尚鲁庆｜南开大学｜学者主页

2026

基于蛋白酶结构的抗病毒药物研究进展

王婧，陈嘉馨，张源元，尚鲁庆

《厦门大学学报(自然科学版)》

2026

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Weilong Deng, Junyu Chen, Yingyue Pang, Yuanyuan Zhang, Siqian Chen, Guoliang You, Xiaoman Tian, Zhongxin Xu, Jing Wang, Luqing Shang

Advanced Science

DOI

2026

Advances in Antiviral Drug Development Targeting Viral Proteases

Yuanyuan Zhang, Jiaxin Chen, Jiaqi Li, Zhongxin Xu, Jing Wang, Luqing Shang

Medicinal Research Reviews

DOI

2024

Discovery of indole analogue Tc3 as a potent pyroptosis inducer and identification of its combination strategy against hepatic carcinoma

Xiao Jie Hu, Xiaomei Tang, Xiaoman Tian, Xing Lv, Yuanyuan Zhang, Yingyue Pang, Weilong Deng, Yali Wang, Changliang Shan, Luqing Shang

Theranostics

DOI

2022

The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate

Hao Wang, Rongjuan Pei, Xin Li, Weilong Deng, Shuai Xing, Yanan Zhang, Chen Zhang, Shuai He, Hao Sun, Shuqi Xiao, Jin Xiong, Yecheng Zhang, Xinwen Chen, Yaxin Wang, Yu Guo, Bo Zhang, Luqing Shang

European Journal of Medicinal Chemistry

DOI

2022

Discovery of SARS-CoV-2 3CLPro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein–Ligand Interactions

Yaxin Wang, Binghong Xu, Sen Ma, Hao Wang, Luqing Shang, Cheng Zhu, Sheng Ye

International Journal of Molecular Sciences

DOI

2021

Insights into SARS-CoV-2: Medicinal Chemistry Approaches to Combat Its Structural and Functional Biology

Linsheng Zhuo, Mingshu Wang, Jing‐Fang Yang, Hong-Chuang Xu, Wei Huang, Luqing Shang, Guang‐Fu Yang

Topics in Current Chemistry

DOI

2021

Reversible covalent inhibitors suppress enterovirus 71 infection by targeting the 3C protease

Meijun Liu, Binghong Xu, Yuying Ma, Luqing Shang, Sheng Ye, Yaxin Wang

Antiviral Research

DOI

2020

Comprehensive Insights into the Catalytic Mechanism of Middle East Respiratory Syndrome 3C-Like Protease and Severe Acute Respiratory Syndrome 3C-Like Protease

Hao Wang, Shuai He, Weilong Deng, Ying Zhang, Guobang Li, Jixue Sun, Wei Guang Zhao, Yu Guo, Zheng Yin, Dongmei Li, Luqing Shang

ACS Catalysis

DOI

2020

Crystal Structure of African Swine Fever Virus pS273R Protease and Implications for Inhibitor Design

Guobang Li, Xiaoxia Liu, Mengyuan Yang, Guangshun Zhang, Zhengyang Wang, Kun Guo, Yuxue Gao, Peng Jiao, Jixue Sun, Cheng Chen, Hao Wang, Weilong Deng, Huihe Xiao, Sizheng Li, Haoru Wu, Ying Wang, Lin Cao, Zihan Jia, Luqing Shang, Cheng Yang, Yu Guo, Zihe Rao

Journal of Virology

DOI

2020

Identification of Interferon Receptor IFNAR2 As a Novel HCV Entry Factor by Using Chemical Probes

Jie Qing, Ming Wu, Rui Luo, Jizheng Chen, Lin Cao, Debin Zeng, Luqing Shang, Junxiu Nong, Qinkai Wu, Bi‐Sen Ding, Xinwen Chen, Zihe Rao, Lei Liu, Zhiyong Lou

ACS Chemical Biology

DOI

2019

Application of Dually Activated Michael Acceptor to the Rational Design of Reversible Covalent Inhibitor for Enterovirus 71 3C Protease

Yuying Ma, Linfeng Li, Shuai He, Chengyou Shang, Yang Sun, Ning Liu, Thomas D. Meek, Yaxin Wang, Luqing Shang

Journal of Medicinal Chemistry

DOI

2018

4-Iminooxazolidin-2-one as a Bioisostere of the Cyanohydrin Moiety: Inhibitors of Enterovirus 71 3C Protease

