林水木｜广州医科大学｜学者主页

期刊论文

2026

Clofoctol-derived amphiphilic peptidomimetics exhibit broadened antimicrobial activity via multiple contributing mechanisms

Liu JiaYong, Jiahui Lin, Wenyi Wang, Hongxia Li, Jiahui Zhengyu, Yuyan Zhang, Mu Chen, Rongcui Zhong, Xing Chong, Yuanye Dang, Huili Chang, Shouping Liu, Shuimu Lin

Journal of Advanced Research

DOI

2025

Rational design of ivacaftor-derived antimicrobial peptidomimetics: Membrane-targeting strategy enhances broad-spectrum antimicrobial efficacy against MDR pathogens

Rongcui Zhong, Lingqing Xu, Jiawei Wu, Mengyi He, Suhua Wu, Zhaozu Luo, Nuotong Han, Yongyi Yao, Jing Zhou, Zhixiong Ruan, Shouping Liu, Shuimu Lin

European Journal of Medicinal Chemistry

DOI

2025

Boronic acid derivatives inhibit Candida albicans growth by compromising energy metabolism

Suhua Wu, Venkatesh Mayandi, Eunice Tze Leng Goh, Wenyi Wang, Nuotong Han, Rongcui Zhong, Zhaozu Luo, Yue Wang, Mu Chen, Rajamani Lakshminarayanan, Zhixiong Ruan, Shouping Liu, Shuimu Lin

Journal of Advanced Research

DOI

2025

Development of xanthone derivatives as effective broad-spectrum antimicrobials: Disrupting cell wall and inhibiting DNA synthesis

Haizhou Li, Wen-Tyng Kang, Yueqin Zheng, Yonglv He, Rongcui Zhong, Shanfang Fang, Weijie Wen, Shouping Liu, Shuimu Lin

Science Advances

DOI

2024

Development of novel bisphenol derivatives with a membrane-targeting mechanism as potent gram-positive antibacterial agents

Rongcui Zhong, Zikai Xu, Shujun Zhang, Minghui Zeng, Haizhou Li, Shouping Liu, Shuimu Lin

European Journal of Medicinal Chemistry

DOI

2024

Development of cannabidiol derivatives as potent broad-spectrum antibacterial agents with membrane-disruptive mechanism

Shanfang Fang, Wen-Tyng Kang, Haizhou Li, Qiongna Cai, Wanxin Liang, Minghui Zeng, Qian Yu, Rongcui Zhong, Yiwen Tao, Shouping Liu, Shuimu Lin

European Journal of Medicinal Chemistry

DOI

2023

Design of phenothiazine-based cationic amphiphilic derivatives incorporating arginine residues: Potential membrane-active broad-spectrum antimicrobials combating pathogenic bacteria in vitro and in vivo

Qian Yu, Qiongna Cai, Wanxin Liang, Kewen Zhong, Liu JiaYong, Hai‐Zhou Li, Yongzhi Chen, Hongxia Li, Shanfang Fang, Rongcui Zhong, Shouping Liu, Shuimu Lin

European Journal of Medicinal Chemistry

DOI

2023

Electrochemical Selenylation of Sulfoxonium Ylides for the Synthesis of gem -Diselenides as Antimicrobials against Fungi

Zhongnan Xu, Jiwen Yao, Kaihui Zhong, Shuimu Lin, Xinwei Hu, Zhixiong Ruan

The Journal of Organic Chemistry

DOI

2022

Membrane-Active Nonivamide Derivatives as Effective Broad-Spectrum Antimicrobials: Rational Design, Synthesis, and Biological Evaluation

Qiongna Cai, Qian Yu, Wanxin Liang, Haizhou Li, Liu JiaYong, Hongxia Li, Yongzhi Chen, Shanfang Fang, Rongcui Zhong, Shouping Liu, Shuimu Lin

Journal of Medicinal Chemistry

DOI

2022

Design and Synthesis of Phenyl Sulfide-Based Cationic Amphiphiles as Membrane-Targeting Antimicrobial Agents against Gram-Positive Pathogens

