陈小芬｜厦门大学｜学者主页

2025

Microglial MS4A4A elevates TREM2 signaling and reduces amyloid pathology

Xiao‐Fen Chen, Hengjun Rao

Alzheimer s & Dementia

DOI

2025

Soluble CSF1R promotes microglial activation and amyloid clearance in alzheimer’s disease

Lianshuai Zhang, Kai Chen, Ruicheng Zeng, Guojun Bu, Xiao‐Fen Chen

Journal of Neuroinflammation

DOI

2025

TREM2 and sTREM2 in Alzheimer’s disease: from mechanisms to therapies

Lianshuai Zhang, Xianyuan Xiang, Y. Li, Guojun Bu, Xiao‐Fen Chen

Molecular Neurodegeneration

DOI

2025

Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders

Dadian Chen, Chen Wang, Xi Chen, Jiayu Li, Shuai Chen, Yanzhong Li, Fangling Ma, Tingting Li, Mengling Zou, Xin Li, Xiaohua Huang, Yun‐wu Zhang, Yingjun Zhao, Guojun Bu, Honghua Zheng, Xiao‐Fen Chen, Jie Zhang, Li Zhong

Science Translational Medicine

DOI

2024

AD8量表在老年人社区筛查中的应用价值及其初筛阳性的影响因素分析

陈小芬

《中国现代药物应用》

2024

Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity

Na Wang, Lujian Cai, Xinyu Pei, Zhihao Lin, Lihong Huang, Chensi Liang, Min Wei, Lin Shao, Tiantian Guo, Fang Huang, Hong Luo, Honghua Zheng, Xiao‐Fen Chen, Lige Leng, Yun-Wu Zhang, Xin Wang, Jie Zhang, Kai Xia Guo, Zhanxiang Wang, Hongsheng Zhang, Yingjun Zhao, Huaxi Xu

iScience

DOI

2024

TREMendous microglial effects on neurons

Xiao‐Fen Chen, Guojun Bu

Immunity

DOI

2023

TREM2 protects against complement‐mediated synaptic loss via binding to C1q in neurodegeneration

Xiao‐Fen Chen

Alzheimer s & Dementia

DOI

2023

Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer’s disease model by restoring BDNF signaling

Wanbing Wang, Yanzhong Li, Fangling Ma, Xuan Sheng, Kai Chen, Rengong Zhuo, Chen Wang, Honghua Zheng, Yun‐wu Zhang, Guojun Bu, Xiao‐Fen Chen, Li Zhong

Brain Behavior and Immunity

DOI

2023

TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration

Li Zhong, Xuan Sheng, Wanbing Wang, Yanzhong Li, Rengong Zhuo, Kai Wang, Lianshuai Zhang, Dandan Hu, Yujuan Hong, Linting Chen, Hengjun Rao, Tingting Li, Muyang Chen, Zhihao Lin, Yun‐wu Zhang, Xin Wang, Xiao‐Xin Yan, Xiaochun Chen, Xiaochun Chen, Guojun Bu, Xiao‐Fen Chen, Xiao‐Fen Chen

Immunity

DOI

2023

E674Q (Shanghai APP mutant), a novel amyloid precursor protein mutation, in familial late-onset Alzheimer's disease

Yongfang Zhang, Xinyi Xie, Boyu Chen, Lina Pan, Jianping Li, Wanbing Wang, Jintao Wang, Ran Tang, Qiang Huang, Xiao‐Fen Chen, Ru‐Jing Ren, Zhentao Zhang, Wei Fu, Gang Wang

Genes & Diseases

DOI

2021

Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology

Xuan Sheng, Yunling Yao, Ruizhi Huang, Ying Xu, Yifei Zhu, Linting Chen, Lianshuai Zhang, Wanbing Wang, Rengong Zhuo, Dan Can, Che-Feng Chang, Yun‐wu Zhang, Huaxi Xu, Guojun Bu, Li Zhong, Xiao‐Fen Chen

Journal of Neuroinflammation

DOI

2020

TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities

Zhaoji Liu, Jinhuan Ning, Xiaoyuan Zheng, Jian Meng, Linkun Han, Honghua Zheng, Li Zhong, Xiao‐Fen Chen, Xian Zhang, Hong Luo, Dan Can, Huaxi Xu, Yun‐wu Zhang

Cell Death and Disease

DOI

2019

The Emerging Roles and Therapeutic Potential of Soluble TREM2 in Alzheimer’s Disease

Li Zhong, Xiao‐Fen Chen

Frontiers in Aging Neuroscience

DOI

2019

Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

Li Zhong, Ying Xu, Rengong Zhuo, Tingting Wang, Kai Wang, Ruizhi Huang, Daxin Wang, Yue Gao, Yifei Zhu, Xuan Sheng, Kai Chen, Na Wang, Lin Zhu, Dan Can, Yuka Marten, Mitsuru Shinohara, Chia‐Chen Liu, Dan Du, Hao Sun, Lei Wen, Huaxi Xu, Guojun Bu, Xiao‐Fen Chen

Nature Communications

DOI

2019

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

Nature Communications

DOI

2018

TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism

Honghua Zheng, Baoying Cheng, Yanfang Li, Xin Li, Xiao‐Fen Chen, Yun‐wu Zhang

Frontiers in Aging Neuroscience

DOI

2018

O4‐02‐01: SOLUBLE TREM2 MODULATES MICROGLIAL FUNCTION AND PROTECTS AGAINST AMYLOID PATHOLOGY

Xiao‐Fen Chen, Li Zhong, Tingting Wang, Zongqi Wang, Guojun Bu

Alzheimer s & Dementia

DOI

2018

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

Li Zhong, Zongqi Wang, Daxin Wang, Zhe Wang, Yuka A. Martens, Linbei Wu, Ying Xu, Kai Wang, Jianguo Li, Ruizhi Huang, Dan Can, Huaxi Xu, Guojun Bu, Xiao‐Fen Chen

