李微｜中国药科大学｜学者主页

2026

FGF21在代谢功能障碍相关脂肪性肝病治疗中的研究进展

周庆峰，李微，王志利，李俊敏，孙勃旸，罗学刚

《中国药理学通报》

2026

Gambogic acid suppresses pancreatic fibrosis via inhibiting YAP1-mediated activation of pancreatic stellate cells

Wei Li, Guangming Li, Yi Wang, Yuxin Zhou

Chinese Journal of Natural Medicines

2026

R-type ginsenoside Rg3 attenuates cisplatin-induce intestinal injury via restoring autophagy flux blockade

Xufei Gao, Junjie Zhang, Junnan Hu, Ming Zhang, Zi Wang, Shuang Jiang, Wei Li

Chinese Journal of Natural Medicines

2025

Dimeric sesquiterpenoids with anti-inflammatory activities from Inula britannica

Juan Zhang, Jiankun Yan, Hongjun Dong, Rui Zhang, Jing Chang, Yanli Feng, Xinrong Xu, Wei Li, Feng Qiu, Chengpeng Sun

Chinese Journal of Natural Medicines

2025

Discovery of Potent and Orally bioavailable Benzoazepinamine-Based SHP2 Allosteric Inhibitors for the Treatment of Inflammatory Diseases

Wenhua Jiang, Qiangqiang Hou, Dexiang Hua, Yi Zeng, Chenyang Huang, Guangmei Luo, Kangming Li, Zijie Jin, Xiaoyu Chen, Wenqiang Li, Wei Li, Qian Chu, Zhiyong Jiang, Xiaoxing Wu

Journal of Medicinal Chemistry

DOI

2025

Dual Anomeric Stereocontrol in 1,1′-Glycosylation via a Remote Directing 2-(Diphenylphosphinoyl)acetyl Group

Xin Huang, Keyu Wang, Zhaolun Zhang, Ao Liu, Zhimei Wang, Wei Li

Organic Letters

DOI

2025

Front Cover: Design and Synthesis of Sulfonium and Selenonium Derivatives Bearing 3′,5′‐ O ‐Benzylidene Acetal Side Chains as Potent α ‐Glucosidase Inhibitors (ChemMedChem 21/2025)

Yao‐Jia Li, Jiahui Zhou, Xiaoxing Wu, Wei Li, Zhe Wang, Jianchen Yang, Genzoh Tanabe, Osamu Muraoka, Weijia Xie

ChemMedChem

DOI

2025

Synthesis of Neokotalanol and Its Derivatives as Potent α-Glucosidase Inhibitors

Yao‐Jia Li, Dan Liu, Xue‐Zheng Zhao, Jiahui Zhou, Yu Li, Genzoh Tanabe, Osamu Muraoka, Wei Li, Weijia Xie

Organic Letters

DOI

2025

Design and Synthesis of Sulfonium and Selenonium Derivatives Bearing 3′,5′‐ O ‐Benzylidene Acetal Side Chains as Potent α ‐Glucosidase Inhibitors

Yao‐Jia Li, Jiahui Zhou, Xiaoxing Wu, Wei Li, Zhe Wang, Jianchen Yang, Genzoh Tanabe, Osamu Muraoka, Weijia Xie

ChemMedChem

DOI

2025

Synthesis of trans‐Fused 3,6‐Anhydro Hexofuranose Frameworks via Catalytic Hydrogenolysis Triggered Debenzylative Intramolecular Acetalation

Yu Li, Zhimei Wang, Wenxiang Tao, Jian‐chen Yang, Genzoh Tanabe, Osamu Muraoka, Wei Li, Wei Li, Wei‐Jia Xie

ChemMedChem

DOI

2024

Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for In Vivo Theranostics of Alzheimer’s Disease

Lei Wang, Tianyu Sun, Tengfei Zhen, Wei Li, Huajing Yang, Suyu Wang, Feng Feng, Yao Chen, Haopeng Sun

Journal of Medicinal Chemistry

DOI

2024

Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors

Jintong Zhou, Mingyu Xia, Zhenghui Huang, Hang Qiao, Guang Yang, Yunan Qian, Peifeng Li, Zhaolun Zhang, Xinai Gao, Lubin Jiang, Jing Wang, Wei Li, Pengfei Fang

