百晓学者学者目录

王鹏飞

助理研究员、博士生导师、教授、研究员，复旦大学

精选作品

期刊论文

2026

Porcine Deltacoronavirus (PDCoV): From Emerging Swine Enteric Coronavirus to a Potential Coronavirus to Infect Humans

Xiaorong Chen, Zhishui Zhang, Hanyu Cheng, Siyuan Qi, Pengfei Wang

Viruses

DOI

2026

CD25 modulation enhances broadly neutralizing antibody response of SARS-CoV-2 subunit vaccine

Fangshen Li, Xin Yu, Xin Yu, Chunhe Zhang, W Liu, Haochen Tian, Pengfei Wang, Pengfei Wang, Bin Yu, Xianghui Yu, Xianghui Yu

Communications Biology

DOI

2026

Age-associated differences in XBB.1.5 trivalent booster vaccine-induced adaptive responses revealed by single-cell RNA sequencing

Shixing Chen, Tao Liu, Jing Chen, Shengxia Yin, Jinqiu Ran, Wen Zhang, Wen Zhang, Juan Zhang, Chen Li, Xun Wang, Pengfei Wang, Chao Wu, Fan Yang, Yuehua Chen

Emerging Microbes & Infections

DOI

2025

Pathogenicity, virological features, and immune evasion of SARS-CoV-2 JN.1-derived variants including JN.1.7, KP.2, KP.3, and KP.3.1.1

Jialu Shi, Xiaoyu Zhao, Xiaohui Jin, Jiayan Li, Yuanchen Liu, Huan Liu, Ye‐Fan Hu, Zhe Chen, Yuxin Xiao, Lei Wang, Yajie Wang, Yixin He, Yue Chai, Bingjie Hu, Huiping Shuai, Yang Wang, Xiangnan Li, Shujun Jiang, Yanliang Zhang, Xiaojuan Zhang, Wan-Mui Chan, Lin‐Lei Chen, Jian‐Piao Cai, Baokun Sui, Honglei Zhang, Dong Ho Yang, Longchao Zhu, Shuofeng Yuan, Jie Zhou, Jian‐Dong Huang, Kwok‐Yung Yuen, Kelvin Kai‐Wang To, Jasper Fuk‐Woo Chan, Bao‐Zhong Zhang, Qiao Wang, Maozhou He, Lei Sun, Pengfei Wang, Hin Chu

Nature Communications

DOI

2025

Orphan broadly RBD-binding antibodies annotate three remaining conserved RBD epitopes along SARS-CoV-2 evolution

Minxiang Xie, Yinong Qiu, Xiaoyu Zhao, Jialu Shi, Yuanchen Liu, Qingsong Zhang, Jiaying He, Jiayan Li, Luotian Liu, Siyuan Sun, Yuzhen Zhu, Qiyu Mao, Yiming Long, Thiago Y. Oliveira, Zijun Wang, Yunjiao Zhou, Yan Yan, Anqi Xia, Wenjing Zai, Christian Thomas Mayer, Youhua Xie, Shibo Jiang, Lu Lu, Rong Xia, Fan Wu, Lei Sun, Pengfei Wang, Hin Chu, Qiao Wang

Nature Communications

DOI

2025

A Synthetic Liposome Nanoparticle Vaccine Platform for Broad-Spectrum Vaccine Design

Mo Zhang, Zihan Gao, Sheng Feng, Xun Wang, Huaiyu Wang, Chumeng Yang, Xiaolei Lin, Zhiqiang Xu, Nan Zhang, Yiyang Li, Haochen Tian, Ningyi Jin, Bin Yu, Pengfei Wang, Chang Li, Xianghui Yu

Nano Letters

DOI

2025

Evolving SARS-CoV-2 Vaccines: From Current Solutions to Broad-Spectrum Protection

Rui Qiao, Jiayan Li, Jiami Gong, Yuchen Shao, Jizhen Yu, Yumeng Chen, Yinying Lu, Luxuan Yang, Luanfeng Lin, Zixin Hu, Pengfei Wang, Xiaoyu Zhao, Wenhong Zhang

