熊鲲｜中南大学｜学者主页

2026

PANoptosis in diabetic wound repair and regeneration: Current evidence and mechanistic perspectives

Xiaoxiang Wang, Fujun Wang, Ziqiang Wang, Tenjie Jin, Yongjian Chen, Kun Xiong, Ronghua Yang

TransMed

DOI

2026

Acetylation of PRDX5 aggravates the oxidative stress and apoptosis of retinal neurons induced by ischemia-reperfusion

Shuang Lu, Lewen Wang, Keting Wang, Kun Xiong, Weitao Yan, Chi Zhang

Tissue and Cell

DOI

2026

Mitochondrial oxidative stress to PANoptosis: Current evidence and therapeutic implications for neurological diseases

Ye He, Limin Guo, Lewen Wang, Zixin Li, Rui Lu, Xinxing Wan, Na Liu, Weitao Yan, Haifeng Wang, Qí Zhāng, Kun Xiong

Journal of Advanced Research

DOI

2026

As a novel ferroptosis inhibitor, primaquine alleviates I/R-induced retinal neuron death via increasing GSTA1 activity

Shuang Lu, Lewen Wang, Keting Wang, Kun Xiong, Weitao Yan

Biomedicine & Pharmacotherapy

DOI

2026

TAK1 activates PANoptosis through the NF-κB signalling pathway to delay diabetic wound healing

Xiaoxiang Wang, Sitong Zhou, Yixun Zhang, Xuewei Zhang, Shuilan Wu, Yan Huang, Julin Xie, Kun Xiong, Ronghua Yang

Burns & Trauma

DOI

2026

Hypoxic preconditioning alleviates hypoxia-induced anapyrexia by attenuating cerebral lactate elevation.

Tian Yang, Jun-Xia Li, Ze-Jun Wang, Kun Xiong, Yu Wang, Lan Feng, Fabo Shan, Qing-Yuan Huang

Neuroscience

DOI

2025

New technologies for the treatment of traumatic brain injury: A narrative review of epigenetic regulation of neuroinflammation

Jiawei Xu, Yanqing Zuo, Tengyue Zhang, Ye He, Tianlin Long, Meng Jiao, Rui Lu, Kun Xiong, Yuhua Chen

Advanced technology in neuroscience .

DOI

2025

Non-canonical role of “S6K1–SGK1” pathway in neuronal necroptosis following traumatic brain injury

Shuchao Wang, Yating Tan, Miaohui Hu, Meijuan Wang, Lu Liang, Xing Luo, Dan Chen, Bing Jiang, Ceshi Chen, Jufang Huang, Kun Xiong

Genes & Diseases

DOI

2025

L-arginine: A promising metabolite in enhancing the protective effects of adipose-derived stem cells against ischemic pathologies

Na Liu, Xin-xing Wan, Weitao Yan, Kun Xiong

World Journal of Stem Cells

DOI

2025

Mechanisms and Mitochondria-targeted Therapies for Retinal Ganglion Cell Degeneration in Glaucoma

Juanjuan Guan, Haibo Li, Kun Xiong

CNS & Neurological Disorders - Drug Targets

DOI

2025

A CoQ10 analog ameliorates cognitive impairment and early brain injury after subarachnoid hemorrhage by regulating ferroptosis and neuroinflammation

Junhui Chen, Zhonghua Shi, Yuhua Chen, Kun Xiong, Yuhai Wang, Hongqi Zhang

Redox Biology

DOI

2025

TAK 1 at the crossroads of multiple regulated cell death pathways: from molecular mechanisms to human diseases

Kun Huang, Qí Zhāng, Hao Wan, Xiao-xia Ban, Xinyu Chen, Xin-xing Wan, Rui Lu, Ye He, Kun Xiong

FEBS Journal

DOI

2025

Noncanonical feedback loop between “RIP3–MLKL” and “4EBP1–eIF4E” promotes neuronal necroptosis

Shuchao Wang, Yun Zhang, Meijuan Wang, Zhihao Zhai, Yating Tan, Weiye Xu, Xiaozhen Ren, Ximin Hu, Jinyou Mo, Jia Liu, Yunfeng Yang, Dan Chen, Bing Jiang, Hualin Huang, Jufang Huang, Kun Xiong

MedComm

DOI

2025

Voltage-dependent anion channel 1 oligomerization regulates PANoptosis in retinal ischemia–reperfusion injury

Hao Wan, Xiao-xia Ban, Ye He, Yandi Yang, Ximin Hu, Lei Shang, Xin-xing Wan, Qí Zhāng, Kun Xiong

