王高乾｜暨南大学｜学者主页

2026

Structural and catalytic mechanisms of two N-hydroxycinnamoyltransferases underlying lycibarbarspermidines biosynthesis in wolfberry

Shao-Yang Li, Jia-Cheng Huang, Ya-Lin Wang, Hong-Ting Zhen, Yu Fan, Zheng-Qun Zhou, G Chen, Jian‐Ming Lv, Gao‐Qian Wang, Dan Hu, Hao Gao

Chinese Chemical Letters

DOI

2026

Biosynthesis of Xyloketals: Furanochromene Skeleton Formed via Heterodimerization of Two Orsellinic Acid-Branched Metabolites

Jia-Hua Huang, Jian‐Ming Lv, Yue Qi, Qian Xu, Fu-Long Lin, Gao‐Qian Wang, Shao-Yang Li, Ping Dai, Xue-Feng Bao, Wen-Tao Chen, Guo‐Dong Chen, Takayoshi Awakawa, Dan Hu, Ikuro Abe, Hao Gao

Journal of the American Chemical Society

DOI

2026

Identification of two multifunctional P450 enzymes for biosynthesis of sesteraltererol-type sesterterpenoids

Yue Liu, Zhuo-Jia Gan, Zhong-Yuan Zhang, Huan Zhao, Shao-Yang Li, Gao‐Qian Wang, Guo‐Dong Chen, Takayoshi Awakawa, Cao Zhi-qin, Jian‐Ming Lv, Dan Hu, Hao Gao

Organic & Biomolecular Chemistry

DOI

2026

Discovery of four novel furanosteroids and a new 4-methylprogesteroid from demethoxyviridin pathway-disrupted mutants of Nodulisporium sp. through cultivation time extension

Yao-Hui Gao, Xiao Pan, Qin-Lian Wang, Xue-Feng Bao, Ping Dai, Sheng-Ying Qin, Shao-Yang Li, Guo‐Dong Chen, Gao‐Qian Wang, Jian‐Ming Lv, Dan Hu, Hao Gao

Organic & Biomolecular Chemistry

DOI

2025

Identification of two novel sesterterpene skeletons offers the first experimental evidence for the cyclization mechanism of mangicdiene synthase

Pan Luo, Jian‐Ming Lv, Hong-Ting Zhen, Ying-Qi Zhao, Jing-Yuan Liu, Jin-Yu Hong, Shao-Yang Li, Gao‐Qian Wang, Guo‐Dong Chen, Shuixing Zhang, Dan Hu, Hao Gao

Chinese Chemical Letters

DOI

2025

Engineered Fusion Enzyme‐Mediated Non‐Consecutive Cyclization‐Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin

Yaohui Gao, Jian‐Ming Lv, Yue Zhong, Zhiqin Cao, Rui Luo, Yue Qi, Gao‐Qian Wang, Shao-Yang Li, Guo‐Dong Chen, Dan Hu, Hao Gao, Xin‐Sheng Yao

Advanced Science

DOI

2025

Generation of two novel furanosteroids via heterologous expression of demethoxyviridin biosynthetic genes in a wortmannin-producing strain

Wei Jiang, Linhuan Li, Lin-Min Zhang, Huan Zhao, Shao-Yang Li, Gao‐Qian Wang, Guo‐Dong Chen, Jian‐Ming Lv, Dan Hu, Hao Gao

Organic & Biomolecular Chemistry

DOI

2024

“科教研创”一体化模式在天然药物化学实验教学中的探索

陈国栋，周正群，王高乾，田丹妹，于洋，李怡芳，高昊

《药学教育》

2024

A Functional Switch Between Asperfumene and Fusicoccadiene Synthase and Entrance to Asperfumene Biosynthesis through a Vicinal Deprotonation‐Reprotonation Process

Jing-Yuan Liu, Fu-Long Lin, Kizerbo A. Taizoumbe, Jian‐Ming Lv, Yongheng Wang, Gao‐Qian Wang, Guodong Chen, Xin‐Sheng Yao, Dan Hu, Hao Gao, Jeroen S. Dickschat

Angewandte Chemie International Edition

DOI

2024

Ein funktioneller Wechsel zwischen Asperfumen‐ und Fusicoccadien‐Synthase und Eintritt in die Asperfumen‐Biosynthese durch einen vicinalen Deprotonierungs‐Reprotonierungsprozess

Jing‐Yuan Liu, Fu-Long Lin, Kizerbo A. Taizoumbe, Jian‐Ming Lv, Yongheng Wang, Gao‐Qian Wang, Guo‐Dong Chen, Xin‐Sheng Yao, Dan Hu, Hao Gao, Jeroen S. Dickschat

Angewandte Chemie

DOI

2024

Functional and structural dissection of glycosyltransferases underlying the glycodiversity of wolfberry-derived bioactive ingredients lycibarbarspermidines

