靳远｜青岛大学｜学者主页

2026

Developing adverse outcome pathways underlying CAR activation-induced liver injuries using HepG2 spheroid model

Congying Jin, Y H Ma, Li Chen, Xiangbing Kong, Changqing Zhang, Meihua Zhang, Wanli Ma, Xiaoxiao Zhu, Honghui Guo, Luyao Jiang, Xia Li, Yuejie Tian, Dianke Yu, Yuan Jin

Archives of Toxicology

DOI

2025

Corrigendum to “Aristolochic acid-induced dyslipidemia and hepatotoxicity: The potential role of FXR and AHR receptors” [Ecotoxicol. Environ. Saf., 287 (2024) 117266]

Yumei Ma, Chenlong Du, Yuzhen Liu, Meiyao Feng, Yingqing Shou, Dianke Yu, Yuan Jin

Ecotoxicology and Environmental Safety

DOI

2024

机器学习方法应用于化学物质毒性测试研究进展

冯驰原，首莹清，靳远，于典科

《中国药理学与毒理学杂志》

2024

Aristolochic acid-induced dyslipidemia and hepatotoxicity: The potential role of FXR and AHR receptors

Yumei Ma, Chenlong Du, Yuzhen Liu, Meiyao Feng, Yingqing Shou, Dianke Yu, Yuan Jin

Ecotoxicology and Environmental Safety

DOI

2023

An entropy weight method to integrate big omics and mechanistically evaluate DILI

Yuan Jin, Yingqing Shou, Qinkai Lei, Chenlong Du, Lin Xu, Ningning Chen, Wanli Ma, Xiaoxiao Zhu, Shuya Zhou, Yuxin Zheng, Dianke Yu

Hepatology

DOI

2023

Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease

Ningning Chen, Jiao Luo, Tao Zhou, Yingqing Shou, Chenlong Du, Ge Song, Lin Xu, Kunming Zhao, Yuan Jin, Chuanhai Li, Dianke Yu

Biochemical Pharmacology

DOI

2023

Diesel exhaust particles exposure induces liver dysfunction: Exploring predictive potential of human circulating microRNAs signature relevant to liver injury risk

Lin Xu, Yanting Li, Wanli Ma, Xueying Sun, Rongrong Fan, Yuan Jin, Ningning Chen, Xiaoxiao Zhu, Huan Guo, Kunming Zhao, Jiao Luo, Chuanhai Li, Yuxin Zheng, Dianke Yu

Journal of Hazardous Materials

DOI

2023

MiR-766-3p and miR-671-5p attenuate aristolochic acid-induced hepatotoxicity by directly targeting the key bioactivating enzyme NQO1

Yuzhen Liu, Heyuan Guan, Meiyao Feng, Chenlong Du, Qianqian Zhang, Yingqing Shou, Guangshuai Qi, Dianke Yu, Yuan Jin

Ecotoxicology and Environmental Safety

DOI

2023

Human health risk assessment of 6:2 Cl-PFESA through quantitative in vitro to in vivo extrapolation by integrating cell-based assays, an epigenetic key event, and physiologically based pharmacokinetic modeling

Chuanhai Li, Lidan Jiang, Donghui Zhang, Yuan Qi, Xinyi Wang, Yuan Jin, Xinya Liu, Yongfeng Lin, Jiao Luo, Lin Xu, Kunming Zhao, Dianke Yu

Environment International

DOI

2023

Binding, activity and risk assessment of bisphenols toward farnesoid X receptor pathway: In vitro and in silico study

Donghui Zhang, Xinya Liu, Yuan Qi, Yongfeng Lin, Kunming Zhao, Yuan Jin, Jiao Luo, Lin Xu, Dianke Yu, Chuanhai Li

The Science of The Total Environment

DOI

2022

The path via pathway-based approaches towards safety assessment: A concise review

Yuan Jin, Guangshuai Qi, Meiyao Feng, Dianke Yu

Toxicology and Applied Pharmacology

DOI

2022

Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes

Chuanhai Li, Lidan Jiang, Yuan Qi, Donghui Zhang, Xinya Liu, Wenchao Han, Wanli Ma, Lin Xu, Yuan Jin, Jiao Luo, Kunming Zhao, Dianke Yu

