李博安｜厦门大学｜学者主页

2025

SOX4 Regulates Thermogenesis in Brown Adipose Tissue via Independent Complexes with EBF2 and PPARγ

Shuai Wang, Ting He, Tong Fu, Yu Zhu, Yixin Wei, Wenlong Xie, Huanming Shen, Ya Luo, Boan Li, Huiling Guo, Weihua Li

Advanced Biology

DOI

2025

Camel-Milk-Derived Extracellular Vesicles Mitigate High-Fat-Diet-Induced Obesity by Enhancing Thermogenesis and Modulating Lipid Metabolism in Mice

Shuai Wang, Shuting Liu, Ting He, Huanming Shen, Chunli Mo, Yu Ying Zhu, Wenlong Xie, Boan Li, Weihua Li, Jian Zhang

Journal of Agricultural and Food Chemistry

DOI

2025

Specific detection of DNA and RNA by the CRISPR-Cas12a system containing spacer split crRNA

Wenjing Ren, Mingzhi Li, Xinyue Liu, Weixin You, Qianqian You, Boan Li, Huiming Ye, Rui Zhang

Analytica Chimica Acta

DOI

2025

An extraction-free one-step pathogen detection system (Ex-opods) based on LAMP and CRISPR-Cas12b

Wenjing Ren, Weixin You, Hongmei Xu, Kangfeng Lin, Jianguang Guo, Ya Bian, Xiangju Guo, Qinghan Li, Caixia Hua, Rui Zhang, Boan Li

Microchemical Journal

DOI

2024

Development of an accurate breast cancer detection classifier based on platelet RNA

Wenlong Xie, Jie Hu, Zehang Zhao, Huixin Lu, Yu Han, Boan Li, Zhong Ouyang

Scientific Reports

DOI

2024

SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice

Shuai Wang, Ting He, Ya Luo, Kexin Ren, Huanming Shen, Lingfeng Hou, Yixin Wei, Tong Fu, Xie Wenlong, Peng Wang, Jie Hu, Yu Zhu, Zhengrong Huang, Qiyuan Li, Weihua Li, Huiling Guo, Boan Li

Cell Death and Differentiation

DOI

2024

Correction: Epigenetic regulation of DNA repair gene program by Hippo/YAP1-TET1 axis mediates sorafenib resistance in HCC

Chunli Mo, Weixin You, Yipeng Rao, Zhenping Lin, Shuai Wang, Ting He, Huanming Shen, Xun� Li, Rui Zhang, Boan Li

Cellular and Molecular Life Sciences

DOI

2024

Epigenetic regulation of DNA repair gene program by Hippo/YAP1-TET1 axis mediates sorafenib resistance in HCC

Chunli Mo, Weixin You, Yipeng Rao, Zhenping Lin, Shuai Wang, Ting He, Huanming Shen, Xun� Li, Rui Zhang, Boan Li

Cellular and Molecular Life Sciences

DOI

2024

Loss of OVOL2 in Triple‐Negative Breast Cancer Promotes Fatty Acid Oxidation Fueling Stemness Characteristics

Ruipeng Lu, Jingjing Hong, Tong Fu, Yu Zhu, Ruiqi Tong, Di Ai, Shuai Wang, Qingsong Huang, Ceshi Chen, Zhiming Zhang, Rui Zhang, Huiling Guo, Boan Li

Advanced Science

DOI

2024

Rapid and sensitive detection of nucleic acids using an RAA-CRISPR/Cas12b one-pot detection assay (Rcod)

Kangfeng Lin, Kaihu Yao, Xiao Li, Qinghan Li, Xiangju Guo, Weixin You, Wenjing Ren, Ya Bian, Jianguang Guo, Zhen Sun, Rui Zhang, Xiaoqing Yang, Zhiyong Li, Boan Li

Talanta

DOI

2023

TET2 is recruited by CREB to promote Cebpb, Cebpa, and Pparg transcription by facilitating hydroxymethylation during adipocyte differentiation

Yunjia Liu, Ting He, Zhuofang Li, Zhen Sun, Shuai Wang, Huanming Shen, Lingfeng Hou, Shengnan Li, Yixin Wei, Bingzhao Zhuo, Shanni Li, Can Zhou, Huiling Guo, Rui Zhang, Boan Li

iScience

DOI

2023

An extraction‐free method for rapid detection of CYP2C19 * 2/3/17 polymorphisms in one tube using melting curve analysis

