王兰｜河南师范大学｜学者主页

2026

H19 promotes the development of idiopathic pulmonary fibrosis by modulating TRIOBP to stimulate the PI3K/AKT signaling pathway

Wen‐Yu Zhao, Hanya Zhao, Tongtong Yang, Shuang Huang, Yulong Chen, Zhongzheng Li, Andrew Leask, Gi-young Kim, Jingshuang Song, Guoying Yu, Lan Wang

Cellular and Molecular Life Sciences

DOI

2026

C/EBPγ interacts with C/EBPα and activates the β-catenin pathway in idiopathic pulmonary fibrosis

Xiaoyue Pan, Cong Xia, Yulong Gan, Ying Cao, Man Zhao, Huibing Liu, Yanlin Zhou, Yuqi Wang, Zhongzheng Li, Bin Li, Lan Wang, Guoying Yu

Cellular and Molecular Life Sciences

DOI

2026

SYISL promotes pulmonary epithelial-mesenchymal transition and fibrosis through DSP–Hippo/YAP pathway

Cong Xia, Sining Hou, Xuqian Wang, Wenyu Zhao, Zhixia Wang, Airu Chang, L C Cheng, Huibing Liu, Jiawei Wang, Bin Li, Xin Pan, Shuang Huang, Ying Cao, Sakamoto Koji, Zhongzheng Li, Qiwen Wang, Andrew Leask, Lan Wang, Guoying Yu

Cellular and Molecular Life Sciences

DOI

2026

Autophagy induced by glycosylated CD147 attenuates fibroblast activation and myofibroblast differentiation

Siqi Long, Shuaichen Ma, Cuncun Chu, Yingying Zhang, Wenyu Zhao, Zhongzheng Li, Ying Cao, Shuang Huang, Juntang Yang, Iván O. Rosas, Mengshu Cao, Guoying Yu, Lan Wang

Journal of Biological Chemistry

DOI

2026

Energetic metabolic reprogramming in idiopathic pulmonary fibrosis: mechanisms and therapeutics

Yanlin Zhou, Yuqing Zhang, Shuang Huang, Xiaoyue Pan, Man Zhao, Yingchun Guo, Yuqi Wang, Xia Cong, Bin Li, Huibing Liu, Zhongzheng Li, Xinghua Pan, Juntang Yang, Qiwen Wang, Lan Wang, Guoying Yu

Journal of Molecular Cell Biology

DOI

2026

Monocyte-Derived LGMN + Macrophages Divert Lung Injury Outcomes toward Fibrosis through Matrix Remodeling

Zhongzheng Li, Y H Zhang, Kun Yang, Diwen Zheng, Yuehua Chen, Y H Zhang, Xin Pan, Peishuo Yan, Iván O. Rosas, G Yu, Lan Wang

Research

DOI

2025

LncRNA SYISL promotes fibroblast myofibroblast transition via miR-23a-mediated TRIOBP regulation

Cong Xia, L C Cheng, Wenyu Zhao, Airu Chang, Zhixia Wang, Huibing Liu, Xin Pan, Wenwen Li, Koji Sakamoto, Zhongzheng Li, Bin Li, Lan Wang, Guoying Yu

Cellular and Molecular Life Sciences

DOI

2025

Integrative analysis of gene expression and chromatin dynamics multi-omics data in mouse models of bleomycin-induced lung fibrosis

Zhongzheng Li, Mengke Zhang, Yujie Zhang, Yulong Gan, Zhao Zhu, Jiawei Wang, Zhou Yanlin, Guoying Yu, Lan Wang

Epigenetics & Chromatin

DOI

2024

Triiodothyronine acts on DAO to regulate pulmonary fibrosis progression by facilitating cell senescence through the p53/p21 signaling pathway

Xiaoshu Guo, Kai Xu, Lan Wang, Linke Ding, Wenwen Li, Xinsheng Zhang, Weiming Zhao, Ningdan Wang, Gaiping Wang, Wenyu Zhao, Iván O. Rosas, Guoying Yu

