顾鹏｜南方医科大学｜学者主页

2026

An optimized engineered bacterium for tyrosinemia type 1 therapy: A multi-species preclinical study

Peng Gu, Yunfei Zhao, Jiajia Hu, Yuguang Tian, Lingyan Zhao, Jingjing Ren, Qin Yang, Jiaxin Li, Wenhao He, Jiayin Guo, Peng Chen

Molecular Therapy

DOI

2025

Panose prevents acute-on-chronic liver failure by reducing bacterial infection in mice

Jiaxin Li, Shihao Xie, Mei‐Ling Chen, Changze Hong, Yuqi Chen, Fengyuan Lyu, Niexin Tang, Tianqi Chen, Lingyan Zhao, Weihao Zou, Hong‐Juan Peng, Jingna Bao, Peng Gu, Bernd Schnabl, Jinjun Chen, Peng Chen

Journal of Clinical Investigation

DOI

2025

Aging‐induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense

Peng Gu, Rongjuan Wei, Ruofan Liu, Qin Yang, Yuxuan He, Jianbin Guan, Wenhao He, Jiaxin Li, Yunfei Zhao, Li Xin Xie, Jie He, Qingling Guo, Jiajia Hu, Jingna Bao, Wandang Wang, Jiayin Guo, Zhenhua Zeng, Zhongqing Chen, Yong Jiang, Zhanguo Liu, Peng Chen

Advanced Science

DOI

2025

Epimedin B attenuates ovariectomy-induced bone loss by suppressing osteoclastogenesis through decreasing ROS production and targeting ESR1.

Yiyi Lai, Hai-Shan Li, Teng-Peng Zhou, Hui-Ting Chen, Jia-Sheng Yang, Guo-Ye Mo, Yongxian Li, Qiang Li, Xiong-Wei Deng, Shaoyong Fan, Peng Gu

Free Radical Biology & Medicine

DOI

2024

Zinc promotes microbial p-coumaric acid production that protects against cholestatic liver injury

Dongping Li, Meijuan Wan, Lan-Feng Xue, Zhelin Zhang, Yifeng Qiu, Fengyi Mei, Niexing Tang, Chunxiao Yu, Yu Yao, Tianqi Chen, Xing Ding, Qin Yang, Qiuyan Liu, Peng Gu, Wei Jia, Yu Chen, Peng Chen

Cell Host & Microbe

DOI

2024

Oral administration of astilbin mitigates acetaminophen-induced acute liver injury in mice by modulating the gut microbiota

Qin Zhao Yang, Wen-Hao He, Li Xie, Tao Chen, Ruofan Liu, Jiajia Hu, Jiayin Guo, Guozhu Tan, Fu-ling Wu, Peng Gu, Peng Chen, Yu Chen

Acta Pharmacologica Sinica

DOI

2024

Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice

Dongping Li, Rongjuan Wei, Xianglong Zhang, Shenhai Gong, Meijuan Wan, Fangzhao Wang, Jiaxin Li, Meiling Chen, Ruofan Liu, Yantong Wan, Yinghao Hong, Zhenhua Zeng, Peng Gu, Zhang Wang, Kutty Selva Nandakumar, Yong Jiang, Hongwei Zhou, Chen Peng

Acta Pharmaceutica Sinica B

DOI

2024

Corylifol A suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss via attenuating ROS production and impairing mitochondrial function.

Hai-Shan Li, Wei Deng, Jiamin Yang, Yuewei Lin, Shi-Yin Zhang, Zixuan Liang, Junchun Chen, Min-Hua Hu, Teng Liu, Guo-Ye Mo, Zhen Zhang, Dong-Ping Wang, Peng Gu, Yongchao Tang, K. Yuan, Liang-Liang Xu, Jia-Ke Xu, Shun-Chang Zhang, Yongxian Li

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

DOI

2023

Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism

Dongping Li, Yu Chen, Meijuan Wan, Fengyi Mei, Fangzhao Wang, Peng Gu, Xianglong Zhang, Rongjuan Wei, Yunong Zeng, Hanzhao Zheng, Bangguo Chen, Qingquan Xiong, Tao Xue, Tianshan Guan, Jiayin Guo, Yuanxin Tian, Liyan Zeng, Zhanguo Liu, Hang Yuan, Ling Yang, Hongbin Liu, Lei Dai, Yu Yao, Yifeng Qiu, Peng Wu, Sanda Win, Tin Aung Than, Riqing Wei, Bernd Schnabl, Neil Kaplowitz, Yong Jiang, Qiang Ma, Peng Chen

Cell Host & Microbe

DOI

2023

An engineered Escherichia coli Nissle strain prevents lethal liver injury in a mouse model of tyrosinemia type 1

Peng Gu, Li Xin Xie, Tao Chen, Qin Zhao Yang, Xianglong Zhang, Ruofan Liu, Jiayin Guo, Rongjuan Wei, Dongping Li, Yong Qing Jiang, Ye Chen, Wei Gong, Peng Chen

Journal of Hepatology

DOI

2023

Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis

Shihao Xie, Jiaxin Li, Fengyuan Lyu, Qingming Xiong, Peng Gu, Yuqi Chen, Meiling Chen, Jingna Bao, Xianglong Zhang, Rongjuan Wei, Youpeng Deng, Hongzheng Wang, Zhenhua Zeng, Zhongqing Chen, Yongqiang Deng, Zhuoshi Lian, Jie V. Zhao, Wei Gong, Ye Chen, Ke‐Xuan Liu, Yi Duan, Yong Jiang, Hongwei Zhou, Peng Chen

