闫永彬

2026

ER‐Localized Deadenylase PNLDC1 Suppresses Colorectal Cancer Progression by Targeting the mRNA Decay of TUBB4B

Exploration

DOI

2022

Fam96b recruits brain-type creatine kinase to fuel mitotic spindle formation

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI

2022

CCT2 is an aggrephagy receptor for clearance of solid protein aggregates

Cell

DOI

2021

Modeling congenital cataract in vitro using patient-specific induced pluripotent stem cells

npj Regenerative Medicine

DOI

2021

Human Ccr4 and Caf1 Deadenylases Regulate Proliferation and Tumorigenicity of Human Gastric Cancer Cells via Modulating Cell Cycle Progression

Cancers

DOI

2021

A novel F30S mutation in γS-crystallin causes autosomal dominant congenital nuclear cataract by increasing susceptibility to stresses

International Journal of Biological Macromolecules

DOI

2020

Diverse functions of deadenylases in DNA damage response and genomic integrity

Wiley Interdisciplinary Reviews - RNA

DOI

2020

Translation Efficiency and Degradation of ER-Associated mRNAs Modulated by ER-Anchored poly(A)-Specific Ribonuclease (PARN)

Cells

DOI

2019

Lanosterol modulates proteostasis via dissolving cytosolic sequestosomes/aggresome-like induced structures

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI

2019

Dissimilarity in the Contributions of the N-Terminal Domain Hydrophobic Core to the Structural Stability of Lens β/γ-Crystallins

Biochemistry

DOI

2019

Contributions of the C-terminal domain to poly(A)-specific ribonuclease (PARN) stability and self-association

Biochemistry and Biophysics Reports

DOI

2019

Molecular genetics of congenital cataracts

Experimental Eye Research

DOI

2019

Semiholoenzyme optimizes activity and stability of a hyperthermostable iron-superoxide dismutase

Biochemical and Biophysical Research Communications

DOI

2019

The Intrinsically Disordered C-Terminal Domain Triggers Nucleolar Localization and Function Switch of PARN in Response to DNA Damage

Cells

DOI

2018

Lanosterol and 25-hydroxycholesterol dissociate crystallin aggregates isolated from cataractous human lens via different mechanisms

Biochemical and Biophysical Research Communications

DOI

2018

Introduction of an extra tryptophan fluorophore by cataract-associating mutations destabilizes βB2-crystallin and promotes aggregation

Biochemical and Biophysical Research Communications

DOI

2018

Synthesis, Evaluation, and Structure–Activity Relationship Study of Lanosterol Derivatives To Reverse Mutant-Crystallin-Induced Protein Aggregation

Journal of Medicinal Chemistry

DOI

2018

The cataract-causing mutation G75V promotes γS-crystallin aggregation by modifying and destabilizing the native structure

International Journal of Biological Macromolecules

DOI

2017

Increasing susceptibility to oxidative stress by cataract-causing crystallin mutations

International Journal of Biological Macromolecules

DOI

2017

Screening novel stress granule regulators from a natural compound library

Protein & Cell

DOI

2017

Effects of cataract-causing mutations W59C and W151C on βB2-crystallin structure, stability and folding

International Journal of Biological Macromolecules

DOI

2016

An Intrinsically Disordered Motif Mediates Diverse Actions of Monomeric C-reactive Protein

Journal of Biological Chemistry

DOI

2016

lanosterol reverse protein aggregation in cataracts

Investigative Ophthalmology & Visual Science

2016

Lanosterol reversal of protein aggregation in cataract

Acta Ophthalmologica

DOI

2016

Cataract-causing mutation S228P promotes βB1-crystallin aggregation and degradation by separating two interacting loops in C-terminal domain

Protein & Cell

DOI

2016

Congenital microcornea-cataract syndrome-causing mutation X253R increases βB1-crystallin hydrophobicity to promote aggregate formation

