郑江｜沈阳药科大学｜学者主页

2026

黄樟素反应性代谢产物与小鼠肝脏蛋白的共价结合研究

梁也，张景钰，王欣，廖玉芬，刘英，郑江，李维维

《贵州医科大学学报》

2025

基于易感基因HLA-B*35:01的何首乌特异质肝损伤的成因机制解析（英文）

肖大可，赵旭，湛小燕，师卓，柏兆方，郑江，肖小河，王伽伯

Science of Traditional Chinese Medicine

2025

抗氧化基因1与神经退行性疾病：从分子机制到靶向药物研究

郑江，刘家豪，刘若萱，曾亮，钟毅，田原僮

《赣南医科大学学报》

2023

4-烯丙基苯甲醚代谢活化及其代谢物与谷胱甘肽共价结合

周梦悦，李靖，程婷，江婷婷，谭荣，陈妍，李维维，郑江

《沈阳药科大学学报》

2023

Formation of RNA adducts resulting from metabolic activation of spice ingredient safrole mediated by P450 enzymes and sulfotransferases.

X. Wang, G. Ran, Yufen Liao, Bowen Gong, Chutian Wu, Ronghui Tan, Ying Liu, Shenmin Zhang, Ying Peng, Wei-Wei Li, Jiang Zheng

Food and Chemical Toxicology

DOI

2023

Reduction of emodin-8-O-ß-D-glucoside content participates in processing-based detoxification of polygoni multiflori radix.

Xu Wang, Guode Zhao, Chengguo Ju, Ling-Wen Dong, Yuyang Liu, Zi-Fang Ding, Wei-Wei Li, Ying Peng, Jiang Zheng

Phytomedicine

DOI

2023

Immunochemical and LC-MS/MS Detection of Protein Adduction Resulting from Metabolic Activation of Columbin In Vitro and In Vivo.

Chutian Wu, Jie Pan, Bowen Gong, Yufen Liao, Ying Zou, Yang Wang, G. Ran, X. Wang, Mengyue Zhou, Ting Liu, Ying Peng, Wei-Wei Li, Jiang Zheng

Chemical Research in Toxicology

DOI

2023

Metabolic activation and cytotoxicity of metaxalone mediated by cytochrome P450 enzymes and sulfotransferases.

Hengming Liu, Zixia Hu, Ningning Han, Yi Yang, Guode Zhao, Mengdie Su, Yue Zhang, Wei-Wei Li, Ying Peng, Jiang Zheng

Chemico-Biological Interactions

DOI

2023

DNA damage and up-regulation of PARP-1 induced by columbin in vitro and in vivo.

Yufen Liao, X. Wang, G. Ran, Shenmin Zhang, Chutian Wu, Ronghui Tan, Ying Liu, Yan He, Ting Liu, Zhongxiu Wu, Ying Peng, Wei-Wei Li, Jiang Zheng

Toxicology Letters

DOI

2023

Inflammation Intensifies Monocrotaline-Induced Liver Injury.

Bowen Gong, Shenmin Zhang, Xin Wang, G. Ran, Xiao-Hong Zhang, Jing Xi, Zhenna Gao, Yuyang Lei, Jie Pan, Y. Liu, Yang Luan, Xin-Yu Zhang, Ying Peng, Wei-Wei Li, Jiang Zheng

Journal of Agricultural and Food Chemistry

DOI

2023

Mechanistic Study of Xanthotoxin-Mediated Inactivation of CYP1A2 and Related Drug-Drug Interaction with Tacrine.

G. Ran, Yufen Liao, X. Wang, Ying Liu, Bowen Gong, Chutian Wu, Zi-Hao Cheng, Ying Peng, Wei-Wei Li, Jiang Zheng

Chemical Research in Toxicology

DOI

2023

In Vitro and In Vivo Metabolic Activation of Tolterodine Mediated by CYP3A.

Aixuan Wang, Qiang Zhao, Minglu Liu, Yang Wang, Guode Zhao, Wei-Wei Li, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2023

Metabolic Activation of Pesticide Isoprocarb Mediated by CYP3A4 and the Possible Correlation with Its Cytotoxicity.

Chun-Jing Guan, Guode Zhao, Chen Sun, Mingyu Zhang, Siyu Liu, Ziying Jiang, Wei-Wei Li, Ying Peng, Jiang Zheng

Journal of Agricultural and Food Chemistry

DOI

2023

Metabolic activation and cytotoxicity of 4-Methylquinoline mediated by CYP3A4 and sulfotransferases in rats.

Kai-Jie Li, Guode Zhao, Lan Yang, Xingyu Gao, Yudi Jia, Yang Wang, Xiao-Hong Zhang, Wei-Wei Li, Ying Peng, Jiang Zheng

Food and Chemical Toxicology

DOI

2023

OAT3 Participates in Drug–Drug Interaction between Bentysrepinine and Entecavir through Interactions with M8—A Metabolite of Bentysrepinine—In Rats and Humans In Vitro

Aijie Zhang, Fanlong Yang, Yang Yuan, Cai Li, Xiao-Kui Huo, Jing Liu, Shenzhi Zhou, Wei Li, Na Zhang, Jian-Feng Liu, Shi-Qi Dong, Hui-Rong Fan, Ying Peng, Jiang Zheng

Molecules

DOI

2023

Effects of xenobiotics on CYP1 enzyme-mediated biotransformation and bioactivation of estradiol

Xu Mao, Hui Li, Jiang Zheng

Drug metabolism reviews (Softcover ed.)

DOI

2023

Difference in hepatotoxicity of furan-containing components in cortex dictamni correlates the efficiency of their metabolic activation.

J. Pan, Chutian Wu, Ronghui Tan, Yufen Liao, Guode Zhao, W. Li, Ying Peng, Wei-Wei Li, Jiang Zheng

Phytomedicine

DOI

2023

Evidence for the Metabolic Activation of Deferasirox In Vitro and In Vivo.

Mengdie Su, Yanjia Zhao, Mei Li, Chen-Yang Jia, He Liu, Yue Zhang, Wei-Wei Li, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2022

倒千里光碱的反应性代谢产物与RNA形成双分子嘌呤共价结合物

程婷，江婷婷，周梦悦，李靖，李维维，郑江

《沈阳药科大学学报》

DOI

2022

Evidence for adduction of biologic amines with reactive metabolite of 8-epidiosbulbin E acetate in vitro and in vivo.

Na Zhang, Shenzhi Zhou, Zhengyu Zhang, W. Li, Ying Peng, Jiang Zheng

Toxicology Letters

DOI

2022

Cysteine-Based Protein Covalent Binding and Hepatotoxicity Induced by Emodin.

