胡天惠｜厦门大学｜学者主页

2026

Apatinib enhances anti-PD-1 efficacy by inhibiting Exo70-mediated exosome secretion in pMMR/MSS colorectal cancer

Lingying Zhao, Chunyi Gao, Xiaoxue Qiao, Fanzhuoran Lou, Bowen Zheng, Miao Fu, Xintian Huang, Xiaowen Xie, Wenqing Zhang, Yongxiang Hong, Kaiyi Rong, Huibo Shi, Li Xiao, Tianhui Hu

npj Precision Oncology

DOI

2026

A full-thickness spatial transcriptomics atlas of medically refractory ulcerative colitis identifies niche signatures associated with biologic non-response

Qingquan Bai, Runyang Li, Zhiruo Liu, Yuying Zhang, Xiao He, Junjie Yao, Shengdong Wu, Jing Huang, Shuqi Mao, Yunzheng Zhao, Yijia Chen, Linwei Wang, Yueping Zheng, Yanyan Zhan, Tianhui Hu, Michael Sigal, Frank Tacke, 陆才德, Cornelius Engelmann, Yiqun Hu

Frontiers in Immunology

DOI

2026

A novel berberine derivative B12 exhibits superior anti-obesity effects via targeting brown and white adipocyte dynamics

W Zhang, Yanhong Feng, Chunyi Gao, Linhai Zhong, W Wang, Minying Xu, Bowen Zheng, Yuehua Zhang, Shengyu Wang, Shaoxiong Yi, Zufang Wu, Yongqing Lin, Beibei Xu, Sijie Cheng, Yan-yan Zhan, Shaoliang Zhang, Xiaoting Hong, Tianhui Hu

International Journal of Obesity

DOI

2026

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

L X Chen, Jintao Guo, Fei Li, Mingjie Gao, Runyang Li, Zhaozhang Huang, Yaolin Zheng, Chunyi Gao, Jihuan Hou, Qiang Yu, Bowen Zheng, Xuemei Chen, Wei Zhang, Xiaoting Hong, Yali Zheng, Daxuan Wang, Qiyuan Li, Tianhui Hu, Yan-yan Zhan

Advanced Science

DOI

2026

YTHDC1 drives senescence evasion in ovarian cancer through m6A-mediated TERT stabilization

Fen Wang, Zhengyang Zhao, Zhuanghua Li, Xiaolei Chen, Weihong Lu, Shuying Yao, Jiameng Xi, Yanshuo Sun, Huirou Luo, Qingyuan Feng, Shuguang Lv, Piao Xu, Lingjia Shen, Wenqing Zhang, Yan-yan Zhan, Liangxi Xie, Tianhui Hu, Xiaoting Hong

Cell Death and Disease

DOI

2026

CDK4/6i reverse PARPi resistance by targeting the E2F1- MCM2/5 pathway

Yujie Feng, Miao Fu, Bowen Zheng, Fanzhuoran Lou, Xintian Huang, Xiaowen Xie, Weijuan Tan, Quan Chen, Wenqing Zhang, Yongxiang Hong, Kaiyi Rong, Huibo Shi, Tianhui Hu, Li Xiao

npj Precision Oncology

DOI

2026

Claudin18.2 promote gastric cancer proliferation by activating MCM2/5

Bowen Zheng, Miao Fu, Fanzhuoran Lou, Yuting He, Lingying Zhao, Xintian Huang, Xiaowen Xie, Weijuan Tan, Quan Chen, Wenqing Zhang, Yongxiang Hong, Kaiyi Rong, Yuyan Lu, Ping Zhan, Jingke Tu, Huibo Shi, Tianhui Hu, Li Xiao

Scientific Reports

DOI

2026

Lentiviral Dendritic Cell Vaccine Targeting Claudin-18.2 Elicits Potent Antitumor Immunity Against Gastric Cancer

Bowen Zheng, Wenqing Zhang, Dan Zhou, Miao Fu, Fanzhuoran Lou, Xintian Huang, Xiaowen Xie, Yunli Gong, Kaiyi Rong, Yongxiang Hong, Yanyan Zhan, Li Xiao, Tianhui Hu

Cancers

DOI

2026

Electrochemical sensor monitoring biomarker molecular structure and clinical diagnosis of prostate cancer: Risk association of neutrophil albumin ratio

Wenjun Wang, Yongcheng Su, Wenqing Zhang, Beibei Xu, Tianhui Hu

Microchemical Journal

DOI

2026

A novel photosensitizer berberine derivative B12 induces apoptosis and suppresses HIF-1α expression in colorectal cancer cells via mitochondria-to-nucleus sequential-targeting