Biochemical Journal

DOI

2016

Creatine kinase in cell cycle regulation and cancer

Amino Acids

DOI

2016

Membrane insertion of αA-crystallin is oligomer-size dependent

Biochemical and Biophysical Research Communications

DOI

2016

A single residue substitution accounts for the significant difference in thermostability between two isoforms of human cytosolic creatine kinase

Scientific Reports

DOI

2015

Erratum: Corrigendum: Lanosterol reverses protein aggregation in cataracts

Nature

DOI

2015

Lanosterol reverses protein aggregation in cataracts

Nature

DOI

2015

Congenital Cataract-Causing Mutation G129C in γC-Crystallin Promotes the Accumulation of Two Distinct Unfolding Intermediates That Form Highly Toxic Aggregates

Journal of Molecular Biology

DOI

2015

DsCaf1 is involved in environmental stress response of Dunaliella salina

International Journal of Biological Macromolecules

DOI

2015

The Intrinsically Disordered C‐terminal Domain Triggers Nucleolus Localization and Protein Interactions of Poly(A)‐specific Ribonuclease

The FASEB Journal

DOI

2015

RNAe: an effective method for targeted protein translation enhancement by artificial non-coding RNA with SINEB2 repeat

Nucleic Acids Research

DOI

2015

Dunaliella salina Hsp90 is halotolerant

International Journal of Biological Macromolecules

DOI

2014

Depletion of poly(A)-specific ribonuclease (PARN) inhibits proliferation of human gastric cancer cells by blocking cell cycle progression

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI

2014

The N-Terminal Extension of βB1-Crystallin Chaperones β-Crystallin Folding and Cooperates with αA-Crystallin

Biochemistry

DOI

2014

Formation of High-Order Oligomers by a Hyperthemostable Fe-Superoxide Dismutase (tcSOD)

PLoS ONE

DOI

2014

Self-association of poly(A)-specific ribonuclease (PARN) triggered by the R3H domain

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

DOI

2014

Cataract-causing mutation R233H affects the stabilities of βB1- and βA3/βB1-crystallins with different pH-dependence

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI

2014

Cataract-linked mutation R188H promotes βB2-crystallin aggregation and fibrillization during acid denaturation

Biochemical and Biophysical Research Communications

DOI

2014

Deadenylation: enzymes, regulation, and functional implications

Wiley Interdisciplinary Reviews - RNA

DOI

2013

Knockdown of creatine kinase B inhibits ovarian cancer progression by decreasing glycolysis

The International Journal of Biochemistry & Cell Biology

DOI

2013

The importance of the last strand at the C-terminus in βB2-crystallin stability and assembly

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI

2013

Biochemical and Biophysical Characterization of the Deadenylase CrCaf1 from Chlamydomonas reinhardtii

PLoS ONE

DOI

2013

Distinct roles of the R3H and RRM domains in poly(A)-specific ribonuclease structural integrity and catalysis

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

DOI

2012

Two Distinct States of Escherichia coli Cells That Overexpress Recombinant Heterogeneous β-Galactosidase

Journal of Biological Chemistry

DOI

2012

The Congenital Cataract-Linked A2V Mutation Impairs Tetramer Formation and Promotes Aggregation of βB2-Crystallin

PLoS ONE

DOI

2012

Increasing βB1-crystallin sensitivity to proteolysis caused by the congenital cataract-microcornea syndrome mutation S129R

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI

2012

DsHsp90 Is Involved in the Early Response of Dunaliella salina to Environmental Stress †

International Journal of Molecular Sciences

DOI

2012

The N-terminus modulates human Caf1 activity, structural stability and aggregation

International Journal of Biological Macromolecules

DOI

2012

A Deadenylase Assay by Size-Exclusion Chromatography

PLoS ONE

DOI

2011

A mitochondria-localized glutamic acid-rich protein (MGARP/OSAP) is highly expressed in retina that exhibits a large area of intrinsic disorder

Molecular Biology Reports

DOI

2011

The Benefits of Being β-Crystallin Heteromers: βB1-Crystallin Protects βA3-Crystallin against Aggregation during Co-refolding

