韩家淮｜厦门大学｜学者主页

2026

《中国科学:化学》

2017

Plasma membrane changes during programmed cell deaths

Yingying Zhang, Xin Chen, C. Gueydan, Jiahuai Han

Cell Research

DOI

2017

2-HG Inhibits Necroptosis by Stimulating DNMT1-Dependent Hypermethylation of the RIP3 Promoter.

Zhen-Tao Yang, Bin Jiang, Yan Wang, H. Ni, Jia Zhang, Jin-Mei Xia, Minggang Shi, L. Hung, Jingsong Ruan, T. Mak, Qinxi Li, Jiahuai Han

Cell Reports

DOI

2017

Nature Immunology

DOI

2017

Differential Sensitivity of Target Genes to Translational Repression by miR-17~92

H. Jin, Hiroyo Oda, Pengda Chen, Chao Yang, Xiaojuan Zhou, S. Kang, Elizabeth R. Valentine, Jennifer M. Kefauver, L. Liao, Yaoyang Zhang, Alicia González-Martín, Jovan Shepherd, G. Morgan, T. Mondala, S. Head, P. Kim, Nengming Xiao, G. Fu, Wen-Hsien Liu, Jiahuai Han, J. Williamson, Changchun Xiao

PLoS Genetics

DOI

2017

The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells

Nature Immunology

DOI

2016

坏死激酶RIP1/RIP3通过特异性结合HSV-1的ICP6蛋白从而启动细胞坏死来抑制病毒在小鼠中的繁殖

Zhe Huang, Su-Qin Wu, 梁耀极, Xiaojuan Zhou, Wanze Chen, Lisheng Li, Jianfeng Wu, Qiuyu Zhuang, Chang'an Chen, Jingxian Li, Chuan-Qi Zhong, Weixiang Xia, Rongbin Zhou, Chunfu Zheng, 韩家淮

《科学新闻》

2016

Li-Li Tian, Jian-Ming Chen, Ming-Liang Chen, C. Gui, Chuan-Qi Zhong, Lixin Hong, Changchuan Xie, Xiu-Rong Wu, Li-Rong Yang, V. Ahmad, Jiahuai Han

Journal of Biological Chemistry

DOI

2014

Ting Wu, Wanze Chen, Jiahuai Han

DOI

2014

p38 MAPK regulates steroidogenesis through transcriptional repression of StAR gene

S. K. Zaidi, Wen-Jun Shen, S. Bittner, Alex Bittner, M. Mclean, Jiahuai Han, R. Davis, F. Kraemer, S. Azhar

Journal of Molecular Endocrinology

DOI

2014

RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway

Xia-Qiong Wang, Wei Jiang, Yiqing Yan, Tao Gong, Jiahuai Han, Z. Tian, R. Zhou

Nature Immunology

DOI

2014

Jiahuai Han, Xuan-Jun Wu, Shoufa Han

2013

RIP3 is involved in host defense against HSV-1 infection via enhancing STING mediated antiviral signaling (P1405)

Yao-Ji Liang, Su-qin Wu, Jiahuai Han

Journal of Immunology

DOI

2013

Functions and Mechanisms of the p 38 MAP Kinase Pathway

Qiu-Yu Zhuang, Jun Liu, Jiahuai Han

2013

Rhodamine-propargylic esters for detection of mitochondrial hydrogen sulfide in living cells.

Xi Chen, Shuqi Wu, Jiahuai Han, Shoufa Han

Bioorganic & Medicinal Chemistry Letters

DOI

2013

of thymocyte development Involvement of p38 mitogen activated protein kinase in different stages

Shu-Ching Hsu, Chia-Cheng Wu, Jiahuai Han, M. Lai

2013

Inflammasome-Dependent Inflammatory Enhances Nlrp 3 Gabarap Gene Deletion of Yanhai

Zhirong Zhang, Xiao-Zheng Xu, Jian-Hui Ma, Jian-Feng Wu, Yan-Hai Wang, R. Zhou, Jiahuai Han

2013

Xuan-Jun Wu, Zhu Li, Liu Yang, Jiahuai Han, Shoufa Han

DOI

2013

Traceless protein delivery with an efficient recyclable nanocarrier.