Vaccines

DOI

2025

Novel Trispecific Neutralizing Antibodies With Enhanced Potency and Breadth Against Pan‐Sarbecoviruses

Rui Qiao, Yuanchen Liu, Qiyu Mao, Jiayan Li, Yinying Lu, Jialu Shi, Chen Li, Jizhen Yu, Jiami Gong, Xun Wang, Yuchen Shao, Lei Sun, Wenhong Zhang, Hongjie Yu, Hin Chu, Pengfei Wang, Xiaoyu Zhao

MedComm

DOI

2025

Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infection

Yu Lei, Yajie Wang, Yuanchen Liu, Xiaomin Xing, Chen Li, Xun Wang, Jialu Shi, Wentai Ma, Jiayan Li, Yanjia Chen, Rui Qiao, Xiaoyu Zhao, Shilei Tian, Ming Gao, Shuhua Wen, Yingxue Xue, Tianyi Qiu, Hongjie Yu, Yongjun Guan, Hin Chu, Lei Sun, Pengfei Wang

Communications Biology

DOI

2024

Lineage-specific pathogenicity, immune evasion, and virological features of SARS-CoV-2 BA.2.86/JN.1 and EG.5.1/HK.3

Yuanchen Liu, Xiaoyu Zhao, Jialu Shi, Yajie Wang, Huan Liu, Ye‐Fan Hu, Bingjie Hu, Huiping Shuai, Terrence Tsz‐Tai Yuen, Yue Chai, Feifei Liu, Hua‐Rui Gong, Jiayan Li, Xun Wang, Shujun Jiang, Xiang Zhang, Yanliang Zhang, Xiangnan Li, Lei Wang, Madeline Hartnoll, Tianrenzheng Zhu, Yuxin Hou, Xiner Huang, Chaemin Yoon, Yang Wang, Yixin He, Minmin Zhou, Lianzhao Du, Xiaojuan Zhang, Wan-Mui Chan, Lin‐Lei Chen, Jian‐Piao Cai, Shuofeng Yuan, Jie Zhou, Jian‐Dong Huang, Kwok‐Yung Yuen, Kelvin Kai‐Wang To, Jasper Fuk‐Woo Chan, Bao‐Zhong Zhang, Lei Sun, Pengfei Wang, Hin Chu

Nature Communications

DOI

2024

Vascular endothelial growth factor receptor 2 as a potential host target for the inhibition of enterovirus replication

Xiaoyu Zhao, Rui Qiao, Meng Hao, Longfa Xu, Dong Wang, Yinying Lu, Jiayan Li, Jing Wu, Yi Li, Tong Cheng, Wenhong Zhang, Jincun Zhao, Pengfei Wang

Journal of Virology

DOI

2024

Bispecific antibodies provide broad neutralization of emerging beta-coronaviruses by targeting ACE2 and viral spikes

Minghui Li, Chaoyue Zhao, Jialu Shi, Xun Wang, Yuanchen Liu, Xiaoyu Zhao, Guonan Cai, Hin Chu, Pengfei Wang

Emerging Microbes & Infections

DOI

2024

Robust neutralization of SARS-CoV-2 variants including JN.1 and BA.2.87.1 by trivalent XBB vaccine-induced antibodies

Xun Wang, Shujun Jiang, Wentai Ma, Chen Li, Changyi Liu, Faren Xie, Jinsheng Zhu, Yan Zhan, Shibo Jiang, Mingkun Li, Yanliang Zhang, Pengfei Wang

Signal Transduction and Targeted Therapy

DOI

2024

Longitudinal Analysis of Humoral and Cellular Immune Response up to 6 Months after SARS-CoV-2 BA.5/BF.7/XBB Breakthrough Infection and BA.5/BF.7-XBB Reinfection

Xun Wang, Manzhu Zhang, Kaifeng Wei, Chen Li, Jinghui Yang, Shujun Jiang, Chaoyue Zhao, Xiaoyu Zhao, Rui Qiao, Yuchen Cui, Yanjia Chen, Jiayan Li, Guonan Cai, Changyi Liu, Jizhen Yu, Wenhong Zhang, Faren Xie, Pengfei Wang, Yanliang Zhang

