谢幼华｜复旦大学｜学者主页

2026

谢幼华

2024

Jie Yu, Zhongliang Shen, Shiqi Chen, Hongyan Liu, Zunguo Du, Richeng Mao, Jinyu Wang, Yongmei Zhang, Haoxiang Zhu, Sisi Yang, Jing Li, Jingwen Wu, Minhui Dong, Mengqi Zhu, Yuxian Huang, Jianhua Li, Zhenghong Yuan, Youhua Xie, Mengji Lu, Jiming Zhang

Antiviral Research

DOI

2022

细胞因子在慢性乙型肝炎治疗中的研究进展

高子翔，沈忠良，刘晶，谢幼华

《临床肝胆病杂志》

2022

谷陈建，吴旸，郭慧敏，朱园飞，徐巍，王玉燕，周瑜，孙志平，蔡霞，李玉瑭，刘晶，黄忠，袁正宏，张荣，邓强，瞿涤，谢幼华

Science Bulletin

2021

张荣，易志刚，王玉燕，滕峥，徐巍，宋武慧，蔡霞，孙志平，谷陈建，周艳秋，陈洪友，叶荣，韩文东，朱云凯，冯飞，房方皓，李崇山，张曦，瞿涤，付晨，谢幼华，袁正宏

《微生物与感染》

2020

SAMHD1对外源DNA的限制作用（英文）

谷陈建，明丽君，方一力，刘雪静，张俊琪，Gennadiy Zelinskyy，邓强，刘晶，谢幼华

Science Bulletin

2020

从新型冠状病毒疫情看生物安全三级实验室的应急能力及内涵建设

蔡霞，韩文东，孙志平，钱韵，陈力，谢幼华，瞿涤

《微生物与感染》

2020

胡孔颖，谷陈建，吴敏乐，陶帅，刘楠楠，刘晶，谢幼华

《微生物与感染》

2019

Ruidong Chen, Xue Zhao, Yongxiang Wang, Youhua Xie, Jing Liu

Scientific Reports

DOI

2016

乙型肝炎病毒Ⅹ蛋白的优势氨基酸序列与热点突变位点的生物信息学分析

王葳，何永刚，浦永兰，潘少坤，谢幼华

《微生物与感染》

2016

人星状病毒临床分离株感染CaCo-2细胞的转录组分析

吴立梦，滕峥，刘晶，张曦，崔晓娴，林庆能，吴寰宇，袁政安，谢幼华

《微生物与感染》

2016

朱立新，谢幼华，李光地，汪垣

Acta Biochimica et Biophysica Sinica

精选作品

期刊论文

上海市2016—2024年H9N2亚型禽流感病毒遗传进化及血凝素蛋白分子特征

HIV-driven virome dysbiosis unveils distinct virome features and inter-viral correlations in blood and respiratory niches

Molecular epidemiology and genetic characteristics of influenza viruses in a local pediatric population of eastern China, 2024

Blood and gut virome remodeling in gastric cancer: Anellovirus expansion and novel virus discovery

Characteristics of SARS-CoV-2 Reinfection and Ancestral RBD-Blocking Antibody Levels: A Cross-Sectional Study in the Post-Zero-COVID Era from Shanghai

Steric hindrance of antibody binding in an Omicron spike fusion intermediate

Development and protective evaluation of mRNA vaccines encoding the glycoprotein precursor of lymphocytic choriomeningitis virus

THU-626 The homeobox family suppresses hepatitis B virus via a key non-Immunosuppressive pathway during the active phases of chronic hepatitis B

Loss of the type VII secretion ATPase EssC promotes biofilm formation of Staphylococcus aureus under acidic stress

Orphan broadly RBD-binding antibodies annotate three remaining conserved RBD epitopes along SARS-CoV-2 evolution

Hepatitis B virus induced cirrhosis and hepatocarcinoma: pathogenesis and therapeutics

Characteristics of a Chinese Cohort of Patients with Chronic Hepatitis C Infection (2019–2023) and a Case Report of Resistance-associated Substitutions to Sofosbuvir-velpatasvir Treatment

Comparisons of blood, upper respiratory tract and gut viromes from patients with lung cancer and healthy persons

Blood virome profiling reveals subtype-specific viral signatures and reduced diversity in non-Hodgkin lymphoma

Development of a replication-defective mpox virus platform for fundamental and therapeutic research

Single-cycle Rift Valley fever virus particles from stable replicon cells enable discovery of antiviral CNX-1351 for multiple RNA viruses

Significant diversity of human anelloviruses revealed by novel viral sequences identified in human metagenomic data

Nucleic Acid Aptamers for Human Norovirus GII.4 and GII.17 Virus-Like Particles (VLPs) Exhibit Specific Binding and Inhibit VLPs from Entering Cells

Optimized Aptamer-Conjugated Gold Nanoparticles for Specific Detection of GII.4 Human Norovirus in Feces

Expression and application of a novel Holin Hol6A3 in phage PD6A3 of Acinetobacter baumannii

DAZAP2 functions as a pan-coronavirus restriction factor by inhibiting viral entry and genomic replication

A branched peptide targets virus and host to block influenza virus and rhinovirus entry

Homeobox protein MSX-1 restricts hepatitis B virus by promoting ubiquitin-independent proteasomal degradation of HBx protein

Manganese is a potent inducer of lysosomal activity that inhibits de novo HBV infection

医学病毒学实验

乙型肝炎病毒核心蛋白通过抑制Rab-GAP促进肝病进展（英文）

Whole-genome analysis of circulating influenza A virus (H3N2) strains in Shanghai, China from 2005 to 2023

In Vitro Culture of Human Norovirus in the Last 20 Years

Development of benzimidazole-based compounds as novel capsid assembly modulators for the treatment of HBV infection.