Xuan-Jun Wu, Yunlong Song, Jiahuai Han, Liu Yang, Shoufa Han

Biomaterials Science

DOI

2013

A potential suppressive effect of natural antisense IL-1β RNA on lipopolysaccharide-induced IL-1β expression

Jiawei Lu, Xiu-Rong Wu, Mao Hong, P. Tobias, Jiahuai Han

Journal of Immunology

DOI

2013

COP1 and GSK3β cooperate to promote c-Jun degradation and inhibit breast cancer cell tumorigenesis.

Jing Shao, Yong Teng, Ravi N. Padia, Sungguan Hong, Hyangsoon Noh, Xiayang Xie, J. Mumm, Z. Dong, Han-Fei Ding, J. Cowell, Jaejik Kim, Jiahuai Han, Shuang Huang

Neoplasia

DOI

张荧荧，李渊越，韩家淮

《中国基础科学》

2012

Protein phosphorylation-acetylation cascade connects growth factor deprivation to autophagy

Shu-Yong Lin, T. Y. Li, Qing Liu, Ci-Xiong Zhang, Xiaotong Li, Yan Chen, Shi-Meng Zhang, G. Lian, Qi Liu, Ka Ruan, Zhen-Bo Wang, Chen-Song Zhang, Kun-Yi Chien, Jiawei Wu, Qinxi Li, Jiahuai Han, Shengxiang Lin

Autophagy

DOI

2012

Fluorogenic detection of hydrogen sulfide via reductive unmasking of o-azidomethylbenzoyl-coumarin conjugate.

Zhi-Sheng Wu, Zhu Li, Liu Yang, Jiahuai Han, Shoufa Han

Chemical Communications

DOI

2012

Jianming Chen, Changchuan Xie, Li-Li Tian, Lixin Hong, Xiu-Rong Wu, Jiahuai Han

Proceedings of the National Academy of Sciences of the United States of America

DOI

张涛，程通，张雅丽，魏丽华，蔡毅君，张军，朱桦，韩家淮，夏宁邵

《病毒学报》

2008

DOI

2007

DOI

2004

Synergistic activation of NF-κB by nontypeable Haemophilus influenzae and tumor necrosis factor α

Takahiro Watanabe, H. Jono, Jiahuai Han, D. Lim, Jian-Dong Li

DOI

杨琨，姜勇，韩家淮，顾军

《中国科学:生命科学》

Guan Chen, M. Hitomi, Jiahuai Han, D. Stacey

Journal of Biological Chemistry

DOI

1999

p38MAPK信号传导通路

姜勇，韩家淮

《生命科学》

1999

一个新的鼠STE20家族激酶的克隆和鉴定

姜勇，韩家淮，顾军

《生物化学与生物物理进展》

1999

Molecular cloning and primary characterization of a novel murine STE20-like serine/threonine kinase

Y. Jiang, J. Han, J. Gu, Jiahuai Han

1999

Regulation of the MEF2 Family of Transcription Factors by p38

Ming-zhe Zhao, L. New, V. Kravchenko, Y. Kato, H. Gram, F. D. di Padova, E. Olson, R. Ulevitch, Jiahuai Han

Molecular and Cellular Biology

DOI

姜勇，赵克森，韩家淮

《中国病理生理杂志》

1998

The p38 MAP kinase pathway and its biological function.

L. New, Jiahuai Han

Trends in cardiovascular medicine

DOI

1998

Cellular activation mechanisms in septic shock.

