王久存｜复旦大学｜学者主页

2026

人类高原习服表型组学研究

王久存，金力

《中国科学:生命科学》

2026

内蒙古蒙古族人群肤纹的表型组

甄文天，张海国，杨海涛，谭婧泽，乔辉，袁子宇，臧俊，严明亮，王久存

《人类学学报》

2026

汉族男性青年急性高原暴露下视网膜血管直径变化与心血管气候适应的相关性分析

黄子扬，尹先宏，谢媛，李轶，乐士冠，金力，王宁利，王久存

《复旦学报(自然科学版)》

2026

Quercetin attenuates skin inflammation and fibrosis in systemic sclerosis by targeting the RELA/c-Jun axis to suppress th17 cell responses

Xiangzhen Kong, H. Leong, M. Du, Jing-Yi Yang, J. Lai, Z. Dong, Meng-Lei Hu, Yifei Gu, Yexin Li, Qiaorui Tan, Hai-Yan Chu, Qing-Mei Liu, Yan-Yun Ma, Wei-Hong Xu, Shan-Ji Li, Yu-Xiao Chen, Dong-Dong Chen, Yuan-Yuan Chen, Wei Lu, Jie Zhu, Jiucun Wang, Lei Wang

Frontiers in Immunology

精选作品

期刊论文

人类高原习服表型组学研究

内蒙古蒙古族人群肤纹的表型组

汉族男性青年急性高原暴露下视网膜血管直径变化与心血管气候适应的相关性分析

Quercetin attenuates skin inflammation and fibrosis in systemic sclerosis by targeting the RELA/c-Jun axis to suppress th17 cell responses

Pharmacological targeting of the TLR8/AP-1 axis ameliorates scleroderma skin inflammation and fibrosis by suppressing monocyte-mediated endothelial injury.

The Tryptophan Metabolite Indole-3-ethanol of Cutibacterium acnes Promotes Skin Barrier Repair via AHR

Conceptual framework for the definition of disease modification in systemic sclerosis and potential implications for drug development and clinical study design

A compact five-gene immuno-fibrotic profile distinguishing systemic sclerosis subtypes with PXDN validated as a fibrosis-associated target

Deep Immunophenotyping Unravels the Double Negative T cells and PD-1-Mediated Inflammatory Exhaustion in Ankylosing Spondylitis

P.013 The stromal vascular fraction mitigates bleomycin-induced fibrosis in mice

Mitochondrial retrograde signaling initiates HIF-1α/BNIP3/NIX-mediated mitophagy in Tibetan high-altitude adaptation

高海拔暴露驱动小鼠肺部血管功能、细胞外基质、凋亡与增殖相关基因表达改变并诱导肺损伤

皮肤微生态与皮肤健康

蓝光照射抑制黑色素细胞NNT基因的表达并诱导线粒体形态功能变化和黑色素合成

STEAP3 alleviates inflammation and fibrosis via iron metabolism in ischemia/reperfusion-associated lung injury.

Iron dysregulation and ferroptosis are associated with pulmonary fibrosis: Insight from idiopathic pulmonary fibrosis, systemic sclerosis, and COVID-19 patients.

A human skin microbiome reference catalog and the skin microbial landscape of plateau adults

Unveiling strain-level dynamics in the human skin microbiome.

A comprehensive reference catalog of human skin DNA virome reveals novel viral diversity and microenvironmental influences

Association of Multi-Kingdom Skin Microbiota With Radiation Dermatitis in Patients With Breast Cancer After Reconstructive Surgery: A Prospective, Longitudinal Study.

Enhanced cytotoxicity of aging associated NKG2C + CD8 + T cells in ankylosing spondylitis via HLA-B27

Spatially informed phenotyping by cyclic-in-situ-hybridisation identifies novel fibroblast populations and their pathogenic niches in systemic sclerosis

The stromal vascular fraction mitigates bleomycin-induced skin fibrosis in mice by modulating vascular lesions and secreting antifibrotic factors at different stages of disease

Spatial multiomics decipher fibroblast–macrophage dynamics in systemic sclerosis

Antifibrotic effects of specific targeting of the 5‐hydroxytryptamine 2B receptor (5‐HT2BR) in murine models and ex vivo models of scleroderma skin

Long-read sequencing of 945 Han individuals identifies structural variants associated with phenotypic diversity and disease susceptibility

FPQuant: A deep learning-based scalable framework for fingerprint phenomics quantification in large-scale biometric population studies

Increase in facial Demodex mite infestation is associated with skin barrier damage and development of sensitive skin in the Chinese population

Genetic landscape of human oocyte/embryo defects

Multiomics Integration of Epigenetics, Proteomics, and Metabolomics Identifies Putative Drug Targets and Improves Early Prediction for Diabetes

Distinct immune cell profiles associated with high‐altitude hypoxia and severe acute mountain sickness

Ferroptosis-Resistant Adipocytes Drive Keloid Pathogenesis via GPX4-Mediated Adipocyte-Mesenchymal Transition and Iron-Cystine Metabolic Communication

Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model

Smoking Promotes AT2 Cell Senescence and Exacerbates Pulmonary Fibrosis by Downregulating POT1 via Integratively Inducing CpG Methylation and MECP2 ‐Mediated FOXP2 Transcriptional Binding Inhibition

WITHDRAWN: Association of sensitive skin with increased facial photo-aging among chinese females

Molecular Hydrogen Ameliorates Anti-Desmoglein 1 Antibody-Induced Pemphigus-Associated Interstitial Lung Disease by Inhibiting Oxidative Stress

Genetic and environmental factors affecting hair density in East Asian populations

TonguExpert: A Deep Learning-Based Algorithm Platform for Fine-Grained Extraction and Classification of Tongue Phenotypes

Increased melanin induces aberrant keratinocyte − melanocyte − basal − fibroblast cell communication and fibrogenesis by inducing iron overload and ferroptosis resistance in keloids

Deep Multi-Modal Skin-Imaging-Based Information-Switching Network for Skin Lesion Recognition

Differences in Pathogenetic Mechanism Between Tibetan and Han High-Altitude Polycythemia Based on a Whole Genome-Wide Association Study

Recibokibart, an anti‐ IL ‐36 receptor monoclonal antibody, for treating generalized pustular psoriasis: Phase 1b trial

A novel efficient algorithm for common variants genotyping from low-coverage sequencing data

益气活血复方治疗硬皮病肺部炎症与纤维化的作用机制:基于生物信息学与网络药理学方法

LEPREL1是特发性肺纤维化的潜在治疗靶点

利用无创测量表征人体面部皮肤老化表型

紫外线B(UVB)损伤人皮肤基底膜屏障的分子特征

Optimizing Skin Surface Metabolomics: A Comprehensive Evaluation of Sampling Methods, Extraction Solvents, and Analytical Techniques.

Identification and validation of anti-protein arginine methyltransferase 5 (PRMT5) antibody as a novel biomarker for systemic sclerosis (SSc)

Genetic Variants Associated with Sweat Gland Phenotypes in 6210 Han Chinese Individuals

miR-3606-3p alleviates skin fibrosis by integratively suppressing the integrin/FAK, p-AKT/p-ERK, and TGF-β signaling cascades

Culture dependent and independent approaches reveal the role of specific bacteria in human skin aging

Mitochondrial DNA Genomes Reveal Relaxed Purifying Selection During Human Population Expansion after the Last Glacial Maximum

Atypical chemokine receptor 1-positive endothelial cells mediate leucocyte infiltration and synergize with secreted frizzled-related protein 2/asporin-positive fibroblasts to promote skin fibrosis in systemic sclerosis

Pulmonary interstitial lesions in pemphigus mouse model: Verifying pemphigus may not be only limited to skin and mucosa

Analysis of blood methylation quantitative trait loci in East Asians reveals ancestry-specific impacts on complex traits

The novel molecular mechanism of pulmonary fibrosis: insight into lipid metabolism from reanalysis of single-cell RNA-seq databases

Characterization of Vascular Niche in Systemic Sclerosis by Spatial Proteomics

Blue light protection factor: a method to assess the protective efficacy of cosmetics against blue light-induced skin damage in the Chinese population

TET1 inhibits liver fibrosis by blocking hepatic stellate cell activation

Aldehyde dehydrogenase 2 serves as a key cardiometabolic adaptation regulator in response to plateau hypoxia in mice

系统性硬化症发生肺动脉高压的独立危险因素分析

The composite phenotype analysis identifies potential concerted responses of physiological systems to high altitude exposure

ColorMeter和VISIA-CR图像提取肤色的方法对比

Integrated Human Skin Bacteria Genome Catalog Reveals Extensive Unexplored Habitat‐Specific Microbiome Diversity and Function

Adipose Tissue and Adipose-Tissue-Derived Cell Therapies for the Treatment of the Face and Hands of Patients Suffering from Systemic Sclerosis

GWASs Identify Genetic Loci Associated with Human Scalp Hair Whorl Direction

Author Correction: Genetic evidence of tri-genealogy hypothesis on the origin of ethnic minorities in Yunnan

The prognostic value of systematic genetic screening in amyotrophic lateral sclerosis patients

Preosteoclast plays a pathogenic role in syndesmophyte formation of ankylosing spondylitis through the secreted PDGFB — GRB2/ERK/RUNX2 pathway

TLR8 aggravates skin inflammation and fibrosis by activating skin fibroblasts in systemic sclerosis

An optimal method for quantifying the facial sebum level and characterizing facial sebum features

Intrinsic capacity and 5-year late-life functional ability trajectories of Chinese older population using ICOPE tool: the Rugao Longevity and Ageing Study

Combined genome-wide association study of 136 quantitative ear morphology traits in multiple populations reveal 8 novel loci

GRB2 serves as a viable target against skin fibrosis in systemic sclerosis by regulating endothelial cell apoptosis

Induced skin aging by blue-light irradiation in human skin fibroblasts via TGF-β, JNK and EGFR pathways

Quantitative Assessment of Ultraviolet-Induced Erythema and Tanning Responses in the Han Chinese Population

Landscape of pathogenic mutations in premature ovarian insufficiency