Identification and characterization of host factor VCPIP1 as a multi-functional positive regulator of hepatitis B virus

Development of a Cell Culture Model for Inducible SARS-CoV-2 Replication

Hepatitis B virus core protein as a Rab-GAP suppressor driving liver disease progression

Construction and efficacy testing of DNA vaccines containing HLA-A*02:01-restricted SARS-CoV-2 T-cell epitopes predicted by immunoinformatics

Intrahepatic homeobox protein MSX-1 is a novel host restriction factor of hepatitis B virus

Cross-reactive antibody response to Monkeypox virus surface proteins in a small proportion of individuals with and without Chinese smallpox vaccination history

Lipid nanoparticle‐mediated delivery of IL‐21‐encoding mRNA induces viral clearance in mouse models of hepatitis B virus persistence

Establishment and characterization of a novel reverse genetic system of BK polyomavirus

A spike-targeting bispecific T cell engager strategy provides dual layer protection against SARS-CoV-2 infection in vivo

Discovery of quinazolin-4-one-based non-covalent inhibitors targeting the severe acute respiratory syndrome coronavirus 2 main protease (SARS-CoV-2 Mpro)

Inhibition of HBV replication by EVA1A via enhancing cellular degradation of HBV components and its potential therapeutic application

细胞因子在慢性乙型肝炎治疗中的研究进展

英国等地不明原因儿童肝炎的暴发情况及病因

A core epitope targeting antibody of SARS-CoV-2

Interleukin-33 mediates both immune-related and non-immune-related inhibitory effects against hepatitis B virus

A CRISPR activation screen identifies genes that enhance SARS-CoV-2 infection

Neutralization mechanism of a human antibody with pan-coronavirus reactivity including SARS-CoV-2

Establishment and characterization of a new cell culture system for hepatitis B virus replication and infection

Survival of SARS‐CoV‐2 in artificial seawater and on the surface of inanimate materials

Author Correction: Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2

Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

Monocytic MDSCs homing to thymus contribute to age-related CD8+ T cell tolerance of HBV

Rapid and ultrasensitive electromechanical detection of ions, biomolecules and SARS-CoV-2 RNA in unamplified samples

SARS-CoV-2 RNA elements share human sequence identity and upregulate hyaluronan via NamiRNA-enhancer network

High mobility group AT-hook 1 (HMGA1) is an important positive regulator of hepatitis B virus (HBV) that is reciprocally upregulated by HBV X protein

A novel STING agonist-adjuvanted pan-sarbecovirus vaccine elicits potent and durable neutralizing antibody and T cell responses in mice, rabbits and NHPs

Neutralizing SARS-CoV-2 by dimeric side chain-to-side chain cross-linked ACE2 peptide mimetics

原卟啉Ⅸ和维替泊芬在细胞水平和小鼠体内有效抑制新型冠状病毒的感染（英文）

微课教学设计：解读乙肝两对半

An ultrapotent pan-β-coronavirus lineage B (β-CoV-B) neutralizing antibody locks the receptor-binding domain in closed conformation by targeting its conserved epitope

Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein

Effect of chlorine dioxide on avian influenza A (H7N9) virus

Receptome profiling identifies KREMEN1 and ASGR1 as alternative functional receptors of SARS-CoV-2

Synthesis and evaluation of enantiomers of hydroxychloroquine against SARS-CoV-2 in vitro

Rapid SARS-CoV-2 Nucleic Acid Testing and Pooled Assay by Tetrahedral DNA Nanostructure Transistor

A non-ACE2 competing human single-domain antibody confers broad neutralization against SARS-CoV-2 and circulating variants

Potent SARS-CoV-2 neutralizing antibodies with protective efficacy against newly emerged mutational variants

Development of recombinant COVID-19 vaccine based on CHO-produced, prefusion spike trimer and alum/CpG adjuvants

Comprehensive mapping of binding hot spots of SARS-CoV-2 RBD-specific neutralizing antibodies for tracking immune escape variants

Direct SARS-CoV-2 Nucleic Acid Detection by Y-Shaped DNA Dual-Probe Transistor Assay

Advancements in detection of SARS-CoV-2 infection for confronting COVID-19 pandemics

Animal Models for COVID-19: Hamsters, Mouse, Ferret, Mink, Tree Shrew, and Non-human Primates

Yeast-produced RBD-based recombinant protein vaccines elicit broadly neutralizing antibodies and durable protective immunity against SARS-CoV-2 infection

A highly potent and stable pan-coronavirus fusion inhibitor as a candidate prophylactic and therapeutic for COVID-19 and other coronavirus diseases

Structural and functional basis for pan-CoV fusion inhibitors against SARS-CoV-2 and its variants with preclinical evaluation

A human cell-based SARS-CoV-2 vaccine elicits potent neutralizing antibody responses and protects mice from SARS-CoV-2 challenge

Prior transient exposure to interleukin-21 delivered by recombinant adeno-associated virus vector protects mice from hepatitis B virus persistence

Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry

Identification of bis-benzylisoquinoline alkaloids as SARS-CoV-2 entry inhibitors from a library of natural products