Wen-bin Pei, Zi-yu Lei, Fu-quan Xie, Peng Chen, Yong-cheng Su, Yu-shan Qin, Jiang-quan Li, Qian-wen Shen, Miaomiao Ma, Chun-yi Gao, Jia-chen Zhu, Yajie Xu, Kai-yue Zhang, Wei Zhang, Yandong Zhang, Tianhui Hu, Beibei Xu

Acta Pharmacologica Sinica

DOI

2026

Single‐Cell Transcriptomics Reveals the Potential Role of GZMK+ CD8+ T Cells in Cell Senescence of Triple‐Negative Breast Cancer

Dan Zhou, Tianhui Hu, Xu Beibei, Jiachen Zhu, Miaomiao Ma, Wei Zhang, Liangxi Xie, Zhong Ouyang, Yidan Xu, Yongcheng Su

International Journal of Genomics

DOI

2025

Exo70通过调控多泡体转运增强外泌体分泌促进胰腺癌细胞的转移

张文青，向鲸舟，胡天惠

《肿瘤防治研究》

2025

HNF4α-Mediated LINC02560 Promotes Papillary Thyroid Carcinoma Progression by Targeting the miR-505-5p/PDE4C Axis

Yongcheng Su, Beibei Xu, Chunyi Gao, Wenbin Pei, Miaomiao Ma, Wenqing Zhang, Tianhui Hu, Fuxing Zhang, Shaoliang Zhang

Biomolecules

DOI

2025

Soluble urokinase plasminogen activator receptor is a prognostic biomarker in decompensated cirrhosis

Sven Lamatsch, Mohsin Hassan, Kai Kappert, Hilmar Berger, Qingquan Bai, Zhengyang Zhao, Nirbaanjot Walia, Carlos de la Peña-Ramirez, Raphael U. Mohr, Münevver Demir, Juan Wang, Fabian Artusa, Richard Sittner, Fausto Andreola, Rhea Veelken, Florian van Boemmel, Jonas Schumacher, Niklas Aehling, Janett Fischer, Rajeshwar P. Mookerjee, Tianhui Hu, Thomas Berg, Rajiv Jalan, Frank Tacke, Pavitra Kumar, Cornelius Engelmann

JHEP Reports

DOI

2025

Associations of the NPAR index with breast cancer incidence and mortality based on the National Health and Nutrition Examination Survey (NHANES) 2001-2018: a cross-sectional study

Yongcheng Su, Beibei Xu, Miaomiao Ma, Wenqing Zhang, Zhong Ouyang, Tianhui Hu

International Journal of Surgery

DOI

2025

Developing Dual-State Emission Berberine Derivatives as Theranostic Agents by Reducing Nonradiative Transition Pathways

Fuquan Xie, Beibei Xu, Peng Chen, Yushan Qin, Wenbin Pei, Jiangquan Li, Tianhui Hu, Qi Gao, Siying Chen, Yandong Zhang, Defa Li, Zhongjian Xie

Journal of Medicinal Chemistry

DOI

2025

The Role of Long Non-Coding RNAs in Modulating the Immune Microenvironment of Triple-Negative Breast Cancer: Mechanistic Insights and Therapeutic Potential

Yongcheng Su, Qingquan Bai, Wenqing Zhang, Beibei Xu, Tianhui Hu

Biomolecules

DOI

2025

Deeper Analysis to Identify the True Benefit of ICIs Immunotherapy in First-Line Treatment for Non-HER2-Positive/HER2-Negative Advanced or Metastatic Advanced or Metastatic Gastric Cancer (GC) or Gastroesophageal Junction Cancer (GEJC)

Bowen Zheng, Fanzhuoran Lou, Yuting He, Miao Fu, Xintian Huang, Weijuan Tan, Quan Cheng, Xiaowen Xie, Tianhui Hu, Li Xiao

Cancers

DOI

2025

Apatinib Degrades PD-L1 and Reconstitutes Colon Cancer Microenvironment via the Regulation of Myoferlin

Chunyi Gao, Lu Chen, Lingying Zhao, Yongcheng Su, Miaomiao Ma, Wenqing Zhang, Xiaoting Hong, Li Xiao, Beibei Xu, Tianhui Hu

Cancers

DOI

2025

α-Methyl-Tryptophan Inhibits SLC6A14 Expression and Exhibits Immunomodulatory Effects in Crohn’s Disease

Yongcheng Su, Jiangquan Li, Yijia Chen, Jiachen Bao, Ziyu Lei, Miaomiao Ma, Wenqing Zhang, Qian Liu, Beibei Xu, Tianhui Hu, Yiqun Hu