Neural Regeneration Research

DOI

2024

Review of: "Synapse Weakening-Induced Caspase-3 Activity Confers Specificity to Microglia-Mediated Synapse Elimination"

Kun Xiong

DOI

2024

Bibliometric and visualized analysis on global trends and hotspots of TAK1 in regulated cell death: 1999 to 2024

Kun Huang, Ye He, Hao Wan, Xiao-xia Ban, Xinyu Chen, Xi-Min Hu, Xin-xing Wan, Lu Rui, Qí Zhāng, Kun Xiong

Frontiers in Immunology

DOI

2024

Pretreatment can alleviate programmed cell death in mesenchymal stem cells

Xin-xing Wan, Xi-Min Hu, Qí Zhāng, Kun Xiong

World Journal of Stem Cells

DOI

2024

Editorial: Neuroinflammation and cognitive impairment

Juan Li, Yang Wang, Kun Xiong, Chengjin Gao

Frontiers in Aging Neuroscience

DOI

2024

WTAP participates in neuronal damage by protein translation of NLRP3 in an m6A-YTHDF1-dependent manner after traumatic brain injury

Yuhua Chen, Tianlin Long, Junhui Chen, Hong Wei, Jiao Meng, Meili Kang, Juning Wang, Xin Zhang, Quanhua Xu, Chi Zhang, Kun Xiong

International Journal of Surgery

DOI

2024

Oroxin A alleviates early brain injury after subarachnoid hemorrhage by regulating ferroptosis and neuroinflammation

Junhui Chen, Zhonghua Shi, Chunlei Zhang, Kun Xiong, Wei Zhao, Yuhai Wang

Journal of Neuroinflammation

DOI

2024

Editorial: Novel strategies to target cell death signaling in cancer and neurodegenerative diseases: new findings and mechanistic studies

Qí Zhāng, Kun Xiong

Frontiers in Cell and Developmental Biology

DOI

2024

Multiple pretreatments can effectively improve the functionality of mesenchymal stem cells

Xin-xing Wan, Ximin Hu, Kun Xiong

World Journal of Stem Cells

DOI

2024

Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases

Xiao-xia Ban, Hao Wan, Xin-xing Wan, Ya-ting Tan, Ximin Hu, Hong-xia Ban, Xinyu Chen, Kun Lun Huang, Qí Zhāng, Kun Xiong

Current Medical Science

DOI

2024

Effects of Herpud1 in Methamphetamine-induced Neuronal Apoptosis

Shuang Lu, Yan Li, Lewen Wang, Kun Xiong, Jie Yan, Zhihao Zhai, Weitao Yan

Current Medicinal Chemistry

DOI

2024

The Role of Sgt1 in Methamphetamine/Hyperthermia-induced Necroptosis

Shuang Lu, Lewen Wang, Lvshuang Liao, Shuliang Niu, Kun Xiong, Jie Yan, Weitao Yan

Current Medicinal Chemistry

DOI

2023

VDAC1, as a downstream molecule of MLKL, participates in OGD/R-induced necroptosis by inducing mitochondrial damage

Hao Wan, Yandi Yang, Qí Zhāng, Yuhua Chen, Ximin Hu, Yanxia Huang, Lei Shang, Kun Xiong

Heliyon

DOI

2023

Regulated Cell Death of Retinal Ganglion Cells in Glaucoma: Molecular Insights and Therapeutic Potentials

Wenjuan Zhao, Chun-ling Fan, Ximin Hu, Xiao-xia Ban, Hao Wan, Ye He, Qí Zhāng, Kun Xiong

Cellular and Molecular Neurobiology

DOI

2023

Akkermansia muciniphila-Nlrp3 is involved in the neuroprotection of phosphoglycerate mutase 5 deficiency in traumatic brain injury mice

Yuhua Chen, Junhui Chen, Hong Wei, Kai Gong, Jiao Meng, Tianlin Long, Guo JianFeng, Jun Ki Hong, Lingjian Yang, Junling Qiu, Kun Xiong, Zhanxiang Wang, Quanhua Xu

Frontiers in Immunology

DOI

2023

HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model

Yifu He, Ximin Hu, Md. Asaduzzaman Khan, Boyao Yu, Yi-cun Sheng, Xianzhong Xiao, Xin-xing Wan, Sipin Tan, Kun Xiong

Mediators of Inflammation

DOI

2023

DTX3L induced NLRP3 ubiquitination inhibit R28 cell pyroptosis in OGD/R injury

Ziyu Zhou, Lei Shang, Qí Zhāng, Ximin Hu, Ju-fang Huang, Kun Xiong

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

DOI

2023

Inhibition of mitochondrial VDAC1 oligomerization alleviates apoptosis and necroptosis of retinal neurons following OGD/R injury