Ecotoxicology and Environmental Safety

DOI

2022

N, N-dimethylformamide exposure induced liver abnormal mitophagy by targeting miR-92a-1-5p-BNIP3L pathway in vivo and vitro

Lin Xu, Wanli Ma, Yuan Jin, Xueying Sun, Ningning Chen, Xiaoxiao Zhu, Jiao Luo, Chuanhai Li, Kunming Zhao, Yuxin Zheng, Dianke Yu

The Science of The Total Environment

DOI

2022

Health risk assessment of cadmium exposure by integration of an in silico physiologically based toxicokinetic model and in vitro tests

Yangchun Zhang, Ziqi Liu, Ziwei Wang, Huan Gao, Yuqing Wang, Mengxing Cui, Honghao Peng, Yongmei Xiao, Yuan Jin, Dianke Yu, Wen Chen, Qing Wang

Journal of Hazardous Materials

DOI

2021

经口六价铬暴露毒作用模式中关键毒性通路的生物信息学分析

蒋欣航，王紫微，彭慧，徐驰，于典科，靳远，陈丽萍，陈雯

《环境与职业医学》

DOI

2021

系统毒理学研究进展

靳远，刘玉真，戚光帅，于典科

《环境与职业医学》

DOI

2021

PIWI-interacting RNA-23210 protects against acetaminophen-induced liver injury by targeting HNF1A and HNF4A

Lin Xu, Wendi Chen, Jing Chen, Yuan Jin, Wanli Ma, Guangshuai Qi, Xueying Sun, Jiao Luo, Chuanhai Li, Kunming Zhao, Yuxin Zheng, Dianke Yu

Biochemical Pharmacology

DOI

2021

Lipid metabolism disorders effects of 6:2 chlorinated polyfluorinated ether sulfonate through Hsa-miRNA-532–3p/Acyl-CoA oxidase 1(ACOX1) pathway

Chuanhai Li, Lidan Jiang, Yuan Jin, Donghui Zhang, Jing Chen, Yuan Qi, Rongrong Fan, Jiao Luo, Lin Xu, Wanli Ma, Kunming Zhao, Dianke Yu

Ecotoxicology and Environmental Safety

DOI

2021

miR-15a-3p Protects Against Isoniazid-Induced Liver Injury via Suppressing N-Acetyltransferase 2 Expression

Xinmei Li, Heng Zhang, Lin Xu, Yuan Jin, Jiao Luo, Chuanhai Li, Kunming Zhao, Yuxin Zheng, Dianke Yu, Yanjie Zhao

Frontiers in Molecular Biosciences

DOI

2021

A novel epigenetic mechanism unravels hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis disease

Jiao Luo, Mengyue Xie, Yufei Hou, Wanli Ma, Yuan Jin, Jing Chen, Chuanhai Li, Kunming Zhao, Ningning Chen, Lin Xu, Yanan Ji, Qianqian Zhang, Yuxin Zheng, Dianke Yu

Biochemical Pharmacology

DOI

2021

A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells

Jiao Luo, Yufei Hou, Wanli Ma, Mengyue Xie, Yuan Jin, Lin Xu, Chuanhai Li, Ying Wang, Jing Chen, Wendi Chen, Yuxin Zheng, Dianke Yu

Biochemical Pharmacology

DOI

2020

Generating adverse outcome pathway (AOP) of inorganic arsenic-induced adult male reproductive impairment via integration of phenotypic analysis in comparative toxicogenomics database (CTD) and AOP wiki

Zili Chai, Chenhao Zhao, Yuan Jin, Yimeng Wang, Peng Zou, Xi Ling, Huan Yang, Niya Zhou, Qing Chen, Lei Sun, Wen Chen, Lin Ao, Jia Cao, Jinyi Liu

Toxicology and Applied Pharmacology

DOI

2020

A toxicity pathway-oriented approach to develop adverse outcome pathway: AHR activation as a case study