Journal of Inflammation Research

DOI

2024

TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis upon LKB1 inactivation

Jihuan Hou, Kunrong Mei, Daxuan Wang, Sunkui Ke, Xiong Chen, Jin Shang, Guixia Li, Yan Gao, Huifang Xiong, Haoran Zhang, Lu Chen, Wenqing Zhang, Yabin Deng, Xiaoting Hong, Di-Ao Liu, Tianhui Hu, Wei Guo, Yan-yan Zhan

Cell Reports

DOI

2024

Exo70 Promotes the Invasion of Pancreatic Cancer Cells via the Regulation of Exosomes

Jingzhou Xiang, Bowen Zheng, Lingying Zhao, Yuting He, Fanzhuoran Lou, Runyang Li, Miao Fu, Xintian Huang, Wenqing Zhang, Xiaoting Hong, Xiao Li, Tianhui Hu

Cancers

DOI

2023

An Integrated Multi-Omics Analysis Identifying Immune Subtypes of Pancreatic Cancer

Yongcheng Su, Fen Wang, Ziyu Lei, Jiangquan Li, Miaomiao Ma, Ying Yan, Wenqing Zhang, Xiaolei Chen, Beibei Xu, Tianhui Hu

International Journal of Molecular Sciences

DOI

2023

Trends and projections of inflammatory bowel disease at the global, regional and national levels, 1990–2050: a bayesian age-period-cohort modeling study

Jiali Zhou, Jia-Chen Bao, Xu-Ying Liao, Yijia Chen, Lin‐Wei Wang, Yanyun Fan, Qinyu Xu, Lan-Xiang Hao, Kun-Jian Li, Ming-Xian Liang, Tianhui Hu, Zhengjin Liu, Yi-Qun Hu

BMC Public Health

DOI

2023

Single-cell landscape of immune cells during the progression from HBV infection to HBV cirrhosis and HBV-associated hepatocellular carcinoma

Qingquan Bai, Runyang Li, Xiao He, Xiaoting Hong, Yan Yan, Zhengyang Zhao, Han Lin, Frank Tacke, Cornelius Engelmann, Tianhui Hu

Frontiers in Immunology

DOI

2023

An ULK1/2‐PXN mechanotransduction pathway suppresses breast cancer cell migration

Peigang Liang, Jiaqi Zhang, Yuchen Wu, Shanyuan Zheng, Zhaopeng Xu, Shuo Yang, Jinfang Wang, Suibin Ma, Li Xiao, Tianhui Hu, Wenxue Jiang, Chaoqun Huang, Qiong Xing, Mondira Kundu, Bo Wang

EMBO Reports

DOI

2023

Single-cell landscape of immune cells in human livers affected by HBV-related cirrhosis

Qingquan Bai, Xiaoting Hong, Han Lin, Xiao He, Runyang Li, Mohsin Hassan, Hilmar Berger, Frank Tacke, Cornelius Engelmann, Tianhui Hu

JHEP Reports

DOI

2023

Identification of m6A-associated LncRNAs as predict factors for the immune infiltration and prognosis of thyroid cancer

Yongcheng Su, Beibei Xu, Jiangquan Li, Qianwen Shen, Ziyu Lei, Miaomiao Ma, Fu-Xing Zhang, Tianhui Hu

Annals of Medicine

DOI

2023

The Prognostic Value and the Oncogenic and Immunological Roles of Vacuolar Protein Sorting Associated Protein 26 A in Pancreatic Adenocarcinoma

Jihuan Hou, Han Wu, Beibei Xu, Jin Shang, Xuechun Xu, Guixia Li, Haoran Zhang, Wenqing Zhang, Yabin Deng, Xiaoting Hong, Tianhui Hu, Mingqing Zhang, Yan-yan Zhan

International Journal of Molecular Sciences

DOI

2023

Pan‑cancer analysis of the deoxyribonuclease gene family

Qingquan Bai, Xiao He, Tianhui Hu

Molecular and Clinical Oncology

DOI

2022

Berplatin: A Conjugate of Berberine and Cisplatin Serving as a Potent Antitumor Agent with Distinctive Tumor Cell Uptake and Minimal Side Effects

Beibei Xu, Xiangjie Luo, Jing Xiong, Qianwen Shen, Yongcheng Su, Ziyu Lei, Jiangquan Li, Hongyu Lin, Wenqing Zhang, Xiaoting Hong, Fu-Xing Zhang, Yan-yan Zhan, Jinhao Gao, Tianhui Hu

Advanced Therapeutics

DOI

2022

Elucidation of the mechanism, target gene, and the most active parts of Fuzheng Yiliu formula in the treatment of hepatocellular carcinoma

