张永清｜湖北大学｜学者主页

期刊论文

2026

脑疾病家犬遗传模型研究进展

陈诗静，齐鹏举，喻子鹏，赵晖，金珊，张永清，毛传樨

《遗传》

2026

Emerging gene-edited dog models for autism spectrum disorder

Siqi Yuan, Qi Shi, Hui Zhao, Kun Guo, Yong‐hui Jiang, Yongqing Zhang

Genomic psychiatry :

DOI

2026

The effects of oxytocin on social behavior and eye gaze: Insights from dog-human partnership

Siqi Yuan, Yongqing Zhang

Neuroscience & Biobehavioral Reviews

DOI

2025

孤独症相关Shank3突变犬触觉敏感性降低的神经机制和干预（英文）

史奇，吴梁，任宝龙，郭昆，姜永辉，张永清，胡理

Science Bulletin

2025

Gene-Edited Canines as Emerging Models for Studies on Mental Disorders

Hui Zhao, Yong‐hui Jiang, Yongqing Zhang

National Science Review

DOI

2025

Autism-like atypical face processing in Shank3 mutant dogs

Siqi Yuan, Chenyu Pang, Liang Wu, Li Yi, Kun Guo, Yong‐hui Jiang, Yongqing Zhang, Shihui Han

Science Advances

DOI

2025

Reduced attention to human eyes in autism-associated Shank3 mutant laboratory beagle dogs

Yumo Li, Qiandong Wang, Siqi Yuan, Tak Kwan Lam, Kun Guo, Yongqing Zhang, Li Yi

Molecular Psychiatry

DOI

2025

Neural mechanisms underlying reduced nocifensive sensitivity in autism-associated Shank3 mutant dogs

Qi Wu Shi, Baolong Ren, Xuejing Lu, Libo Zhang, Liang Sheng Wu, Li Hu, Yongqing Zhang

Molecular Psychiatry

DOI

2025

Oxytocin improves maternal licking behavior deficits in autism-associated Shank3 mutant dogs

Wen Lyu, Yuan Li, Aiyu Yao, Qing-quan Tan, Rong Zhang, Jianping Zhao, Kun Guo, Yong‐hui Jiang, Rui Tian, Yongqing Zhang

Translational Psychiatry

DOI

2024

Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity

Xin-jia Zhu, Y. Joo, Simone Bossi, Ross A. McDevitt, Ao-Ji Xie, Yue Wang, Yutong Xue, Shuaikun Su, S. K. Lee, N. Sah, Shi-Liang Zhang, Rong Ye, Alejandro Pinto, Yongqing Zhang, Kimi Araki, M. Araki, Marisela Morales, M. P. Mattson, H. van Praag, Weidong Wang

Progress in neurobiology

DOI

2024

Disrupted Human–Dog Interbrain Neural Coupling in Autism‐Associated Shank3 Mutant Dogs

Wei Ren, Shan Ping Yu, Kun Guo, Chunming Lu, Yongqing Zhang

Advanced Science

DOI

2024

VDGE: a data repository of variation database for gene-edited animals across multiple species

Wenwen Shi, Enhui Jin, Fang Lü, Yanling Sun, Zhuojing Fan, Junwei Zhu, Chengzhi Liang, Ya‐Ping Zhang, Yongqing Zhang, Yong Qiang Zhang, Yong Qiang Zhang, Guodong Wang, Wenming Zhao

Nucleic Acids Research

DOI

2024

Impaired tactile processing in autism-associated Shank3 mutant dogs: neural mechanism and intervention

Qi Shi, Liang Sheng Wu, Baolong Ren, Kun Guo, Yong‐hui Jiang, Yongqing Zhang, Li Hu

《中国科学通报：英文版》

DOI

2024

Impaired synaptic function and hyperexcitability of the pyramidal neurons in the prefrontal cortex of autism-associated Shank3 mutant dogs

Feipeng Zhu, Qi Wu Shi, Yong‐hui Jiang, Yongqing Zhang, Hui Zhao

Molecular Autism

DOI

2023

Modeling SHANK3-associated autism spectrum disorder in Beagle dogs via CRISPR/Cas9 gene editing

Rui Tian, Yuan Li, Hui Zhao, Wen Lyu, Jianping Zhao, Xiaomin Wang, Heng Lu, Huijuan Xu, Wei Ren, Qing-quan Tan, Qi Wu Shi, Guodong Wang, Ya‐Ping Zhang, Ya-ping Zhang, Liangxue Lai, Jidong Mi, Yongqing Zhang, Yongqing Zhang, Yongqing Zhang

