邓文波｜厦门大学｜学者主页

2026

UDEDB: A Comprehensive Database for Dynamic Molecular Expression Changes in Uterine Endometrium

Yu Ni, Xiaojing Liu, Yang Liu, Hualan Zhou, Enhao Zhang, Fanjing Meng, Faminzi Li, Xinyi Li, Yedong Tang, He Zhu, Yun Gao, Haili Bao, Wenbo Deng, H W Sun, Haibin Wang, Guijun Yan, Shuangbo Kong

Interdisciplinary Sciences Computational Life Sciences

DOI

2025

Decrypting spatiotemporal code of human endometrial receptivity

Yang Liu, Yao Wang, Leilei Zhang, Yedong Tang, Yetao Hong, Meng Liu, Mengyuan Wang, Ya Sun, 沈晓月, Jie Mei, Min Wu, Na Kong, Shuangbo Kong, Haili Bao, Wenbo Deng, Guijun Yan, Haibin Wang, Haixiang Sun

Nature Communications

DOI

2025

GSK3β‐Regulated Lipolysis is Required for Histone Acetylation and Decidualization in Early Pregnancy

Peiran Wang, Yedong Tang, Xueling Zhao, Yu Ni, Hualan Zhou, Enhao Zhang, Gaizhen Li, Han Cai, Yinan Wang, James Robert Woodgett, Wenbo Deng, Haibin Wang, Zhongxian Lu, Haili Bao, Shuangbo Kong

Advanced Science

DOI

2025

Pathogenic mechanism of abnormal expression of HDAC3 in ovulatory granulosa cells inducing oocyte maturation disorder and its application in IVM

Huarong Wang, Huarong Wang, Han Cai, Meiling Zhang, Chuanhui Guo, Peike Wang, Na Deng, Haili Bao, Fanjing Meng, Qing Li, Shuiying Ma, Shuangbo Kong, Wenbo Deng, Hua Zhang, Guoliang Xia, Chao Wang, Chao Wang, Haibin Wang, Haibin Wang

Journal of Biological Chemistry

DOI

2024

Deciphering decidual deficiencies in recurrent spontaneous abortion and the therapeutic potential of mesenchymal stem cells at single-cell resolution

Beibei Jin, Xiaoying Ding, Jiamin Dai, Peng Chen, Chunyu Zhu, Qinru Wei, Xinyi Chen, Ronghui Qiang, Xiaoyi Ding, Hongxiang Du, Wenbo Deng, Xiaoqing Yang

Stem Cell Research & Therapy

DOI

2024

TFEB safeguards trophoblast syncytialization in humans and mice

Wanshan Zheng, Yue Zhang, Peiqun Xu, Zexin Wang, Xuan Shao, C. Chen, Han Cai, Yinan Wang, Yinan Wang, Ming-an Sun, Wenbo Deng, Fan Liu, Jinhua Lu, Xueqin Zhang, Dunjin Cheng, Indira U. Mysorekar, Haibin Wang, Yanling Wang, Yanling Wang, Xiaoqian Hu, Bin Cao

Proceedings of the National Academy of Sciences

DOI

2024

PR-SET7 epigenetically restrains uterine interferon response and cell death governing proper postnatal stromal development

Haili Bao, Yang Sun, Na Deng, Leilei Zhang, Yuanyuan Jia, Gaizhen Li, Yun Gao, Xinyi Li, Yedong Tang, Han Cai, Jinhua Lu, Haibin Wang, Wenbo Deng, Shuangbo Kong

Nature Communications

DOI

2024

Trophoblastic signals facilitate endometrial interferon response and lipid metabolism, ensuring normal decidualization

Ningjie Yang, Yang Sun, Bing Han, Na Deng, Gaizhen Li, Qian Han, Yinan Wang, Han Cai, Fan Liu, Bin Cao, Wenbo Deng, Haili Bao, Shuangbo Kong, Jinhua Lu, Haibin Wang

Cell Reports

DOI

2024

H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation

Na Deng, Gaizhen Li, Leilei Zhang, Peiran Wang, Mengying Liu, Bo He, Yedong Tang, Han Cai, Jinhua Lu, Haibin Wang, Wenbo Deng, Haili Bao, Shuangbo Kong

Cell Death and Differentiation

DOI

2024

Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos

Dan Zhang, Wenbo Deng, Ting Jiang, Yinan Zhao, Dandan Bai, Yingpu Tian, Shuangbo Kong, Leilei Zhang, Haibin Wang, Shaorong Gao, Zhongxian Lu