Qingquan Bai, Tianhui Hu

Pharmacological Research - Modern Chinese Medicine

DOI

2022

Studies of the Efficacy of Low-Dose Apatinib Monotherapy as Third-Line Treatment in Patients with Metastatic Colorectal Cancer and Apatinib’s Novel Anticancer Effect by Inhibiting Tumor-Derived Exosome Secretion

Lingying Zhao, Qiang Yu, Chunyi Gao, Jingzhou Xiang, Bowen Zheng, Yujie Feng, Runyang Li, Wenqing Zhang, Xiaoting Hong, Yan-yan Zhan, Xiao Li, Tianhui Hu

Cancers

DOI

2022

LIMK2 Is a Novel Prognostic Biomarker and Correlates With Tumor Immune Cell Infiltration in Lung Squamous Cell Carcinoma

Yongcheng Su, Beibei Xu, Qianwen Shen, Ziyu Lei, Wenqing Zhang, Tianhui Hu

Frontiers in Immunology

DOI

2022

Gap junctions mediate glucose transfer to promote colon cancer growth in three-dimensional spheroid culture

Ke Gong, Qingqi Hong, Huiwen Wu, Fen Wang, Linhai Zhong, Lingjia Shen, Piao Xu, Wenqing Zhang, Hanwei Cao, Yan-yan Zhan, Tianhui Hu, Xiaoting Hong

Cancer Letters

DOI

2021

阿帕替尼抗肿瘤作用机制研究进展

赵灵颖，张文青，李存玺，胡天惠

《肿瘤防治研究》

2021

抗血管生成药物阿帕替尼改善肿瘤免疫微环境的研究进展

高纯一，胡天惠

《赣南医科大学学报》

2021

The HNF4α-BC200-FMR1–Positive Feedback Loop Promotes Growth and Metastasis in Invasive Mucinous Lung Adenocarcinoma

Xiong Chen, Yujie Zhao, Daxuan Wang, Ying Lin, Jihuan Hou, Xiaolin Xu, Jianben Wu, Linhai Zhong, Yitong Zhou, Jinying Shen, Wenqing Zhang, Hanwei Cao, Xiaoting Hong, Tianhui Hu, Yan-yan Zhan

Cancer Research

DOI

2021

Deregulation of Exo70 Facilitates Innate and Acquired Cisplatin Resistance in Epithelial Ovarian Cancer by Promoting Cisplatin Efflux

Yujie Zhao, Xiaoting Hong, Xiong Chen, Chun Hu, Weihong Lu, Baoying Xie, Linhai Zhong, Wenqing Zhang, Hanwei Cao, Binbin Chen, Qian Liu, Yan-yan Zhan, Xiao Li, Tianhui Hu

Cancers

DOI

2021

Combination of anti-angiogenic therapy Apatinib and immune therapy potentiate tumor microenvironment

Chunyi Gao, Tianhui Hu

Trends in Immunotherapy

DOI

2021

Genetic Determinants of Somatic Selection of Mutational Processes in 3,566 Human Cancers

Jintao Guo, Ying Zhou, Chaoqun Xu, Qinwei Chen, Zsófia M. Sztupinszki, Judit Börcsök, Canqiang Xu, Feng Ye, Weiwei Tang, Jiapeng Kang, Lu Yang, Jiaxin Zhong, Taoling Zhong, Tianhui Hu, Rongshan Yu, Zoltán Szállási, Xianming Deng, Qiyuan Li

Cancer Research

DOI

2021

Research Progress on Antitumor Mechanism of Apatinib

ZHAO Lingying, Wenqing Zhang, Cunxi Li, Tianhui Hu

DOAJ (DOAJ: Directory of Open Access Journals)

DOI

2020

ULK1 phosphorylates Exo70 to suppress breast cancer metastasis

Liyuan Mao, Yan-yan Zhan, Bin Yan Wu, Qiang Yu, Liang Xu, Xiaoting Hong, Linhai Zhong, Panying Mi, Xiao Li, Xinquan Wang, Hanwei Cao, Wenqing Zhang, Binbin Chen, Jingzhou Xiang, Kunrong Mei, Ravi Radhakrishnan, Wei Guo, Tianhui Hu

Nature Communications

DOI

2020

Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway

Jiahui Yuan, Gongye Zhang, Xiaomei Li, Qiujuan Ma, Weipeng Cheng, Weiwei Wang, Bing Zhang, Tianhui Hu, Gang Song

International Journal of Molecular Sciences

DOI

2020

Structure–Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as the RXRα Activator to Inhibit Colon Cancer