Biochemistry

DOI

2011

A novel mutation impairing the tertiary structure and stability of γC-crystallin (CRYGC) leads to cataract formation in humans and zebrafish lens

Human Mutation

DOI

2011

Metallothioneins protect cytosolic creatine kinases against stress induced by nitrogen-based oxidants

Biochemical Journal

DOI

2011

Dissimilarity in the Folding of Human Cytosolic Creatine Kinase Isoenzymes

PLoS ONE

DOI

2011

The Congenital Cataract-Linked G61C Mutation Destabilizes γD-Crystallin and Promotes Non-Native Aggregation

PLoS ONE

DOI

2011

Dissimilar Roles of the Four Conserved Acidic Residues in the Thermal Stability of Poly(A)-Specific Ribonuclease

International Journal of Molecular Sciences

DOI

2011

Impact of the 237th Residue on the Folding of Human Carbonic Anhydrase II

International Journal of Molecular Sciences

DOI

2011

Slow skeletal muscle myosin-binding protein-C (MyBPC1) mediates recruitment of muscle-type creatine kinase (CK) to myosin

Biochemical Journal

DOI

2011

A novel mutation in CRYBB1 associated with congenital cataract-microcornea syndrome: the p.Ser129Arg mutation destabilizes the βB1/βA3-crystallin heteromer but not the βB1-crystallin homomer

Human Mutation

DOI

2010

A novel CRYGD mutation (p.Trp43Arg) causing autosomal dominant congenital cataract in a Chinese family

Human Mutation

DOI

2010

Generation of the oxidized form protects human brain type creatine kinase against cystine-induced inactivation

International Journal of Biological Macromolecules

DOI

2010

Sequential Events in the Irreversible Thermal Denaturation of Human Brain-Type Creatine Kinase by Spectroscopic Methods

International Journal of Molecular Sciences

DOI

2010

Dissecting the key residues crucial for the species-specific thermostability of muscle-type creatine kinase

International Journal of Biological Macromolecules

DOI

2010

Isoenzyme-specific thermostability of human cytosolic creatine kinase

International Journal of Biological Macromolecules

DOI

2010

Effects of congenital cataract mutation R116H on αA-crystallin structure, function and stability

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

DOI

2009

Contributions of the C-Terminal Helix to the Structural Stability of a Hyperthermophilic Fe-Superoxide Dismutase (TcSOD)

International Journal of Molecular Sciences

DOI

2009

Effects of Acrylamide on the Activity and Structure of Human Brain Creatine Kinase

International Journal of Molecular Sciences

DOI

2009

Inactivation and Unfolding of the Hyperthermophilic Inorganic Pyrophosphatase from Thermus thermophilus by Sodium Dodecyl Sulfate

International Journal of Molecular Sciences

DOI

2009

Conformational stability and multistate unfolding of poly(A)‐specific ribonuclease

FEBS Journal

DOI

2009

Mutation of the conserved Asp122 in the linker impedes creatine kinase reactivation and refolding

International Journal of Biological Macromolecules

DOI

2008

Allosteric regulation of human poly(A)-specific ribonuclease by cap and potassium ions

Biochemical and Biophysical Research Communications

DOI

2008

The conserved Cys254 plays a crucial role in creatine kinase refolding under non-reduced conditions but not in its activity or stability

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

DOI

2008

Oligomerization and Aggregation of Bovine Pancreatic Ribonuclease A:Backbone Hydration Probed by Infrared Band-Shift

Protein and Peptide Letters

DOI

2008

A novel mutation in AlphaA-crystallin (CRYAA) caused autosomal dominant congenital cataract in a large Chinese family

Human Mutation

DOI

2008

Biophysical and biochemical characterization of recombinant human Pop2 deadenylase

Protein Expression and Purification

DOI

2008

Multistate folding of a hyperthermostable Fe-superoxide dismutase (TcSOD) in guanidinium hydrochloride: The importance of the quaternary structure

