杨立朝｜厦门大学｜学者主页

百晓学者学者目录

精选作品

期刊论文

2026

Lysosome-targeted cascade nanoprobe reveals Aβ-induced cholesterol dysregulation via dual-mode imaging in Alzheimer’s disease models

Fei Gao, Wanquan Lin, Xiaorong Jiao, Yanxia Zhang, Tingting Zhao, Jinlong Zhang, Dong Pei, 邸多隆, Lichao Yang, Jun Hai

Sensors and Actuators B Chemical

DOI

2026

HIF-1 plays a dual regulatory role in hippocampal neuronal PANoptosis in Alzheimer's disease via the HK2/VDAC1/NLRP3 axis and RIPK3 signaling

Siqi Wang, Laixi Luo, Xilin Jiang, Jun Hai, Weilin Liu, Xianhui Zhou, Ying Li, Lichao Yang

Pharmacological Research

DOI

2026

PPARα deficiency exacerbates atherosclerosis progressing through enhancing pTh17 cells-macrophage crosstalk

Tong Ren, Xilin Jiang, Jianfeng Wu, Changsheng Yan, Peng Lü, Caixia Chen, Wenjun Li, Weiyi Wang, Xin Jin, Lichao Yang

European Journal of Pharmacology

DOI

2025

脑缺血损伤释放的线粒体碎片诱发卒中复发的作用及机制研究

罗来熙，姜熙林，杨立朝

《神经药理学报》

2025

多发性硬化症中少突胶质细胞泛凋亡及靶向治疗策略

罗来熙，郑锦珍，杨立朝

《神经药理学报》

2025

缺血诱导的PPARα缺失加剧神经元泛凋亡

李成晨，罗来熙，杨立朝

《神经药理学报》

2025

Pterostilbene mitigates scopolamine-induced cognitive impairment by modulating cholinergic pathway and reducing neuroinflammation

Chenxu Wang, Ling Chen, Rou Wen, Lu Peng, Caixia Chen, Rengong Zhuo, Yun Zhao, Yan Qiu, Lichao Yang, Yu Zhou

Phytomedicine

DOI

2025

Engineering of an Enzyme-Activatable Ratiometric DNA Nanosensor for Spatially Resolved pH Imaging in Ischemic Stroke

Tingting Zhao, Wanquan Lin, Fei Gao, Jing Zhao, Jinlong Zhang, Duolong Di, Dong Pei, Lichao Yang, Jun Hai

Analytical Chemistry

DOI

2025

Visual Whole-Process Monitoring Dynamic Phase Separation of Autophagic Lysosomes in Alzheimer’s Disease by a Lysosome-Targeted pH-Activated Fluorescence Probe

Fei Gao, Wanquan Lin, Tingting Zhao, Jinlong Zhang, Dong Pei, Duolong Di, Zhongxiong Fan, Lichao Yang, Jun Hai

Analytical Chemistry

DOI

2025

Spatiotemporally controlled imaging of lysosomal pH via NIR/pH dual-activatable DNA nanomachines for early Alzheimer's disease detection

Fei Gao, Wanquan Lin, Tingting Zhao, Jinlong Zhang, Dong Pei, Duolong Di, Lichao Yang, Jun Hai

Sensors and Actuators B Chemical

DOI

2025

PPARα deletion induces depressive-like behaviors by impairing neuronal synaptic plasticity and transmission

Rengong Zhuo, Xiao-Ling Cheng, Luying Yang, Canmao Wang, Lichao Yang, Yanan Zhang, Ying Zeng, Ying Li

Neuroscience

DOI

2025

Targeting microglial PPARα ameliorates the outcome of ischemic stroke by enhancing interaction with infiltrating peripheral monocytes/macrophages

Tong Ren, Maoshu Zhu, Xilin Jiang, Lanxi Xu, Hao Jin, Yu Zhou, Yun Zhao, Rengong Zhuo, Wenjun Li, Caixia Chen, Peng Lü, Xin Jin, Ying Li, Lichao Yang

Cell Reports

DOI

2025

Oleoylethanolamide exerts neuroprotection following ischemic stroke through microglial PPARα signal

Ying Li, Chuang Kuo Wu, Yanan Zhang, Qing Wang, Yingbai Huang, Yihui Xie, Lichao Yang, Lanxi Xu, Siqi Wang