Beibei Xu, Xunjin Jiang, Jing Xiong, Jun Lan, Yuan Tian, Linhai Zhong, Xinquan Wang, Ning Xu, Hanwei Cao, Wenqing Zhang, Hao Zhang, Xiaoting Hong, Yan-yan Zhan, Yandong Zhang, Tianhui Hu

Journal of Medicinal Chemistry

DOI

2020

Protective effects of iridoid glycosides on acute colitis via inhibition of the inflammatory response mediated by the STAT3/NF-кB pathway

Jiahui Yuan, Weipeng Cheng, Gongye Zhang, Qiujuan Ma, Xiaomei Li, Bing Zhang, Tianhui Hu, Gang Song

International Immunopharmacology

DOI

2020

Phosphoinositide specific phospholipase Cγ1 inhibition-driven autophagy caused cell death in human lung adenocarcinoma A549 cells in vivo and in vitro

Xiaohong Lü, Haijing Fu, Rui Chen, Yue Wang, Yan-yan Zhan, Gang Song, Tianhui Hu, Chun Xia, Xuemei Tian, Bing Zhang

International Journal of Biological Sciences

DOI

2019

潞党参口服液对免疫抑制小鼠的免疫调节作用

胡天惠，林超，项媛媛，辜卫红

《药学与临床研究》

DOI

2019

Matrine Reverses the Warburg Effect and Suppresses Colon Cancer Cell Growth via Negatively Regulating HIF-1α

Xiaoting Hong, Linhai Zhong, Yurou Xie, Kaifeng Zheng, Jinglong Pang, Yesen Li, Yifan Yang, Xiaolin Xu, Panying Mi, Hanwei Cao, Wenqing Zhang, Tianhui Hu, Gang Song, Daxuan Wang, Yan-yan Zhan

Frontiers in Pharmacology

DOI

2019

Ubiquitin-specific peptidase 39 regulates the process of proliferation and migration of human ovarian cancer via p53/p21 pathway and EMT

Congcong Yan, Jiahui Yuan, Jiajia Xu, Gongye Zhang, Xiaomei Li, Bing Zhang, Tianhui Hu, Xiaohua Huang, Yubin Mao, Gang Song

Medical Oncology

DOI

2019

Identification of Chaetocin as a Potent non-ROS-mediated Anticancer Drug Candidate for Gastric Cancer

Xinwen Liao, Yaqiong Fan, Jihuan Hou, Xiong Chen, Xiaolin Xu, Yifan Yang, Jinying Shen, Panying Mi, Xiaohua Huang, Wenqing Zhang, Hanwei Cao, Xiaoting Hong, Tianhui Hu, Yan-yan Zhan

Journal of Cancer

DOI

2019

TNF-α and IFN-γ synergistically inhibit the repairing ability of mesenchymal stem cells on mice colitis and colon cancer.

Shaoping Hu, Jiahui Yuan, Jiajia Xu, Xiaomei Li, Gongye Zhang, Qiujuan Ma, Bing Zhang, Tianhui Hu, Gang Song

PubMed

2018

High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer

Dandan Li, Li Xiao, Yuetan Ge, Yu Fu, Wenqing Zhang, Hanwei Cao, Binbin Chen, Haibin Wang, Yan-yan Zhan, Tianhui Hu

Molecular Cancer

DOI

2018

Corilagin inhibits breast cancer growth via reactive oxygen species‐dependent apoptosis and autophagy

Yinping Tong, Gongye Zhang, Li Yang, Jiajia Xu, Jiahui Yuan, Bing Zhang, Tianhui Hu, Gang Song

Journal of Cellular and Molecular Medicine

DOI

2017

Phosphoinositide-specific phospholipase Cγ1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells

Lianzhi Dai, Xiaolei Chen, Xiaohong Lü, Fen Wang, Yan-yan Zhan, Gang Song, Tianhui Hu, Chun Xia, Bing Zhang

Scientific Reports

DOI

2016

Musk xylene induces malignant transformation of human liver cell line L02 via repressing the TGF-β signaling pathway

Youyu Zhang, Lixing Huang, Yujie Zhao, Tianhui Hu

Chemosphere

DOI

2016

Lentivirus-mediated PLCγ1 gene short-hairpin RNA suppresses tumor growth and metastasis of human gastric adenocarcinoma

Bingchang Zhang, Fen Wang, Lianzhi Dai, Heguo Cai, Yan-yan Zhan, Gang Song, Tianhui Hu, Chun Xia, Bing Zhang

Oncotarget

DOI

2016

Nuclear Receptors as Potential Pharmacological Targets for Colorectal Cancer Therapy via Regulating Wnt/β-catenin Signaling

Tianhui Hu

Medical Research Archives

DOI

2015

Akt Signaling Is Associated with the Berberine-Induced Apoptosis of Human Gastric Cancer Cells