Shao-Yang Li, Gao‐Qian Wang, Liang Long, Jia-Ling Gao, Zheng-Qun Zhou, Yongheng Wang, Jian‐Ming Lv, Guo‐Dong Chen, Dan Hu, Ikuro Abe, Hao Gao

Nature Communications

DOI

2024

Biosynthesis of Enfumafungin-type Antibiotic Reveals an Unusual Enzymatic Fusion Pattern and Unprecedented C–C Bond Cleavage

Zhiqin Cao, Gao‐Qian Wang, Rui Luo, Yaohui Gao, Jian‐Ming Lv, Sheng-Ying Qin, Guo‐Dong Chen, Takayoshi Awakawa, Xue-Feng Bao, Qinghua Mei, Xin‐Sheng Yao, Dan Hu, Ikuro Abe, Hao Gao

Journal of the American Chemical Society

DOI

2024

Absolute Configuration of Oxabornyl Polyenes Prugosenes A1–A3 and Structural Revision of Prugosene A2

Fu-Long Lin, Jia-Ling Gao, Qian Xu, Gao‐Qian Wang, Liang-Yan Xiao, Lu Dong, Wei Fang Tang, Jian‐Ming Lv, Guo‐Dong Chen, Ying Wang, Zhinan Yin, Ligong Lu, Dan Hu, Hao Gao

Journal of Natural Products

DOI

2024

Identification of three novel P450 enzymes involved in the oxidative modification of a newly discovered fusicoccane diterpene

Dong Lu, Jing-Yuan Liu, Gao‐Qian Wang, Pan Luo, Jia-Hua Huang, Jian‐Ming Lv, Guo‐Dong Chen, Weibin Cheng, Junzhang Tian, Fu-Long Lin, Dan Hu, Hao Gao

Bioorganic Chemistry

DOI

2024

Biosynthesis of fungal terpenoids

Pan Luo, Jia-Hua Huang, Jian‐Ming Lv, Gao‐Qian Wang, Dan Hu, Hao Gao

Natural Product Reports

DOI

2024

Mechanistic characterisation of a fungal fusicoccane-type diterpene synthase involved in the biosynthesis of talaro-7,13-diene

Fu-Long Lin, Kizerbo A. Taizoumbe, Yixuan Wang, Jia-Hua Huang, Gao‐Qian Wang, Guo‐Dong Chen, Jian‐Ming Lv, Dan Hu, Hao Gao, Jeroen S. Dickschat

Organic & Biomolecular Chemistry

DOI

2022

Biosynthetic characterization of the antifungal fernane-type triterpenoid polytolypin for generation of new analogues via combinatorial biosynthesis

Xinyu Li, Jian‐Ming Lv, Zhiqin Cao, Gao‐Qian Wang, Fu-Long Lin, Guo‐Dong Chen, Sheng-Ying Qin, Dan Hu, Hao Gao, Xin‐Sheng Yao

Organic & Biomolecular Chemistry

DOI

2022

Characterization of a new fusicoccane-type diterpene synthase and an associated P450 enzyme

Jia-Hua Huang, Jian‐Ming Lv, Liang-Yan Xiao, Qian Xu, Fu-Long Lin, Gao‐Qian Wang, Guodong Chen, Sheng-Ying Qin, Dan Hu, Hao Gao

Beilstein Journal of Organic Chemistry

DOI

2019

呋喃甾体去甲氧绿胶霉素的生物合成机制研究

王高乾

《暨南大学》

2018

真菌三萜及甾体的生物合成研究进展

高铫晖，王高乾，黄蕙芸，高昊，姚新生，胡丹

《有机化学》

2018

Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

Gao‐Qian Wang, Guo‐Dong Chen, Sheng-Ying Qin, Dan Hu, Takayoshi Awakawa, Shao-Yang Li, Jian‐Ming Lv, Chuanxi Wang, Xin‐Sheng Yao, Ikuro Abe, Hao Gao

Nature Communications

DOI

2018

Biosynthesis of Fungal Triterpenoids and Steroids

Yaohui Gao, Gao‐Qian Wang, Huiyun Huang, Hao Gao, Xin‐Sheng Yao, Dan Hu

Chinese Journal of Organic Chemistry

DOI

2017

Development of a versatile and conventional technique for gene disruption in filamentous fungi based on CRISPR-Cas9 technology

Yanmei Zheng, Fu-Long Lin, Hao Gao, Gen Zou, Jiang-Wei Zhang, Gao‐Qian Wang, Guo‐Dong Chen, Zhihua Zhou, Xin‐Sheng Yao, Dan Hu

Scientific Reports

DOI

2015

Pericolactines A–C, a New Class of Diterpenoid Alkaloids with Unusual Tetracyclic Skeleton

Yue-Hua Wu, Guo‐Dong Chen, Rong‐Rong He, Chuanxi Wang, Dan Hu, Gao‐Qian Wang, Liang‐Dong Guo, Xin‐Sheng Yao, Hao Gao

Scientific Reports

DOI

2015

Nodulisporisteroids C–L, new 4-methyl-progesteroid derivatives from Nodulisporium sp.