Communications Biology

DOI

2024

Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction

Yang Liu, Jingjing Jiang, Shao-yue Du, Liangshan Mu, Jianjun Fan, Junchi Hu, Ye Yao, Meng Ding, Wei-yu Zhou, Qiuhan Yu, Yi-fan Xia, Hongyu Xu, Yi-jie Shi, Shuwen Qian, Yan Tang, Wei Li, Yongjun Dang, Xi Dong, Xiao-ying Li, Congjian Xu, Qi‐Qun Tang

Science

DOI

2024

Synthesis and Structural Revision of a Natural Tetrasaccharide from Starfish Asterias rollestoni Bell

Ao Liu, Longwei Gao, Xintong Tang, Xudong Yang, Xianglai Liu, Weijia Xie, Jin Qi, Wei Li

Chemistry - A European Journal

DOI

2024

Direct Synthesis of α- and β-2′-Deoxynucleosides with Stereodirecting Phosphine Oxide via Remote Participation

Xintong Tang, Yueer Zhou, Yingjie Wang, Yetong Lin, S. Pan, Qianwei Che, Jinpeng Sang, Ziming Gao, Weiting Zhang, Yuanyuan Wang, Guolong Li, Longwei Gao, Zhimei Wang, Xudong Yang, Ao Liu, Suyu Wang, Biao Yu, Peng Hui Xu, Zhe Wang, Zhaolun Zhang, Peng Yang, Weijia Xie, Haopeng Sun, Wei Li

Journal of the American Chemical Society

DOI

2024

Sokotrasterol Sulfate Suppresses IFN-γ-Induced PD-L1 Expression by Inhibiting JAK Activity

Xiaobo Wang, Wenlong Xu, Zeng-Yiyi Wang, Qian Yu, Li Yuan, Yihang Liu, Jinpeng Sang, Wei Li, Sanyong Zhu, Wei Jiang, Zengxia Li, Wen Zhang, Yongjun Dang

Journal of Natural Products

DOI

2023

Design and Synthesis of Sulfonium Derivatives: A Novel Class of α-Glucosidase Inhibitors with Potent In Vivo Antihyperglycemic Activities

Lu Lu, Jingyi Chen, Wenxiang Tao, Zhimei Wang, Dan Liu, Jiahui Zhou, Xiaoxing Wu, Haopeng Sun, Wei Li, Genzoh Tanabe, Osamu Muraoka, Bo Zhao, Liang Wu, Weijia Xie

Journal of Medicinal Chemistry

DOI

2023

Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions

He‐wei Jiang, Hong Chen, Yun-xiao Zheng, Xuening Wang, Qingfeng Meng, Jin Han Xie, Jiong Zhang, ChangSheng Zhang, Zhaowei Xu, Ziqing Chen, Lei Wang, Wei-Sha Kong, Kuan Zhou, Ming‐liang Ma, Hainan Zhang, Shujuan Guo, Jun‐biao Xue, Jingli Hou, Zhe-Yi Liu, Wen-Xue Niu, Fangjun Wang, Tao Wang, Wei Li, Ruina Wang, Yongjun Dang, Daniel Mark Czajkowsky, Yu Qiao, Jiajia Dong, Jianfeng Pei, Sheng‐ce Tao

Science China Life Sciences

DOI

2023

Gram-Scale Synthesis of the C14–C23 Fragment of Eribulin

Qiuhan Yu, Yueer Zhou, Xinai Gao, Shuheng Pan, Feng Lin, Wei Li

Organic Process Research & Development

DOI

2023

Tyrosine-targeted covalent inhibition of a tRNA synthetase aided by zinc ion

Hang Qiao, Mingyu Xia, Yiyuan Cheng, Jintong Zhou, Zheng Li, Wei Li, Jing Wang, Pengfei Fang

Communications Biology

DOI

2022

N-Benzyl Benzamide Derivatives as Selective Sub-Nanomolar Butyrylcholinesterase Inhibitors for Possible Treatment in Advanced Alzheimer’s Disease

Chenxi Du, Lei Wang, Qianwen Guan, Hongyu Yang, Tingkai Chen, Yijun Liu, Qihang Li, Weiping Lyu, Xin Lü, Ying Chen, Ying Chen, Yang Liu, Hui Liu, Feng Feng, Wenyuan Liu, Zongliang Liu, Wei Li, Chen Yao, Chen Yao, Haopeng Sun

Journal of Medicinal Chemistry

DOI

2022

Palladium-Catalyzed Asymmetric C–C Bond Activation/Carbonylation of Cyclobutanones