Tingting Yi, Luhua Zhuang, Gang Song, Bing Zhang, Guideng Li, Tianhui Hu

Nutrition and Cancer

DOI

2014

苦参碱对乙基硝基亚硝基胍诱导大鼠胃癌的化学预防作用

阮航，赵玉洁，吴丹红，胡天惠

《中国生化药物杂志》

2014

苦参碱通过线粒体通路诱导HepG2细胞凋亡的机制研究

周欢，徐敏英，雷宇，梁凯，郭晴，胡天惠

《广西医学》

2014

Metformin targets liver tumor-initiating cells through the PI3K/Akt/mTOR survival pathway

Fen Lin, Wei Yan, Gang Song, Wen Ting, Tianhui Hu, Guoyang Wu

Chinese Science Bulletin

DOI

2014

Matrine inhibits proliferation and induces apoptosis via BID-mediated mitochondrial pathway in esophageal cancer cells

Qiao Wang, Haoxin Du, Guojun Geng, Huan Zhou, Minying Xu, Hanwei Cao, Bing Zhang, Gang Song, Tianhui Hu

Molecular Biology Reports

DOI

2014

Metastasis of human gastric adenocarcinoma partly depends on phosphoinositide-specific phospholipase γ1 expression

Luhua Zhuang, Bingchang Zhang, Guoqing Zeng, Lianzhi Dai, Hongliu Qian, Tianhui Hu, Gang Song, Bing Zhang, Chun Xia

Folia Histochemica et Cytobiologica

DOI

2014

Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor

Huan Zhou, Minying Xu, Ya Gao, Zhigang Deng, Hanwei Cao, Wenqing Zhang, Qiao Wang, Bing Zhang, Gang Song, Yan-yan Zhan, Tianhui Hu

Molecular Cancer

DOI

2013

磷脂酶D在肿瘤发生中的作用机制研究进展

高雅，曹函溦，胡天惠

《肿瘤防治研究》

2013

A Monoclonal Antibody Produced Against Naked2

Chang Cao, Shengyu Wang, Sha Lv, Zhe Li, Xianjiang Wang, Fanwei Zeng, Haipeng Zhang, Yujuan Dai, Xiaofeng Dou, Xiaoli Chen, Xiudong Li, lingli Luo, Tianhui Hu, Jianghua Yan

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy

DOI

2013

Berberine ameliorates cartilage degeneration in interleukin‐1β‐stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling

Honghai Zhao, Tongen Zhang, Chun Xia, Lei Shi, Shaojie Wang, Xinpeng Zheng, Tianhui Hu, Bing Zhang

Journal of Cellular and Molecular Medicine

DOI

2013

Chemopreventive effects of berberine on intestinal tumor development in Apc min/+mice

Hailong Cao, Shuli Song, Hui Zhang, Yujie Zhang, Rui Qu, Boli Yang, Jing Yang, Tianhui Hu, Fang Yan, Bangmao Wang

BMC Gastroenterology

DOI

2013

Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling

Junfang Zhang, Hailong Cao, Bing Zhang, Hanwei Cao, Xiuqin Xu, Hang Ruan, Tingting Yi, Li Tan, Rui Qu, Gang Song, Bangmao Wang, Tianhui Hu

Journal of Cellular and Molecular Medicine

DOI

2012

HBsAg Inhibits the Translocation of JTB into Mitochondria in HepG2 Cells and Potentially Plays a Role in HCC Progression

Yunpeng Liu, Xiaoning Yang, Amarsanaa Jazag, Jin‐Shui Pan, Tianhui Hu, Jingjing Liu, Bayasi Guleng, Jianlin Ren

PLoS ONE

DOI

2011

人参皂甙肠道细菌代谢物Compound K抗肿瘤研究进展

胡春，宋刚，胡天惠

《肿瘤防治研究》

2010

Myristoylated Naked2 Antagonizes Wnt-β-Catenin Activity by Degrading Dishevelled-1 at the Plasma Membrane

Tianhui Hu, Cunxi Li, Zheng Cao, Terence J. Van Raay, Jason G. Smith, Karl Willert, Lilianna Solnica‐Krezel, Robert J. Coffey

Journal of Biological Chemistry

DOI

2010

Roles of phospholipase D in phorbol myristate acetate-stimulated neutrophil respiratory burst

Tianhui Hu, Zhaoxia Liu, Xun Shen

Journal of Cellular and Molecular Medicine

DOI

2010

Convergence between Wnt-β-catenin and EGFR signaling in cancer

Tianhui Hu, Cunxi Li

Molecular Cancer

DOI

精选作品

期刊论文

Apatinib enhances anti-PD-1 efficacy by inhibiting Exo70-mediated exosome secretion in pMMR/MSS colorectal cancer

