge-Yang Xu

Science Signaling

DOI

2024

Author response: Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

Yanling Huang, Haocong Mo, Jie Yang, Luyang Gao, Tian Tao, Qing Shu, Wenying Guo, Yawen Zhao, Jingya Lyu, Qimeng Wang, Jinghui Guo, Hening Zhai, Linyan Zhu, Hui Chen, Geyang Xu

DOI

2022

机械敏感性离子通道Piezo1在代谢性疾病中的作用

刘阳，黄燕玲，赵雅雯，许戈阳

《中国病理生理杂志》

2022

The Role of Pancreatic Fatty Acid Synthesis in Islet Morphology and Function after Caloric Restriction or Roux-En-Y Gastric Bypass Surgery in Mice

Haocong Mo, Yang Liu, Mengyuan Zhang, Zirui Qiu, Yi-Lin Li, Zhejiao Zhang, Yan-Ting Li, Geyang Xu

Genes

DOI

2022

DOCK4 regulates ghrelin production in gastric X/A-like cells

Y. Huang, Yaorong Yang, Yutong Zhao, Daji Guo, Lin-Yun Chen, L. Shi, Geyang Xu

Journal of Endocrinological Investigation

DOI

2021

DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation

Tingfeng Qin, Jie Yang, Dayin Huang, Zhi-Jun Zhang, Yan-Ling Huang, Hui Chen, Geyang Xu

Journal of Cellular Physiology

DOI

2021

Caloric restriction and Roux-en-Y Gastric Bypass promote white adipose tissue browning in mice

Di Huang, ZhenHao Zhang, Zhiyong Dong, R Liu, Jiana Huang, Geyang Xu

Journal of Endocrinological Investigation

DOI

2020

热量限制对能量代谢的影响及其机制

樊晓娜，陈琳茜，许戈阳

《生理学报》

DOI

2020

Interleukin-27 decreases ghrelin production through signal transducer and activator of transcription 3—mechanistic target of rapamycin signaling

Heng Zhang, Qingjie Li, Yuxin Teng, Yubi Lin, Shaojian Li, Tingfeng Qin, Linxi Chen, Jiana Huang, He-ning Zhai, Quan Yu, Geyang Xu

Acta Pharmaceutica Sinica B

DOI

2020

De novo lipogenesis is elicited dramatically in human hepatocellular carcinoma especially in hepatitis C virus‐induced hepatocellular carcinoma

Shaojian Li, Ruonan Liu, Qinling Pan, Gen-Shu Wang, Dao-Rou Cheng, Jie Yang, Hui Chen, Geyang Xu

MedComm

DOI

2020

[The effects and mechanism of caloric restriction on energy metabolism].

Xiao-Na Fan, Linxi Chen, Geyang Xu

PubMed

2019

Stat3-mTOR signaling mediates the stimulation of GLP-1 production induced by IL-27.

Guoqing Lei, Linxi Chen, Miao Peng, Bo Zeng, Qiaoxi Yang, He-ning Zhai, Geyang Xu

Journal of Molecular Endocrinology

DOI

2019

Hepatic mTOR-AKT2-Insig2 signaling pathway contributes to the improvement of hepatic steatosis after Roux-en-Y Gastric Bypass in mice.

Qinling Pan, Tingfeng Qin, Yuan Gao, Shaojian Li, Dan-Jie Li, Miao Peng, He-ning Zhai, Geyang Xu

Biochimica et Biophysica Acta - Molecular Basis of Disease

DOI

2018

Hypothalamic peroxisome proliferator-activated receptor gamma regulates ghrelin production and food intake.

Qingjie Li, Quan Yu, Li Lin, Heng Zhang, Miao Peng, Chunxia Jing, Geyang Xu

Neuropeptides

DOI

2018

Gastric Mammalian Target of Rapamycin Signaling Contributes to Inhibition of Ghrelin Expression Induced by Roux-En-Y Gastric Bypass

Dan-Jie Li, Shaojian Li, Qinling Pan, He-ning Zhai, Miao Peng, Xuan-Xuan Wang, Geyang Xu

Cellular Physiology and Biochemistry

DOI

2018

Takeda G Protein-Coupled Receptor 5-Mechanistic Target of Rapamycin Complex 1 Signaling Contributes to the Increment of Glucagon-Like Peptide-1 Production after Roux-en-Y Gastric Bypass

He-ning Zhai, Zhi Li, Miao Peng, Zhao-Qi Huang, Tingfeng Qin, Linxi Chen, Hanbing Li, Heng Zhang, Weizhen Zhang, Geyang Xu

EBioMedicine

DOI

2017

肥胖2型糖尿病患者与大鼠胃旁路术后血清总胆汁酸水平的变化

何伟丽，翟贺宁，许戈阳，杨景哥，杨华，王存川

《中国病理生理杂志》

2016

AMPK-dependent regulation of GLP1 expression in L-like cells.

