张元伟｜广州大学｜学者主页

2026

The role of chloride ions in serotonin transport

Jiahui Huang, Angela Bäcker, Stacy Uchendu, Bethlehem Bekele, Chan Li, Qingyang Chen, Esam A. Orabi, Robyn Stix, Jasper D. Shide, Yuan‐Wei Zhang, Gary Rudnick, Eva Hellsberg, Lucy R. Forrest

Proceedings of the National Academy of Sciences

DOI

2026

Optogenetic Regulation of Localization and Function of Serotonin Transporter by Modulating Its Interaction with Soluble Guanylate Cyclase

Duanbin Tan, Huangjie Ye, Yuting Chen, Xingyu Huang, Xiaoqi Cai, Yuehui Tian, Yuan‐Wei Zhang

International Journal of Molecular Sciences

DOI

2026

An emerging therapeutic strategy for major depressive disorder: targeting the protein-protein interactions

Xingyu Huang, Jiayan Lin, Yuan‐Wei Zhang

Neurochemistry International

DOI

2026

Microbiota-Derived SCFAs Mediate the Synergistic Antidepressant Effects of Dajianzhong Decoction and Ketamine via FFAR2-NLRP3-IL-1β Signaling

Wenting Zhang, Xin Guo, Jiping Zhang, Yuan‐Wei Zhang, Chan Li

Pharmaceuticals

DOI

2026

Disrupting the physical interaction between serotonin transporter and soluble guanylate cyclase produces a fast-acting antidepressant activity

Xingyu Huang, Chan Li, Jiayan Lin, Xintong Zhang, Yanhong Xu, Yuan‐Wei Zhang

Pharmacological Research

DOI

2026

The Role of Cholesterol at the CHOL2 Site and the Dimeric Interface in the Regulation of Serotonin Transporter Function and Dimerization

Jie Yang, Chan Li, Xingyu Huang, Yuan‐Wei Zhang

Biomolecules

DOI

2026

Cochlear nucleus spatial transcriptomes of normal and hearing loss mice reveal a critical role of Spp1 in bushy cells

Hui-Hui Liu, Shangfeng Liao, Xiao-Wei Li, Li Song, Muming Poo, Jing Zhao, Weijun Zhou, Ruijie Cai, Meijian Wang, Xiao-Tong Ma, Shao-Shien Lin, Xing-Le Zhao, Ningyuan Zhu, Yuanwei Zhang, Junpu Mei, Lei Song, Li-Jian Zhao, Sidi Liu, Ying Chen, Hao Wu

Cell Research

DOI

2026

Single-Nucleus Profiling Reveals a BBB Senescence Unit Driving AD Pathology in Human Brain

Yuanwei Zhang, Zhong-Man Jin, Ruizhen Rao, L. Si, Zhiru Zhang, R. Ma, Yi Min, Junpu Mei, Zhen Yue, Xiaodong Fang, Hui Wei

Molecular Neurobiology

DOI

2025

Control of Conformational Transitions by the Conserved GX9P Motif in the Fifth Transmembrane Domain of Neurotransmitter Sodium Symporters

Xintong Zhang, Yanhong Xu, Qingyang Chen, Chan Li, Yuan‐Wei Zhang

International Journal of Molecular Sciences

DOI

2024

Identification of the potassium-binding site in serotonin transporter

Eva Hellsberg, Danila Boytsov, Qingyang Chen, Marco Niello, Michael Freissmuth, Gary Rudnick, Yuan‐Wei Zhang, Walter Sandtner, Lucy R. Forrest

Proceedings of the National Academy of Sciences

DOI

2024

A Conserved Intramolecular Ion-Pair Plays a Critical but Divergent Role in Regulation of Dimerization and Transport Function among the Monoamine Transporters

Sixiang Chen, Xingyu Huang, Xintong Zhang, Chan Li, Yuan‐Wei Zhang

International Journal of Molecular Sciences

DOI

2024

(-)-Syringaresinol Exerts an Antidepressant-like Activity in Mice by Noncompetitive Inhibition of the Serotonin Transporter

Yingyao Wu, Jianxin Cai, Hanhe Liu, Chan Li, Qingfa Tang, Yuan‐Wei Zhang

Pharmaceuticals

DOI

2023

Unique Substrate Recognition and Sodium–Substrate Binding Stoichiometry in a Bacterial Serotonin Transporter, TuriSERT

Mu Li, Xintong Zhang, Sixiang Chen, Hanhe Liu, Yuan‐Wei Zhang

International Journal of Molecular Sciences

DOI

2023

The synergistic mechanism of action of Dajianzhong decoction in conjunction with ketamine in the treatment of depression

Chan Li, Jiping Zhang, Hanhe Liu, Huijie Yuan, Jianxin Cai, Manoela V. Fogaça, Yuan‐Wei Zhang