A full-thickness spatial transcriptomics atlas of medically refractory ulcerative colitis identifies niche signatures associated with biologic non-response

A novel berberine derivative B12 exhibits superior anti-obesity effects via targeting brown and white adipocyte dynamics

FUCA2 Sustains AKT Signaling and Suppresses Senescence by Antagonizing FUT3‐Mediated ErbB3 Fucosylation in Lung Adenocarcinoma

YTHDC1 drives senescence evasion in ovarian cancer through m6A-mediated TERT stabilization

CDK4/6i reverse PARPi resistance by targeting the E2F1- MCM2/5 pathway

Claudin18.2 promote gastric cancer proliferation by activating MCM2/5

Lentiviral Dendritic Cell Vaccine Targeting Claudin-18.2 Elicits Potent Antitumor Immunity Against Gastric Cancer

Electrochemical sensor monitoring biomarker molecular structure and clinical diagnosis of prostate cancer: Risk association of neutrophil albumin ratio

A novel photosensitizer berberine derivative B12 induces apoptosis and suppresses HIF-1α expression in colorectal cancer cells via mitochondria-to-nucleus sequential-targeting

Single‐Cell Transcriptomics Reveals the Potential Role of GZMK+ CD8+ T Cells in Cell Senescence of Triple‐Negative Breast Cancer

Exo70通过调控多泡体转运增强外泌体分泌促进胰腺癌细胞的转移

HNF4α-Mediated LINC02560 Promotes Papillary Thyroid Carcinoma Progression by Targeting the miR-505-5p/PDE4C Axis

Soluble urokinase plasminogen activator receptor is a prognostic biomarker in decompensated cirrhosis

Associations of the NPAR index with breast cancer incidence and mortality based on the National Health and Nutrition Examination Survey (NHANES) 2001-2018: a cross-sectional study

Developing Dual-State Emission Berberine Derivatives as Theranostic Agents by Reducing Nonradiative Transition Pathways

The Role of Long Non-Coding RNAs in Modulating the Immune Microenvironment of Triple-Negative Breast Cancer: Mechanistic Insights and Therapeutic Potential

Deeper Analysis to Identify the True Benefit of ICIs Immunotherapy in First-Line Treatment for Non-HER2-Positive/HER2-Negative Advanced or Metastatic Advanced or Metastatic Gastric Cancer (GC) or Gastroesophageal Junction Cancer (GEJC)

Apatinib Degrades PD-L1 and Reconstitutes Colon Cancer Microenvironment via the Regulation of Myoferlin

α-Methyl-Tryptophan Inhibits SLC6A14 Expression and Exhibits Immunomodulatory Effects in Crohn’s Disease

TGM1/3-mediated transamidation of Exo70 promotes tumor metastasis upon LKB1 inactivation

Exo70 Promotes the Invasion of Pancreatic Cancer Cells via the Regulation of Exosomes

An Integrated Multi-Omics Analysis Identifying Immune Subtypes of Pancreatic Cancer

Trends and projections of inflammatory bowel disease at the global, regional and national levels, 1990–2050: a bayesian age-period-cohort modeling study

Single-cell landscape of immune cells during the progression from HBV infection to HBV cirrhosis and HBV-associated hepatocellular carcinoma

An ULK1/2‐PXN mechanotransduction pathway suppresses breast cancer cell migration

Single-cell landscape of immune cells in human livers affected by HBV-related cirrhosis

Identification of m6A-associated LncRNAs as predict factors for the immune infiltration and prognosis of thyroid cancer

The Prognostic Value and the Oncogenic and Immunological Roles of Vacuolar Protein Sorting Associated Protein 26 A in Pancreatic Adenocarcinoma

Pan‑cancer analysis of the deoxyribonuclease gene family

Berplatin: A Conjugate of Berberine and Cisplatin Serving as a Potent Antitumor Agent with Distinctive Tumor Cell Uptake and Minimal Side Effects

Elucidation of the mechanism, target gene, and the most active parts of Fuzheng Yiliu formula in the treatment of hepatocellular carcinoma

Studies of the Efficacy of Low-Dose Apatinib Monotherapy as Third-Line Treatment in Patients with Metastatic Colorectal Cancer and Apatinib’s Novel Anticancer Effect by Inhibiting Tumor-Derived Exosome Secretion

LIMK2 Is a Novel Prognostic Biomarker and Correlates With Tumor Immune Cell Infiltration in Lung Squamous Cell Carcinoma