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics

DOI

2007

Blocking creatine kinase refolding by trace amounts of copper ions

Journal of Inorganic Biochemistry

DOI

2007

Reshaping the folding energy landscape of human carbonic anhydrase II by a single point genetic mutation Pro237His

The International Journal of Biochemistry & Cell Biology

DOI

2007

Role of the RRM domain in the activity, structure and stability of poly(A)-specific ribonuclease

Archives of Biochemistry and Biophysics

DOI

2007

The Generation of the Oxidized Form of Creatine Kinase Is a Negative Regulation on Muscle Creatine Kinase

Journal of Biological Chemistry

DOI

2007

Role of the linker between the N- and C-terminal domains in the stability and folding of rabbit muscle creatine kinase

The International Journal of Biochemistry & Cell Biology

DOI

2007

Effects of glycerol on the compaction and stability of the wild type and mutated rabbit muscle creatine kinase

Proteins Structure Function and Bioinformatics

DOI

2007

The R3H domain stabilizes poly(A)-specific ribonuclease by stabilizing the RRM domain

Biochemical and Biophysical Research Communications

DOI

2007

Effect of magnesium ions on the thermal stability of human poly(A)‐specific ribonuclease

FEBS Letters

DOI

2006

Effects of the single point genetic mutation D54G on muscle creatine kinase activity, structure and stability

The International Journal of Biochemistry & Cell Biology

DOI

2006

Polyvinylpyrrolidone 40 Assists the Refolding of Bovine Carbonic Anhydrase B by Accelerating the Refolding of the First Molten Globule Intermediate

Journal of Biological Chemistry

DOI

2006

Dissecting the Pretransitional Conformational Changes in Aminoacylase I Thermal Denaturation

Biophysical Journal

DOI

2006

Impact of intra‐subunit domain–domain interactions on creatine kinase activity and stability

FEBS Letters

DOI

2006

Effects of hydroxypropyl cyclodextrins on the reactivation of SDS-denatured aminoacylase

International Journal of Biological Macromolecules

DOI

2006

Assisting the Reactivation of Guanidine Hydrochloride-Denatured Aminoacylase by Hydroxypropyl Cyclodextrins

Biophysical Journal

DOI

2006

Oligomerization and Aggregation of Bovine Pancreatic Ribonuclease A: Characteristic Events Observed by FTIR Spectroscopy

Biophysical Journal

DOI

2005

Probing conformational changes of proteins by quantitative second-derivative infrared spectroscopy

Analytical Biochemistry

DOI

2005

Catalysis of Creatine Kinase Refolding by Protein Disulfide Isomerase Involves Disulfide Cross-link and Dimer to Tetramer Switch

Journal of Biological Chemistry

DOI

2005

Conformational Change in the C-Terminal Domain Is Responsible for the Initiation of Creatine Kinase Thermal Aggregation

Biophysical Journal

DOI

2005

Increase of soluble expression in Escherichia coli cytoplasm by a protein disulfide isomerase gene fusion system

Protein Expression and Purification

DOI

2004

Osmophobic Effect of Glycerol on Irreversible Thermal Denaturation of Rabbit Creatine Kinase

Biophysical Journal

DOI

2004

Protein Thermal Aggregation Involves Distinct Regions: Sequential Events in the Heat-Induced Unfolding and Aggregation of Hemoglobin

Biophysical Journal

DOI

2003

Two-Dimensional Infrared Correlation Spectroscopy Study of Sequential Events in the Heat-Induced Unfolding and Aggregation Process of Myoglobin

Biophysical Journal

DOI

2003

Three-dimensional solution structure of ω-conotoxin SO3 determined by1H NMR

Chinese Science Bulletin

DOI

2002

Biphasic reductive unfolding of ribonuclease A is temperature dependent

European Journal of Biochemistry

DOI

2002

Two-state kinetics characterized by image analysis of nuclear magnetic resonance spectra

Chinese Science Bulletin

DOI

2015

Public impact, prevention, and treatment of cataracts

Science China Life Sciences

DOI