Biomedicine & Pharmacotherapy

DOI

2022

Cross-Linking and Functional Analyses for Dimerization of a Cysteine Mutant of Glycine Transporter 1

Jingru Wang, Hanhe Liu, Yuan‐Wei Zhang

International Journal of Molecular Sciences

DOI

2022

Determining Ligand and Ion-Induced Conformational Changes in Serotonin Transporter with Its Fluorescent Substrates

Mu Li, Qingyang Chen, Yuan‐Wei Zhang

International Journal of Molecular Sciences

DOI

2022

Molecular docking and biochemical validation of (-)-syringaresinol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside binding to an allosteric site in monoamine transporters

Hanhe Liu, Yingyao Wu, Chan Li, Qingfa Tang, Yuan‐Wei Zhang

Frontiers in Pharmacology

DOI

2022

Two Lignan Glycosides from Albizia julibrissin Durazz. Noncompetitively Inhibit Serotonin Transporter

Bishan Huang, Hanhe Liu, Yingyao Wu, Chan Li, Qingfa Tang, Yuan‐Wei Zhang

Pharmaceuticals

DOI

2021

Chloride-dependent conformational changes in the GlyT1 glycine transporter

Yuan‐Wei Zhang, Stacy Uchendu, Vanessa Leone, Richard T. Bradshaw, Ntumba Sangwa, Lucy R. Forrest, Gary Rudnick

Proceedings of the National Academy of Sciences

DOI

2021

Chinese Herbal Medicine for the Treatment of Depression: Effects on the Neuroendocrine-Immune Network

Chan Li, Bishan Huang, Yuan‐Wei Zhang

Pharmaceuticals

DOI

2020

Traditional Chinese Medicine in Depression Treatment: From Molecules to Systems

Chan Li, Junying Huang, Yung‐Chi Cheng, Yuan‐Wei Zhang

Frontiers in Pharmacology

DOI

2019

Challenge and Prospect of Traditional Chinese Medicine in Depression Treatment

Yuan‐Wei Zhang, Yung‐Chi Cheng

Frontiers in Neuroscience

DOI

2018

Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT

Yuan‐Wei Zhang, Sotiria Tavoulari, Steffen Sinning, Antoniya A. Aleksandrova, Lucy R. Forrest, Gary Rudnick

Proceedings of the National Academy of Sciences

DOI

张元伟

精选作品

期刊论文

The role of chloride ions in serotonin transport

Optogenetic Regulation of Localization and Function of Serotonin Transporter by Modulating Its Interaction with Soluble Guanylate Cyclase

An emerging therapeutic strategy for major depressive disorder: targeting the protein-protein interactions

Microbiota-Derived SCFAs Mediate the Synergistic Antidepressant Effects of Dajianzhong Decoction and Ketamine via FFAR2-NLRP3-IL-1β Signaling

Disrupting the physical interaction between serotonin transporter and soluble guanylate cyclase produces a fast-acting antidepressant activity

The Role of Cholesterol at the CHOL2 Site and the Dimeric Interface in the Regulation of Serotonin Transporter Function and Dimerization

Cochlear nucleus spatial transcriptomes of normal and hearing loss mice reveal a critical role of Spp1 in bushy cells

Single-Nucleus Profiling Reveals a BBB Senescence Unit Driving AD Pathology in Human Brain

Control of Conformational Transitions by the Conserved GX9P Motif in the Fifth Transmembrane Domain of Neurotransmitter Sodium Symporters

Identification of the potassium-binding site in serotonin transporter

A Conserved Intramolecular Ion-Pair Plays a Critical but Divergent Role in Regulation of Dimerization and Transport Function among the Monoamine Transporters

(-)-Syringaresinol Exerts an Antidepressant-like Activity in Mice by Noncompetitive Inhibition of the Serotonin Transporter

Unique Substrate Recognition and Sodium–Substrate Binding Stoichiometry in a Bacterial Serotonin Transporter, TuriSERT

The synergistic mechanism of action of Dajianzhong decoction in conjunction with ketamine in the treatment of depression

Cross-Linking and Functional Analyses for Dimerization of a Cysteine Mutant of Glycine Transporter 1

Determining Ligand and Ion-Induced Conformational Changes in Serotonin Transporter with Its Fluorescent Substrates

Molecular docking and biochemical validation of (-)-syringaresinol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside binding to an allosteric site in monoamine transporters

Two Lignan Glycosides from Albizia julibrissin Durazz. Noncompetitively Inhibit Serotonin Transporter

Chloride-dependent conformational changes in the GlyT1 glycine transporter

Chinese Herbal Medicine for the Treatment of Depression: Effects on the Neuroendocrine-Immune Network

Traditional Chinese Medicine in Depression Treatment: From Molecules to Systems

Challenge and Prospect of Traditional Chinese Medicine in Depression Treatment

Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT

研究方向