Xu Wang, Zi-Fang Ding, Kaiqi Ma, Chen Sun, Xiao-Jiao Zheng, Yutong You, Shiyu Zhang, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2022

2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside, a mechanism-based inactivator of CYP2C19 and CYP3A4, potentiates hepatic protein adduction and hepatotoxicity induced by emodin in vivo.

Xu Wang, Lin Dong, Guode Zhao, Wei-Wei Li, Ying Peng, Jiang Zheng

Chemico-Biological Interactions

DOI

2022

Metabolic activation of 3-aminodibenzofuran mediated by P450 enzymes and sulfotransferases.

Yang Wang, Kunna Li, Ying Zou, Mengyue Zhou, Jing Li, Chutian Wu, Ronghui Tan, Yufen Liao, Wei-Wei Li, Jiang Zheng

Toxicology Letters

DOI

2022

Diosbulbin B: An important component responsible for hepatotoxicity and protein covalent binding induced by Dioscorea bulbifera L.

Rong Tan, Zixia Hu, Mengyue Zhou, Ying Liu, Yang Wang, Ying Zou, Kunna Li, Shiyu Zhang, Jie Pan, Ying Peng, Wei-Wei Li, Jiang Zheng

Phytomedicine

DOI

2022

Metabolic Activation of Gemfibrozil Mediated by Cytochrome P450 Enzymes and Sulfotransferases.

Min Zhao, Jun-ping Shi, Wei Li, Chun-Jing Guan, Chen Sun, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2022

Metabolic Activation and Cytotoxicity of Propafenone Mediated by CYP2D6.

Jiaru Li, Jun-ping Shi, Chen-Yang Jia, Wei Li, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2022

2-Naphthalenemethanol participates in metabolic activation of 2-methylnaphthalene

Kunna Li, Ying Zou, Yang Wang, Mengyue Zhou, Jing Li, Ronghui Tan, Shenmin Zhang, Wei-Wei Li, Jiang Zheng

Xenobiotica; the fate of foreign compounds in biological systems

DOI

2022

Hepatic RNA adduction derived from metabolic activation of retrorsine in vitro and in vivo.

Wei-Wei Li, Ting Cheng, Tingting Jiang, Mengyue Zhou, Bowen Gong, Guode Zhao, Jing Li, Ronghui Tan, Xiao-Jing Yang, Kandarp Joshi, Ying Peng, M. Cheng, Ting Liu, D. Wang, Jiang Zheng

Chemico-Biological Interactions

DOI

2022

In Vitro and In Vivo Metabolic Activation and Hepatotoxicity of Environmental Pollutant 2,6-Dimethylphenol.

Mingyu Zhang, Yao-Ping Hu, Wei Li, Chen Sun, Chun-Jing Guan, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2022

Anastrozole and related glucuronic acid conjugate are electrophilic species

S. Ding, Siyu Liu, Ya-Xuan Chen, Ying Peng, Jiang Zheng

Xenobiotica; the fate of foreign compounds in biological systems

DOI

2022

Metabolic Activation and Hepatotoxicity of Furan-Containing Compounds

M. Tian, Ying Peng, Jiang Zheng

Drug Metabolism And Disposition

DOI

2022

Evidence for Metabolic Activation of Omeprazole In Vitro and In Vivo.

Yanjia Zhao, Chen Sun, Mengdie Su, Jun-ping Shi, Zixia Hu, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2022

Metabolic Activation and Cytotoxicity of Fungicide Carbendazim Mediated by CYP1A2.

Jun-ping Shi, Min Zhao, Kai-Jie Li, Yanjia Zhao, Wei Li, Ying Peng, Jiang Zheng

Journal of Agricultural and Food Chemistry

DOI

2022

Evaluating and predicting the correlations of hepatic concentration and pyrrole-protein adduction with hepatotoxicity induced by retrorsine based on pharmacokinetic/pharmacodynamic model.

Jing Li, Ximei Li, Mengyue Zhou, Xiaoqiong Lai, Wei-Wei Li, Jiang Zheng

Toxicology Letters

DOI

2022

Configurational Alteration Results in Change in Hepatotoxicity of Asarone.

Guode Zhao, Yufei Ma, Xu Wang, Wei Li, Yu-Qing Chen, Wei-Wei Li, Ying Peng, Jiang Zheng

Journal of Agricultural and Food Chemistry

DOI

2022

Development of a mechanism-based biomarker for Dioscorea bulbifera L. exposure and hepatotoxicity in rats.

Zixia Hu, Yanjia Zhao, Yi Yang, Wei Li, Ronghui Tan, Lin-Hua Zhao, X. Tong, Ying Peng, Jiang Zheng

Phytomedicine

DOI

2022

Identification of Metoprolol Tartrate-Derived Reactive Metabolites Possibly Correlated with Its Cytotoxicity.

Xiao-Nan Li, Gang Xing, Xinxin Guo, Yang Wang, Zixia Hu, Mao-Sheng Cheng, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2022

Metabolic Activation of Perampanel Mediated by CYP1A2.

Zi-Fang Ding, Xu Wang, Ning Zhang, Chen Sun, Guode Zhao, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2022

A Metabolic Activation-Based Chemoproteomic Platform to Profile Adducted Proteins Derived from Furan-Containing Compounds.

Wei Li, Zixia Hu, Chen Sun, Yuwei Wang, Wei-Wei Li, Ying Peng, Jiang Zheng

ACS Chemical Biology

DOI

2022

Unique Oxidative Metabolism of Bufalin Generates Two Reactive Metabolites That Strongly Inactivate Human Cytochrome P450 3A.

Dongzhu Tu, Jing Ning, Li-Wei Zou, Ping Wang, Yani Zhang, Xiang-Ge Tian, Feng Zhang, Jiang Zheng, Guangbo Ge

Journal of Medicinal Chemistry

DOI

2022

Phytochemistry, synthesis, analytical methods, pharmacological activity, and pharmacokinetics of loganin: A comprehensive review

Fanhua Zhang, Yu Yan, Jia Zhang, Li Li, Yu-wei Wang, Cong-yuan Xia, Wenwen Lian, Ying Peng, Jiang Zheng, Jun He, Jie-Kun Xu, Wei‐Ku Zhang

Phytotherapy Research

DOI

2022

DNA damage by reactive oxygen species resulting from metabolic activation of 8-epidiosbulbin E acetate in vitro and in vivo.

Shiyu Zhang, Ying Liu, Ting Liu, Jie Pan, Rong Tan, Zixia Hu, Bowen Gong, Yufen Liao, Peng Luo, Q. Zeng, Wei-Wei Li, Jiang Zheng

Toxicology and Applied Pharmacology

DOI

2022

Metabolic Activation of Militarine In Vitro and In Vivo.