Jianguang Guo, Weixin You, Kangfeng Lin, Qinghan Li, Xiangju Guo, Shuai Wang, Ya Bian, Wenjing Ren, Rui Zhang, Yanping Wang, Boan Li

Biotechnology Journal

DOI

2023

Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesity

Ting He, Shuai Wang, Shengnan Li, Huanming Shen, Lingfeng Hou, Yunjia Liu, Yixin Wei, Fuan Xie, Zhiming Zhang, Zehang Zhao, Chunli Mo, Huiling Guo, Qingsong Huang, Rui Zhang, Dong‐Yan Shen, Boan Li

iScience

DOI

2023

Fast and visual detection of nucleic acids using a one-step RPA-CRISPR detection (ORCD) system unrestricted by the PAM

Kangfeng Lin, Jianguang Guo, Xiangju Guo, Qinghan Li, Xiao Li, Zhen Cui Sun, Zehang Zhao, Jiao Weng, Jinzhun Wu, Rui Zhang, Boan Li

Analytica Chimica Acta

DOI

2022

Loss of Mst1/2 activity promotes non-mitotic hair cell generation in the neonatal organ of Corti

Xiaoling Lu, Huiqian Yu, Jiaoyao Ma, Kunkun Wang, Luo Guo, Yanping Zhang, Boan Li, Zehang Zhao, Huawei Li, Shan Sun

npj Regenerative Medicine

DOI

2022

An NF-κB/OVOL2 circuit regulates glucose import and cell survival in non-small cell lung cancer

Rui Zhang, Guojun Geng, Jianguang Guo, Yanjun Mi, Xiaolei Zhu, Ning Li, Hongming Liu, Lin Jun-feng, Jian-Weng Wang, Guang Sheng Zhao, Guanzhi Ye, Boan Li, Qicong Luo, Jie Jiang

Cell Communication and Signaling

DOI

2022

An automated nucleic acid detection platform using digital microfluidics with an optimized Cas12a system

Zhen Cui Sun, Kangfeng Lin, Zehang Zhao, Yang Wang, Xin-Xin Hong, Jianguang Guo, Qingyu Ruan, Lianyu Lu, Xiao Li, Rui Zhang, Chaoyong James Yang, Boan Li

Science China Chemistry

DOI

2022

SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex

Huanming Shen, Ting He, Shuai Wang, Lingfeng Hou, Yixin Wei, Yunjia Liu, Chunli Mo, Zehang Zhao, Weixin You, Huiling Guo, Boan Li

Theranostics

DOI

2021

基于质谱的蛋白质组学技术在泌尿生殖系统肿瘤标记物检测中的研究进展

逄瑷博，李博安，田亚平

《武警医学》

DOI

2021

Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt

Chenfeng Liu, Lei Ma, Yuxuan Wang, Jiayi Zhao, Pengda Chen, Xian Chen, Yingxin Wang, Yanyan Hu, Yun Liu, Xian Jia, Zhang‐Hua Yang, Xingzhi Yin, Jianfeng Wu, Suqin Wu, Haiping Zheng, Xiaohong Ma, Xiufeng Sun, Ying He, Lianghua Lin, Yubing Fu, Kunyu Liao, Xiaojuan Zhou, Shan Jiang, Guofeng Fu, Guofeng Fu, Jian Tang, Wei Han, Xiao Lei Chen, Wenzhu Fan, Yazhen Hong, Jiahuai Han, Xiangyang Huang, Boan Li, Changchun Xiao, Changchun Xiao, Guo Fu, Guo Fu, Wen‐Hsien Liu

Science Advances

DOI

2021

“ HLA‐10‐SNP ”: A new qPCR ‐based system for rapid, effective, and accurate detection of 10 important SNPs in the HLA region

Zhong‐Zheng Zheng, Daiyang Li, Ke‐ming Du, Xiang Xu, Ning‐Juan Wang, Zhi‐Yang Yuan, Boan Li

HLA

DOI

2020

HLA Class II alleles and association with HPV Infection prevalence in high-risk HPV-positive Han women in southern China