Sushi Jiang, He-ning Zhai, Dan-Jie Li, Jiana Huang, Heng Zhang, Zi-Ru Li, Wei-Zhen Zhang, Geyang Xu

Journal of Molecular Endocrinology

DOI

2016

Intermedin/adrenomedullin 2 polypeptide promotes adipose tissue browning and reduces high-fat diet-induced obesity and insulin resistance in mice

Hong-Quan Zhang, Song-yang Zhang, Chang-Tao Jiang, Y. Li, Geyang Xu, Min-Juan Xu, Xun-Cheng Wang

International Journal of Obesity

DOI

2016

Exendin-4 decreases ghrelin levels through mTOR signaling.

Xiao-Si Hong, Heng Zhang, Hongbin Liang, Dan-Jie Li, Jiana Huang, Zhi Li, Sibo Jiang, Wei-Zhen Zhang, Geyang Xu

Molecular and Cellular Endocrinology

DOI

2015

mTOR信号通路在糖代谢中作用

许戈阳，刘芬婷，沈哲民，张炜真

《生理科学进展》

2015

肠道mTOR信号分子调节GLP-1生成

许戈阳，张炜真

《中国病理生理杂志》

2015

GLP-1合成与分泌的分子机制及其影响因素

郭松，黄丽明，许戈阳

《生理科学进展》

2015

Intestinal mTOR regulates GLP-1 production in mouse L cells

Geyang Xu, Zi-Ru Li, L. Ding, Hong Tang, Song Guo, Hongbin Liang, Hua-Dong Wang, Wei-Zhen Zhang

Diabetologia

DOI

2015

The Role of Hormones in Glucose Homeostasis and Diabetes Treatment

Heng Zhang, Sushi Jiang, Xiao-Si Hong, Jiana Huang, Dan-Jie Li, Fenting Liu, Geyang Xu

2015

The Role of Histone Deacetylases in Glucose Metabolism: a Mini- Review

Fenting Liu, Zhemin Shen, Heng Zhang, Geyang Xu

DOI

2015

Regulation of Food Intake by Fuel Sensors

Sushi Jiang, Xiao-Si Hong, Geyang Xu

2015

Ghrelin regulates GLP-1 production through mTOR signaling in L cells.

Geyang Xu, Xiao-Si Hong, Hong Tang, Sushi Jiang, Fenting Liu, Zhemin Shen, Zi-Ru Li, Wei-Zhen Zhang

Molecular and Cellular Endocrinology

DOI

2014

Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARγ signaling pathway

Zi-Ru Li, Geyang Xu, Yan Qin, Chao Zhang, Hong Tang, Yue Yin, X. Xiang, Yin Li, Jing Zhao, Michael Mulholland, Wei-Zhen Zhang

Proceedings of the National Academy of Sciences of the United States of America

DOI

2012

Modulation of gastric nesfatin by rapamycin

Zi-Ru Li, Geyang Xu, Yin Li, Jin Zhao, Wei-Zhen Zhang

DOI

2012

mTOR-dependent Modulation of Gastric Nesfatin-1/NUCB2

Zi-Ru Li, Geyang Xu, Yin Li, Jing Zhao, M. Mulholland, Wei-Zhen Zhang

Cellular Physiology and Biochemistry

DOI

2011

Gastric mammalian target of rapamycin signaling, hormone production and energy metabolism.

Geyang Xu, Yin Li, Wei-Zhen Zhang

World Journal of Gastrointestinal Pathophysiology

DOI

2010

Regulation of ghrelin production by gastric mTOR signaling

Wei-Zhen Zhang, Geyang Xu, Yin Li, Wenjiao An, M. Mulholland

DOI

2010

Modulation of Ghrelin O-Acyltransferase Expression in Pancreatic Islets

Wenjiao An, Yin Li, Geyang Xu, Jing Zhao, X. Xiang, Li Ding, Jing Li, Y. Guan, Xian Wang, Chaosu Tang, Xiao-Ying Li, M. Mulholland, Wei-Zhen Zhang

Cellular Physiology and Biochemistry

DOI

2010

Regulation of gastric hormones by systemic rapamycin

Geyang Xu, Yin Li, Wenjiao An, Jing Zhao, X. Xiang, L. Ding, Zi-Ru Li, Y. Guan, Xian Wang, Chao-Shu Tang, Yi Zhu, Nan-Ping Wang, Xiao-Ying Li, M. Mulholland, Wei-Zhen Zhang

Peptides

DOI

2010

Gastric fuel sensing, ghrelin production and food intake

Geyang Xu, Yin Li, Wei-Zhen Zhang

2009

Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake.

Geyang Xu, Yin Li, Wenjiao An, Shen-Duo Li, Y. Guan, Nan-Ping Wang, Chao-Shu Tang, Xian Wang, Yi Zhu, Xiaoying Li, M. Mulholland, Wei-Zhen Zhang

Endocrinology

DOI

2009

Ghrelin fluctuation, what determines its production?

Xuefeng Yin, Yin Li, Geyang Xu, Wenjiao An, Wei-Zhen Zhang

Acta Biochimica et Biophysica Sinica

DOI

2008

Ghrelin and cell differentiation.