International Immunopharmacology

DOI

2025

Metformin-induced precise targeted inhibition of ischemic neuronal death by a programable endogenous ROS-responsive nanoprodrug

Xiaofeng Tan, Ying Li, Ying Li, Hao Jin, Yu Zhou, Wenjun Li, Wenjun Li, Yun Zhao, Jun Hai, Jinyao Li, Zhongxiong Fan, Lichao Yang

Chemical Engineering Journal

DOI

2024

RVG-peptide-camouflaged iron-coordinated engineered polydopamine nanoenzyme with ROS scavenging and inhibiting inflammatory response for ischemic stroke therapy

Heng Liu, Rengong Zhuo, Chuanyang Zou, Shuyu Xu, Xin-ying Cai, Yuxue Ge, Gang Liu, Chuang Kuo Wu, Cuilian Dai, Jinyao Li, Zhongxiong Fan, Lichao Yang, Ying Li

International Journal of Biological Macromolecules

DOI

2024

Intrinsic Capacity, Polygenic Risk Score, APOE Genotype, and Risk of Dementia

Meng-Tong Sun, Qi-Da He, Na Sun, Qiang Han, Yu Wang, Hanqing Zhao, Guoxian Li, Ze Ma, Zhaolong Feng, Tongxing Li, Lichao Yang, Yue-Ping Shen

Neurology

DOI

2023

无载体ROS响应性纳米药物对缺血性脑卒中的治疗作用

谭晓锋，杨立朝

《中国药理学与毒理学杂志》

2023

脑缺血后小胶质细胞线粒体碎片介导神经元铁死亡及靶向干预策略

金昊，杨立朝

《中国药理学与毒理学杂志》

2023

Oleoylethanolamide ameliorates motor dysfunction through PPARα ‐mediates oligodendrocyte differentiation and white matter integrity after ischemic stroke

Rengong Zhuo, Zhengmao Song, Yun Wang, Maoshu Zhu, Feng Liu, Pingli Lin, Rong Rao, Yudong Zhou, Yun Zhao, Zhongxiong Fan, Lishan Cui, Hongtao Liu, Jingwen Li, Ying Li, Han Guo, Cheng Fu Cai, Lichao Yang

Phytotherapy Research

DOI

2023

URB597 exerts neuroprotective effects against transient brain ischemia injury in mice by regulating autophagic flux and necroptosis

Xiaoqian Yuan, Wenxuan Ye, Ling Chen, Doudou Luo, Li Zhou, Li Zhou, Yan Qiu, Yun Zhao, Yun Zhao, Peng Lu, Lichao Yang, Xin Jin, Yu Zhou

European Journal of Pharmacology

DOI

2023

ROS-responsive hierarchical targeting vehicle-free nanodrugs for three-pronged Parkinson’s disease therapy

Zhongxiong Fan, Hao Jin, Xiaofeng Tan, Ying Li, Dao Shi, Qiuli Wang, Jiahao Meng, Wenjun Li, Caixia Chen, Lu Peng, Zhenqing Hou, Jingwen Li, Xin Jin, Lichao Yang

Chemical Engineering Journal

DOI

2023

Oleoylethanolamide Protects against Acute Ischemic Stroke by Promoting PPARα-Mediated Microglia/Macrophage M2 Polarization

Ying Li, Yanan Zhang, Qing Wang, Chuang Kuo Wu, Guicheng Du, Lichao Yang

Pharmaceuticals

DOI

2023

Dementia classification using a graph neural network on imaging of effective brain connectivity

Jun Cao, Lichao Yang, P. Sarrigiannis, Daniel Blackburn, Yifan Zhao

Comput. Biol. Medicine

DOI

2022

Aβ-responsive metformin-based supramolecular synergistic nanodrugs for Alzheimer's disease via enhancing microglial Aβ clearance

Zhongxiong Fan, Tong Ren, Youjun Wang, Hao Jin, Dao Shi, Xiaofeng Tan, Dongtao Ge, Zhenqing Hou, Xin Jin, Lichao Yang

Biomaterials

DOI

2022

Trojan-Horse Diameter-Reducible Nanotheranostics for Macroscopic/Microscopic Imaging-Monitored Chemo-Antiangiogenic Therapy

Zhongxiong Fan, Dao Shi, Wenbao Zuo, Juan Feng, Dongtao Ge, Guanghao Su, Lichao Yang, Zhenqing Hou