Zhong-Zheng Zheng, Qingqing He, Lin An, Daiyang Li, Ningjuan Wang, Liping Wang, Qin Sun, Jian Wang, Pei-Li Xiao, Ke‐ming Du, Boan Li

Infectious Diseases Now

DOI

2018

Poly(ADP-ribosyl)ation of OVOL2 regulates aneuploidy and cell death in cancer cells

Rui Zhang, Jing-Jing Hong, Qiaoyun Yang, Chin‐Tong Ong, Boan Li, Yih‐Cherng Liou

Oncogene

DOI

2018

Pygo2 Regulates Adiposity and Glucose Homeostasis via β-Catenin–Axin2–GSK3β Signaling Pathway

Yuanyuan Xie, Chunli Mo, Yihuang Cai, Wenjie Wang, Xin-Xin Hong, Kunkun Zhang, Qingfeng Liu, Yun-Jia Liu, Jing-Jing Hong, Ting He, Zhong-Zheng Zheng, Wei Mo, Boan Li

Diabetes

DOI

2018

Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer

Lingyun Lin, Yang Li, Qiang Zeng, Lin Wang, Mao-Li Chen, Zehang Zhao, Guo-Dong Ye, Qicong Luo, Pei-Yu Lv, Qiwei Guo, Boan Li, Jianchun Cai, Wangyu Cai

Molecular Cancer

DOI

2017

Development of a multiplexed tumor-associated autoantibody-based blood test for the detection of colorectal cancer

Chung‐Wei Fan, Yung‐Bin Kuo, Geng-Pin Lin, Si-Min Chen, Shih-Hsien Chang, Boan Li, Err–Cheng Chan

Clinica Chimica Acta

DOI

2017

OVOL2 antagonizes TGF-β signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis

Rong-Si Wu, Jing-Jing Hong, Jiafa Wu, Shen Yan, Di Wu, Na Liu, Qingfeng Liu, Qiu-Wan Wu, Yuanyuan Xie, Yun-Jia Liu, Zhong-Zheng Zheng, Err–Cheng Chan, Zhiming Zhang, Boan Li

Oncotarget

DOI

2016

Ovol2 gene inhibits the Epithelial-to-Mesenchymal Transition in lung adenocarcinoma by transcriptionally repressing Twist1

Zhihai Wang, Zhong Alan Li, Meng Hu, Qingjie Yang, Shen Yan, Rong-Si Wu, Boan Li, Ming Guo

Gene

DOI

2016

Yes‐associated protein/TEA domain family member and hepatocyte nuclear factor 4‐alpha (HNF4α) repress reciprocally to regulate hepatocarcinogenesis in rats and mice

Wangyu Cai, Lingyun Lin, Han Hao, Sai‐Man Zhang, Fei Ma, Xin‐Xin Hong, Hui Zhang, Qing‐Feng Liu, Guo‐Dong Ye, Guang‐Bin Sun, Yun‐Jia Liu, Sheng‐Nan Li, Yuanyuan Xie, Jianchun Cai, Boan Li

Hepatology

DOI

2015

OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors

Guo-Dong Ye, Guang‐Bin Sun, Peng Jiao, Chen Chen, Qingfeng Liu, Huang Xiao-li, Rui Zhang, Wangyu Cai, Sheng-Nan Li, Jiafa Wu, Yun-Jia Liu, Rong-Si Wu, Yuanyuan Xie, Err–Cheng Chan, Yih‐Cherng Liou, Boan Li

Gastroenterology

DOI

2015

Expression of CBY and Methylation of CBY at Promoter Region in Human Laryngeal Squamous Cell Carcinoma

Gang Ren, Dean Zhao, Jue Xu, Boan Li

Tumori Journal

DOI

2014

Downregulated Chibby in laryngeal squamous cell carcinoma with increased expression in laryngeal carcinoma Hep-2 cells

Jue Xu, Gang Ren, Dean Zhao, Boan Li, Chengfu Cai, Yi Zhou, Xianyang Luo

Oncology Reports

DOI

2013

β-catenin拮抗因子Chibby在鼻咽癌中的表达及意义

蔡成福，赵德安，任刚，李博安，方建林

《中国耳鼻咽喉头颈外科》

2013

Wnt/β-catenin pathway represses let-7 microRNAs expression via transactivation of Lin28 to augment breast cancer stem cell expansion