Long Chen, Cong Shi, Wei Li, Bo Li, Jie Zhu, Aijun Lin, Hequan Yao

Organic Letters

DOI

2022

Direct Synthesis of 2,6‐Dideoxy‐β‐glycosides and β‐Rhamnosides with a Stereodirecting 2‐(Diphenylphosphinoyl)acetyl Group

Xianglai Liu, Yetong Lin, Wenyi Peng, Zhaolun Zhang, Longwei Gao, Yueer Zhou, Zhe Song, Yingjie Wang, Peng Hui Xu, Biao Yu, Haopeng Sun, Weijia Xie, Wei Li

Angewandte Chemie

DOI

2022

More than a Leaving Group: N‐Phenyltrifluoroacetimidate as a Remote Directing Group for Highly α‐Selective 1,2‐cis Glycosylation

Xianglai Liu, Yingying Song, Ao Liu, Yueer Zhou, Qian Zhu, Yetong Lin, Huiyong Sun, Kaidi Zhu, Wei Liu, Ning Ding, Weijia Xie, Haopeng Sun, Biao Yu, Peng Hui Xu, Wei Li

Angewandte Chemie

DOI

2021

Alterations of DNA damage response pathway:Biomarker and therapeutic strategy for cancer immunotherapy

Minlin Jiang, Keyi Jia, Lei Wang, Wei Li, Bin Chen, Yu Liu, Hao Wang, Sha Zhao, Yayi He, Caicun Zhou

Acta Pharmaceutica Sinica B

2021

S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling

Pingping Luo, Ming Zheng, Rui Zhang, Hong Zhang, Yingxia Liu, Wei Li, Xiaoming Sun, Qian Yu, George L.Tipoe, Jia Xiao

Acta Pharmaceutica Sinica B

2021

Strategies for Structural Modification of Small Molecules to Improve Blood–Brain Barrier Penetration: A Recent Perspective

Baichen Xiong, Yuanyuan Wang, Ying Chen, Shuaishuai Xing, Qinghong Liao, Yao Chen, Qi Li, Wei Li, Haopeng Sun

Journal of Medicinal Chemistry

DOI

2021

2‐Diphenylphosphinoyl ‐acetyl as a Remote Directing Group for the Highly Stereoselective Synthesis of β‐Glycosides

Xianglai Liu, Yetong Lin, Ao Liu, Qianhui Sun, Huiyong Sun, Peng Hui Xu, Guolong Li, Yingying Song, Weijia Xie, Haopeng Sun, Biao Yu, Wei Li

Chinese Journal of Chemistry

DOI

2021

Novel diosgenin-1,4-quinone hybrids: Synthesis, antitumor evaluation, and mechanism studies

Guolong Li, Qi Li, Haopeng Sun, Wei Li

The Journal of Steroid Biochemistry and Molecular Biology

DOI

2021

Microwave‐Assisted Synthesis of d/l‐Agrimonolide

Yu‐Ang Cui, Guangyu Zhang, Yun‐Zhi Li, Wei Li, Genzoh Tanabe, Osamu Muraoka, Weijia Xie

Asian Journal of Organic Chemistry

DOI

2021

A Practical Synthetic Route to Artepillin C and Drupanin

Xue‐Zheng Zhao, Lu Wang, Xiaoya Li, Qingqing Zhang, Wei Li, Aijun Lin, Jinyi Xu, Xiao‐Ming Wu, Weijia Xie

Asian Journal of Organic Chemistry

DOI

2020

Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase

Jintong Zhou, Zheng Li, Zhoufei Hei, Wei Li, Jing Wang, Biao Yu, Pengfei Fang

ACS Chemical Biology

DOI

2020

Synthesis of Pashinintide A, a Natural Cyclic Hexapeptide Supposedly Capable of Forming a Complex with Sucrose

Xuejian Yin, Wei Li, Biao Yu

Asian Journal of Organic Chemistry

DOI

2019

Mucoadhesive buccal film containing ornidazole and dexamethasone for oral ulcers: in vitro and in vivo studies

Chengliang Zhang, Ya-Nan Liu, Wei Li, P. Gao, Dong Xiang, Xiu-Hua Ren, Dong Liu

Pharmaceutical development and technology (Print)

DOI

2019

Practical Route to Neokotalanol and Its Natural Analogues: Sulfonium Sugars with Antidiabetic Activities

Yuhao Huang, Yunlong Gao, Weigang He, Zihao Wang, Wei Li, Aijun Lin, Jinyi Xu, Genzoh Tanabe, Osamu Muraoka, Xiaoming Wu, Weijia Xie