Vaccines

DOI

2024

Corrigendum to “Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron” [Cytokine Growth Factor Rev. 70 (2023) 13–25]

Lidong Wang, Michelle Møhlenberg, Pengfei Wang, Hao Zhou

Cytokine & Growth Factor Reviews

DOI

2024

Potent and broadly neutralizing antibodies against sarbecoviruses induced by sequential COVID-19 vaccination

Xiaoyu Zhao, Tianyi Qiu, Xiner Huang, Qiyu Mao, Yajie Wang, Rui Qiao, Jiayan Li, Tiantian Mao, Yuan Wang, Yewei Cun, Caicui Wang, Cuiting Luo, Chaemin Yoon, Xun Wang, Chen Li, Yuchen Cui, Chaoyue Zhao, Minghui Li, Yanjia Chen, Guonan Cai, Wenye Geng, Zixin Hu, Jinglei Cao, Wenhong Zhang, Zhiwei Cao, Hin Chu, Lei Sun, Pengfei Wang

Cell Discovery

DOI

2024

Multi-omics landscapes reveal heterogeneity in long COVID patients characterized with enhanced neutrophil activity

Ke Lin, Jian‐Peng Cai, Jingxin Guo, Haocheng Zhang, Gangqiang Sun, Xun Wang, Kun Zhu, Quanlin Xue, Feng Zhu, Pengfei Wang, Guanmin Yuan, Yuhan Sun, Sen Wang, Jingwen Ai, Wenhong Zhang

Journal of Translational Medicine

DOI

2023

Enhanced neutralization of SARS-CoV-2 variant BA.2.86 and XBB sub-lineages by a tetravalent COVID-19 vaccine booster

Xun Wang, Shujun Jiang, Wentai Ma, Xiangnan Li, Kaifeng Wei, Faren Xie, Chaoyue Zhao, Xiaoyu Zhao, Shidi Wang, Chen Li, Rui Qiao, Yuchen Cui, Yanjia Chen, Jiayan Li, Guonan Cai, Changyi Liu, Jizhen Yu, Jixi Li, Zixin Hu, Wenhong Zhang, Shibo Jiang, Mingkun Li, Yanliang Zhang, Pengfei Wang

Cell Host & Microbe

DOI

2023

Neutralization against Omicron subvariants after BA.5/BF.7 breakthrough infection weakened as virus evolution and aging despite repeated prototype-based vaccination 1

Hongyu Wang, Quanlin Xue, H. C. Zhang, Guanmin Yuan, Xun Wang, Kai Sheng, Chen Li, Jianpeng Cai, Yuhan Sun, Jingjing Zhao, Jiahuan Lu, Shuyu Fang, Yongfeng Yang, Yeting Zhang, Ying Huang, Jiancui Wang, Jonathan H. Xu, Melissa X. Jiang, Xinyu Wang, Lei Shen, Yuanyuan Liu, Qihui Liu, Qiran Zhang, Sen Wang, Pengfei Wang, Chao Qiu, Jingwen Ai, Wenhong Zhang

Emerging Microbes & Infections

DOI

2023

In Vitro Antibody-Dependent Enhancement of SARS-CoV-2 Infection Could Be Abolished by Adding Human IgG

Xun Wang, Minghui Li, Panpan Lu, Chen Li, Chaoyue Zhao, Xiaoyu Zhao, Rui Qiao, Yuchen Cui, Yanjia Chen, Jiayan Li, Guonan Cai, Pengfei Wang

Pathogens

DOI

2023

Periodic Mesoporous Organosilica as a Nanoadjuvant for Subunit Vaccines Elicits Potent Antigen-Specific Germinal Center Responses by Activating Naive B Cells

Fangshen Li, Xinyao Feng, Jiaxing Huang, Mo Zhang, Wenmo Liu, Xupu Wang, Rui Zhu, Xun Wang, Pengfei Wang, Bin Yu, Wei Li, Zhen‐An Qiao, Xianghui Yu