Ying Zou, Yang Wang, Kunna Li, Mengyue Zhou, Jing Li, Xu Wang, Rong Tan, Chutian Wu, Ying Liu, Wei-Wei Li, Jiang Zheng

Chemical Research in Toxicology

DOI

2022

Asparagine and Glutamine Residues Participate in Protein Covalent Binding by Epoxide Metabolite of 8-Epidiosbulbin E Acetate In Vitro and In Vivo.

Na Zhang, Yi Yang, Wei Li, Shenzhi Zhou, Wei-Wei Li, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2021

Toxicokinetic and bioavailability studies on retrorsine in mice, and ketoconazole-induced alteration in toxicokinetic properties.

Jing Li, Mengyue Zhou, Xiaoqiong Lai, Yang Wang, Ying Zou, Kunna Li, Wei-Wei Li, Jiang Zheng

Biomedical chromotography

DOI

2021

RNA adduction derived from electrophilic species in vitro and in vivo.

Mengyue Zhou, D. Wang, Wei-Wei Li, Jiang Zheng

Chemico-Biological Interactions

DOI

2021

Metabolic activation of deferiprone mediated by CYP2A6

Xiao-Jiao Zheng, Xu Wang, Zi-Fang Ding, Wei Li, Ying Peng, Jiang Zheng

Xenobiotica; the fate of foreign compounds in biological systems

DOI

2021

Metabolic Activation of Atomoxetine Mediated by Cytochrome P450 2D6.

Yutong You, Xu Wang, Kaiqi Ma, Jiaru Li, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2021

Oxypeucedanin is a mechanism-based inactivator of CYP2B6 and CYP2D6.

Kehan Zhang, Yilin Li, Yao Fu, T. Cui, Qian Wang, Xu Mao, Ying Peng, Jiang Zheng

Current drug metabolism

DOI

2021

Icotinib Induces Mechanism-Based Inactivation of Recombinant Human CYP3A4/5 Possibly via Heme Destruction by Ketene Intermediate

Chen Sun, Huimin Zhao, Wei Li, Yudi Jia, Yi Yang, Ying Peng, Jiang Zheng

Drug Metabolism And Disposition

DOI

2021

Amino acid and biogenic amine adductions derived from reactive metabolites.

Zhengyu Zhang, Ying Peng, Jiang Zheng

Current drug metabolism

DOI

2021

Metabolic activation of zolmitriptan mediated by CYP2D6

Lingling Han, Yudi Jia, Yanjia Zhao, Chen Sun, Min Zhao, Ying Peng, Jiang Zheng

Xenobiotica; the fate of foreign compounds in biological systems

DOI

2021

Glutathione conjugation and protein modification resulting from metabolic activation of venlafaxine in vitro and in vivo

Yilin Li, Yang Wang, N. Zhang, Shenzhi Zhou, Ying Peng, Jiang Zheng

Xenobiotica; the fate of foreign compounds in biological systems

DOI

2021

Metabolic Activation and Cytotoxicity of Labetalol Hydrochloride Mediated by Sulfotransferases.

Lan Yang, Li-Hua Xin, J. Shi, Wei Li, M. Tian, Zixia Hu, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2021

Mechanistic study of bergamottin-induced inactivation of CYP2C9.

Ying Liu, Shi-Yu Zhang, Tingting Jiang, Rong Tan, Yao Fu, Xiao-Jing Yang, Bowen Gong, Ying Zou, Wei-Wei Li, Jiang Zheng

Food and Chemical Toxicology

DOI

2021

Metabolic activation of aegeline mediated by CYP2C19

M. Tian, Shenzhi Zhou, Wei Li, Jiaru Li, Lan Yang, Ying Peng, Jiang Zheng

Xenobiotica; the fate of foreign compounds in biological systems

DOI

2020

Reply to letter from Veeravalli and Dash on ""Tofacitinib is a mechanism-based inactivator of cytochrome P450 3A4": Revisiting the significance of the epoxide intermediate and glutathione trapping".

Xiucai Guo, Zixia Hu, Wei Li, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2020

Bergaptol, a mechanism-based inactivator of CYP2C9

Tingting Jiang, Ting Cheng, Jing Li, Meng Zhou, Ronghui Tan, Xiao-Jing Yang, Yang Wang, Wei-Wei Li, Jiang Zheng

Medicinal Chemistry Research

DOI

2020

Metabolic activation of pirfenidone mediated by cytochrome P450s and sulfotransferases.

Shenzhi Zhou, Wei Li, M. Tian, Na Zhang, Xiao-Jing Yang, Wei-Wei Li, Ying Peng, Jiang Zheng

Journal of Medicinal Chemistry

DOI

2020

Evidence for polyamine, biogenic amine, and amino acid adduction resulting from metabolic activation of diosbulbin B.

Zhengyu Zhang, Hui Li, Wei Li, Yukun Feng, Zixia Hu, Shenzhi Zhou, Na Zhang, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2020

Mechanism-based inactivation of cytochrome P450 2D6 by Notopterol.

Yao Fu, Xiao-Xiao Tian, Lingling Han, Yilin Li, Ying Peng, Jiang Zheng

Chemico-Biological Interactions

DOI

2020

In Vitro and In Vivo Evidence for RNA Adduction Resulting from Metabolic Activation of Methyleugenol.

Xiao-Jing Yang, Yukun Feng, Zhengyu Zhang, Hui Wang, Wei-Wei Li, D. Wang, Ying Peng, Jiang Zheng

Journal of Agricultural and Food Chemistry

DOI

2020

Antibody-based detection of lysine modification of hepatic protein in mice treated with retrorsine.

Ting Cheng, Wei-Wei Li, Xiao-Jing Yang, Huali Wang, Fan Zhang, Na Li, G. Lin, Jiang Zheng

Journal of environmental science and health. Part C, Toxicology and carcinogenesis

DOI

2020

Glutathione conjugation and protein adduction by environmental pollutant 2,4-dichlorophenol in vitro and in vivo.

Qingmei Li, Wei Li, Jiaxing Zhao, Xiucai Guo, Qian Zou, Zixin Yang, Ruixue Tian, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2020

Dioscorea bulbifera L.-induced hepatotoxicity and involvement of metabolic activation of furanoterpenoids

Hui Li, Ying Peng, Jiang Zheng

Drug metabolism reviews (Softcover ed.)

DOI

2020

Immunochemical Detection of Protein Modification Derived from Metabolic Activation of 8-Epidiosbulbin E Acetate.

Shenzhi Zhou, Na Zhang, Zixia Hu, Dong-Ju Lin, Wei-Wei Li, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2019

2018年中国药物代谢研究进展

余露山，毕惠嫦，吴宝剑，葛广波，郑江，乔海灵，曾苏

《药学学报》

DOI

2019

Tofacitinib is a mechanism-based inactivator of cytochrome P450 3A4.