Molecular Neurodegeneration

DOI

2017

TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway

Li Zhong, Zhen-Lian Zhang, Xinxiu Li, Chunyan Liao, Pengfei Mou, Tingting Wang, Zongqi Wang, Zhe Wang, Min Wei, Huaxi Xu, Guojun Bu, Xiao‐Fen Chen

Frontiers in Aging Neuroscience

DOI

2017

Soluble TREM2 induces inflammatory responses and enhances microglial survival

Li Zhong, Xiao‐Fen Chen, Tingting Wang, Zhe Wang, Chunyan Liao, Zongqi Wang, Ruizhi Huang, Daxin Wang, Xinxiu Li, Linbei Wu, Lin Jia, Honghua Zheng, Meghan M. Painter, Yuka Atagi, Chia‐Chen Liu, Yun‐wu Zhang, John Denis Fryer, Huaxi Xu, Guojun Bu

The Journal of Experimental Medicine

DOI

2017

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

Honghua Zheng, Lin Jia, Chia‐Chen Liu, Zhouyi Rong, Li Zhong, Longyu Yang, Xiao‐Fen Chen, John Denis Fryer, Xin Wang, Yun‐wu Zhang, Huaxi Xu, Guojun Bu

Journal of Neuroscience

DOI

2016

LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways

Longyu Yang, Chia‐Chen Liu, Honghua Zheng, Takahisa Kanekiyo, Yuka Atagi, Lin Jia, Daxin Wang, Aurelie N’Songo, Dan Can, Huaxi Xu, Xiao‐Fen Chen, Guojun Bu

Journal of Neuroinflammation

DOI

2016

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

Honghua Zheng, Chia‐Chen Liu, Yuka Atagi, Xiao‐Fen Chen, Lin Jia, Longyu Yang, Wencan He, Xilin Zhang, Silvia S. Kang, Terrone L. Rosenberry, John Denis Fryer, Yun‐wu Zhang, Huaxi Xu, Guojun Bu

Neurobiology of Aging

DOI

2016

TREMs in Alzheimer's disease: Genetic and clinical investigations

Jia Rong Cheng, XiaoFeng Guo, Tian Zhang, Li Zhong, Guojun Bu, Xiao‐Fen Chen

Clinica Chimica Acta

DOI

2015

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

Yuka Atagi, Chia‐Chen Liu, Meghan M. Painter, Xiao‐Fen Chen, Christophe Verbeeck, Honghua Zheng, Xia Li, Rosa Rademakers, Silvia S. Kang, Huaxi Xu, Steven G. Younkin, Pritam Das, John Denis Fryer, Guojun Bu

Journal of Biological Chemistry

DOI

2015

DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response

Li Zhong, Xiao‐Fen Chen, Zhen-Lian Zhang, Zhe Wang, Xin-Zhen Shi, Kai Xu, Yun‐wu Zhang, Huaxi Xu, Guojun Bu

Journal of Biological Chemistry

DOI

2015

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

Jin Hu, Chia‐Chen Liu, Xiao‐Fen Chen, Yun‐wu Zhang, Huaxi Xu, Guojun Bu

Molecular Neurodegeneration

DOI

2013

Transcriptional regulation and its misregulation in Alzheimer’s disease

Xiao‐Fen Chen, Yun‐wu Zhang, Huaxi Xu, Guojun Bu

Molecular Brain

DOI

陈小芬

精选作品

期刊论文

Microglial MS4A4A elevates TREM2 signaling and reduces amyloid pathology

Soluble CSF1R promotes microglial activation and amyloid clearance in alzheimer’s disease

TREM2 and sTREM2 in Alzheimer’s disease: from mechanisms to therapies

Brain-wide microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders

AD8量表在老年人社区筛查中的应用价值及其初筛阳性的影响因素分析

Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity

TREMendous microglial effects on neurons

TREM2 protects against complement‐mediated synaptic loss via binding to C1q in neurodegeneration

Microglial repopulation reverses cognitive and synaptic deficits in an Alzheimer’s disease model by restoring BDNF signaling

TREM2 receptor protects against complement-mediated synaptic loss by binding to complement C1q during neurodegeneration

E674Q (Shanghai APP mutant), a novel amyloid precursor protein mutation, in familial late-onset Alzheimer's disease

Identification of the minimal active soluble TREM2 sequence for modulating microglial phenotypes and amyloid pathology

TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities

The Emerging Roles and Therapeutic Potential of Soluble TREM2 in Alzheimer’s Disease

Author Correction: Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer’s disease model

TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism

O4‐02‐01: SOLUBLE TREM2 MODULATES MICROGLIAL FUNCTION AND PROTECTS AGAINST AMYLOID PATHOLOGY

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway

Soluble TREM2 induces inflammatory responses and enhances microglial survival

TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

LRP1 modulates the microglial immune response via regulation of JNK and NF-κB signaling pathways

Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation

TREMs in Alzheimer's disease: Genetic and clinical investigations

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

Transcriptional regulation and its misregulation in Alzheimer’s disease

研究方向