Frontiers in Pharmacology

DOI

2024

The role of the cytoskeleton in fibrotic diseases

Caoyuan Niu, Yanan Hu, Kai Xu, Xiaoyue Pan, Lan Wang, Guoying Yu

Frontiers in Cell and Developmental Biology

DOI

2024

CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production

Peishuo Yan, Kun Yang, Mengwei Xu, Miaomiao Zhu, Yudi Duan, Wenwen Li, Lulu Liu, Chenxi Liang, Zhongzheng Li, Xin Pan, Lan Wang, Guoying Yu

Journal of Molecular Cell Biology

DOI

2024

Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts

Juntang Yang, Xin Pan, Min Xu, Yingge Li, Chenxi Liang, Lulu Liu, Zhongzheng Li, Lan Wang, Guoying Yu

Respiratory Research

DOI

2024

NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence

Ruyan Wan, Siqi Long, Shuaichen Ma, Peishuo Yan, Zhongzheng Li, Kai Xu, Hui Lian, Wenwen Li, Yudi Duan, Miaomiao Zhu, Lan Wang, Guoying Yu

Respiratory Research

DOI

2024

Fatty acid synthase inhibition alleviates lung fibrosis via β-catenin signal in fibroblasts

Hui Lian, Yujie Zhang, Zhao Zhu, Ruyan Wan, Zhixia Wang, Kun Jin Yang, Shuaichen Ma, Yaxuan Wang, Kai Xu, L C Cheng, Wenyu Zhao, Yajun Li, Lan Wang, Guoying Yu

Life Science Alliance

DOI

2024

TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA

Xin Pan, Lan Wang, Juntang Yang, Yingge Li, Min Xu, Chenxi Liang, Lulu Liu, Zhongzheng Li, Cong Xia, Jiaojiao Pang, Mengyuan Wang, Meng Li, Saiya Guo, Peishuo Yan, Chen Ding, Iván O. Rosas, Guoying Yu

Nature Communications

DOI

2024

Aging-Associated Metabolite Methylmalonic Acid Increases Susceptibility to Pulmonary Fibrosis

Kai Xu, Linke Ding, Wenwen Li, Yaxuan Wang, Shuaichen Ma, Hui Lian, Xiaoyue Pan, Ruyan Wan, Weiming Zhao, Juntang Yang, Iván O. Rosas, Lan Wang, Guoying Yu

American Journal Of Pathology

DOI

2024

Loss of PTPN21 disrupted mitochondrial metabolic homeostasis and aggravated experimental pulmonary fibrosis

Hui Lian, Kai Xu, Airu Chang, Yaxuan Wang, Shuaichen Ma, L C Cheng, Wenyu Zhao, Cong Xia, Lan Wang, Guoying Yu

Respiratory Research

DOI

2024

The Thyroid Hormone Analog GC‐1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization

Bin Li, Cong Xia, Wanyu He, Jingyi Liu, Ruoyu Duan, Zhihua Ji, Xiaoyue Pan, Yanlin Zhou, Guoying Yu, Lan Wang

Advanced Science

DOI

2024

Repair and regeneration of the alveolar epithelium in lung injury

Yaxuan Wang, Lan Wang, Shuaichen Ma, L C Cheng, Guoying Yu

The FASEB Journal

DOI

2023

TRIOBP modulates β-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis

Lan Wang, Wenyu Zhao, Cong Xia, Shuaichen Ma, Zhongzheng Li, Ningdan Wang, Linke Ding, Yaxuan Wang, L C Cheng, Huibing Liu, Juntang Yang, Yajun Li, Iván O. Rosas, Guoying Yu

Cellular and Molecular Life Sciences

DOI

2023

Glycolysis Reprogramming in Idiopathic Pulmonary Fibrosis: Unveiling the Mystery of Lactate in the Lung

Peishuo Yan, Jingyi Liu, Zhenwei Li, Jiawei Wang, Zhao Zhu, Lan Wang, Guoying Yu

International Journal of Molecular Sciences

DOI

2023

Injured Endothelial Cell: A Risk Factor for Pulmonary Fibrosis

Weiming Zhao, Lan Wang, Yaxuan Wang, Hongmei Yuan, Mengxia Zhao, Hui Lian, Shuaichen Ma, Kai Xu, Zhongzheng Li, Guoying Yu