Jocelyn S. Downey, Jiahuai Han

Frontiers in Bioscience

DOI

1998

PRAK, a novel protein kinase regulated by the p38 MAP kinase

L. New, Yong Jiang, Ming-zhe Zhao, Kang Z. Liu, Wei Zhu, Laura J. Flood, Y. Kato, Graham C. N. Parry, Jiahuai Han

EMBO Journal

DOI

1998

Jiahuai Han, T. Brown, B. Beutler

Journal of Experimental Medicine

DOI

精选作品

期刊论文

敬业、开拓和务实——纪念生物化学家张龙翔先生诞辰110周年

Author Correction: The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells

Mapping the holonomic signaling network that drives pathological changes in endotoxic shock

Author Correction: Gut stem cell necroptosis by genome instability triggers bowel inflammation

The structural basis of TRIM25-mediated regulation of RIG-I

Activation of GSDME by all- trans -retinal increases sensitivity to photoreceptor ferroptosis

Reticulophagy receptor FAM134C restrains BMP receptor signaling

p38 signaling enhances short-lived effector cell differentiation and weakens central memory CD8+ T-cell formation

RIPK1 S161 phosphorylation promotes further autophosphorylation and cecal necroptosis in TNF-treated mice

Fluorescence Labeling to Visualize Low-Expressed Proteins in Zebrafish

Signal-Sustained Imaging of Mitophagy with an Enzyme-Activatable Metabolic Lipid Labeling Probe

A GSDMD agonist boosts specific antitumor immunity

AMPK targets PDZD8 to trigger carbon source shift from glucose to glutamine

Cell biology is…

Residue Y362 is crucial for FLIPL to impart catalytic activity to pro-caspase-8 to suppress necroptosis

p38α–eIF6–Nsun2 axis promotes ILC3’s rapid response to protect host from intestinal inflammation

Cecal necroptosis triggers lethal cardiac dysfunction in TNF-induced severe SIRS

ZBTB21 suppresses CRE-mediated transcription to impair synaptic function in Down syndrome

Author Correction: RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis

Phosphorylation of caspase-8 by RSKs via organ-constrained effects controls the sensitivity to TNF-induced death

Bypassing PELO-mediated ATPase activation of the NLR is a common pathogenic cause of NLR-associated autoinflammatory diseases

COVID-19 vaccines and beyond

Anthrax lethal toxin and tumor necrosis factor-α synergize on intestinal epithelia to induce mouse death

Sensitive imaging of Endoplasmic reticulum (ER) autophagy with an acidity-reporting ER-Tracker

Dear-DIA XMBD : Deep Autoencoder Enables Deconvolution of Data-Independent Acquisition Proteomics

Optimal tagging strategies for illuminating expression profiles of genes with different abundance in zebrafish

Protocol for reconstitution of oligomeric assembly of NAIP5-NLRC4 inflammasome in vitro

Fluorescence-On Imaging of Reticulophagy Enabled by an Acidity-Reporting Solvatochromic Probe

Data from The miR-17-92 Cluster of MicroRNAs Confers Tumorigenicity by Inhibiting Oncogene-Induced Senescence

Ribosome-rescuer PELO catalyzes the oligomeric assembly of NOD-like receptor family proteins via activating their ATPase enzymatic activity

用敬致知，绽放时代华章——厦门大学生物学科百年历程

Biocapture-Directed Chemical Labeling for Discerning Stressed States of Organelles.

A p38α-BLIMP1 signalling pathway is essential for plasma cell differentiation

Protocol to estimate cell type proportions from bulk RNA-seq using DAISM-DNNXMBD

Immunostaining of phospho-RIPK3 in L929 cells, murine yolk sacs, ceca, and small intestines

Dual ligand engagement for noncanonical inflammasome activation

Mosaic composition of RIP1–RIP3 signalling hub and its role in regulating cell death

MSSort-DIAXMBD: A deep learning classification tool of the peptide precursors quantified by OpenSWATH

Rethinking sepsis after a two-year battle with COVID-19

RIP1-dependent linear and nonlinear recruitments of caspase-8 and RIP3 respectively to necrosome specify distinct cell death outcomes

An organelle-directed chemical ligation approach enables dual-color detection of mitophagy

Gasdermin E mediates photoreceptor damage by all-trans-retinal in the mouse retina

Pyroptosis of syncytia formed by fusion of SARS-CoV-2 spike and ACE2-expressing cells

Imaging of Mitophagy Enabled by an Acidity-Reporting Probe Anchored on the Mitochondrial Inner Membrane.