ACS Applied Materials & Interfaces

DOI

2022

Cinnamic Acid Improved Lipopolysaccharide-Induced Depressive-Like Behaviors by Inhibiting Neuroinflammation and Oxidative Stress in Mice

Rengong Zhuo, Xiaoling Cheng, Lili Luo, Luying Yang, Yun Zhao, Yu Zhou, Peng Lü, Xin Jin, Lishan Cui, Feng Liu, Lichao Yang

Pharmacology

DOI

2021

Phytochemical wedelolactone reverses obesity by prompting adipose browning through SIRT1/AMPK/ PPARα pathway via targeting nicotinamide N-methyltransferase

En‐Hui Yao, Xiazhen Yang, Xuefeng Huang, Yuchen Mi, Xiaoqian Wu, Meijuan Fang, Jinhua Huang, Yan Qiu, Xiaoting Hong, Peng Lu, Jie Ren, Rui Huang, Caixia Chen, Lichao Yang, Yu Zhou, Rengong Zhuo, Xin Jin, Yun Zhao

Phytomedicine

DOI

2021

A Revised Hilbert-Huang Transformation to Track Non-Stationary Association of Electroencephalography Signals

Xiaocai Shan, S. Huo, Lichao Yang, Jun Cao, Jiaru Zou, Liangyu Chen, P. Sarrigiannis, Yi-Fan Zhao

IEEE transactions on neural systems and rehabilitation engineering

DOI

2020

Oleoylethanolamide Increases Glycogen Synthesis and Inhibits Hepatic Gluconeogenesis via the LKB1/AMPK Pathway in Type 2 Diabetic Model

Tong Ren, Ang Ma, Rengong Zhuo, Huaying Zhang, Peng Lu, Xin Jin, En‐Hui Yao, Lichao Yang

Journal of Pharmacology and Experimental Therapeutics

DOI

2020

Oleoylethanolamide stabilizes atherosclerotic plaque through regulating macrophage polarization via AMPK-PPARα pathway

Zhengdong Chen, Rengong Zhuo, Yun Zhao, Lichao Yang, Yudong Zhou, Xiaoling Cheng, Peng Lu, Xin Jin, Yiqing Wang

Biochemical and Biophysical Research Communications

DOI

2019

Chronic oleoylethanolamide treatment attenuates diabetes-induced mice encephalopathy by triggering peroxisome proliferator-activated receptor alpha in the hippocampus

Tong Ren, Jinfeng Liu, Yunlong Ge, Rengong Zhuo, Peng Lu, Feng Liu, Xin Jin, Lichao Yang

Neurochemistry International

DOI

2019

Moringa oleifera seed extract protects against brain damage in both the acute and delayed stages of ischemic stroke

Kai-yue Zeng, Ying Li, Wushuang Yang, Yunlong Ge, Lanxi Xu, Tong Ren, Huijun Zhang, Rengong Zhuo, Lu Peng, Caixia Chen, Yudong Zhou, Yun Zhao, Wen Jun Li, Xin Jin, Lichao Yang

Experimental Gerontology

DOI

2019

Immunomodulatory effect of oleoylethanolamide in dendritic cells via TRPV1/AMPK activation

En‐Hui Yao, Guixiang Zhang, Jinhua Huang, Xiazhen Yang, Peng Lu, Xuefeng Huang, Xiaoxin Luo, Jie Ren, Rui Huang, Lichao Yang, Yudong Zhou, Rengong Zhuo, Yun Zhao, Xin Jin

Journal of Cellular Physiology

DOI

2019

Integration of phospholipid-complex nanocarrier assembly with endogenous N-oleoylethanolamine for efficient stroke therapy

Xiangrui Yang, Lanxi Xu, Juan Zhou, Yunlong Ge, Shichao Wu, Junxiong Huang, Ying Li, Maoshu Zhu, Xin Jin, Lichao Yang

Journal of Nanobiotechnology

DOI

2019

Oleoylethanolamide inhibits glial activation via moudulating PPARα and promotes motor function recovery after brain ischemia

Doudou Luo, Yali Zhang, Xiaoqian Yuan, Yilin Pan, Lichao Yang, Yun Zhao, Rengong Zhuo, Caixia Chen, Lu Peng, Wenjun Li, Xin Jin, Yu Zhou