International Journal of Molecular Sciences

DOI

2023

Cellular Senescence: A Troy Horse in Pulmonary Fibrosis

Ruyan Wan, Lan Wang, Miaomiao Zhu, Wenwen Li, Yudi Duan, Guoying Yu

International Journal of Molecular Sciences

DOI

2023

ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis

Lan Wang, Hongmei Yuan, Wenwen Li, Peishuo Yan, Mengxia Zhao, Zhongzheng Li, Huabin Zhao, Shenghui Wang, Ruyan Wan, Yajun Li, Juntang Yang, Xin Pan, Iván O. Rosas, Guoying Yu

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI

2023

ADRB2 inhibition combined with antioxidant treatment alleviates lung fibrosis by attenuating TGFβ/SMAD signaling in lung fibroblasts

Ruyan Wan, Lan Wang, Yudi Duan, Miaomiao Zhu, Wenwen Li, Mengxia Zhao, Hongmei Yuan, Kai Xu, Zhongzheng Li, Xiao Zhang, Guoying Yu

Cell Death Discovery

DOI

2023

Single-Cell RNA Sequencing Provides New Insights into Therapeutic Roles of Thyroid Hormone in Idiopathic Pulmonary Fibrosis

Lan Wang, Zhongzheng Li, Ruyan Wan, Xin Pan, Bin Li, Huabin Zhao, Juntang Yang, Weiming Zhao, Shenghui Wang, Qiwen Wang, Peishuo Yan, Chi Ma, Hongmei Yuan, Mengxia Zhao, Iván O. Rosas, Chen Ding, Baofa Sun, Guoying Yu

American Journal of Respiratory Cell and Molecular Biology

DOI

2023

High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters

Juntang Yang, Chenxi Liang, Lulu Liu, Lan Wang, Guoying Yu

Biomolecules

DOI

2023

Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration

Weiming Zhao, Lan Wang, Juntang Yang, Xinyu Chen, Xiaoshu Guo, Kai Xu, Ningdan Wang, Wenyu Zhao, Cong Xia, Hui Lian, Iván O. Rosas, Guoying Yu

Cell Communication and Signaling

DOI

2023

Serum Proteomics Identifies Biomarkers Associated With the Pathogenesis of Idiopathic Pulmonary Fibrosis

Lan Wang, Minghui Zhu, Yan Li, Peishuo Yan, Zhongzheng Li, Xiuping Chen, Juntang Yang, Xin Pan, Huabin Zhao, Shenghui Wang, Hongmei Yuan, Mengxia Zhao, Xiaogang Sun, Ruyan Wan, Fei Li, Xiaobo Wang, Hongtao Yu, Iván O. Rosas, Chen Ding, Guoying Yu

Molecular & Cellular Proteomics

DOI

2023

Artificial neural network identified the significant genes to distinguish Idiopathic pulmonary fibrosis

Zhongzheng Li, Shenghui Wang, Huabin Zhao, Peishuo Yan, Hongmei Yuan, Mengxia Zhao, Ruyan Wan, Guoying Yu, Lan Wang

Scientific Reports

DOI

2023

Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly

Caoyuan Niu, Kai Xu, Yanan Hu, Yanling Jia, Yuexia Yang, Xiaoyue Pan, Ruyan Wan, Hui Lian, Qiwen Wang, Juntang Yang, Yajun Li, Iván O. Rosas, Lan Wang, Guoying Yu

Respiratory Research

DOI

2022

TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 in IPF

Lan Wang, Wenyu Zhao, Cong Xia, Zhongzheng Li, Weiming Zhao, Kai Xu, Ningdan Wang, Hui Lian, Iván O. Rosas, Guoying Yu

International Journal of Molecular Sciences

DOI

2022

Fenbendazole Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice via Suppression of Fibroblast-to-Myofibroblast Differentiation

Lan Wang, Kai Xu, Ningdan Wang, Linke Ding, Wenyu Zhao, Ruyan Wan, Weiming Zhao, Xiaoshu Guo, Xin Pan, Juntang Yang, Iván O. Rosas, Guoying Yu

International Journal of Molecular Sciences

DOI

2022

Inhibition of MAD2L1 Mediates Pulmonary Fibrosis through Impairment of Mitochondrial Function and Induction of Cell Senescence