Wanxin Liang, Qian Yu, Zixian Zheng, Liu JiaYong, Qiongna Cai, Shouping Liu, Shuimu Lin

Journal of Medicinal Chemistry

DOI

2022

Design, synthesis, and biological evaluation of tetrahydroquinoline amphiphiles as membrane-targeting antimicrobials against pathogenic bacteria and fungi

Liu JiaYong, Hongxia Li, Qile He, Kaiting Chen, Yongzhi Chen, Rongcui Zhong, Haizhou Li, Shanfang Fang, Shouping Liu, Shuimu Lin

European Journal of Medicinal Chemistry

DOI

2022

Membrane-Active Antibacterial Agents Based on Calix[4]arene Derivatives: Synthesis and Biological Evaluation

Shanfang Fang, Yuanye Dang, Haizhou Li, Hongxia Li, Liu JiaYong, Rongcui Zhong, Yongzhi Chen, Shouping Liu, Shuimu Lin

Frontiers in Chemistry

DOI

2021

Synthesis and biological evaluation of indole-based peptidomimetics as antibacterial agents against Gram-positive bacteria

Yongzhi Chen, Hongxia Li, Liu JiaYong, Rongcui Zhong, Haizhou Li, Shanfang Fang, Shouping Liu, Shuimu Lin

European Journal of Medicinal Chemistry

DOI

2021

Rational Design of Dipicolylamine-Containing Carbazole Amphiphiles Combined with Zn2+ as Potent Broad-Spectrum Antibacterial Agents with a Membrane-Disruptive Mechanism

Liu JiaYong, Hongxia Li, Haizhou Li, Shanfang Fang, Jinguo Shi, Yongzhi Chen, Rongcui Zhong, Shouping Liu, Shuimu Lin

Journal of Medicinal Chemistry

DOI

2021

Design, Synthesis, and Biological Evaluation of Membrane-Active Bakuchiol Derivatives as Effective Broad-Spectrum Antibacterial Agents

Hongxia Li, Liu JiaYong, Chuan‐Fa Liu, Hai‐Zhou Li, Jiachun Luo, Shanfang Fang, Yongzhi Chen, Rongcui Zhong, Shouping Liu, Shuimu Lin

Journal of Medicinal Chemistry

DOI

2021

Development of Amphiphilic Coumarin Derivatives as Membrane-Active Antimicrobial Agents with Potent In Vivo Efficacy against Gram-Positive Pathogenic Bacteria

Rongcui Zhong, Haizhou Li, Hongxia Li, Shanfang Fang, Liu JiaYong, Yongzhi Chen, Shouping Liu, Shuimu Lin

ACS Infectious Diseases

DOI

2020

De Novo Design of Flavonoid-Based Mimetics of Cationic Antimicrobial Peptides: Discovery, Development, and Applications

Shuimu Lin, John D. Wade, Shouping Liu

Accounts of Chemical Research

DOI

2020

Development of Highly Potent Carbazole Amphiphiles as Membrane-Targeting Antimicrobials for Treating Gram-Positive Bacterial Infections

Shuimu Lin, Liu JiaYong, Hongxia Li, Ying Liu, Yongzhi Chen, Jiachun Luo, Shouping Liu

Journal of Medicinal Chemistry

DOI

2020

Design, synthesis, and evaluation of amphiphilic sofalcone derivatives as potent Gram-positive antibacterial agents

Shuimu Lin, Yongzhi Chen, Hongxia Li, Liu JiaYong, Shouping Liu

European Journal of Medicinal Chemistry

DOI

2020

In Vitro and in Vivo Evaluation of Membrane-Active Flavone Amphiphiles: Semisynthetic Kaempferol-Derived Antimicrobials against Drug-Resistant Gram-Positive Bacteria

Shuimu Lin, Hongxia Li, Yiwen Tao, Liu JiaYong, Wenchang Yuan, Yongzhi Chen, Ying Liu, Shouping Liu

Journal of Medicinal Chemistry

DOI

2020

Potent in vitro and in vivo antimicrobial activity of semisynthetic amphiphilic γ-mangostin derivative LS02 against Gram-positive bacteria with destructive effect on bacterial membrane