Pharmacological Research

DOI

2018

The effect of dexmedetomidine on inflammatory inhibition and microglial polarization in BV-2 cells

Zhiheng Sun, Yi Lin, Ying Li, Tong Ren, Guicheng Du, Jia Wang, Xin Jin, Lichao Yang

Neurological Research

DOI

2018

Oleoylethanolamide alleviates macrophage formation via AMPK/PPARα/STAT3 pathway

Yun Zhao, Yan Lu, Peng Lu, Xuefeng Huang, GuiXiang Zhang, BingQian Chen, Jie Ren, Yu Zhou, Lichao Yang, Li Peng, Xin Jin, Yiqing Wang

Pharmacological Reports

DOI

2018

Vernonia amygdalina Delile extract inhibits the hepatic gluconeogenesis through the activation of adenosine-5’monophosph kinase

Xiu-mi Wu, Tong Ren, Jinfeng Liu, Yijun Liu, Lichao Yang, Xin Jin

Biomedicine & Pharmacotherapy

DOI

2018

Moringa oleifera Seed Extract Alleviates Scopolamine-Induced Learning and Memory Impairment in Mice

Juan Zhou, Wushuang Yang, Daqin Suo, Ying Li, Lu Peng, Lanxi Xu, Kai-yue Zeng, Tong Ren, Ying Wang, Yudong Zhou, Yun Zhao, Lichao Yang, Xin Jin

Frontiers in Pharmacology

DOI

2018

A novel PPARα/γ agonist, propane-2-sulfonic acid octadec-9-enyl-amide, ameliorates insulin resistance and gluconeogenesis in vivo and vitro

Tong Ren, Wushuang Yang, Yi Lin, Jinfeng Liu, Ying Li, Lichao Yang, Kai-yue Zeng, Peng Lu, Yijun Liu, Zhen-hong Ye, Xiu-Mei Luo, Yu-jie Ke, Yong Diao, Xin Jin

European Journal of Pharmacology

DOI

2018

N-oleoylethanolamide suppresses intimal hyperplasia after balloon injury in rats through AMPK/PPARα pathway

Yun Zhao, Yijun Liu, Jing Long Zuo, Peng Lu, Peng Jin, Yangbin Lin, Yu Zhou, Lichao Yang, Jie Ren, Qiang Xie, Xin Jin

Biochemical and Biophysical Research Communications

DOI

2017

Propane-2-sulfonic acid octadec-9-enyl-amide, a novel PPARα/γ dual agonist, protects against ischemia-induced brain damage in mice by inhibiting inflammatory responses

Ying Li, Lanxi Xu, Kaiyue Zeng, Zhentian Xu, Daqin Suo, Lu Peng, Tong Ren, Zhiheng Sun, Wushuang Yang, Xin Jin, Lichao Yang

Brain Behavior And Immunity，Vol. 66

DOI

2017

Wedelolactone, a plant coumarin, prevents vascular smooth muscle cell proliferation and injury-induced neointimal hyperplasia through Akt and AMPK signaling

Peng Lu, Xuefeng Huang, Xin Jin, Jing Long Zuo, Lichao Yang, Yu Zhou, Jie Ren, Yun Zhao

Experimental Gerontology

DOI

2016

Oleoylethanolamide attenuates apoptosis by inhibiting the TLR4/NF-κB and ERK1/2 signaling pathways in mice with acute ischemic stroke

Hao Zhou, Wushuang Yang, Ying Li, Tong Ren, Peng Lu, Han Guo, Jinfeng Liu, Yudong Zhou, Yun Zhao, Lichao Yang, Xin Jin

Naunyn-Schmiedeberg s Archives of Pharmacology

DOI

2016

Oleoylethanolamide exerts anti-inflammatory effects on LPS-induced THP-1 cells by enhancing PPARα signaling and inhibiting the NF-κB and ERK1/2/AP-1/STAT3 pathways

Lichao Yang, Han Guo, Ying Li, Xianglan Meng, Yan Lu, Dan Zhang, San‐Gang Wu, Hao Zhou, Peng Lu, Qiang Xie, Xin Jin

Scientific Reports

DOI

2016

A novel PPARα agonist propane-2-sulfonic acid octadec-9-enyl-amide inhibits inflammation in THP-1 cells