Wangyu Cai, Tong-Zhen Wei, Qicong Luo, Qiu-Wan Wu, Qingfeng Liu, Meng Yang, Guo-Dong Ye, Jiafa Wu, Yuanyuan Chen, Guang‐Bin Sun, Yun-Jia Liu, Wenxiu Zhao, Zhiming Zhang, Boan Li

Journal of Cell Science

DOI

2013

Double-negative feedback loop between Wnt/β-catenin signaling and HNF4α regulates epithelial-mesenchymal transition in hepatocellular carcinoma

Meng Yang, Sheng-Nan Li, Khalid Mahmood Anjum, Long‐Xin Gui, Shanshan Zhu, Jun Liu, Jiakun Chen, Qingfeng Liu, Guo-Dong Ye, Wenjie Wang, Jiafa Wu, Wangyu Cai, Guang‐Bin Sun, Yun-Jia Liu, Rongfu Liu, Zhiming Zhang, Boan Li

Journal of Cell Science

DOI

2012

A novel tumor suppressor miRNA miR-520e contributes to suppression of hepatoma

Boan Li

Acta Pharmacologica Sinica

DOI

2011

缺氧诱导因子1α的RNAi表达载体构建及其在前列腺癌PC-3细胞研究中的作用

刘荣福，耿爱民，李博安

《生物医学工程学杂志》

2011

The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling

Hang‐zi Chen, Qingfeng Liu, Li Li, Wei-Jia Wang, Lu-Ming Yao, Meng Yang, Bo Liu, Wei Chen, Yan-yan Zhan, Mingqing Zhang, Jian-Chun Cai, Zhonghui Zheng, Sheng‐Cai Lin, Boan Li, Qiao Wu

Gut

DOI

2010

Pygo2转基因小鼠模型的建立及表型的初步分析

袁圆阳，骆启聪，李超，李博安

《厦门大学学报(自然科学版)》

2010

Pygo2 Associates with MLL2 Histone Methyltransferase and GCN5 Histone Acetyltransferase Complexes To Augment Wnt Target Gene Expression and Breast Cancer Stem-Like Cell Expansion

Jiakun Chen, Qicong Luo, Yuanyang Yuan, Xiaoli Huang, Wangyu Cai, Chao Li, Tong-Zhen Wei, Ludi Zhang, Meng Yang, Qingfeng Liu, Guodong Ye, Xing Dai, Boan Li

Molecular and Cellular Biology

DOI

2010

The role of Pygopus 2 in rat glioma cell growth

Yuying Chen, Boan Li, Haidong Wang, Xi-yao Liu, Guowei Tan, Yong-hui Ma, Shang-Hang Shen, Hongwei Zhu, Zhanxiang Wang

Medical Oncology

DOI

2010

Decreased pygopus 2 expression suppresses glioblastoma U251 cell growth

Zhanxiang Wang, Yuying Chen, Boan Li, Guowei Tan, Xi-yao Liu, Shang-Hang Shen, Hongwei Zhu, Haidong Wang

Journal of Neuro-Oncology

DOI

2009

Cytokeratin expression during mouse embryonic and early postnatal mammary gland development

Peng Sun, Yuanyang Yuan, Aihua Li, Boan Li, Xing Dai

Histochemistry and Cell Biology

DOI

2009

Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation

Bingnan Gu, Peng Sun, Yuanyang Yuan, Ricardo Moraes, Aihua Li, Andy Teng, Anshu Agrawal, Catherine Rhéaume, Virginia Bilanchone, Jacqueline M. Veltmaat, Ken‐Ichi Takemaru, Sarah E. Millar, Eva Y.-H.P. Lee, Michael T. Lewis, Boan Li, Xing Dai

The Journal of Cell Biology

DOI

2008

Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation

Mahalakshmi Nair, Ippei Nagamori, Peng Sun, Durga Prasad Mishra, Catherine Rhéaume, Boan Li, Paolo Sassone‐Corsi, Xing Dai

Developmental Biology

DOI

精选作品

期刊论文

SOX4 Regulates Thermogenesis in Brown Adipose Tissue via Independent Complexes with EBF2 and PPARγ

Camel-Milk-Derived Extracellular Vesicles Mitigate High-Fat-Diet-Induced Obesity by Enhancing Thermogenesis and Modulating Lipid Metabolism in Mice