Journal of Cellular Physiology

DOI

2023

Deciphering a critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution

Meng Liu, Mengjun Ji, Jianghong Cheng, Yingzhe Li, Yingpu Tian, Hui Zhao, Yang Wang, Sijing Zhu, Leilei Zhang, Xinmei Xu, Gen‐Sheng Feng, Xiao‐Huan Liang, Haili Bao, Yedong Tang, Shuangbo Kong, Jinhua Lu, Haibin Wang, Zhongxian Lu, Wenbo Deng

Nature Communications

DOI

2023

Progesterone and cAMP synergistically induce SHP2 expression via PGR and CREB1 during uterine stromal decidualization

Peiyi Zhou, Liqun Ouyang, Ting Jiang, Yingpu Tian, Wenbo Deng, Haibin Wang, Shuangbo Kong, Zhongxian Lu

FEBS Journal

DOI

2023

Stromal cells-specific retinoic acid determines parturition timing at single-cell and spatial-temporal resolution

Hui Zhao, Yang Wang, Hui Xu, Meng Liu, Xinmei Xu, Sijing Zhu, Zhao Liu, Han Cai, Yinan Wang, Jinhua Lu, Xiaoqing Yang, Shuangbo Kong, Haili Bao, Haibin Wang, Wenbo Deng

iScience

DOI

2023

Dingkun pill alleviates metabolic abnormalities in polycystic ovary syndrome through brown adipose tissue activation

Mengqing Gu, Han Cai, Weinan Deng, Yedong Tang, Shuailin Du, Peiran Wang, Wenbo Deng, Haibin Wang, Aijun Sun, Shuangbo Kong

Journal of Ovarian Research

DOI

2023

Gαq-PKD/PKCμ signal regulating the nuclear export of HDAC5 to induce the IκB expression and limit the NF-κB-mediated inflammatory response essential for early pregnancy

Yufei Jiang, Yan He, Songting Liu, Gaizhen Li, Dunjin Chen, Wenbo Deng, Ping Li, Ying Zhang, Jinxiang Wu, Jianing Li, Longmei Wang, Jiajing Lin, Haibin Wang, Shuangbo Kong, Guixiu Shi

eLife

DOI

2023

Trophoblast PR-SET7 dysfunction induces viral mimicry response and necroptosis associated with recurrent miscarriage

Xiaobo Zhou, Yingchun Xu, Shengnan Ren, Ningjie Yang, Yang Sun, Qibing Yang, Yue Zhang, Han Cai, Wenbo Deng, Jingsi Chen, Dunjin Chen, Bin Cao, Hongbo Qi, Haibin Wang, Jinhua Lu

Proceedings of the National Academy of Sciences

DOI

2023

Tissue‐Specific RNA Localization in the Uterus During Implantation, Decidualization and Placentation: Technical Nuances of Various Labeling Approaches

Amanda Dewar, Wenbo Deng, Xiaofei Sun, Sudhansu K. Dey

Current Protocols

DOI

2023

Author response: Gαq-PKD/PKCμ signal regulating the nuclear export of HDAC5 to induce the IκB expression and limit the NF-κB-mediated inflammatory response essential for early pregnancy

Yufei Jiang, Yan He, Songting Liu, Gaizhen Li, Dunjin Chen, Wenbo Deng, Ping Li, Ying Zhang, Jinxiang Wu, Jianing Li, Longmei Wang, Jiajing Lin, Haibin Wang, Shuangbo Kong, Guixiu Shi

DOI

2023

Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization

Miao Yu, Xiaoqian Hu, Zihang Pan, Cui Du, Jing Jiang, Wanshan Zheng, Han Cai, Yinan Wang, Wenbo Deng, Haibin Wang, Jinhua Lu, Ming‐an Sun, Bin Cao

Nucleic Acids Research

DOI

2022

Adgrg1 is a new transcriptional target of Hand1 during trophoblast giant cell differentiation

Yongqin Yu, Change Mu, Yingchun Xu, Yuanyuan Li, Shengnan Ren, Shuangbo Kong, Wenbo Deng, Yinan Wang, Haibin Wang, Jinhua Lu

Journal of Reproductive Immunology

DOI

2022

Maternal anxiety affects embryo implantation via impairing adrenergic receptor signaling in decidual cells

Jinxiang Wu, Lin Shu, Pinxiu Huang, Lingling Qiu, Yufei Jiang, Ying Zhang, Nan Meng, Meiqing Meng, Lemeng Wang, Wenbo Deng, Zhao Liu, Chuanhui Guo, Jinhua Lu, Haibin Wang, Shuangbo Kong