Yun Zhao, Yan Lu, Xiu-Mei Luo, Peng Lu, Han Guo, Jing Long Zuo, Lichao Yang, Rong Hu, Xuan Wang, Xuefeng Huang, Yiqing Wang, Xin Jin

European Journal of Pharmacology

DOI

2016

N-Oleoylethanolamine Reduces Inflammatory Cytokines and Adhesion Molecules in TNF-α-induced Human Umbilical Vein Endothelial Cells by Activating CB2 and PPAR-α

Xudong Xu, Han Guo, Jing Long Zuo, Lichao Yang, Caixia Chen, Peng Lu, Xiaoqing Wang, Yan Lu, Rongting Ye, Xin Jin, Yiqing Wang

Journal of Cardiovascular Pharmacology

DOI

2015

Chronic oleoylethanolamide treatment improves spatial cognitive deficits through enhancing hippocampal neurogenesis after transient focal cerebral ischemia

Lichao Yang, Han Guo, Hao Zhou, Daqin Suo, Wenjun Li, Yudong Zhou, Yun Zhao, Wushuang Yang, Xin Jin

Biochemical Pharmacology

DOI

2015

Wedelolactone Regulates Lipid Metabolism and Improves Hepatic Steatosis Partly by AMPK Activation and Up-Regulation of Expression of PPARα/LPL and LDLR

Yun Zhao, Peng Lu, Lichao Yang, Xudong Xu, Weijie Li, Xiu-mei Luo, Xin Jin

PLoS ONE

DOI

2015

Effect of propane-2-sulfonic acid octadec-9-enyl-amide on the expression of adhesion molecules in human umbilical vein endothelial cells

Caixia Chen, Lichao Yang, Xudong Xu, Xiao Wei, Ya-Ting Gai, Peng Lu, Han Guo, Hao-Zhou, Yiqing Wang, Xin Jin

European Journal of Pharmacology

DOI

2012

非诺贝特对小鼠急性局灶性脑缺血再灌注损伤的保护作用

马昂，周宇，杨立朝，杨武双，张雪梅，金鑫

《中国药学杂志》

2012

Orally administered oleoylethanolamide protects mice from focal cerebral ischemic injury by activating peroxisome proliferator-activated receptor α

Yu Zhou, Lichao Yang, Ang Ma, Xuemei Zhang, Weijie Li, Wushuang Yang, Caixia Chen, Xin Jin

Neuropharmacology

DOI

2010

前胡甲素对小鼠局灶性脑缺血的保护作用

杨武双，滕伯刚，杨立朝，周宇，王瑶，金鑫

《中国生化药物杂志》

2009

油酰乙醇胺对小鼠局灶性脑缺血的保护作用

杨立朝，杨武双，周宇，金鑫

《中国药理学通报》

会议论文

2018

PPARα调控脑卒中后小胶质细胞M1/M2极化的作用及机制研究

徐岚溪，任桐，张慧君，张一娇，金鑫，杨立朝

《首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会论文集》

DOI

2017

PPARα在脑缺血后小胶质细胞表型转化中的作用研究

徐岚溪，曾恺悦，任桐，张慧君，金鑫，杨立朝

《第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会论文集》

DOI

2015

白花前胡甲素(Pd‐Ia)对脑缺血再灌注损伤的保护作用研究

杨武双，杨立朝，金鑫

《中国中西医结合学会神经外科专业委员会第二届学术大会论文集》

2009

油酰乙醇胺对小鼠局灶性脑缺血的保护作用及对PPARαmRNA表达的影响

杨立朝，杨武双，周宇，金鑫

《中国药理学会第十次全国学术会议专刊》

预印本

2026

Exercise Delays Cognitive Decline Through Galntl6-Mediated O-Glycosylation Moudulating Synaptic Plasticity of Hippocampus in Aged Mice

Sinuo Wang, Yuwei Ye, Rui Li, Wenju Wang, Lei Yang, Qian Li, Yajun Cao, Yangling Zheng, Jia Lin, Yaling Dai, Huawei Lin, Jianhong Li, Junzi Wang, Yulu Liu, Yangyang Yu, Jing Tao, Lidian Chen, Minguang Yang, Lichao Yang, Weilin Liu

SSRN Electronic Journal

DOI

研究方向

神经系统疾病的发病机制新药开发及药物递送研究

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