Angewandte Chemie

DOI

2018

Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan

Yiqiao Gao, Wěi Li, Jiaqing Chen, Xu Wang, Yingtong Lv, Yin Huang, Zunjian Zhang, Fengguo Xu

Acta Pharmaceutica Sinica B

DOI

2018

Editorial Preface for Targeted Cancer Therapy

Guan Chen, Wei Li

Acta Pharmaceutica Sinica B

2018

Taxane resistance in castration-resistant prostate cancer: mechanisms and therapeutic strategies

Brandon Bumbaca, Wei Li

Acta Pharmaceutica Sinica B

2018

A Glycal Approach to the Synthesis of Pregnane Glycoside P57

Chao Liu, Yuyong Ma, Chengfeng Pei, Wei Li, Biao Yu

Chinese Journal of Chemistry

DOI

2017

气管内雾化脂多糖致大鼠肺部炎症损伤模型研究

李微，盛云华，航艾，王宇，姜珠慧，谷舒怡，张素慧，唐黎明

《中国药学杂志》

2017

基于细胞高内涵分析表征氮芥HN-3的细胞毒性

魏爱丽，龙隆，李微，丁锐，陈伟，王莉莉

《中国药理学与毒理学杂志》

2016

Preparation, in Vitro and in Vivo Evaluations of Compound Calculus Bovis Sativus and Ornidazole Film.

Wei Li, Wenxi He, P. Gao, Chengliang Zhang, H. Cai, Ying Chen, Dong Liu

Biological and Pharmaceutical Bulletin

DOI

2015

HIF-1α pathway: role, regulation and intervention for cancer therapy

Georgina N.Masoud, Wei Li

Acta Pharmaceutica Sinica B

2015

Development of a rapid and simple LC-MS/MS method for identification and quality control of natural Calculus bovis and Calculus bovis sativus

Chengyang Feng, Xi-Ping Li, Chengliang Zhang, Guang-Zhao He, Yanjiao Xu, Wei Li, Zao-Qin Yu, H. Cai, Dong Liu

DOI

2014

新型微管靶向化合物WX-127-07体外抗肿瘤活性及作用机制

关芳，龙隆，李微，冯帆，李菲菲，谢蓝，王莉莉

《中国药理学与毒理学杂志》

2014

应用高内涵分析技术识别雄激素受体激动剂

冯帆，龙隆，李微，王莉莉

《中国药理学与毒理学杂志》

2011

mTEL-cFms激酶结构域融合蛋白真核表达载体的构建及其对信号转导和转录激活因子核转位的影响

杨胜乾，龙隆，李微，王莉莉

《中国药理学与毒理学杂志》

精选作品

期刊论文

FGF21在代谢功能障碍相关脂肪性肝病治疗中的研究进展

Gambogic acid suppresses pancreatic fibrosis via inhibiting YAP1-mediated activation of pancreatic stellate cells

R-type ginsenoside Rg3 attenuates cisplatin-induce intestinal injury via restoring autophagy flux blockade

Dimeric sesquiterpenoids with anti-inflammatory activities from Inula britannica

Discovery of Potent and Orally bioavailable Benzoazepinamine-Based SHP2 Allosteric Inhibitors for the Treatment of Inflammatory Diseases

Dual Anomeric Stereocontrol in 1,1′-Glycosylation via a Remote Directing 2-(Diphenylphosphinoyl)acetyl Group

Front Cover: Design and Synthesis of Sulfonium and Selenonium Derivatives Bearing 3′,5′‐ O ‐Benzylidene Acetal Side Chains as Potent α ‐Glucosidase Inhibitors (ChemMedChem 21/2025)

Synthesis of Neokotalanol and Its Derivatives as Potent α-Glucosidase Inhibitors

Design and Synthesis of Sulfonium and Selenonium Derivatives Bearing 3′,5′‐ O ‐Benzylidene Acetal Side Chains as Potent α ‐Glucosidase Inhibitors

Synthesis of trans‐Fused 3,6‐Anhydro Hexofuranose Frameworks via Catalytic Hydrogenolysis Triggered Debenzylative Intramolecular Acetalation

Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for In Vivo Theranostics of Alzheimer’s Disease

Structure-guided conversion from an anaplastic lymphoma kinase inhibitor into Plasmodium lysyl-tRNA synthetase selective inhibitors

Artemisinins ameliorate polycystic ovarian syndrome by mediating LONP1-CYP11A1 interaction