Yuying Ma, Chengyou Shang, Peng Hui Yang, Linfeng Li, Yangyang Zhai, Zheng Yin, Binghe Wang, Luqing Shang

Journal of Medicinal Chemistry

DOI

2018

3D‐quantitative structure‐activity relationship study for the design of novel enterovirus A71 3C protease inhibitors

Quandeng Nie, Xiaoyi Xu, Qi Zhang, Yuying Ma, Zheng Qin Yin, Luqing Shang

Chemical Biology & Drug Design

DOI

2018

Target-guided screening of fragments (TGSOF) in the discovery of inhibitors against EV-A71 3C protease

Shengjun Fu, Quandeng Nie, Yuying Ma, Ping Song, Xuejiao Ren, Cheng Yu Luo, Luqing Shang, Yin Zheng

Chemical Communications

DOI

2017

Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease Inhibitor

Yaxin Wang, Lin Cao, Yangyang Zhai, Zheng Qin Yin, Yuna Sun, Luqing Shang

Antimicrobial Agents and Chemotherapy

DOI

2017

Inhibition of enterovirus 71 replication by an α-hydroxy-nitrile derivative NK-1.9k

Yaxin Wang, Lin Cao, Yangyang Zhai, Jiaming Ma, Quandeng Nie, Ting Li, Zheng Qin Yin, Yuna Sun, Luqing Shang

Antiviral Research

DOI

2016

Structure–activity relationship study of peptidomimetic aldehydes as enterovirus 71 3C protease inhibitors

Yangyang Zhai, Yuying Ma, Fei Ma, Quandeng Nie, Xuejiao Ren, Yaxin Wang, Luqing Shang, Zheng Qin Yin

European Journal of Medicinal Chemistry

DOI

2016

The discovery of indole derivatives as novel hepatitis C virus inhibitors

Zhiqiang Han, Xiao Huan Liang, Yaxin Wang, Jie Qing, Lin Cao, Luqing Shang, Zheng Qin Yin

European Journal of Medicinal Chemistry

DOI

2016

Discovery of 2′-α-C-Methyl-2′-β-C-fluorouridine Phosphoramidate Prodrugs as Inhibitors of Hepatitis C Virus

Debin Zeng, Rui Zhang, Quandeng Nie, Lin Cao, Luqing Shang, Zheng Qin Yin

ACS Medicinal Chemistry Letters

DOI

2016

Synthesis and structure–activity relationship of α-keto amides as enterovirus 71 3C protease inhibitors

Debin Zeng, Yuying Ma, Rui Zhang, Quandeng Nie, Zhengjie Cui, Yaxin Wang, Luqing Shang, Zheng Qin Yin

Bioorganic & Medicinal Chemistry Letters

DOI

2015

Cyanohydrin as an Anchoring Group for Potent and Selective Inhibitors of Enterovirus 71 3C Protease

Yangyang Zhai, Xiangshuai Zhao, Zhengjie Cui, Man Wang, Yaxin Wang, Linfeng Li, Qi Sun, Xi Nan Yang, Debin Zeng, Ying Liu, Yuna Sun, Zhiyong Lou, Luqing Shang, Zheng Qin Yin

Journal of Medicinal Chemistry

DOI

2014

Structure‐guided Discovery of a Novel Non‐peptide Inhibitor of Dengue Virus NS2B–NS3 Protease

Linfeng Li, Chandrakala Basavannacharya, Kitti Wing Ki Chan, Luqing Shang, Subhash G. Vasudevan, Zheng Qin Yin

Chemical Biology & Drug Design

DOI

2014

Biochemical Characterization of Recombinant Enterovirus 71 3C Protease with Fluorogenic Model Peptide Substrates and Development of a Biochemical Assay

Luqing Shang, Shumei Zhang, Xi Nan Yang, Jixue Sun, Linfeng Li, Zhengjie Cui, Qiuhong He, Yu Guo, Yuna Sun, Zheng Qin Yin

Antimicrobial Agents and Chemotherapy

DOI

2014

An adenosine nucleoside analogue NITD008 inhibits EV71 proliferation

Luqing Shang, Yaxin Wang, Jie Qing, Bo Shu, Lin Cao, Zhiyong Lou, Peng Gong, Yuna Sun, Zheng Qin Yin