Geyang Xu, Yin Li, Wenjiao An, Wei-Zhen Zhang

Acta Biochimica et Biophysica Sinica

DOI

2007

脂肪组织内源性产生的H2S是胰岛素抵抗发病的重要因素

冯雪娟，姜志胜，陈瑜，陈晶晶，唐志晗，赵战芝，卜梓斌，许戈阳，耿彬，唐朝枢

《中国动脉硬化杂志》

2007

红细胞内源性硫化氢的测定

赵晶，房立平，许戈阳，唐朝枢，耿彬

《北京大学学报(医学版)》

DOI

精选作品

期刊论文

温度敏感性离子通道TRPM3在糖脂代谢中的多面性作用

L-cell-specific Abca1 deficiency impairs glucose homeostasis through defective GLP-1 production in mice

The TRPM family: key players and mechanisms in energy metabolism.

Hepatocyte PIEZO1 Negatively Regulates Lipogenesis and Ameliorates MASLD by Sensing Membrane Tension and Activating AMPK

Intestinal L-cell mechanoreception regulates hepatic lipid metabolism through GLP-1

Regulation of Ghrelin Production and Food Intake by Gastric Adenylyl Cyclase Type 8

Adcy8 deficiency contributes to impaired lipolysis and an increased prevalence of obesity in mice.

Hepatocyte Piezo1 regulates glycogen metabolism via the FGF21-STAT3 pathway

Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake

Mechanical regulation of lipid and sugar absorption by Piezo1 in enterocytes

Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

Mechano-sensor Piezo1 inhibits glucagon production in pancreatic α-cells.

Mechanosensing by Piezo1 in gastric ghrelin cells contributes to hepatic lipid homeostasis in mice

Author response: Mechano-regulation of GLP-1 production by Piezo1 in intestinal L cells

机械敏感性离子通道Piezo1在代谢性疾病中的作用

The Role of Pancreatic Fatty Acid Synthesis in Islet Morphology and Function after Caloric Restriction or Roux-En-Y Gastric Bypass Surgery in Mice

DOCK4 regulates ghrelin production in gastric X/A-like cells

DOCK4 stimulates MUC2 production through its effect on goblet cell differentiation

Caloric restriction and Roux-en-Y Gastric Bypass promote white adipose tissue browning in mice

热量限制对能量代谢的影响及其机制

Interleukin-27 decreases ghrelin production through signal transducer and activator of transcription 3—mechanistic target of rapamycin signaling

De novo lipogenesis is elicited dramatically in human hepatocellular carcinoma especially in hepatitis C virus‐induced hepatocellular carcinoma

[The effects and mechanism of caloric restriction on energy metabolism].

Stat3-mTOR signaling mediates the stimulation of GLP-1 production induced by IL-27.

Hepatic mTOR-AKT2-Insig2 signaling pathway contributes to the improvement of hepatic steatosis after Roux-en-Y Gastric Bypass in mice.

Hypothalamic peroxisome proliferator-activated receptor gamma regulates ghrelin production and food intake.

Gastric Mammalian Target of Rapamycin Signaling Contributes to Inhibition of Ghrelin Expression Induced by Roux-En-Y Gastric Bypass

Takeda G Protein-Coupled Receptor 5-Mechanistic Target of Rapamycin Complex 1 Signaling Contributes to the Increment of Glucagon-Like Peptide-1 Production after Roux-en-Y Gastric Bypass

肥胖2型糖尿病患者与大鼠胃旁路术后血清总胆汁酸水平的变化

AMPK-dependent regulation of GLP1 expression in L-like cells.

Intermedin/adrenomedullin 2 polypeptide promotes adipose tissue browning and reduces high-fat diet-induced obesity and insulin resistance in mice

Exendin-4 decreases ghrelin levels through mTOR signaling.

mTOR信号通路在糖代谢中作用

肠道mTOR信号分子调节GLP-1生成

GLP-1合成与分泌的分子机制及其影响因素

Intestinal mTOR regulates GLP-1 production in mouse L cells

The Role of Hormones in Glucose Homeostasis and Diabetes Treatment

The Role of Histone Deacetylases in Glucose Metabolism: a Mini- Review

Regulation of Food Intake by Fuel Sensors

Ghrelin regulates GLP-1 production through mTOR signaling in L cells.

Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARγ signaling pathway

Modulation of gastric nesfatin by rapamycin

mTOR-dependent Modulation of Gastric Nesfatin-1/NUCB2

Gastric mammalian target of rapamycin signaling, hormone production and energy metabolism.

Regulation of ghrelin production by gastric mTOR signaling

Modulation of Ghrelin O-Acyltransferase Expression in Pancreatic Islets

Regulation of gastric hormones by systemic rapamycin

Gastric fuel sensing, ghrelin production and food intake

Gastric mammalian target of rapamycin signaling regulates ghrelin production and food intake.

Ghrelin fluctuation, what determines its production?

Ghrelin and cell differentiation.

脂肪组织内源性产生的H2S是胰岛素抵抗发病的重要因素

红细胞内源性硫化氢的测定

会议论文

中链脂肪酸合成酶的纯化

mTOR调节nesfatin的生成

胰岛素对ghrelin O-酰基转移酶表达的调控及机制

研究方向