Specific detection of DNA and RNA by the CRISPR-Cas12a system containing spacer split crRNA

An extraction-free one-step pathogen detection system (Ex-opods) based on LAMP and CRISPR-Cas12b

Development of an accurate breast cancer detection classifier based on platelet RNA

SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice

Correction: Epigenetic regulation of DNA repair gene program by Hippo/YAP1-TET1 axis mediates sorafenib resistance in HCC

Epigenetic regulation of DNA repair gene program by Hippo/YAP1-TET1 axis mediates sorafenib resistance in HCC

Loss of OVOL2 in Triple‐Negative Breast Cancer Promotes Fatty Acid Oxidation Fueling Stemness Characteristics

Rapid and sensitive detection of nucleic acids using an RAA-CRISPR/Cas12b one-pot detection assay (Rcod)

TET2 is recruited by CREB to promote Cebpb, Cebpa, and Pparg transcription by facilitating hydroxymethylation during adipocyte differentiation

An extraction‐free method for rapid detection of CYP2C19 * 2/3/17 polymorphisms in one tube using melting curve analysis

Suppression of preadipocyte determination by SOX4 limits white adipocyte hyperplasia in obesity

Fast and visual detection of nucleic acids using a one-step RPA-CRISPR detection (ORCD) system unrestricted by the PAM

Loss of Mst1/2 activity promotes non-mitotic hair cell generation in the neonatal organ of Corti

An NF-κB/OVOL2 circuit regulates glucose import and cell survival in non-small cell lung cancer

An automated nucleic acid detection platform using digital microfluidics with an optimized Cas12a system

SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex

基于质谱的蛋白质组学技术在泌尿生殖系统肿瘤标记物检测中的研究进展

Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt

“ HLA‐10‐SNP ”: A new qPCR ‐based system for rapid, effective, and accurate detection of 10 important SNPs in the HLA region

HLA Class II alleles and association with HPV Infection prevalence in high-risk HPV-positive Han women in southern China

Poly(ADP-ribosyl)ation of OVOL2 regulates aneuploidy and cell death in cancer cells

Pygo2 Regulates Adiposity and Glucose Homeostasis via β-Catenin–Axin2–GSK3β Signaling Pathway

Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer

Development of a multiplexed tumor-associated autoantibody-based blood test for the detection of colorectal cancer

OVOL2 antagonizes TGF-β signaling to regulate epithelial to mesenchymal transition during mammary tumor metastasis

Ovol2 gene inhibits the Epithelial-to-Mesenchymal Transition in lung adenocarcinoma by transcriptionally repressing Twist1

Yes‐associated protein/TEA domain family member and hepatocyte nuclear factor 4‐alpha (HNF4α) repress reciprocally to regulate hepatocarcinogenesis in rats and mice

OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors

Expression of CBY and Methylation of CBY at Promoter Region in Human Laryngeal Squamous Cell Carcinoma

Downregulated Chibby in laryngeal squamous cell carcinoma with increased expression in laryngeal carcinoma Hep-2 cells

β-catenin拮抗因子Chibby在鼻咽癌中的表达及意义

Wnt/β-catenin pathway represses let-7 microRNAs expression via transactivation of Lin28 to augment breast cancer stem cell expansion

Double-negative feedback loop between Wnt/β-catenin signaling and HNF4α regulates epithelial-mesenchymal transition in hepatocellular carcinoma

A novel tumor suppressor miRNA miR-520e contributes to suppression of hepatoma

缺氧诱导因子1α的RNAi表达载体构建及其在前列腺癌PC-3细胞研究中的作用

The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling

Pygo2转基因小鼠模型的建立及表型的初步分析

Pygo2 Associates with MLL2 Histone Methyltransferase and GCN5 Histone Acetyltransferase Complexes To Augment Wnt Target Gene Expression and Breast Cancer Stem-Like Cell Expansion

The role of Pygopus 2 in rat glioma cell growth

Decreased pygopus 2 expression suppresses glioblastoma U251 cell growth

Cytokeratin expression during mouse embryonic and early postnatal mammary gland development

Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation

Nuclear regulator Pygo2 controls spermiogenesis and histone H3 acetylation

会议论文

Orphan receptor TR3 represses intestinal tumorigenesis via negative regulation of Wnt signaling

研究方向