Communications Biology

DOI

2022

P38α MAPK is a gatekeeper of uterine progesterone responsiveness at peri-implantation via Ube3c-mediated PGR degradation

Yedong Tang, Jingtao Qiu, Zhenzhou Tang, Gaizhen Li, Mengqing Gu, Yang Wang, Haili Bao, Wenbo Deng, Zhongxian Lu, Kinya Otsu, Zhengchao Wang, Haibin Wang, Shuangbo Kong

Proceedings of the National Academy of Sciences

DOI

2022

Efficient cell chatting between embryo and uterus ensures embryo implantation

Wenbo Deng, Haibin Wang

Biology of Reproduction

DOI

2022

Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling

Mengying Liu, Wenbo Deng, Lu Tang, Meng Liu, Haili Bao, Chuanhui Guo, Chang Xian Zhang, Jinhua Lu, Haibin Wang, Zhongxian Lu, Shuangbo Kong

Nature Communications

DOI

2022

Deciphering the endometrial niche of human thin endometrium at single-cell resolution

Haining Lv, Guangfeng Zhao, Peipei Jiang, Huiyan Wang, Zhiyin Wang, Simin Yao, Zhenhua Zhou, Limin Wang, Dan Liu, Wenbo Deng, Jianwu Dai, Yali Hu

Proceedings of the National Academy of Sciences

DOI

2022

Author response: SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization

Pinxiu Huang, Wenbo Deng, Haili Bao, Zhong Lin, Mengying Liu, Jinxiang Wu, Xiaobo Zhou, Manting Qiao, Yihua Yang, Han Cai, Faiza Rao, Jingsi Chen, Dunjin Chen, Jinhua Lu, Haibin Wang, Aiping Qin, Shuangbo Kong

DOI

2022

Shp2 in uterine stromal cells critically regulates on time embryo implantation and stromal decidualization by multiple pathways during early pregnancy

Jianghong Cheng, Liang Jia, Yingzhe Li, Xia Gao, Mengjun Ji, Mengying Liu, Yingpu Tian, Gen‐Sheng Feng, Wenbo Deng, Haibin Wang, Shuangbo Kong, Zhongxian Lu

PLoS Genetics

DOI

2021

Maternal Determinants of Pregnancy Success

Wenbo Deng, Dong‐bao Chen, Haibin Wang

Maternal-Fetal Medicine

DOI

2021

Single‐cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortion

Lili Du, Wenbo Deng, Shanshan Zeng, Pei Xu, Lijun Huang, Yingyu Liang, Yang Wang, Hui Xu, Jingman Tang, Shilei Bi, Lizi Zhang, Yulian Li, Luwen Ren, Lin Lin, Weinan Deng, Mingxing Liu, Jingsi Chen, Haibin Wang, Dunjin Chen

Cell Proliferation

DOI

2021

Single-cell RNA-seq revealed diverse cell types in the mouse placenta at mid-gestation

Xiaobo Zhou, Yingchun Xu, Shengnan Ren, Dong Liu, Ningjie Yang, Qian Han, Shuangbo Kong, Haibin Wang, Wenbo Deng, Hongbo Qi, Jinhua Lu

Experimental Cell Research

DOI

2021

Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation

Chan Zhou, Meiying Lv, Peike Wang, Chuanhui Guo, Zhangli Ni, Haili Bao, Yedong Tang, Han Cai, Jinhua Lu, Wenbo Deng, Xiaoyu Yang, Guoliang Xia, Haibin Wang, Chao Wang, Shuangbo Kong

Journal of Molecular Cell Biology

DOI

2020

Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2

Haili Bao, Dong Liu, Yingchun Xu, Yang Sun, Change Mu, Yongqin Yu, Chunping Wang, Qian Han, Sanmei Liu, Han Cai, Fan Liu, Shuangbo Kong, Wenbo Deng, Bin Cao, Haibin Wang, Qiang Wang, Jinhua Lu

BMC Biology

DOI

2019

Primary decidual zone formation requires Scribble for pregnancy success in mice

Jia Yuan, Shizu Aikawa, Wenbo Deng, Amanda Bartos, Gerd Walz, Florian Grahammer, Tobias Bruno Huber, Xiaofei Sun, Sudhansu K. Dey

Nature Communications

DOI

2019

Uterine deficiency of high-mobility group box-1 (HMGB1) protein causes implantation defects and adverse pregnancy outcomes

Shizu Aikawa, Wenbo Deng, Xiao‐Huan Liang, Jia Yuan, Amanda Bartos, Xiaofei Sun, Sudhansu K. Dey

Cell Death and Differentiation

DOI

2012

Heparin-Binding Epidermal Growth Factor-Like Growth Factor (HB-EGF) Induction on Snail Expression During Mouse Decidualization.