Hao Wan, Yan-di Yan, Xi-min Hu, Lei Shang, Yuhua Chen, Yanxia Huang, Qí Zhāng, Weitao Yan, Kun Xiong

Annals of Anatomy - Anatomischer Anzeiger

DOI

2023

Netrin-1 Alleviates Early Brain Injury by Regulating Ferroptosis via the PPARγ/Nrf2/GPX4 Signaling Pathway Following Subarachnoid Hemorrhage

Junhui Chen, Yuhai Wang, Mingchang Li, Xun Zhu, Zhuang‐Hua Liu, Qianxue Chen, Kun Xiong

Translational Stroke Research

DOI

2023

Targeting Necroptosis: A Novel Therapeutic Option for Retinal Degenerative Diseases

Qí Zhāng, Ximin Hu, Wenjuan Zhao, Xiao-xia Ban, Yan Li, Yanxia Huang, Hao Wan, Ye He, Lvshuang Liao, Lei Shang, Bin Jiang, Guoping Qing, Kun Xiong

International Journal of Biological Sciences

DOI

2023

A New Paradigm in Spinal Cord Injury Therapy: from Cell-free Treatment to Engineering Modifications.

Bo Qin, Xi-Min Hu, Yan-Xia Huang, Rong Yang, Kun Xiong

CNS and Neurological Disorders - Drug Targets

DOI

2022

ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic Implications

Xinyu Chen, Yinghong Dai, Xin-xing Wan, Ximin Hu, Wenjuan Zhao, Xiao-xia Ban, Hao Wan, Kun Huang, Qí Zhāng, Kun Xiong

Molecules

DOI

2022

Molecular mechanisms of neuronal death in brain injury after subarachnoid hemorrhage

Junhui Chen, Mingchang Li, Zhuang‐Hua Liu, Yuhai Wang, Kun Xiong

Frontiers in Cellular Neuroscience

DOI

2022

PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons

Weitao Yan, Wenjuan Zhao, Ximin Hu, Xiao-xia Ban, Wen-Ya Ning, Hao Wan, Qí Zhāng, Kun Xiong

Neural Regeneration Research

DOI

2022

The regulatory role of Pin1 in neuronal death

Kun Xiong, Shuchao Wang, Ximin Hu

Neural Regeneration Research

DOI

2022

Insight into Crosstalk Between Mitophagy and Apoptosis/Necroptosis: Mechanisms and Clinical Applications in Ischemic Stroke

Yandi Yang, Zi-xin Li, Ximin Hu, Hao Wan, Qí Zhāng, Rui Xiao, Kun Xiong

Current Medical Science

DOI

2021

青光眼性视网膜神经节细胞程序性坏死的机制

赵文娟，范春玲，洪俊，何烨，胡熙敏，张齐，熊鲲

《中国医刊》

2021

Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies

Qí Zhāng, Kun Xiong, Weitao Yan, Yandi Yang, Ximin Hu, Wen-Ya Ning, Lyu-Shuang Liao, Shuang Lu, Wenjuan Zhao

Neural Regeneration Research

DOI

2021

Regulatory Strategies for Cell Death in Neurological Diseases

Yuhua Chen, Kun Xiong

CNS & Neurological Disorders - Drug Targets

DOI

2021

The Role of HSP90α in Methamphetamine/Hyperthermia-Induced Necroptosis in Rat Striatal Neurons

Lvshuang Liao, Shuang Lu, Weitao Yan, Shu‐chao Wang, Limin Guo, Yandi Yang, Kai Huang, Ximin Hu, Qí Zhāng, Jie Yan, Kun Xiong

Frontiers in Pharmacology

DOI

2021

Adenosine A3 receptor activated in H2O2 oxidative stress of primary open-angle glaucoma

Ziyu Zhou, Zhaolin Gao, Weitao Yan, Yun Zhang, Jufang Huang, Kun Xiong

Annals of Translational Medicine

DOI

2021

Guidelines for Regulated Cell Death Assays: A Systematic Summary, A Categorical Comparison, A Prospective

Ximin Hu, Zhixin Li, Ruihan Lin, Jia-qi Shan, Qingwei Yu, Ruixuan Wang, Lvshuang Liao, Weitao Yan, Wang Zhen, Lei Shang, Yanxia Huang, Qí Zhāng, Kun Xiong

Frontiers in Cell and Developmental Biology

DOI

2021

iTRAQ-based proteomic analysis of the rat striatum in response to methamphetamine preconditioning