Xiucai Guo, Wei Li, Qingmei Li, Yan Chen, Guode Zhao, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2019

Characterization of glutathione conjugates derived from reactive metabolites of seven silymarin isomers

Yan Chen, Jing-hua Yu, Xu Wang, Hui Li, Xu Mao, Ying Peng, Jiang Zheng

Xenobiotica; the fate of foreign compounds in biological systems

DOI

2019

Metabolism-based herb-drug interaction of Corydalis Bungeanae Herba with berberine in vitro and in vivo in rats.

Xu Mao, Huimin Zhao, Qian Wang, Hui Li, Lan Yang, Zixia Hu, Fengjiao Zhang, Xiucai Guo, Ying Peng, Jiang Zheng

Biomedical chromotography

DOI

2019

Identification of Quinone Methide Intermediate Resulting from Metabolic Activation of Icaritin in Vitro and in Vivo.

Yan Chen, Xiucai Guo, Yufei Ma, Xingjia Hu, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2019

Glutathione Conjugation and Protein Adduction Derived from Oxidative Debromination of Benzbromarone in Mice

Hui Wang, Wen-Bao Wang, Bowen Gong, Zedan Wang, Yukun Feng, Wei-Ge Zhang, Shaojie Wang, Ying Peng, Jiang Zheng

Drug Metabolism And Disposition

DOI

2019

Studies on hepatotoxicity and toxicokinetics of colchicine

Xiucai Guo, Yan Chen, Qingmei Li, Xiao-Jing Yang, Guode Zhao, Ying Peng, Jiang Zheng

Journal of biochemical and molecular toxicology

DOI

2019

Nitidine Chloride–Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism

Xu Mao, Jian Wang, Qian Wang, Lan Yang, Yilin Li, Hao Lin, Ying Peng, Jiang Zheng

Drug Metabolism And Disposition

DOI

2019

Metabolic Activation and Cytotoxicity of Aloe-Emodin Mediated by Sulfotransferases.

Ruihong Li, Wei Li, Yutong You, Xiucai Guo, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2019

Chemical Reactivity of Aloe-Emodin and Its Hydroxylation Metabolites to Thiols.

Xu Wang, Xin Xin, Ying Sun, Lizhu Zou, Hui Li, Yufei Zhao, Ruihong Li, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2019

Prenatal exposure to pyrrolizidine alkaloids induced hepatotoxicity and pulmonary injury in fetal rats.

Yu Guo, Di Xiao, Xiao-Jing Yang, Jiang Zheng, Shuwei Hu, Panfeng Wu, Xiao-Xia Li, H. Kou, Hui Wang

Reproductive Toxicology

DOI

2019

Metabolic activation of tofacitinib mediated by myeloperoxidase in vitro.

Xiucai Guo, Yudi Jia, Lingling Han, Yanhong Zhao, Wei Li, Zhengyu Zhang, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2019

Sex difference in monocrotaline-induced developmental toxicity and fetal hepatotoxicity in rats.

Jinyuan Luo, Xiao-Jing Yang, Shuaikai Qiu, Xia Li, E. Xiang, Yan Fang, Yan-Qing Wang, Li Zhang, Hui Wang, Jiang Zheng, Yu Guo

Toxicology

DOI

2019

Electron Deficiency of Nitro Group Determines Hepatic Cytotoxicity of Nitrofurantoin.

Hui Li, Zhengyu Zhang, Xiao-Jing Yang, Xu Mao, Ying Wang, Jian Wang, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2019

In vitro and in vivo studies of the metabolic activation of chelidonine.

Yuyang Liu, Ying Peng, Zhengyu Zhang, Xiucai Guo, M. Ji, Jiang Zheng

Chemico-Biological Interactions

DOI

2019

Piperine Is a Mechanism-Based Inactivator of CYP3A

T. Cui, Qian Wang, Xiao-Xiao Tian, Kehan Zhang, Ying Peng, Jiang Zheng

Drug Metabolism And Disposition

DOI

2018

Identification of Ketene-Reactive Intermediate of Erlotinib Possibly Responsible for Inactivation of P450 Enzymes

Huimin Zhao, Siyuan Li, Zixin Yang, Ying Peng, Xiaohui Chen, Jiang Zheng

Drug Metabolism And Disposition

DOI

2018

Metabolite profile analysis and pharmacokinetic study of emodin, baicalin and geniposide in rats

Jing-hua Yu, Xiucai Guo, Qingqing Zhang, Ying Peng, Jiang Zheng

Xenobiotica; the fate of foreign compounds in biological systems

DOI

2018

Nitidine Chloride Is a Mechanism-Based Inactivator of CYP2D6

Xu Mao, Zixia Hu, Qian Wang, Na Zhang, Shenzhi Zhou, Ying Peng, Jiang Zheng

Drug Metabolism And Disposition

DOI

2018

A Difference in Internal Exposure Makes Newly Weaned Mice More Susceptible to the Hepatotoxicity of Retrorsine Than Adult Mice.

Xiao-Jing Yang, Wei-Wei Li, Hui Li, Xu Wang, Yan Chen, Xiucai Guo, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2018

Mechanism‐based inactivation of cytochrome P450 2D6 by chelidonine

Yuyang Liu, T. Cui, Ying Peng, M. Ji, Jiang Zheng

Journal of biochemical and molecular toxicology

DOI

2018

Development of Polyclonal Antibodies for Detection of Diosbulbin B-Derived cis-Enedial Protein Adducts.

Zixia Hu, Shenzhi Zhou, Na Zhang, Wei-Wei Li, Dong-Ju Lin, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2018

In Vitro and in Vivo Studies of the Electrophilicity of Physcion and its Oxidative Metabolites.

X. Qin, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2018

In vitro and in vivo metabolic activation of rhein and characterization of glutathione conjugates derived from rhein.

Yang Xu, Xu Mao, Bo-Yang Qin, Ying Peng, Jiang Zheng

Chemico-Biological Interactions

DOI

2018

Cytochrome P450 mediated metabolic activation of chrysophanol.

Ying Sun, Xin Xin, Kehan Zhang, T. Cui, Ying Peng, Jiang Zheng

Chemico-Biological Interactions

DOI

2018

Maternal-Fetal Disposition and Metabolism of Retrorsine in Pregnant Rats

Xia Li, Xiao-Jing Yang, E. Xiang, Jinyuan Luo, Shuaikai Qiu, Yan Fang, Li Zhang, Yu Guo, Jiang Zheng, Hui Wang

Drug Metabolism And Disposition

DOI

2018

In Vitro DNA Adduction Resulting from Metabolic Activation of Diosbulbin B and 8-Epidiosbulbin E Acetate.