Molecular Psychiatry

DOI

2023

Altered pupil responses to social and non-social stimuli in Shank3 mutant dogs

Wei Ren, Kang Huang, Yumo Li, Yang Qin, Liping Wang, Kun Guo, Pengfei Wei, Yongqing Zhang

Molecular Psychiatry

DOI

2016

Angelman综合征蛋白Ube3a通过抑制BMP信号通路调控神经突触的生长发育和内吞

姚爱玉，张永清

《遗传》

2015

自闭症谱系障碍的分子遗传学研究进展

赵晖，张永超，张永清

《遗传》

2015

智障相关基因调控神经突触的生长发育

姚爱玉，张永清

《中国科学:生命科学》

会议论文

2015

突触发育与智障和自闭症

张永清

《第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议论文集》

2012

ACSL4,a mental retardation related protein,inhibits synaptic growth through regulating endocytic recycling of BMP receptors

张永清

《第二届模式生物与人类健康研讨会会议论文集》

2007

脆性X智力低下蛋白调控果蝇细胞骨架蛋白的稳定性

王丹，姚爱玉，张永清

《遗传学进步与人口健康高峰论坛论文集》

2007

TBCE对果蝇微管结构与功能的调节

金珊，张永清

《遗传学进步与人口健康高峰论坛》

2005

以果蝇为模型研究脆性X智力低下的分子遗传机制

林欣大，姜芳芳，李聪，刘志华，姚爱玉，张永清

《第六次全国医学遗传学学术会议文摘汇编》

2005

神经突触拆组装的分子和细胞机制

陈严，刘志伟，王丹，张永清

《中国细胞生物学学会2005年学术大会、青年学术研讨会》

2005

以果蝇为模型研究脆性X智力低下的分子和细胞机制

林欣大，姜芳芳，李聪，刘志华，姚爱玉，张永清

《中国细胞生物学学会2005年学术大会、青年学术研讨会》

预印本

2026

Shank3 mutation disrupts affective touch encoding in the dorsal medial prefrontal cortex of Beagle dogs

Yanhe Zhou, Yue He, Minna Dan, Lintao Jia, Kun Guo, Ying Fang, Li Hu, Xiang Yu, Jinfen Wang, Dajun Xing, Yongqing Zhang

bioRxiv (Cold Spring Harbor Laboratory)

DOI

张永清

精选作品

期刊论文

脑疾病家犬遗传模型研究进展

Emerging gene-edited dog models for autism spectrum disorder

The effects of oxytocin on social behavior and eye gaze: Insights from dog-human partnership

孤独症相关Shank3突变犬触觉敏感性降低的神经机制和干预（英文）

Gene-Edited Canines as Emerging Models for Studies on Mental Disorders

Autism-like atypical face processing in Shank3 mutant dogs

Reduced attention to human eyes in autism-associated Shank3 mutant laboratory beagle dogs

Neural mechanisms underlying reduced nocifensive sensitivity in autism-associated Shank3 mutant dogs

Oxytocin improves maternal licking behavior deficits in autism-associated Shank3 mutant dogs

Tdrd3-null mice show post-transcriptional and behavioral impairments associated with neurogenesis and synaptic plasticity

Disrupted Human–Dog Interbrain Neural Coupling in Autism‐Associated Shank3 Mutant Dogs

VDGE: a data repository of variation database for gene-edited animals across multiple species

Impaired tactile processing in autism-associated Shank3 mutant dogs: neural mechanism and intervention

Impaired synaptic function and hyperexcitability of the pyramidal neurons in the prefrontal cortex of autism-associated Shank3 mutant dogs

Modeling SHANK3-associated autism spectrum disorder in Beagle dogs via CRISPR/Cas9 gene editing

Altered pupil responses to social and non-social stimuli in Shank3 mutant dogs

Angelman综合征蛋白Ube3a通过抑制BMP信号通路调控神经突触的生长发育和内吞

自闭症谱系障碍的分子遗传学研究进展

智障相关基因调控神经突触的生长发育

会议论文

突触发育与智障和自闭症

ACSL4,a mental retardation related protein,inhibits synaptic growth through regulating endocytic recycling of BMP receptors

脆性X智力低下蛋白调控果蝇细胞骨架蛋白的稳定性

TBCE对果蝇微管结构与功能的调节

以果蝇为模型研究脆性X智力低下的分子遗传机制

神经突触拆组装的分子和细胞机制

以果蝇为模型研究脆性X智力低下的分子和细胞机制

预印本

Shank3 mutation disrupts affective touch encoding in the dorsal medial prefrontal cortex of Beagle dogs

研究方向