Shuang Lu, Yandi Yang, Lvshuang Liao, Weitao Yan, Kun Xiong, Jie Yan

Acta Biochimica et Biophysica Sinica

DOI

2021

Bibliometric Analysis of the Inflammasome and Pyroptosis in Brain

Yuhua Chen, Yan Li, Limin Guo, Jun Young Hong, Wenjuan Zhao, Ximin Hu, Cuicui Chang, Wei Liu, Kun Xiong

Frontiers in Pharmacology

DOI

2021

c-FLIP regulates pyroptosis in retinal neurons following oxygen-glucose deprivation/recovery via a GSDMD-mediated pathway

Yanxia Huang, Shuchao Wang, Fei Huang, Qí Zhāng, Bo Qin, Lvshuang Liao, Mi Wang, Hao Wan, Weitao Yan, Dan Chen, Fengxia Liu, Bing Jiang, Dan Ji, Xiaobo Xia, Jufang Huang, Kun Xiong

Annals of Anatomy - Anatomischer Anzeiger

DOI

2021

Research trends, hot spots and prospects for necroptosis in the field of neuroscience

Kun Xiong, Weitao Yan, Shuang Lu, Yandi Yang, Wen-Ya Ning, Yan Cai, Xi-Min Hu, Qí Zhāng

Neural Regeneration Research

DOI

2020

Cdk5-mediated Drp1 phosphorylation drives mitochondrial defects and neuronal apoptosis in radiation-induced optic neuropathy

Rong Rong, Xiaobo Xia, Haiqin Peng, Haibo Li, Mengling You, Zhuotao Liang, Fei Yao, Xueyan Yao, Kun Xiong, Jufang Huang, Rongrong Zhou, Dan Ji

Cell Death and Disease

DOI

2020

NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1

Jie Zhu, Likun Yang, Qiuhong Wang, Wei Lin, Yi Feng, Ye-Ping Xu, Wei-Liang Chen, Kun Xiong, Yuhai Wang

Molecular Medicine Reports

DOI

2020

Regulatory Role of Chinese Herbal Medicine in Regulated Neuronal Death

Xiuyu Wu, Ximin Hu, Qí Zhāng, Fengxia Liu, Kun Xiong

CNS & Neurological Disorders - Drug Targets

DOI

2020

RSK3 mediates necroptosis by regulating phosphorylation of RIP3 in rat retinal ganglion cells

Mi Wang, Hao Wan, Shuchao Wang, Lvshuang Liao, Yanxia Huang, Limin Guo, Fengxia Liu, Lei Shang, Jufang Huang, Dan Ji, Xiaobo Xia, Bin Jiang, Dan Chen, Kun Xiong

Journal of Anatomy

DOI

2019

RIP3/MLKL-mediated neuronal necroptosis induced by methamphetamine at 39°C

Jie Yan, Kun Xiong, Limin Guo, Zhen Wang, Shiping Li, Mi Wang, Weitao Yan, Fengxia Liu, Chudong Wang, Xu-Dong Zhang, Dan Chen

Neural Regeneration Research

DOI

2019

Regional Expression of Act-MMP3 Contributes to the Selective Loss of Neurons in Ganglion Cell Layers following Acute Retinal ischemia/Reperfusion Injury

Tu Hu, Shuchao Wang, Leping Zeng, Kun Xiong, Dan Chen, Jufang Huang

Current Eye Research

DOI

2019

Silencing of GAS5 Alleviates Glaucoma in Rat Models by Reducing Retinal Ganglion Cell Apoptosis

Rongrong Zhou, Haibo Li, Qi Sheng You, Rong Rong, Mengling You, Kun Xiong, Ju-Fang Huang, Xiaobo Xia, Dan Ji

Human Gene Therapy

DOI

2019

Antioxidant cascades confer neuroprotection in ethanol, morphine, and methamphetamine preconditioning

Shuang Lu, Lvshuang Liao, Bing Zhang, Weitao Yan, Liangpei Chen, Yan He, Limin Guo, Shanshan Lu, Kun Xiong, Jie Yan

Neurochemistry International

DOI

2019

Pin1 Is Regulated by CaMKII Activation in Glutamate-Induced Retinal Neuronal Regulated Necrosis

Shuchao Wang, Lvshuang Liao, Yanxia Huang, Mi Wang, Hongkang Zhou, Dan Chen, Fengxia Liu, Dan Ji, Xiaobo Xia, Bing Jiang, Jufang Huang, Kun Xiong