Dong-Ju Lin, Wei-Wei Li, Xutong Tian, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2018

Urinary Methyleugenol-deoxyadenosine Adduct as a Potential Biomarker of Methyleugenol Exposure in Rats.

Yukun Feng, Saide Wang, Hui Wang, Ying Peng, Jiang Zheng

Journal of Agricultural and Food Chemistry

DOI

2017

Oxidative bioactivation of nitrofurantoin in rat liver microsomes

Hui Li, Dong-Ju Lin, Ying Peng, Jiang Zheng

Xenobiotica; the fate of foreign compounds in biological systems

DOI

2017

Sensitive bromine-based screening of potential toxic furanoids in Dioscorea bulbifera L.

Zhengyu Zhang, Dong-Ju Lin, Wei-Wei Li, Hui-Yuan Gao, Ying Peng, Jiang Zheng

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

DOI

2017

Chemical Identity of Interaction of Protein with Reactive Metabolite of Diosbulbin B In Vitro and In Vivo

Kai Wang, Dong-Ju Lin, Xiucai Guo, Wenlin Huang, Ying Peng, Jiang Zheng

Toxins

DOI

2017

Immunoassay approach for diagnosis of exposure to pyrrolizidine alkaloids

Na Li, Fan Zhang, Wei Lian, Huali Wang, Jiang Zheng, G. Lin

Journal of Environmental Science And Health Part C - Environmental Carcinogenesis & Ecotoxicology Reviews

DOI

2017

Metabolic Epoxidation Is a Critical Step for the Development of Benzbromarone-Induced Hepatotoxicity

Hui Wang, Ying Peng, Ting-Jian Zhang, Qun-Sheng Lan, Huimin Zhao, Wen-Bao Wang, Yufei Zhao, Xu Wang, Jianxin Pang, Shaojie Wang, Jiang Zheng

Drug Metabolism And Disposition

DOI

2017

Metabolic Activation and Toxicities of bis-Benzylisoquinoline Alkaloids

Ye Tian, Jiang Zheng

DOI

2017

Comparative Study of Hepatotoxicity of Pyrrolizidine Alkaloids Retrorsine and Monocrotaline.

Xiao-Jing Yang, Wei-Wei Li, Yingqiong Sun, Xiucai Guo, Wenlin Huang, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2017

Influence of Shenxiong Glucose Injection on the Activities of Six CYP Isozymes and Metabolism of Warfarin in Rats Assessed Using Probe Cocktail and Pharmacokinetic Approaches

Jia Sun, Yuan Lu, Yue-Ting Li, Jie Pan, Chun-Hua Liu, Zipeng Gong, Jing-Zhuo Huang, Jiang Zheng, Lin Zheng, Yong-Jun Li, Ting Liu, Yong-Lin Wang

Molecules

DOI

2017

Chemical Interaction of Protein Cysteine Residues with Reactive Metabolites of Methyleugenol.

Yukun Feng, Hui Wang, Qian Wang, Wenlin Huang, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2017

In vitro and in vivo metabolic activation of berbamine to quinone methide intermediate

Yao Sun, Tong Yao, Hui Li, Ying Peng, Jiang Zheng

Journal of biochemical and molecular toxicology

DOI

2016

Metabolic activation of furan moiety makes Diosbulbin B hepatotoxic

Wei-Wei Li, Dong-Ju Lin, Hui-Yuan Gao, Youjun Xu, Dongya Meng, C. V. Smith, Ying Peng, Jiang Zheng

Archives of Toxicology

DOI

2016

Role of Metabolic Activation in 8-Epidiosbulbin E Acetate-Induced Liver Injury: Mechanism of Action of the Hepatotoxic Furanoid.

Dong-Ju Lin, Wei-Wei Li, Ying Peng, Chunfeng Jiang, Youjun Xu, Hui-Yuan Gao, Jiang Zheng

Chemical Research in Toxicology

DOI

2016

Identification of Epoxide-Derived Metabolite(s) of Benzbromarone

Kai Wang, Hui Wang, Ying Peng, Jiang Zheng

Drug Metabolism And Disposition

DOI

2016

Lysine- and cysteine-based protein adductions derived from toxic metabolites of 8-epidiosbulbin E acetate.

Dong-Ju Lin, Kai Wang, Xiucai Guo, Hui-Yuan Gao, Ying Peng, Jiang Zheng

Toxicology Letters

DOI

2016

Cysteine-Based Protein Adduction by Epoxide-Derived Metabolite(s) of Benzbromarone.

Hui Wang, Yukun Feng, Qian Wang, Xiucai Guo, Wenlin Huang, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2016

Detection of protein adduction derived from dauricine by alkaline permethylation

Honglei Xie, Yuyang Liu, Ying Peng, Dong-Mei Zhao, Jiang Zheng

Analytical and Bioanalytical Chemistry

DOI

2016

Cytochrome P450 Mediated Bioactivation of Saracatinib.

Jiaming Chen, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2016

Lysine Adduction by Reactive Metabolite(s) of Monocrotaline.

Wei-Wei Li, Kai Wang, G. Lin, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2016

Chemical Reactivity of Emodin and Its Oxidative Metabolites to Thiols.

Bo-Yang Qin, Yang Xu, Jiaming Chen, Wenlin Huang, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2016

Mechanism-based inactivation of cytochrome P450 2B6 by isopsoralen

D. Lu, Lin Ji, Li-Wei Zheng, Jiaojiao Cao, Ying Peng, Jiang Zheng

Xenobiotica; the fate of foreign compounds in biological systems

DOI

2016

Electrophilicities and Protein Covalent Binding of Demethylation Metabolites of Colchicine.

Xiucai Guo, Dong-Ju Lin, Wei-Wei Li, Kai Wang, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2016

Identification of glutathione and related cysteine conjugates derived from reactive metabolites of methyleugenol in rats.

Huina Yao, Ying Peng, Jiang Zheng

Chemico-Biological Interactions

DOI

2016

Characterization of glutathione conjugates derived from reactive metabolites of bakuchiol.

Meina Chi, Ying Peng, Jiang Zheng

Chemico-Biological Interactions

DOI

2016

Metabolic Activation and Toxicities of Furanoterpenoids

Hui Li, Ying Peng, Jiang Zheng

DOI

2016

9-Glutathionyl-6,7-dihydro-1-hydroxymethyl-5H-pyrrolizine Is the Major Pyrrolic Glutathione Conjugate of Retronecine-Type Pyrrolizidine Alkaloids in Liver Microsomes and in Rats.