Synthesis and Structural Revision of a Natural Tetrasaccharide from Starfish Asterias rollestoni Bell

Direct Synthesis of α- and β-2′-Deoxynucleosides with Stereodirecting Phosphine Oxide via Remote Participation

Sokotrasterol Sulfate Suppresses IFN-γ-Induced PD-L1 Expression by Inhibiting JAK Activity

Design and Synthesis of Sulfonium Derivatives: A Novel Class of α-Glucosidase Inhibitors with Potent In Vivo Antihyperglycemic Activities

Specific pupylation as IDEntity reporter (SPIDER) for the identification of protein-biomolecule interactions

Gram-Scale Synthesis of the C14–C23 Fragment of Eribulin

Tyrosine-targeted covalent inhibition of a tRNA synthetase aided by zinc ion

N-Benzyl Benzamide Derivatives as Selective Sub-Nanomolar Butyrylcholinesterase Inhibitors for Possible Treatment in Advanced Alzheimer’s Disease

Palladium-Catalyzed Asymmetric C–C Bond Activation/Carbonylation of Cyclobutanones

Direct Synthesis of 2,6‐Dideoxy‐β‐glycosides and β‐Rhamnosides with a Stereodirecting 2‐(Diphenylphosphinoyl)acetyl Group

More than a Leaving Group: N‐Phenyltrifluoroacetimidate as a Remote Directing Group for Highly α‐Selective 1,2‐cis Glycosylation

Alterations of DNA damage response pathway:Biomarker and therapeutic strategy for cancer immunotherapy

S-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling

Strategies for Structural Modification of Small Molecules to Improve Blood–Brain Barrier Penetration: A Recent Perspective

2‐Diphenylphosphinoyl ‐acetyl as a Remote Directing Group for the Highly Stereoselective Synthesis of β‐Glycosides

Novel diosgenin-1,4-quinone hybrids: Synthesis, antitumor evaluation, and mechanism studies

Microwave‐Assisted Synthesis of d/l‐Agrimonolide

A Practical Synthetic Route to Artepillin C and Drupanin

Atomic Resolution Analyses of Isocoumarin Derivatives for Inhibition of Lysyl-tRNA Synthetase

Synthesis of Pashinintide A, a Natural Cyclic Hexapeptide Supposedly Capable of Forming a Complex with Sucrose

Mucoadhesive buccal film containing ornidazole and dexamethasone for oral ulcers: in vitro and in vivo studies

Practical Route to Neokotalanol and Its Natural Analogues: Sulfonium Sugars with Antidiabetic Activities

Pharmacometabolomic prediction of individual differences of gastrointestinal toxicity complicating myelosuppression in rats induced by irinotecan

Editorial Preface for Targeted Cancer Therapy

Taxane resistance in castration-resistant prostate cancer: mechanisms and therapeutic strategies

A Glycal Approach to the Synthesis of Pregnane Glycoside P57

气管内雾化脂多糖致大鼠肺部炎症损伤模型研究

基于细胞高内涵分析表征氮芥HN-3的细胞毒性

Preparation, in Vitro and in Vivo Evaluations of Compound Calculus Bovis Sativus and Ornidazole Film.

HIF-1α pathway: role, regulation and intervention for cancer therapy

Development of a rapid and simple LC-MS/MS method for identification and quality control of natural Calculus bovis and Calculus bovis sativus

新型微管靶向化合物WX-127-07体外抗肿瘤活性及作用机制

应用高内涵分析技术识别雄激素受体激动剂

mTEL-cFms激酶结构域融合蛋白真核表达载体的构建及其对信号转导和转录激活因子核转位的影响

会议论文

Comparative Studies of The Pharmacokinetics And TissueDistribution Of Propylene Glycol In Rat by Inhalation AndIntracheal Instillation(摘要)

气管内雾化脂多糖致大鼠肺损伤模型研究

糜烂性毒剂对原代培养人皮肤细胞的动态损伤效应

高内涵细胞多参数分析技术快速锁定硫芥皮肤损伤AOP的起始事件

采用高内涵细胞分析技术快速筛查雷公藤甲素的肝细胞毒性机制

Effects of dicamba on mRNA transcription of thyroid hormone regulation in Chinese Rare Minnow(Gobiocypris rarus)

预印本

Exploration on Generating Traditional Chinese Medicine Prescription from Symptoms with an End-to-End method

书籍章节

Temporary ether protecting groups at the anomeric center in complex carbohydrate synthesis