Frontiers in Cellular Neuroscience

DOI

2019

Current status and potential role of circular RNAs in neurological disorders

Shanshan Lu, Xue Feng Yang, Chudong Wang, Siqi Chen, Shuang Lu, Weitao Yan, Kun Xiong, Fengxia Liu, Jie Yan

Journal of Neurochemistry

DOI

2019

Redox regulation in hydrogen sulfide action: From neurotoxicity to neuroprotection

Xue Feng Yang, Chudong Wang, Xudong Zhang, Siqi Chen, Liangpei Chen, Shanshan Lu, Shuang Lu, Xisheng Yan, Kun Xiong, Fengxia Liu, Jie Yan

Neurochemistry International

DOI

2019

Expression signatures of long non-coding RNA and mRNA in human traumatic brain injury

Yuhai Wang, Likun Yang, Jie Zhu, Jun-Hui Chen, Yu-Hai Wang, Kun Xiong

Neural Regeneration Research

DOI

2018

RSK3及其生物学功能

王咪，熊鲲

《暨南大学学报(自然科学与医学版)》

2018

Calpain2 but not calpain1 mediated by calpastatin following glutamate-induced regulated necrosis in rat retinal neurons

Shuchao Wang, Yanxia Huang, Yuhan Yan, Hongkang Zhou, Mi Wang, Lvshuang Liao, Zhen Wang, Dan Chen, Dan Ji, Xiaobo Xia, Fengxia Liu, Jufang Huang, Kun Xiong

Annals of Anatomy - Anatomischer Anzeiger

DOI

2018

Progress in studies of necroptosis and its relationship to disease processes

Zhen Wang, Limin Guo, Shu‐chao Wang, Dan Chen, Jie Yan, Fengxia Liu, Ju-fang Huang, Kun Xiong

Pathology - Research and Practice

DOI

2018

Using drugs to target necroptosis: dual roles in disease therapy.

Zhen Wang, Li Guo, Hong Kang Zhou, Hongke Qu, Shu Chao Wang, Feng Xia Liu, Dan Chen, Ju Huang, Kun Xiong

PubMed

DOI

2018

The Main Molecular Mechanisms Underlying Methamphetamine- Induced Neurotoxicity and Implications for Pharmacological Treatment

Xue Feng Yang, Yong Wang, Qiyan Li, Yaxian Zhong, Liangpei Chen, Yajun Du, Jing He, Lvshuang Liao, Kun Xiong, Chun‐Xia Yi, Jie Yan

Frontiers in Molecular Neuroscience

DOI

2018

Pin1 Promotes Regulated Necrosis Induced by Glutamate in Rat Retinal Neurons via CAST/Calpain2 Pathway

Shuchao Wang, Lvshuang Liao, Mi Wang, Hongkang Zhou, Yanxia Huang, Zhen Wang, Dan Chen, Dan Ji, Xiaobo Xia, Yong Wang, Fengxia Liu, Jufang Huang, Kun Xiong

Frontiers in Cellular Neuroscience

DOI

2018

Regulatory role of calpain in neuronal death

Kun Xiong, Siying Cheng, Shu‐chao Wang, Ming Lei, Zhen Wang

Neural Regeneration Research

DOI

2017

热休克蛋白调控α-突触核蛋白在帕金森病治疗中的研究进展

汤镇维，熊鲲

《解剖学杂志》

2017

c-FLIP:细胞死亡和组织稳态的调控器

李鸿儒，沈元龙，胡勇军，熊鲲

《解剖学杂志》

2017

Inhibition of HSP90α protects cultured neurons from oxygen‐glucose deprivation induced necroptosis by decreasing RIP3 expression

Zhen Wang, Limin Guo, Yong Wang, Hong‐kang Zhou, Shu‐chao Wang, Dan Chen, Ju‐fang Huang, Kun Xiong

Journal of Cellular Physiology

DOI

2017

Circular RNAs: A Novel Player in Development and Disease of the Central Nervous System

Lili Xie, Mao Mao, Kun Xiong, Bing‐Hua Jiang

Frontiers in Cellular Neuroscience

DOI

2017

Mixed lineage kinase domain-like protein induces RGC-5 necroptosis following elevated hydrostatic pressure

Lvshuang Liao, Lei Shang, Na Li, Shuchao Wang, Mi Wang, Yanxia Huang, Dan Chen, Jufang Huang, Kun Xiong

Acta Biochimica et Biophysica Sinica

DOI

2017

Overview of long non-coding RNA and mRNA expression in response to methamphetamine treatment in vitro