Mei-Xia Chen, Liang Li, D. Zhong, Shui-Jie Shen, Jiang Zheng, Xiao-Yan Chen

Chemical Research in Toxicology

DOI

2015

Imperatorin Is a Mechanism-Based Inactivator of CYP2B6

Li-Wei Zheng, Jiaojiao Cao, D. Lu, Lin Ji, Ying Peng, Jiang Zheng

Drug Metabolism And Disposition

DOI

2015

CYP3A5 mediates bioactivation and cytotoxicity of tetrandrine

Ye Tian, Shui-Jie Shen, Yan Jiang, Qian Shen, S. Zeng, Jiang Zheng

Archives of Toxicology

DOI

2015

Psoralen, a mechanism-based inactivator of CYP2B6.

Lin Ji, D. Lu, Jiaojiao Cao, Li-Wei Zheng, Ying Peng, Jiang Zheng

Chemico-Biological Interactions

DOI

2015

Detection of cysteine- and lysine-based protein adductions by reactive metabolites of 2,5-dimethylfuran.

Kai Wang, Wei-Wei Li, Jiaming Chen, Ying Peng, Jiang Zheng

Analytica Chimica Acta

DOI

2015

N-acetyl lysine/glutathione-derived pyrroles as potential ex vivo biomarkers of bioactivated furan-containing compounds.

Chun-Yan Li, Dong-Ju Lin, Hui-Yuan Gao, Huiming Hua, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2015

In vitro and in vivo studies of the metabolic activation of 8-epidiosbulbin E acetate.

Dong-Ju Lin, Xiucai Guo, Hui-Yuan Gao, Li Cheng, Mao-Sheng Cheng, Shao-Jiang Song, Ying Peng, Jiang Zheng

Chemical Research in Toxicology

DOI

2015

In Vitro and In Vivo Characterization of Reactive Intermediates of Corynoline

Xu Mao, Ying Peng, Jiang Zheng

Drug Metabolism And Disposition

DOI

2015

Blood Pyrrole-Protein Adducts—A Biomarker of Pyrrolizidine Alkaloid-Induced Liver Injury in Humans

Jian-Qing Ruan, Hong Gao, Na Li, Junyi Xue, Jie Chen, Chang-qiang Ke, Yang Ye, Peter P. Fu, Jiang Zheng, Ji-Yao Wang, G. Lin

Journal of Environmental Science And Health Part C - Environmental Carcinogenesis & Ecotoxicology Reviews

DOI

2015

Mechanism-based inactivation of cytochrome P450 2B6 by isoimperatorin.

Jiaojiao Cao, Li-Wei Zheng, Lin Ji, D. Lu, Ying Peng, Jiang Zheng

Chemico-Biological Interactions

DOI

2015

Mechanism-based inactivation of CYP2C9 by linderane

Hui Wang, Kai Wang, Xu Mao, Qingqing Zhang, Tong Yao, Ying Peng, Jiang Zheng

Xenobiotica; the fate of foreign compounds in biological systems

DOI

2014

Selective and sensitive platform for function-based screening of potentially harmful furans.

Kai Wang, Li-Wei Zheng, Ying Peng, Juan-e Song, Jiang Zheng

Analytical Chemistry

DOI

2013

Synergistic effects of pyrrolizidine alkaloids and lipopolysaccharide on preterm delivery and intrauterine fetal death in mice.

Yu Guo, Zhenguo Ma, H. Kou, Rongze Sun, Hanxiao Yang, C. V. Smith, Jiang Zheng, Hui Wang

Toxicology Letters

DOI

2013

The interaction between human breast cancer resistance protein (BCRP) and five bisbenzylisoquinoline alkaloids.

Ye Tian, Sainan Qian, Yan Jiang, Qian Shen, Jiang Zheng, Hui Zhou, S. Zeng

International journal of pharmaceutics

DOI

2013

Metabolism of styrene to styrene oxide and vinylphenols in cytochrome P450 2F2- and P450 2E1-knockout mouse liver and lung microsomes

Shui-Jie Shen, Lei Li, Xin-Xin Ding, Jiang Zheng

Chemical Research in Toxicology

DOI

2012

Structure-toxicity relationship study of para-halogenated styrene analogues in CYP2E1 transgenic cells

Jou-Ku Chung, Shui-Jie Shen, Zhiteng Jiang, W. Yuan, Jiang Zheng

Toxicology Letters

DOI

2012

CYP3A-mediated apoptosis of dauricine in cultured human bronchial epithelial cells and in lungs of CD-1 mice.

Hua Jin, Shui-Jie Shen, Xiao-Yan Chen, D. Zhong, Jiang Zheng

Toxicology and Applied Pharmacology

DOI

2011

2',5,6',7-四羟基二氢黄酮醇对内毒素诱导巨噬细胞活化的影响

葛迪，史清海，伏建峰，刘正祥，郑江

《解放军药学学报》

2011

Hepatic sinusoidal obstruction syndrome associated with consumption of Gynura segetum.

G. Lin, Ji-Yao Wang, Na Li, Mi Li, Hong Gao, Yuan Ji, Fan Zhang, Huali Wang, Yan Zhou, Yang Ye, Hong-Xi Xu, Jiang Zheng

Journal of Hepatology

DOI

2011

Pulmonary toxicity and metabolic activation of tetrandrine in CD-1 mice.

Hua Jin, Liang Li, D. Zhong, Jia Liu, Xiao-Yan Chen, Jiang Zheng

Chemical Research in Toxicology

DOI

2010

黄芩药材中2′,5,6′,7-四羟基二氢黄酮醇的分离与鉴定

伏建峰，王宁，史清海，冉继华，袁文常，刘正祥，葛迪，郑江

《中国药房》

2010

Pulmonary Toxicity and Metabolic Activation of Dauricine in CD-1 Mice

Hua Jin, Jieyu Dai, Xiao-Yan Chen, Jia Liu, D. Zhong, Yan-Song Gu, Jiang Zheng

Journal of Pharmacology and Experimental Therapeutics

DOI

2010

Evidence for the bioactivation of 4-nonylphenol to quinone methide and ortho-benzoquinone metabolites in human liver microsomes.

Pan Deng, D. Zhong, F. Nan, Sheng Liu, Dandan Li, Tao Yuan, Xiao-Yan Chen, Jiang Zheng

Chemical Research in Toxicology

DOI

2010

Evidence for cellular protein covalent binding derived from styrene metabolite

W. Yuan, Hua Jin, Jou-Ku Chung, Jiang Zheng

Chemico-Biological Interactions

DOI

2010

Retrorsine, but not monocrotaline, is a mechanism-based inactivator of P450 3A4.