ZBP1, a dsRNA Sensor for Cell Death and Inflammation

In cellulo synthesis of dendrimeric sensors for fluorescence-on imaging of bacterial phagocytosis.

A unique death pathway keeps RIPK1 D325A mutant mice in check at embryonic day 10.5

The essential role of PRAK in tumor metastasis and its therapeutic potential

Installation of High-affinity Siglec-1 Ligand on Tumor Surface for Macrophage-engaged Tumor Suppression.

NLRC4 inflammasome–dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice

Glycogen synthase kinase 3 drives thymocyte egress by suppressing β-catenin activation of Akt

Editor's Note: p38 Mitogen-activated Protein Kinase Pathway Suppresses Cell Survival by Inducing Dephosphorylation of Mitogen-activated Protein/Extracellular Signal-regulated Kinase Kinase1,2.

Targeting RIPK3 oligomerization blocks necroptosis without inducing apoptosis

Organelle-Directed Metabolic Glycan Labeling and Optical Tracking of Dysfunctional Lysosomes Thereof.

Detection of necroptosis by phospho-MLKL immunohistochemical labeling

Erratum to: "Macrophage p38 alpha promotes nutritional steatohepatitis through M1 polarization (J Hepatol 2019; 71(1):163-174)".

RNA m6A methyltransferase METTL3 facilitates colorectal cancer by activating m6A-GLUT1-mTORC1 axis and is a therapeutic target.

Gut stem cell necroptosis by genome instability triggers bowel inflammation

Endogenous retroelement activation by epigenetic therapy reverses the Warburg effect and elicits mitochondrial-mediated cancer cell death.

SAMD4 family members suppress human hepatitis B virus by directly binding to the Smaug recognition region of viral RNA

A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade.

Manipulation of Host Cell Death Pathways by Herpes Simplex Virus.

The p38‐interacting protein p38IP suppresses TCR and LPS signaling by targeting TAK1

An overview of mammalian p38 mitogen-activated protein kinases, central regulators of cell stress and receptor signaling

Correction: High mobility group box 1 enables bacterial lipids to trigger receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis and apoptosis in mice.

High mobility group box 1 enables bacterial lipids to trigger receptor-interacting protein kinase 3 (RIPK3)-mediated necroptosis and apoptosis in mice

ZBP1 mediates interferon-induced necroptosis

An in cellulo-activated multicolor cell labeling approach used to image dying cell clearance.

Inactivation of Cyclic AMP Response Element Transcription Caused by Constitutive p38 Activation Is Mediated by Hyperphosphorylation-Dependent CRTC2 Nucleocytoplasmic Transport

Quantification of Dynamic Protein Interactions and Phosphorylation in LPS Signaling Pathway by SWATH-MS*

An Organelle-redirected Chameleon Sensor Enabled Live Cell Imaging of Mitochondrial DNA.

Macrophage p38α promotes nutritional steatohepatitis through M1 polarization.

Efficient engulfment of necroptotic and pyroptotic cells by nonprofessional and professional phagocytes

Bacterial Endotoxin Activates the Coagulation Cascade through Gasdermin D-Dependent Phosphatidylserine Exposure.

2-HG通过上调RIP3启动子的甲基化水平抑制细胞坏死

miR-30 Disrupts Senescence and Promotes Cancer by Targeting both p16INK4A and DNA Damage Pathways

Tom20 senses iron-activated ROS signaling to promote melanoma cell pyroptosis

RIP3 is an upregulator of aerobic metabolism and the enhanced respiration by necrosomal RIP3 feeds back on necrosome to promote necroptosis