Kun Xiong, Lingling Long, Xudong Zhang, Hongke Qu, Haixiao Deng, Yanjun Ding, Jifeng Cai, Shuchao Wang, Wang Mi, Lvshuang Liao, Jufang Huang, Chun‐Xia Yi, Jie Yan

Toxicology in Vitro

DOI

2016

Inhibition of Calpain on Oxygen Glucose Deprivation-induced RGC-5 Necroptosis

陈爽，闫杰，邓海霄，龙玲玲，胡勇军，王咪，尚蕾，陈旦，黄菊芳，熊鲲

Current Medical Science

2016

The effects and regulatory mechanism of RIP3 on RGC-5 necroptosis following elevated hydrostatic pressure

Lei Shang, Wei Ding, Na Li, Lvshuang Liao, Dan Chen, Jufang Huang, Kun Xiong

Acta Biochimica et Biophysica Sinica

DOI

2016

Necroptosis contributes to methamphetamine-induced cytotoxicity in rat cortical neurons

Kun Xiong, Huidan Liao, Lingling Long, Yanjun Ding, Jufang Huang, Jie Yan

Toxicology in Vitro

DOI

2016

The Toxic Effect of ALLN on Primary Rat Retinal Neurons

Na Li, Lei Shang, Shuchao Wang, Lvshuang Liao, Dan Chen, Ju-Fang Huang, Kun Xiong

Neurotoxicity Research

DOI

2015

线粒体在神经元程序性死亡中的作用新进展

丁伟，尚蕾，熊鲲

《现代生物医学进展》

2015

钙蛋白酶调控细胞死亡的研究进展

李娜，尚蕾，熊鲲，黄菊芳

《解剖学杂志》

2015

Receptor interacting protein 3-induced RGC-5 cell necroptosis following oxygen glucose deprivation

Wei Ding, Lei Shang, Ju-Fang Huang, Na Li, Dan Chen, Lixiang Xue, Kun Xiong

BMC Neuroscience

DOI

2014

The effect and underlying mechanism of Timosaponin B-II on RGC-5 necroptosis induced by hydrogen peroxide

San-Hong Jiang, Lei Shang, Lixiang Xue, Wei Ding, Shuang Chen, Ruo-Fei Ma, Ju-Fang Huang, Kun Xiong

BMC Complementary and Alternative Medicine

DOI

2014

Regulatory effects of inhibiting the activation of glial cells on retinal synaptic plasticity

Dan Chen, Jufang Huang, Lihong Zhou, Hui Wang, Jia Luo, Kun Xiong, Leping Zeng

Neural Regeneration Research

DOI

2013

Distribution of thrombospondins and their neuronal receptor α2δ1 in the rat retina

Jufang Huang, Lihong Zhou, Hui Wang, Jia Luo, Leping Zeng, Kun Xiong, Dan Chen

Experimental Eye Research

DOI

2013

γ‐Secretase binding sites in aged and A lzheimer's disease human cerebrum: the choroid plexus as a putative origin of CSF A β

Fei Liu, Zhi‐Qin Xue, Si-Hao Deng, Kun Xiong, Xuegang Luo, Peter R. Patrylo, Gregory M. Rose, Huaibin Cai, Robert G. Struble, Yan Cai, Xiao‐Xin Yan

European Journal of Neuroscience

DOI

2013

Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response

Ju-Fang Huang, Lei Shang, Mengqi Zhang, Hui Wang, Dan Chen, Jianbin Tong, He Huang, Xiao‐Xin Yan, Leping Zeng, Kun Xiong

BMC Neuroscience

DOI

2013

Expression of Glutamate and GABA during the Process of Rat Retinal Synaptic Plasticity Induced by Acute High Intraocular Pressure

Lihong Zhou, Jufang Huang, Hui Wang, Jia Luo, Leping Zeng, Kun Xiong, Dan Chen

ACTA HISTOCHEMICA ET CYTOCHEMICA

DOI

2012

脑神经元死亡的研究进展

黄菊芳，李岚，尚蕾，熊鲲

《中国现代医学杂志》

2012

金属污染物对神经系统损害及毒性机制研究进展

范洁琳，徐丽伟，王慧，江汉臣，熊鲲

《生态毒理学报》

2012

触觉剥夺后豚鼠桶状皮质DCX阳性细胞的实验研究

高俊彦，李明，薛志琴，贺旭，杨燕，严小新，熊鲲

《现代生物医学进展》

2012

Timosaponin-BII inhibits the up-regulation of BACE1 induced by Ferric Chloride in rat retina

Ju-Fang Huang, Lei Shang, Pei Liu, Mengqi Zhang, Shuang Chen, Dan Chen, Chunling Fan, Hui Wang, Kun Xiong

BMC Complementary and Alternative Medicine

DOI

2012

Spatiotemporal alterations of presynaptic elements in the retina after high intraocular pressure.