Jieyu Dai, Fan Zhang, Jiang Zheng

Chemico-Biological Interactions

DOI

2010

Detection of Protein Adduction Derived from Styrene Oxide to Cysteine Residues by Alkaline Permethylation

Jieyu Dai, Fan Zhang, Jiang Zheng

Analytical Biochemistry

DOI

2010

Detection of Phenolic Metabolites of Styrene in Mouse Liver and Lung Microsomal Incubations

Shui-Jie Shen, Fan Zhang, Ling-Bo Gao, S. Zeng, Jiang Zheng

Drug Metabolism And Disposition

DOI

2009

HPLC法测定黄芩中2′,5,6′,7-四羟基二氢黄酮醇的含量

伏建峰，郑新川，王宁，史清海，冉继华，袁文常，郑江

《中国药房》

2009

Development of Enantioselective Polyclonal Antibodies to Detect Styrene Oxide Protein Adducts

Shui-Jie Shen, Fan Zhang, S. Zeng, Ye Tian, Xiaojuan Chai, Shirley M. Gee, B. Hammock, Jiang Zheng

Analytical Chemistry

DOI

2009

Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile.

Yuya Wang, D. Zhong, Xiao-Yan Chen, Jiang Zheng

Chemical Research in Toxicology

DOI

2008

应用生物传感器技术筛选拮抗细菌基因组DNA中药的研究

龙宇鹏，郑江

《中国药房》

2008

青蒿琥酯对盲肠结扎穿孔术脓毒症小鼠的保护作用

王宁，刘鑫，周红，曹红卫，李斌，鲁永玲，郑江

《中国临床药理学与治疗学》

2008

An approach based on liquid chromatography/electrospray ionization–mass spectrometry to detect diol metabolites as biomarkers of exposure to styrene and 1,3-butadiene

Shui-Jie Shen, Fan Zhang, S. Zeng, Jiang Zheng

Analytical Biochemistry

DOI

2007

金黄色葡萄球菌细胞壁可溶性肽聚糖的分离纯化和鉴定

张向武，郑江，伏建峰，郭毅斌，陈益国，鲁永玲

《中国临床药理学与治疗学》

2007

以PBP2a为靶点应用生物传感器技术筛选拮抗MRSA中药

和生琦，李军，吴翀，郑江，龙宇鹏，罗平，张蓉，周红

《解放军药学学报》

2007

Development of polyclonal antibodies for the detection of styrene oxide modified proteins.

W. Yuan, Jou-Ku Chung, S. Gee, B. Hammock, Jiang Zheng

Chemical Research in Toxicology

DOI

2007

Deacetylclivorine: A Gender-Selective Metabolite of Clivorine Formed in Female Sprague-Dawley Rat Liver Microsomes

G. Lin, Jun Tang, Xiao-Quan Liu, Yan Jiang, Jiang Zheng

Drug Metabolism And Disposition

DOI

2006

青蒿素对脓毒症大鼠肝脏脂质过氧化损伤的影响

曹红卫，郭毅斌，魏利召，王宁，曲海，郑江

《中国临床药理学与治疗学》

2006

诃子抗CPG ODN组分的分离及活性评价

姚婕，郑江，蒋栋能，鲁永玲，魏利召

《中国临床药理学与治疗学》

2006

Investigation of bioactivation and toxicity of styrene in CYP2E1 transgenic cells.

Jou-Ku Chung, W. Yuan, Guangxian Liu, Jiang Zheng

Toxicology

DOI

2005

以CpG ODN为靶点应用生物传感器技术筛选抗炎中药

程娟，郑江，周红，蒋栋能，吴翀，陈益国，张向武，姚婕

《中国临床药理学与治疗学》

2005

以Lipid A为靶点拮抗内毒素中药的筛选

陈益国，姚婕，张向武，蒋栋能，郭毅斌，魏利召，程娟，吴翀，郑江

《中国临床药理学与治疗学》

2005

生物传感器技术在分离赤芍抗内毒素单体成分中的研究

吕根法，卫国，郭毅斌，郑江，肖光夏

《中国药房》

2005

抗内毒素多肽对内毒素休克模型家兔的治疗作用

卫国，吕根法，郭毅斌，郑江

《中国临床药理学与治疗学》

2005

赤芍拮抗内毒素活性的实验研究

魏利召，郑江，蒋栋能

《中国临床药理学与治疗学》

2004

多粘菌素B对LPS刺激巨噬细胞Toll4TNF-α IL-6 mRNA表达的影响

吕根法，王良喜，郭毅斌，卫国，肖光夏，郑江

《解放军药学学报》

2004

生物传感器技术在筛选赤芍中抗内毒素有效成分的应用研究

吕根法，卫国，郭毅斌，郑江，肖光夏

《中国药房》

2004

DETECTION OF GLUTATHIONE CONJUGATES DERIVED FROM 4-IPOMEANOL METABOLISM IN BILE OF RATS BY LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY

T. Alvarez-Diez, Jiang Zheng

Drug Metabolism And Disposition

DOI

2004

Mechanism-based inactivation of cytochrome P450 3A4 by 4-ipomeanol.

T. Alvarez-Diez, Jiang Zheng

Chemical Research in Toxicology

DOI

2003

感染性疾病治疗中抗生素诱导的内毒素释放研究进展

周红，郑江，王浴生

《解放军药学学报》

2002

重视医学本科生的临床药理学教学

周红，张乐之，李福涛，郑江

《四川生理科学杂志》

精选作品

期刊论文

黄樟素反应性代谢产物与小鼠肝脏蛋白的共价结合研究

基于易感基因HLA-B*35:01的何首乌特异质肝损伤的成因机制解析（英文）

抗氧化基因1与神经退行性疾病：从分子机制到靶向药物研究

4-烯丙基苯甲醚代谢活化及其代谢物与谷胱甘肽共价结合

Formation of RNA adducts resulting from metabolic activation of spice ingredient safrole mediated by P450 enzymes and sulfotransferases.

Reduction of emodin-8-O-ß-D-glucoside content participates in processing-based detoxification of polygoni multiflori radix.

Immunochemical and LC-MS/MS Detection of Protein Adduction Resulting from Metabolic Activation of Columbin In Vitro and In Vivo.

Metabolic activation and cytotoxicity of metaxalone mediated by cytochrome P450 enzymes and sulfotransferases.

DNA damage and up-regulation of PARP-1 induced by columbin in vitro and in vivo.

Inflammation Intensifies Monocrotaline-Induced Liver Injury.

Mechanistic Study of Xanthotoxin-Mediated Inactivation of CYP1A2 and Related Drug-Drug Interaction with Tacrine.

In Vitro and In Vivo Metabolic Activation of Tolterodine Mediated by CYP3A.

Metabolic Activation of Pesticide Isoprocarb Mediated by CYP3A4 and the Possible Correlation with Its Cytotoxicity.

Metabolic activation and cytotoxicity of 4-Methylquinoline mediated by CYP3A4 and sulfotransferases in rats.