Antiviral Research

DOI

2012

Antiviral drug discovery for the treatment of enterovirus 71 infections

Luqing Shang, Mengying Xu, Zheng Qin Yin

Antiviral Research

DOI

2011

Tripeptide inhibitors of dengue and West Nile virus NS2B–NS3 protease

Andreas Schüller, Zheng Qin Yin, C. S. Brian Chia, Danny N.P. Doan, Hyeong-Kyu Kim, Luqing Shang, Teck‐Peng Loh, Jeffery Hill, Subhash G. Vasudevan

Antiviral Research

DOI

2009

1，2-二氨基-3-苯丙烷类氨肽酶N抑制剂的设计、合成及其活性研究

尚鲁庆

《山东大学》

2005

化学基因组学与药物发现

尚鲁庆，徐文方

《食品与药品》

尚鲁庆

精选作品

期刊论文

基于蛋白酶结构的抗病毒药物研究进展

Targeted Degradation of Picornaviral 3C Protease via PROTACs Confers High Barrier to Viral Resistance and Broad‐Spectrum Antiviral Activity

Advances in Antiviral Drug Development Targeting Viral Proteases

Discovery of indole analogue Tc3 as a potent pyroptosis inducer and identification of its combination strategy against hepatic carcinoma

The structure-based design of peptidomimetic inhibitors against SARS-CoV-2 3C like protease as Potent anti-viral drug candidate

Discovery of SARS-CoV-2 3CLPro Peptidomimetic Inhibitors through the Catalytic Dyad Histidine-Specific Protein–Ligand Interactions

Insights into SARS-CoV-2: Medicinal Chemistry Approaches to Combat Its Structural and Functional Biology

Reversible covalent inhibitors suppress enterovirus 71 infection by targeting the 3C protease

Comprehensive Insights into the Catalytic Mechanism of Middle East Respiratory Syndrome 3C-Like Protease and Severe Acute Respiratory Syndrome 3C-Like Protease

Crystal Structure of African Swine Fever Virus pS273R Protease and Implications for Inhibitor Design

Identification of Interferon Receptor IFNAR2 As a Novel HCV Entry Factor by Using Chemical Probes

Application of Dually Activated Michael Acceptor to the Rational Design of Reversible Covalent Inhibitor for Enterovirus 71 3C Protease

4-Iminooxazolidin-2-one as a Bioisostere of the Cyanohydrin Moiety: Inhibitors of Enterovirus 71 3C Protease

3D‐quantitative structure‐activity relationship study for the design of novel enterovirus A71 3C protease inhibitors

Target-guided screening of fragments (TGSOF) in the discovery of inhibitors against EV-A71 3C protease

Structure of the Enterovirus 71 3C Protease in Complex with NK-1.8k and Indications for the Development of Antienterovirus Protease Inhibitor

Inhibition of enterovirus 71 replication by an α-hydroxy-nitrile derivative NK-1.9k

Structure–activity relationship study of peptidomimetic aldehydes as enterovirus 71 3C protease inhibitors

The discovery of indole derivatives as novel hepatitis C virus inhibitors

Discovery of 2′-α-C-Methyl-2′-β-C-fluorouridine Phosphoramidate Prodrugs as Inhibitors of Hepatitis C Virus

Synthesis and structure–activity relationship of α-keto amides as enterovirus 71 3C protease inhibitors

Cyanohydrin as an Anchoring Group for Potent and Selective Inhibitors of Enterovirus 71 3C Protease

Structure‐guided Discovery of a Novel Non‐peptide Inhibitor of Dengue Virus NS2B–NS3 Protease

Biochemical Characterization of Recombinant Enterovirus 71 3C Protease with Fluorogenic Model Peptide Substrates and Development of a Biochemical Assay

An adenosine nucleoside analogue NITD008 inhibits EV71 proliferation

Antiviral drug discovery for the treatment of enterovirus 71 infections

Tripeptide inhibitors of dengue and West Nile virus NS2B–NS3 protease

1，2-二氨基-3-苯丙烷类氨肽酶N抑制剂的设计、合成及其活性研究

化学基因组学与药物发现

会议论文

针对EV71 3C蛋白酶的抗病毒新药发现

以氨肽酶N/CD13为靶点的抗癌药物研究

研究方向