Zeng‐Ming Yang, Xiuhong Zhang, Xuan Liang, Tong-Song Wang, Zhirong Zhang, Ru-Juan Zuo, Wenbo Deng, Xiao‐Huan Liang, Funiu Qin, Zhen‐Ao Zhao

Biology of Reproduction

DOI

2008

前列腺素在胚胎着床和蜕膜化中的作用

邓文波，杨增明

《中国细胞生物学学报》

精选作品

期刊论文

UDEDB: A Comprehensive Database for Dynamic Molecular Expression Changes in Uterine Endometrium

Decrypting spatiotemporal code of human endometrial receptivity

GSK3β‐Regulated Lipolysis is Required for Histone Acetylation and Decidualization in Early Pregnancy

Pathogenic mechanism of abnormal expression of HDAC3 in ovulatory granulosa cells inducing oocyte maturation disorder and its application in IVM

Deciphering decidual deficiencies in recurrent spontaneous abortion and the therapeutic potential of mesenchymal stem cells at single-cell resolution

TFEB safeguards trophoblast syncytialization in humans and mice

PR-SET7 epigenetically restrains uterine interferon response and cell death governing proper postnatal stromal development

Trophoblastic signals facilitate endometrial interferon response and lipid metabolism, ensuring normal decidualization

H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation

Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos

Deciphering a critical role of uterine epithelial SHP2 in parturition initiation at single cell resolution

Progesterone and cAMP synergistically induce SHP2 expression via PGR and CREB1 during uterine stromal decidualization

Stromal cells-specific retinoic acid determines parturition timing at single-cell and spatial-temporal resolution

Dingkun pill alleviates metabolic abnormalities in polycystic ovary syndrome through brown adipose tissue activation

Gαq-PKD/PKCμ signal regulating the nuclear export of HDAC5 to induce the IκB expression and limit the NF-κB-mediated inflammatory response essential for early pregnancy

Trophoblast PR-SET7 dysfunction induces viral mimicry response and necroptosis associated with recurrent miscarriage

Tissue‐Specific RNA Localization in the Uterus During Implantation, Decidualization and Placentation: Technical Nuances of Various Labeling Approaches

Author response: Gαq-PKD/PKCμ signal regulating the nuclear export of HDAC5 to induce the IκB expression and limit the NF-κB-mediated inflammatory response essential for early pregnancy

Endogenous retrovirus-derived enhancers confer the transcriptional regulation of human trophoblast syncytialization

Adgrg1 is a new transcriptional target of Hand1 during trophoblast giant cell differentiation

Maternal anxiety affects embryo implantation via impairing adrenergic receptor signaling in decidual cells

P38α MAPK is a gatekeeper of uterine progesterone responsiveness at peri-implantation via Ube3c-mediated PGR degradation

Efficient cell chatting between embryo and uterus ensures embryo implantation

Menin directs regionalized decidual transformation through epigenetically setting PTX3 to balance FGF and BMP signaling

Deciphering the endometrial niche of human thin endometrium at single-cell resolution

Author response: SOX4 facilitates PGR protein stability and FOXO1 expression conducive for human endometrial decidualization

Shp2 in uterine stromal cells critically regulates on time embryo implantation and stromal decidualization by multiple pathways during early pregnancy

Maternal Determinants of Pregnancy Success

Single‐cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortion

Single-cell RNA-seq revealed diverse cell types in the mouse placenta at mid-gestation

Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation

Hyperactivated Wnt-β-catenin signaling in the absence of sFRP1 and sFRP5 disrupts trophoblast differentiation through repression of Ascl2

Primary decidual zone formation requires Scribble for pregnancy success in mice

Uterine deficiency of high-mobility group box-1 (HMGB1) protein causes implantation defects and adverse pregnancy outcomes

Heparin-Binding Epidermal Growth Factor-Like Growth Factor (HB-EGF) Induction on Snail Expression During Mouse Decidualization.

前列腺素在胚胎着床和蜕膜化中的作用

会议论文

雄激素在小鼠胚胎着床过程中的作用

预印本

ERBB2 establishes the timing of progesterone priming required for uterine receptivity

Uterine ERBB3 signaling is critical to cultivate stromal environment for functional gland branching

Mst1-Mediated Phosphorylation of Nur77 is Required for Embryo Implantation