OAT3 Participates in Drug–Drug Interaction between Bentysrepinine and Entecavir through Interactions with M8—A Metabolite of Bentysrepinine—In Rats and Humans In Vitro

Effects of xenobiotics on CYP1 enzyme-mediated biotransformation and bioactivation of estradiol

Difference in hepatotoxicity of furan-containing components in cortex dictamni correlates the efficiency of their metabolic activation.

Evidence for the Metabolic Activation of Deferasirox In Vitro and In Vivo.

倒千里光碱的反应性代谢产物与RNA形成双分子嘌呤共价结合物

Evidence for adduction of biologic amines with reactive metabolite of 8-epidiosbulbin E acetate in vitro and in vivo.

Cysteine-Based Protein Covalent Binding and Hepatotoxicity Induced by Emodin.

2,3,5,4'-Tetrahydroxy stilbene-2-Ο-β-D-glucoside, a mechanism-based inactivator of CYP2C19 and CYP3A4, potentiates hepatic protein adduction and hepatotoxicity induced by emodin in vivo.

Metabolic activation of 3-aminodibenzofuran mediated by P450 enzymes and sulfotransferases.

Diosbulbin B: An important component responsible for hepatotoxicity and protein covalent binding induced by Dioscorea bulbifera L.

Metabolic Activation of Gemfibrozil Mediated by Cytochrome P450 Enzymes and Sulfotransferases.

Metabolic Activation and Cytotoxicity of Propafenone Mediated by CYP2D6.

2-Naphthalenemethanol participates in metabolic activation of 2-methylnaphthalene

Hepatic RNA adduction derived from metabolic activation of retrorsine in vitro and in vivo.

In Vitro and In Vivo Metabolic Activation and Hepatotoxicity of Environmental Pollutant 2,6-Dimethylphenol.

Anastrozole and related glucuronic acid conjugate are electrophilic species

Metabolic Activation and Hepatotoxicity of Furan-Containing Compounds

Evidence for Metabolic Activation of Omeprazole In Vitro and In Vivo.

Metabolic Activation and Cytotoxicity of Fungicide Carbendazim Mediated by CYP1A2.

Evaluating and predicting the correlations of hepatic concentration and pyrrole-protein adduction with hepatotoxicity induced by retrorsine based on pharmacokinetic/pharmacodynamic model.

Configurational Alteration Results in Change in Hepatotoxicity of Asarone.

Development of a mechanism-based biomarker for Dioscorea bulbifera L. exposure and hepatotoxicity in rats.

Identification of Metoprolol Tartrate-Derived Reactive Metabolites Possibly Correlated with Its Cytotoxicity.

Metabolic Activation of Perampanel Mediated by CYP1A2.

A Metabolic Activation-Based Chemoproteomic Platform to Profile Adducted Proteins Derived from Furan-Containing Compounds.

Unique Oxidative Metabolism of Bufalin Generates Two Reactive Metabolites That Strongly Inactivate Human Cytochrome P450 3A.

Phytochemistry, synthesis, analytical methods, pharmacological activity, and pharmacokinetics of loganin: A comprehensive review

DNA damage by reactive oxygen species resulting from metabolic activation of 8-epidiosbulbin E acetate in vitro and in vivo.

Metabolic Activation of Militarine In Vitro and In Vivo.

Asparagine and Glutamine Residues Participate in Protein Covalent Binding by Epoxide Metabolite of 8-Epidiosbulbin E Acetate In Vitro and In Vivo.

Toxicokinetic and bioavailability studies on retrorsine in mice, and ketoconazole-induced alteration in toxicokinetic properties.

RNA adduction derived from electrophilic species in vitro and in vivo.

Metabolic activation of deferiprone mediated by CYP2A6

Metabolic Activation of Atomoxetine Mediated by Cytochrome P450 2D6.

Oxypeucedanin is a mechanism-based inactivator of CYP2B6 and CYP2D6.

Icotinib Induces Mechanism-Based Inactivation of Recombinant Human CYP3A4/5 Possibly via Heme Destruction by Ketene Intermediate

Amino acid and biogenic amine adductions derived from reactive metabolites.

Metabolic activation of zolmitriptan mediated by CYP2D6

Glutathione conjugation and protein modification resulting from metabolic activation of venlafaxine in vitro and in vivo

Metabolic Activation and Cytotoxicity of Labetalol Hydrochloride Mediated by Sulfotransferases.

Mechanistic study of bergamottin-induced inactivation of CYP2C9.

Metabolic activation of aegeline mediated by CYP2C19

Reply to letter from Veeravalli and Dash on ""Tofacitinib is a mechanism-based inactivator of cytochrome P450 3A4": Revisiting the significance of the epoxide intermediate and glutathione trapping".

Bergaptol, a mechanism-based inactivator of CYP2C9

Metabolic activation of pirfenidone mediated by cytochrome P450s and sulfotransferases.

Evidence for polyamine, biogenic amine, and amino acid adduction resulting from metabolic activation of diosbulbin B.

Mechanism-based inactivation of cytochrome P450 2D6 by Notopterol.

In Vitro and In Vivo Evidence for RNA Adduction Resulting from Metabolic Activation of Methyleugenol.

Antibody-based detection of lysine modification of hepatic protein in mice treated with retrorsine.

Glutathione conjugation and protein adduction by environmental pollutant 2,4-dichlorophenol in vitro and in vivo.

Dioscorea bulbifera L.-induced hepatotoxicity and involvement of metabolic activation of furanoterpenoids

Immunochemical Detection of Protein Modification Derived from Metabolic Activation of 8-Epidiosbulbin E Acetate.

2018年中国药物代谢研究进展

Tofacitinib is a mechanism-based inactivator of cytochrome P450 3A4.

Characterization of glutathione conjugates derived from reactive metabolites of seven silymarin isomers

Metabolism-based herb-drug interaction of Corydalis Bungeanae Herba with berberine in vitro and in vivo in rats.

Identification of Quinone Methide Intermediate Resulting from Metabolic Activation of Icaritin in Vitro and in Vivo.

Glutathione Conjugation and Protein Adduction Derived from Oxidative Debromination of Benzbromarone in Mice

Studies on hepatotoxicity and toxicokinetics of colchicine

Nitidine Chloride–Induced CYP1 Enzyme Inhibition and Alteration of Estradiol Metabolism

Metabolic Activation and Cytotoxicity of Aloe-Emodin Mediated by Sulfotransferases.

Chemical Reactivity of Aloe-Emodin and Its Hydroxylation Metabolites to Thiols.

Prenatal exposure to pyrrolizidine alkaloids induced hepatotoxicity and pulmonary injury in fetal rats.

Metabolic activation of tofacitinib mediated by myeloperoxidase in vitro.