Shuimu Lin, Chunjie Zhu, Hongxia Li, Yongzhi Chen, Shouping Liu

Biochimica et Biophysica Acta (BBA) - Biomembranes

DOI

数据集

2026

Raw data for the article "Discovery and Mechanism of Action of a Novel Desloratadine Derivative Inhibiting Mycobacterium tuberculosis 3-Dehydroquinate Synthase''

Belachew Aweke Mulu, Hai‐Zhou Li, Buhari Yusuf, Lijie Li, Aweke Mulu Belachew, Xirong Tian, Cuiting Fang, Zhiyong Liu, Liqiang Feng, Shouping Liu, Aleksey A. Vatlin, Andrey Egorovich Shchekotikhin, H. M. Adnan Hameed, Shuimu Lin, Tianyu Zhang

ScienceDB

DOI

林水木

精选作品

期刊论文

Clofoctol-derived amphiphilic peptidomimetics exhibit broadened antimicrobial activity via multiple contributing mechanisms

Rational design of ivacaftor-derived antimicrobial peptidomimetics: Membrane-targeting strategy enhances broad-spectrum antimicrobial efficacy against MDR pathogens

Boronic acid derivatives inhibit Candida albicans growth by compromising energy metabolism

Development of xanthone derivatives as effective broad-spectrum antimicrobials: Disrupting cell wall and inhibiting DNA synthesis

Development of novel bisphenol derivatives with a membrane-targeting mechanism as potent gram-positive antibacterial agents

Development of cannabidiol derivatives as potent broad-spectrum antibacterial agents with membrane-disruptive mechanism

Design of phenothiazine-based cationic amphiphilic derivatives incorporating arginine residues: Potential membrane-active broad-spectrum antimicrobials combating pathogenic bacteria in vitro and in vivo

Electrochemical Selenylation of Sulfoxonium Ylides for the Synthesis of gem -Diselenides as Antimicrobials against Fungi

Membrane-Active Nonivamide Derivatives as Effective Broad-Spectrum Antimicrobials: Rational Design, Synthesis, and Biological Evaluation

Design and Synthesis of Phenyl Sulfide-Based Cationic Amphiphiles as Membrane-Targeting Antimicrobial Agents against Gram-Positive Pathogens

Design, synthesis, and biological evaluation of tetrahydroquinoline amphiphiles as membrane-targeting antimicrobials against pathogenic bacteria and fungi

Membrane-Active Antibacterial Agents Based on Calix[4]arene Derivatives: Synthesis and Biological Evaluation

Synthesis and biological evaluation of indole-based peptidomimetics as antibacterial agents against Gram-positive bacteria

Rational Design of Dipicolylamine-Containing Carbazole Amphiphiles Combined with Zn2+ as Potent Broad-Spectrum Antibacterial Agents with a Membrane-Disruptive Mechanism

Design, Synthesis, and Biological Evaluation of Membrane-Active Bakuchiol Derivatives as Effective Broad-Spectrum Antibacterial Agents

Development of Amphiphilic Coumarin Derivatives as Membrane-Active Antimicrobial Agents with Potent In Vivo Efficacy against Gram-Positive Pathogenic Bacteria

De Novo Design of Flavonoid-Based Mimetics of Cationic Antimicrobial Peptides: Discovery, Development, and Applications

Development of Highly Potent Carbazole Amphiphiles as Membrane-Targeting Antimicrobials for Treating Gram-Positive Bacterial Infections

Design, synthesis, and evaluation of amphiphilic sofalcone derivatives as potent Gram-positive antibacterial agents

In Vitro and in Vivo Evaluation of Membrane-Active Flavone Amphiphiles: Semisynthetic Kaempferol-Derived Antimicrobials against Drug-Resistant Gram-Positive Bacteria

Potent in vitro and in vivo antimicrobial activity of semisynthetic amphiphilic γ-mangostin derivative LS02 against Gram-positive bacteria with destructive effect on bacterial membrane

数据集

Raw data for the article "Discovery and Mechanism of Action of a Novel Desloratadine Derivative Inhibiting Mycobacterium tuberculosis 3-Dehydroquinate Synthase''

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