ACS Nano

DOI

2023

Defining a highly conserved cryptic epitope for antibody recognition of SARS-CoV-2 variants

Aihua Hao, Wenping Song, Cheng Li, Xiang Zhang, Chao Tu, Xun Wang, Pengfei Wang, Yanling Wu, Tianlei Ying, Lei Sun

Signal Transduction and Targeted Therapy

DOI

2023

Neutralization of SARS-CoV-2 BQ.1.1, CH.1.1, and XBB.1.5 by breakthrough infection sera from previous and recent waves in China

Xun Wang, Shuai Jiang, Shujun Jiang, Xiangnan Li, Jingwen Ai, Ke Lin, Shiyun Lv, Shixuan Zhang, Minghui Li, Jixi Li, Lili Dai, Zixin Hu, Wenhong Zhang, Yanliang Zhang, Pengfei Wang

Cell Discovery

DOI

2023

Immune evasion of neutralizing antibodies by SARS-CoV-2 Omicron

Lidong Wang, Michelle Møhlenberg, Pengfei Wang, Hao Zhou

Cytokine & Growth Factor Reviews

DOI

2023

Limited enhancement of antibody and B‐cell responses to prototype booster vaccination following SARS‐CoV‐2 Delta breakthrough infection

Xun Wang, Xing He, Shujun Jiang, Zhangfan Fu, Shuai Jiang, Xiaoyu Zhao, Chaoyue Zhao, Yaning Li, Dianfan Li, Wenhong Zhang, Jingwen Ai, Yanliang Zhang, Chenqi Xu, Pengfei Wang

Journal of Medical Virology

DOI

2023

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance specific cytotoxic activity against HIV Env+ cells in vivo

Hanyu Pan, Xinyi Yang, Jing Wang, Huitong Liang, Zhengtao Jiang, Lin Zhao, Yanan Wang, Zhiming Liang, Xiaoting Shen, Qinru Lin, Yue Liang, Jinglong Yang, Panpan Lu, Yuqi Zhu, Min Li, Pengfei Wang, Jianqing Xu, Hongzhou Lu, Huanzhang Zhu

Virologica Sinica

DOI

2022

Neutralization of Omicron BA.4/BA.5 and BA.2.75 by booster vaccination or BA.2 breakthrough infection sera

Xun Wang, Jingwen Ai, Xiangnan Li, Xiaoyu Zhao, Jing Wu, H. C. Zhang, Xing He, Chaoyue Zhao, Rui Qiao, Minghui Li, Yuchen Cui, Yanjia Chen, Lulu Yang, Zixin Hu, Chenqi Xu, Wenhong Zhang, Pengfei Wang

Cell Discovery

DOI

2022

Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses

Yanjia Chen, Xiaoyu Zhao, Hao Zhou, Huanzhang Zhu, Shibo Jiang, Pengfei Wang

Nature reviews. Immunology

DOI

2022

Neutralization of distinct Omicron sublineages by longitudinal vaccination sera

Xun Wang, Xiaoyu Zhao, Yuchen Cui, Rui Qiao, Minghui Li, Yanjia Chen, Lulu Yang, Shibo Jiang, Pengfei Wang

Journal of Medical Virology

DOI

2022

Rock1 is a novel host dependency factor of human enterovirus A71: Implication as a drug target

Xiaoyu Zhao, Cun Li, Man Chun Chiu, Rui Qiao, Shibo Jiang, Pengfei Wang, Jie Zhou

Journal of Medical Virology

DOI

2022

Sensitivity to Vaccines, Therapeutic Antibodies, and Viral Entry Inhibitors and Advances To Counter the SARS-CoV-2 Omicron Variant

Hao Zhou, Michelle Møhlenberg, Jigarji Chaturji Thakor, Hardeep Singh Tuli, Pengfei Wang, Yehuda G. Assaraf, Kuldeep Dhama, Shibo Jiang