Lan Wang, Ruyan Wan, Xinyu Chen, Xiaoshu Guo, Zhongzheng Li, Weiming Zhao, Peishuo Yan, Guoying Yu

Canadian Respiratory Journal

DOI

2020

Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis

Juntang Yang, Xin Pan, Lan Wang, Guoying Yu

Molecular Medicine

DOI

精选作品

期刊论文

H19 promotes the development of idiopathic pulmonary fibrosis by modulating TRIOBP to stimulate the PI3K/AKT signaling pathway

C/EBPγ interacts with C/EBPα and activates the β-catenin pathway in idiopathic pulmonary fibrosis

SYISL promotes pulmonary epithelial-mesenchymal transition and fibrosis through DSP–Hippo/YAP pathway

Autophagy induced by glycosylated CD147 attenuates fibroblast activation and myofibroblast differentiation

Energetic metabolic reprogramming in idiopathic pulmonary fibrosis: mechanisms and therapeutics

Monocyte-Derived LGMN + Macrophages Divert Lung Injury Outcomes toward Fibrosis through Matrix Remodeling

LncRNA SYISL promotes fibroblast myofibroblast transition via miR-23a-mediated TRIOBP regulation

Integrative analysis of gene expression and chromatin dynamics multi-omics data in mouse models of bleomycin-induced lung fibrosis

Triiodothyronine acts on DAO to regulate pulmonary fibrosis progression by facilitating cell senescence through the p53/p21 signaling pathway

The role of the cytoskeleton in fibrotic diseases

CCT6A alleviates pulmonary fibrosis by inhibiting HIF-1α-mediated lactate production

Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblasts

NR2F2 alleviates pulmonary fibrosis by inhibition of epithelial cell senescence

Fatty acid synthase inhibition alleviates lung fibrosis via β-catenin signal in fibroblasts

TRβ activation confers AT2-to-AT1 cell differentiation and anti-fibrosis during lung repair via KLF2 and CEBPA

Aging-Associated Metabolite Methylmalonic Acid Increases Susceptibility to Pulmonary Fibrosis

Loss of PTPN21 disrupted mitochondrial metabolic homeostasis and aggravated experimental pulmonary fibrosis

The Thyroid Hormone Analog GC‐1 Mitigates Acute Lung Injury by Inhibiting M1 Macrophage Polarization

Repair and regeneration of the alveolar epithelium in lung injury

TRIOBP modulates β-catenin signaling by regulation of miR-29b in idiopathic pulmonary fibrosis

Glycolysis Reprogramming in Idiopathic Pulmonary Fibrosis: Unveiling the Mystery of Lactate in the Lung

Injured Endothelial Cell: A Risk Factor for Pulmonary Fibrosis

Cellular Senescence: A Troy Horse in Pulmonary Fibrosis

ACSS3 regulates the metabolic homeostasis of epithelial cells and alleviates pulmonary fibrosis

ADRB2 inhibition combined with antioxidant treatment alleviates lung fibrosis by attenuating TGFβ/SMAD signaling in lung fibroblasts

Single-Cell RNA Sequencing Provides New Insights into Therapeutic Roles of Thyroid Hormone in Idiopathic Pulmonary Fibrosis

High-Fat Diet Related Lung Fibrosis-Epigenetic Regulation Matters

Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration

Serum Proteomics Identifies Biomarkers Associated With the Pathogenesis of Idiopathic Pulmonary Fibrosis

Artificial neural network identified the significant genes to distinguish Idiopathic pulmonary fibrosis

Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly

TRIB3 Mediates Fibroblast Activation and Fibrosis though Interaction with ATF4 in IPF

Fenbendazole Attenuates Bleomycin-Induced Pulmonary Fibrosis in Mice via Suppression of Fibroblast-to-Myofibroblast Differentiation

Inhibition of MAD2L1 Mediates Pulmonary Fibrosis through Impairment of Mitochondrial Function and Induction of Cell Senescence

Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis

预印本

LAPTM4B Alleviates Pulmonary Fibrosis by Enhancing NEDD4L-Mediated TGF-β Signaling Suppression

研究方向