Gut

DOI

2023

A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis

Peng Gu, Ruofan Liu, Qin Yang, Li Xin Xie, Rongjuan Wei, Jiaxin Li, Fengyi Mei, Tao Chen, Zhenhua Zeng, Yan He, Hongwei Zhou, Hong‐Juan Peng, Kutty Selva Nandakumar, Huikuan Chu, Yong Jiang, Wei Gong, Ye Chen, Bernd Schnabl, Peng Chen

Cellular and Molecular Immunology

DOI

2021

CRISPR/Cas9介导的代谢重编程在酪氨酸血症小型猪模型制备及治疗中的应用研究

顾鹏

《南方医科大学》

2021

Genetically blocking HPD via CRISPR-Cas9 protects against lethal liver injury in a pig model of tyrosinemia type I

Peng Gu, Qin Zhao Yang, Bangzhu Chen, Yanan Bie, Wen Liu, Yu-Guang Tian, Hongquan Luo, Tao Xu, Chunjin Liang, Xing Ye, Yan Liu, Xiangwu Tang, Weiwang Gu

Molecular Therapy — Methods & Clinical Development

DOI

2020

Genome-Wide Characterization and Comparative Analyses of Simple Sequence Repeats among Four Miniature Pig Breeds

Hongyang Wang, Yang Fu, Peng Gu, Yingying Zhang, Weilong Tu, Zhe Chao, Huali Wu, Jianguo Cao, Xiang Zhou, Bang Liu, Zhihua Jiang, Chun Chieh Fan, Yongsong Tan

Animals

DOI

2020

Yinning Tablet, a hospitalized preparation of Chinese herbal formula for hyperthyroidism, ameliorates thyroid hormone-induced liver injury in rats: Regulation of mitochondria-mediated apoptotic signals

Qin Zhao Yang, Wenqin Liu, Dongmei Sun, Chunxia Wang, Yangxue Li, Bi Xiao-li, Peng Gu, Haixing Feng, Fuling Wu, Lianbing Hou, Chuqi Hou, Yuhao Li

Journal of Ethnopharmacology

DOI

2019

TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway

Yanan Bie, Peng Gu, Yuting Chen, Xiaoxu Zhou, Yu-Guang Tian, Qin Zhao Yang, Haiyan Li, Xia Lin, Yan-hong Guan, Taoyan Lin, Xun Lu, Hong-Fen Shen, T. Fang, Yumin Liu, Dong Xiao, Weiwang Gu

Journal of Translational Medicine

DOI

2019

Optimization Strategy for Generating Gene-edited Tibet Minipigs by Synchronized Oestrus and Cytoplasmic Microinjection

Bangzhu Chen, Peng Gu, Jun-Shuang Jia, Wei Liu, Yumin Liu, Wen Liu, Tao Xu, Xiaolin Lin, Taoyan Lin, Yu Liu, Hengwei Chen, Mingchen Xu, Jin Yuan, Jianing Zhang, Yinghui Zhang, Dong Xiao, Weiwang Gu

International Journal of Biological Sciences

DOI

2018

Abnormalities of hair structure and skin histology derived from CRISPR/Cas9-based knockout of phospholipase C-delta 1 in mice

Yumin Liu, Wei Liu, Jun-Shuang Jia, Bang-Zhu Chen, Hengwei Chen, Yu Liu, Yanan Bie, Peng Gu, Yan Sun, Dong Xiao, Weiwang Gu

Journal of Translational Medicine

DOI

顾鹏

精选作品

期刊论文

An optimized engineered bacterium for tyrosinemia type 1 therapy: A multi-species preclinical study

Panose prevents acute-on-chronic liver failure by reducing bacterial infection in mice

Aging‐induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense

Epimedin B attenuates ovariectomy-induced bone loss by suppressing osteoclastogenesis through decreasing ROS production and targeting ESR1.

Zinc promotes microbial p-coumaric acid production that protects against cholestatic liver injury

Oral administration of astilbin mitigates acetaminophen-induced acute liver injury in mice by modulating the gut microbiota

Gut commensal metabolite rhamnose promotes macrophages phagocytosis by activating SLC12A4 and protects against sepsis in mice

Corylifol A suppresses osteoclastogenesis and alleviates ovariectomy-induced bone loss via attenuating ROS production and impairing mitochondrial function.

Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism

An engineered Escherichia coli Nissle strain prevents lethal liver injury in a mouse model of tyrosinemia type 1

Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis

A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis

CRISPR/Cas9介导的代谢重编程在酪氨酸血症小型猪模型制备及治疗中的应用研究

Genetically blocking HPD via CRISPR-Cas9 protects against lethal liver injury in a pig model of tyrosinemia type I

Genome-Wide Characterization and Comparative Analyses of Simple Sequence Repeats among Four Miniature Pig Breeds

Yinning Tablet, a hospitalized preparation of Chinese herbal formula for hyperthyroidism, ameliorates thyroid hormone-induced liver injury in rats: Regulation of mitochondria-mediated apoptotic signals

TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway

Optimization Strategy for Generating Gene-edited Tibet Minipigs by Synchronized Oestrus and Cytoplasmic Microinjection

Abnormalities of hair structure and skin histology derived from CRISPR/Cas9-based knockout of phospholipase C-delta 1 in mice