Qin Zhao, Gao‐Qian Wang, Guo‐Dong Chen, Dan Hu, Xiao-Xia Li, Liang‐Dong Guo, Yan Li, Xin‐Sheng Yao, Hao Gao

Steroids

DOI

2015

New α-pyrone and phthalide from the Xylariaceae fungus

Jian Zou, Jun Li, Zu‐Yan Wu, Qin Zhao, Gao‐Qian Wang, Huan Zhao, Guo‐Dong Chen, Xiang Sun, Liang‐Dong Guo, Hao Gao

Journal of Asian Natural Products Research

DOI

2015

Nodulisporipyrones A–D, new bioactive α-pyrone derivatives fromNodulisporiumsp.

Qin Zhao, Chuanxi Wang, Yang Yu, Gao‐Qian Wang, Qichang Zheng, Guo‐Dong Chen, Yun-Yang Lian, Lin Feng, Liang‐Dong Guo, Hao Gao

Journal of Asian Natural Products Research

DOI

2014

Diphenyl ethers from Aspergillus sp. and their anti-Aβ42 aggregation activities

Huan Zhao, Gao‐Qian Wang, Xupeng Tong, Guo‐Dong Chen, Yuan-Fan Huang, Jia-Yu Cui, Ming-Zhu Kong, Liang‐Dong Guo, Yizhi Zheng, Xin‐Sheng Yao, Hao Gao

Fitoterapia

DOI

王高乾

精选作品

期刊论文

Structural and catalytic mechanisms of two N-hydroxycinnamoyltransferases underlying lycibarbarspermidines biosynthesis in wolfberry

Biosynthesis of Xyloketals: Furanochromene Skeleton Formed via Heterodimerization of Two Orsellinic Acid-Branched Metabolites

Identification of two multifunctional P450 enzymes for biosynthesis of sesteraltererol-type sesterterpenoids

Discovery of four novel furanosteroids and a new 4-methylprogesteroid from demethoxyviridin pathway-disrupted mutants of Nodulisporium sp. through cultivation time extension

Identification of two novel sesterterpene skeletons offers the first experimental evidence for the cyclization mechanism of mangicdiene synthase

Engineered Fusion Enzyme‐Mediated Non‐Consecutive Cyclization‐Glycosylation Enables Heterologous Synthesis of Antifungal Enfumafungin

Generation of two novel furanosteroids via heterologous expression of demethoxyviridin biosynthetic genes in a wortmannin-producing strain

“科教研创”一体化模式在天然药物化学实验教学中的探索

A Functional Switch Between Asperfumene and Fusicoccadiene Synthase and Entrance to Asperfumene Biosynthesis through a Vicinal Deprotonation‐Reprotonation Process

Ein funktioneller Wechsel zwischen Asperfumen‐ und Fusicoccadien‐Synthase und Eintritt in die Asperfumen‐Biosynthese durch einen vicinalen Deprotonierungs‐Reprotonierungsprozess

Functional and structural dissection of glycosyltransferases underlying the glycodiversity of wolfberry-derived bioactive ingredients lycibarbarspermidines

Biosynthesis of Enfumafungin-type Antibiotic Reveals an Unusual Enzymatic Fusion Pattern and Unprecedented C–C Bond Cleavage

Absolute Configuration of Oxabornyl Polyenes Prugosenes A1–A3 and Structural Revision of Prugosene A2

Identification of three novel P450 enzymes involved in the oxidative modification of a newly discovered fusicoccane diterpene

Biosynthesis of fungal terpenoids

Mechanistic characterisation of a fungal fusicoccane-type diterpene synthase involved in the biosynthesis of talaro-7,13-diene

Biosynthetic characterization of the antifungal fernane-type triterpenoid polytolypin for generation of new analogues via combinatorial biosynthesis

Characterization of a new fusicoccane-type diterpene synthase and an associated P450 enzyme

呋喃甾体去甲氧绿胶霉素的生物合成机制研究

真菌三萜及甾体的生物合成研究进展

Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage

Biosynthesis of Fungal Triterpenoids and Steroids

Development of a versatile and conventional technique for gene disruption in filamentous fungi based on CRISPR-Cas9 technology

Pericolactines A–C, a New Class of Diterpenoid Alkaloids with Unusual Tetracyclic Skeleton

Nodulisporisteroids C–L, new 4-methyl-progesteroid derivatives from Nodulisporium sp.

New α-pyrone and phthalide from the Xylariaceae fungus

Nodulisporipyrones A–D, new bioactive α-pyrone derivatives fromNodulisporiumsp.

Diphenyl ethers from Aspergillus sp. and their anti-Aβ42 aggregation activities

研究方向