Yuan Jin, Meiyao Feng, Wanli Ma, Yanhong Wei, Guangshuai Qi, Jiao Luo, Lin Xu, Xinmei Li, Chuanhai Li, Wang Ying, Daochuan Li, Jing Chen, Yanjie Zhao, Yufei Hou, Qianwen Zhao, Lidan Jiang, Mengyue Xie, Yuxin Zheng, Dianke Yu

Environmental Pollution

DOI

2020

Integration of proteomics, lipidomics, and metabolomics reveals novel metabolic mechanisms underlying N, N-dimethylformamide induced hepatotoxicity

Lin Xu, Qianwen Zhao, Jiao Luo, Wanli Ma, Yuan Jin, Chuanhai Li, Yufei Hou, Meiyao Feng, Ying Wang, Jing Chen, Jinquan Zhao, Yuxin Zheng, Dianke Yu

Ecotoxicology and Environmental Safety

DOI

2020

Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells

Dianke Yu, Jing Chen, Si Chen, Lin Xu, Leihong Wu, Dongying Li, Jiao Luo, Yuan Jin, Yanjie Zhao, Bridgett Knox, William H. Tolleson, Xubing Wang, Lei Guo, Weida Tong, Baitang Ning

Drug Metabolism and Disposition

DOI

靳远

精选作品

期刊论文

Developing adverse outcome pathways underlying CAR activation-induced liver injuries using HepG2 spheroid model

Corrigendum to “Aristolochic acid-induced dyslipidemia and hepatotoxicity: The potential role of FXR and AHR receptors” [Ecotoxicol. Environ. Saf., 287 (2024) 117266]

机器学习方法应用于化学物质毒性测试研究进展

Aristolochic acid-induced dyslipidemia and hepatotoxicity: The potential role of FXR and AHR receptors

An entropy weight method to integrate big omics and mechanistically evaluate DILI

Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease

Diesel exhaust particles exposure induces liver dysfunction: Exploring predictive potential of human circulating microRNAs signature relevant to liver injury risk

MiR-766-3p and miR-671-5p attenuate aristolochic acid-induced hepatotoxicity by directly targeting the key bioactivating enzyme NQO1

Human health risk assessment of 6:2 Cl-PFESA through quantitative in vitro to in vivo extrapolation by integrating cell-based assays, an epigenetic key event, and physiologically based pharmacokinetic modeling

Binding, activity and risk assessment of bisphenols toward farnesoid X receptor pathway: In vitro and in silico study

The path via pathway-based approaches towards safety assessment: A concise review

Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes

N, N-dimethylformamide exposure induced liver abnormal mitophagy by targeting miR-92a-1-5p-BNIP3L pathway in vivo and vitro

Health risk assessment of cadmium exposure by integration of an in silico physiologically based toxicokinetic model and in vitro tests

经口六价铬暴露毒作用模式中关键毒性通路的生物信息学分析

系统毒理学研究进展

PIWI-interacting RNA-23210 protects against acetaminophen-induced liver injury by targeting HNF1A and HNF4A

Lipid metabolism disorders effects of 6:2 chlorinated polyfluorinated ether sulfonate through Hsa-miRNA-532–3p/Acyl-CoA oxidase 1(ACOX1) pathway

miR-15a-3p Protects Against Isoniazid-Induced Liver Injury via Suppressing N-Acetyltransferase 2 Expression

A novel epigenetic mechanism unravels hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis disease

A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells

Generating adverse outcome pathway (AOP) of inorganic arsenic-induced adult male reproductive impairment via integration of phenotypic analysis in comparative toxicogenomics database (CTD) and AOP wiki

A toxicity pathway-oriented approach to develop adverse outcome pathway: AHR activation as a case study

Integration of proteomics, lipidomics, and metabolomics reveals novel metabolic mechanisms underlying N, N-dimethylformamide induced hepatotoxicity

Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells

会议论文

基于PBTK模型和体外实验评估镉暴露的健康风险

苯并芘靶器官毒性分析及相关毒性通路研究

焦炉逸散物致肺癌的转录组学研究

预印本

FXR and AHR mediate aristolochic acid-induced liver injury: mode of action from the nuclear receptors' point of view

研究方向