Clinical Microbiology Reviews

DOI

2022

Antibody evasion of SARS-CoV-2 Omicron BA.1, BA.1.1, BA.2, and BA.3 sub-lineages

Jingwen Ai, Xun Wang, Xinyi He, Xiaoyu Zhao, Yi Zhang, Yuchao Jiang, Minghui Li, Yuchen Cui, Yanjia Chen, Rui Qiao, Lin Li, Lulu Yang, Yi Li, Zixin Hu, Wenhong Zhang, Pengfei Wang

Cell Host & Microbe

DOI

2022

Homologous or heterologous booster of inactivated vaccine reduces SARS-CoV-2 Omicron variant escape from neutralizing antibodies

Xun Wang, Xiaoyu Zhao, Jieyu Song, Jing Wu, Yuqi Zhu, Minghui Li, Yuchen Cui, Yanjia Chen, Lulu Yang, Jun Liu, Huanzhang Zhu, Shibo Jiang, Pengfei Wang

Emerging Microbes & Infections

DOI

2017

Reactivation of HIV-1 from Latency by an Ingenol Derivative from Euphorbia Kansui

Pengfei Wang, Panpan Lu, Xiying Qu, Yinzhong Shen, Hanxian Zeng, Xiaoli Zhu, Yuqi Zhu, Xian Li, Hao Wu, Jianqing Xu, Hongzhou Lu, Zhongjun Ma, Huanzhang Zhu

Scientific Reports

DOI

2016

The BET inhibitor OTX015 reactivates latent HIV-1 through P-TEFb

Panpan Lu, Xiying Qu, Yinzhong Shen, Zhengtao Jiang, Pengfei Wang, Hanxian Zeng, Haiyan Ji, Junxiao Deng, Xinyi Yang, Xian Li, Hongzhou Lu, Huanzhang Zhu

Scientific Reports

DOI

2016

Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter

Haiyan Ji, Zhengtao Jiang, Panpan Lu, Li Ma, Chuan Li, Hanyu Pan, Zheng Fu, Xiying Qu, Pengfei Wang, Junxiao Deng, Xinyi Yang, Jianhua Wang, Huanzhang Zhu

Molecular Therapy

DOI

2015

Two cellular microRNAs, miR-196b and miR-1290, contribute to HIV-1 latency

Pengfei Wang, Xiying Qu, Xin Zhou, Yinzhong Shen, Haiyan Ji, Zheng Fu, Junxiao Deng, Panpan Lu, Wenbo Yu, Hongzhou Lu, Huanzhang Zhu

Virology

DOI

2014

Dilazep synergistically reactivates latent HIV-1 in latently infected cells

Hanxian Zeng, Sijie Liu, Pengfei Wang, Xiying Qu, Haiyan Ji, Xiaohui Wang, Xiaoli Zhu, Zhishuo Song, Xinyi Yang, Zhongjun Ma, Huanzhang Zhu

Molecular Biology Reports

DOI

2014

Zinc finger nuclease: a new approach for excising HIV-1 proviral DNA from infected human T cells

Xiying Qu, Pengfei Wang, Donglin Ding, Xiaohui Wang, Gongmin Zhang, Xin Zhou, Lin Liu, Xiaoli Zhu, Hanxian Zeng, Huanzhang Zhu

Molecular Biology Reports

DOI

2013

CEA的多表位疫苗基因的设计及构建的表达载体在原核表达系统中的表达

王鹏飞，朱茜，张丽芳，朱冠保

《医学研究杂志》

2013

Zinc-finger-nucleases mediate specific and efficient excision of HIV-1 proviral DNA from infected and latently infected human T cells

Xiying Qu, Pengfei Wang, Donglin Ding, Lin Li, Haibo Wang, Li Ma, Xin Zhou, Shaohui Liu, Shiguan Lin, Xiaohui Wang, Gongmin Zhang, Sijie Liu, Lin Liu, Jian‐Hua Wang, Feng Zhang, Daru Lu, Huanzhang Zhu

Nucleic Acids Research

DOI

会议论文

2009

CEA多表位疫苗的新型设计及其重组原核表达载体的构建

王鹏飞，朱冠保，张丽芳

《2009年浙江省外科学学术年会论文汇编》

研究方向

抗病毒药物和疫苗

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