Jufang Huang, Lihong Zhou, Hui Wang, Jia Luo, Kun Xiong, Leping Zeng, Dan Chen

PubMed

DOI

2012

Research progress in death mechanisms of neurons

Kun Xiong

Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi

2011

RIP3及其生物学功能研究进展

尚蕾，熊鲲，王慧，黄菊芳

《中国细胞生物学学报》

2009

雷公藤甲素抑制APP/PS1双转基因AD模型小鼠海马内Aβ沉积和老年斑形成

雷德亮，李明波，熊鲲，邓小华，罗学港

《解剖学报》

2008

β-位点淀粉样前体蛋白剪切酶-1与阿尔茨海默病

熊鲲，邓小华，罗学港，严小新，王慧

《解剖学杂志》

2006

脑源性神经营养因子对急性高眼压后大鼠视网膜 Müller 细胞的影响

熊鲲，黄菊芳，蒋丽珠，陈旦，王慧，童建斌，罗学港

《解剖学杂志》

2006

脑源性神经营养因子预处理后急性高眼压下大鼠视网膜TrkB的表达变化

黄菊芳，蒋丽珠，童建斌，陈旦，熊鲲，曾乐平

《解剖学杂志》

精选作品

期刊论文

PANoptosis in diabetic wound repair and regeneration: Current evidence and mechanistic perspectives

Acetylation of PRDX5 aggravates the oxidative stress and apoptosis of retinal neurons induced by ischemia-reperfusion

Mitochondrial oxidative stress to PANoptosis: Current evidence and therapeutic implications for neurological diseases

As a novel ferroptosis inhibitor, primaquine alleviates I/R-induced retinal neuron death via increasing GSTA1 activity

TAK1 activates PANoptosis through the NF-κB signalling pathway to delay diabetic wound healing

Hypoxic preconditioning alleviates hypoxia-induced anapyrexia by attenuating cerebral lactate elevation.

New technologies for the treatment of traumatic brain injury: A narrative review of epigenetic regulation of neuroinflammation

Non-canonical role of “S6K1–SGK1” pathway in neuronal necroptosis following traumatic brain injury

L-arginine: A promising metabolite in enhancing the protective effects of adipose-derived stem cells against ischemic pathologies

Mechanisms and Mitochondria-targeted Therapies for Retinal Ganglion Cell Degeneration in Glaucoma

A CoQ10 analog ameliorates cognitive impairment and early brain injury after subarachnoid hemorrhage by regulating ferroptosis and neuroinflammation

TAK 1 at the crossroads of multiple regulated cell death pathways: from molecular mechanisms to human diseases

Noncanonical feedback loop between “RIP3–MLKL” and “4EBP1–eIF4E” promotes neuronal necroptosis

Voltage-dependent anion channel 1 oligomerization regulates PANoptosis in retinal ischemia–reperfusion injury

Review of: "Synapse Weakening-Induced Caspase-3 Activity Confers Specificity to Microglia-Mediated Synapse Elimination"

Bibliometric and visualized analysis on global trends and hotspots of TAK1 in regulated cell death: 1999 to 2024

Pretreatment can alleviate programmed cell death in mesenchymal stem cells

Editorial: Neuroinflammation and cognitive impairment

WTAP participates in neuronal damage by protein translation of NLRP3 in an m6A-YTHDF1-dependent manner after traumatic brain injury

Oroxin A alleviates early brain injury after subarachnoid hemorrhage by regulating ferroptosis and neuroinflammation

Editorial: Novel strategies to target cell death signaling in cancer and neurodegenerative diseases: new findings and mechanistic studies

Multiple pretreatments can effectively improve the functionality of mesenchymal stem cells

Copper Metabolism and Cuproptosis: Molecular Mechanisms and Therapeutic Perspectives in Neurodegenerative Diseases

Effects of Herpud1 in Methamphetamine-induced Neuronal Apoptosis

The Role of Sgt1 in Methamphetamine/Hyperthermia-induced Necroptosis

VDAC1, as a downstream molecule of MLKL, participates in OGD/R-induced necroptosis by inducing mitochondrial damage

Regulated Cell Death of Retinal Ganglion Cells in Glaucoma: Molecular Insights and Therapeutic Potentials

Akkermansia muciniphila-Nlrp3 is involved in the neuroprotection of phosphoglycerate mutase 5 deficiency in traumatic brain injury mice

HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model

DTX3L induced NLRP3 ubiquitination inhibit R28 cell pyroptosis in OGD/R injury

Inhibition of mitochondrial VDAC1 oligomerization alleviates apoptosis and necroptosis of retinal neurons following OGD/R injury

Netrin-1 Alleviates Early Brain Injury by Regulating Ferroptosis via the PPARγ/Nrf2/GPX4 Signaling Pathway Following Subarachnoid Hemorrhage

Targeting Necroptosis: A Novel Therapeutic Option for Retinal Degenerative Diseases

A New Paradigm in Spinal Cord Injury Therapy: from Cell-free Treatment to Engineering Modifications.