Gap junctions mediate glucose transfer to promote colon cancer growth in three-dimensional spheroid culture

阿帕替尼抗肿瘤作用机制研究进展

抗血管生成药物阿帕替尼改善肿瘤免疫微环境的研究进展

The HNF4α-BC200-FMR1–Positive Feedback Loop Promotes Growth and Metastasis in Invasive Mucinous Lung Adenocarcinoma

Deregulation of Exo70 Facilitates Innate and Acquired Cisplatin Resistance in Epithelial Ovarian Cancer by Promoting Cisplatin Efflux

Combination of anti-angiogenic therapy Apatinib and immune therapy potentiate tumor microenvironment

Genetic Determinants of Somatic Selection of Mutational Processes in 3,566 Human Cancers

Research Progress on Antitumor Mechanism of Apatinib

ULK1 phosphorylates Exo70 to suppress breast cancer metastasis

Knocking down USP39 Inhibits the Growth and Metastasis of Non-Small-Cell Lung Cancer Cells through Activating the p53 Pathway

Structure–Activity Relationship Study Enables the Discovery of a Novel Berberine Analogue as the RXRα Activator to Inhibit Colon Cancer

Protective effects of iridoid glycosides on acute colitis via inhibition of the inflammatory response mediated by the STAT3/NF-кB pathway

Phosphoinositide specific phospholipase Cγ1 inhibition-driven autophagy caused cell death in human lung adenocarcinoma A549 cells in vivo and in vitro

潞党参口服液对免疫抑制小鼠的免疫调节作用

Matrine Reverses the Warburg Effect and Suppresses Colon Cancer Cell Growth via Negatively Regulating HIF-1α

Ubiquitin-specific peptidase 39 regulates the process of proliferation and migration of human ovarian cancer via p53/p21 pathway and EMT

Identification of Chaetocin as a Potent non-ROS-mediated Anticancer Drug Candidate for Gastric Cancer

TNF-α and IFN-γ synergistically inhibit the repairing ability of mesenchymal stem cells on mice colitis and colon cancer.

High expression of Tob1 indicates poor survival outcome and promotes tumour progression via a Wnt positive feedback loop in colon cancer

Corilagin inhibits breast cancer growth via reactive oxygen species‐dependent apoptosis and autophagy

Phosphoinositide-specific phospholipase Cγ1 inhibition induces autophagy in human colon cancer and hepatocellular carcinoma cells

Musk xylene induces malignant transformation of human liver cell line L02 via repressing the TGF-β signaling pathway

Lentivirus-mediated PLCγ1 gene short-hairpin RNA suppresses tumor growth and metastasis of human gastric adenocarcinoma

Nuclear Receptors as Potential Pharmacological Targets for Colorectal Cancer Therapy via Regulating Wnt/β-catenin Signaling

Akt Signaling Is Associated with the Berberine-Induced Apoptosis of Human Gastric Cancer Cells

苦参碱对乙基硝基亚硝基胍诱导大鼠胃癌的化学预防作用

苦参碱通过线粒体通路诱导HepG2细胞凋亡的机制研究

Metformin targets liver tumor-initiating cells through the PI3K/Akt/mTOR survival pathway

Matrine inhibits proliferation and induces apoptosis via BID-mediated mitochondrial pathway in esophageal cancer cells

Metastasis of human gastric adenocarcinoma partly depends on phosphoinositide-specific phospholipase γ1 expression

Matrine induces caspase-independent program cell death in hepatocellular carcinoma through bid-mediated nuclear translocation of apoptosis inducing factor

磷脂酶D在肿瘤发生中的作用机制研究进展

A Monoclonal Antibody Produced Against Naked2

Berberine ameliorates cartilage degeneration in interleukin‐1β‐stimulated rat chondrocytes and in a rat model of osteoarthritis via Akt signalling

Chemopreventive effects of berberine on intestinal tumor development in Apc min/+mice

Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling

HBsAg Inhibits the Translocation of JTB into Mitochondria in HepG2 Cells and Potentially Plays a Role in HCC Progression

人参皂甙肠道细菌代谢物Compound K抗肿瘤研究进展

Myristoylated Naked2 Antagonizes Wnt-β-Catenin Activity by Degrading Dishevelled-1 at the Plasma Membrane

Roles of phospholipase D in phorbol myristate acetate-stimulated neutrophil respiratory burst

Convergence between Wnt-β-catenin and EGFR signaling in cancer

预印本

Multi-omics analysis reveals prognostic and immune characteristics of cuproptosis in lung adenocarcinoma

ULK1 Is Associated with Poor Prognosis and Functions As an Oncogenic EGFR Regulator in the Development of Colon Cancer