ZBP1-Mediated Necroptosis: Mechanisms and Therapeutic Implications

Molecular mechanisms of neuronal death in brain injury after subarachnoid hemorrhage

PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons

The regulatory role of Pin1 in neuronal death

Insight into Crosstalk Between Mitophagy and Apoptosis/Necroptosis: Mechanisms and Clinical Applications in Ischemic Stroke

青光眼性视网膜神经节细胞程序性坏死的机制

Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies

Regulatory Strategies for Cell Death in Neurological Diseases

The Role of HSP90α in Methamphetamine/Hyperthermia-Induced Necroptosis in Rat Striatal Neurons

Adenosine A3 receptor activated in H2O2 oxidative stress of primary open-angle glaucoma

Guidelines for Regulated Cell Death Assays: A Systematic Summary, A Categorical Comparison, A Prospective

iTRAQ-based proteomic analysis of the rat striatum in response to methamphetamine preconditioning

Bibliometric Analysis of the Inflammasome and Pyroptosis in Brain

c-FLIP regulates pyroptosis in retinal neurons following oxygen-glucose deprivation/recovery via a GSDMD-mediated pathway

Research trends, hot spots and prospects for necroptosis in the field of neuroscience

Cdk5-mediated Drp1 phosphorylation drives mitochondrial defects and neuronal apoptosis in radiation-induced optic neuropathy

NDRG2 attenuates ischemia-induced astrocyte necroptosis via the repression of RIPK1

Regulatory Role of Chinese Herbal Medicine in Regulated Neuronal Death

RSK3 mediates necroptosis by regulating phosphorylation of RIP3 in rat retinal ganglion cells

RIP3/MLKL-mediated neuronal necroptosis induced by methamphetamine at 39°C

Regional Expression of Act-MMP3 Contributes to the Selective Loss of Neurons in Ganglion Cell Layers following Acute Retinal ischemia/Reperfusion Injury

Silencing of GAS5 Alleviates Glaucoma in Rat Models by Reducing Retinal Ganglion Cell Apoptosis

Antioxidant cascades confer neuroprotection in ethanol, morphine, and methamphetamine preconditioning

Pin1 Is Regulated by CaMKII Activation in Glutamate-Induced Retinal Neuronal Regulated Necrosis

Current status and potential role of circular RNAs in neurological disorders

Redox regulation in hydrogen sulfide action: From neurotoxicity to neuroprotection

Expression signatures of long non-coding RNA and mRNA in human traumatic brain injury

RSK3及其生物学功能

Calpain2 but not calpain1 mediated by calpastatin following glutamate-induced regulated necrosis in rat retinal neurons

Progress in studies of necroptosis and its relationship to disease processes

Using drugs to target necroptosis: dual roles in disease therapy.

The Main Molecular Mechanisms Underlying Methamphetamine- Induced Neurotoxicity and Implications for Pharmacological Treatment

Pin1 Promotes Regulated Necrosis Induced by Glutamate in Rat Retinal Neurons via CAST/Calpain2 Pathway

Regulatory role of calpain in neuronal death

热休克蛋白调控α-突触核蛋白在帕金森病治疗中的研究进展

c-FLIP:细胞死亡和组织稳态的调控器

Inhibition of HSP90α protects cultured neurons from oxygen‐glucose deprivation induced necroptosis by decreasing RIP3 expression

Circular RNAs: A Novel Player in Development and Disease of the Central Nervous System

Mixed lineage kinase domain-like protein induces RGC-5 necroptosis following elevated hydrostatic pressure

Overview of long non-coding RNA and mRNA expression in response to methamphetamine treatment in vitro

Inhibition of Calpain on Oxygen Glucose Deprivation-induced RGC-5 Necroptosis

The effects and regulatory mechanism of RIP3 on RGC-5 necroptosis following elevated hydrostatic pressure

Necroptosis contributes to methamphetamine-induced cytotoxicity in rat cortical neurons

The Toxic Effect of ALLN on Primary Rat Retinal Neurons