徐东升｜暨南大学｜学者主页

2026

[18F]AlF-RESCA-R8B4 and [68Ga]Ga-NOTA-R8B4: A Pair of Novel CD70-Targeted ImmunoPET/CT Imaging Agents for Clinical Use

You Zhang, Qianyun Wu, Shu-Xian An, Dongsheng Xu, Wen-Zhi Jia, Zhou-Mi Hu, Cheng Wang, Gang Huang, Jin Zhang, Jian-Jun Liu, Wei-Jun Wei

Chemical & Biomedical Imaging

DOI

2026

Trop2 immunoPET/CT in annotating differential Trop2 expression in lung cancers: a prospective clinical study

You Zhang, Qiu-Fang Liu, Cheng Ma, Daoqiang Tang, Qianyun Wu, Dongsheng Xu, Wen-Zhi Jia, Shu-Xian An, Cheng Wang, Xiao-Jing Zhao, Gang Huang, Min Cao, Wei-Jun Wei, Jian-Jun Liu

The EANM Journal

DOI

2026

Immuno-PET/CT Imaging of Trop2 Expression with [18F]AlF-RESCA-RT4 Enhances Diagnosis of Breast Cancers and the Metastases

Wen-Zhi Jia, Tingting Yan, Shu-Xian An, You Zhang, Qianyun Wu, Zi-Ping Wu, Dongsheng Xu, Zhou-Mi Hu, Cheng Wang, Gang Huang, Jian-Jun Liu, Yan-Ping Lin, Wei-Jun Wei

Journal of Nuclear Medicine

DOI

2026

Trop2-Targeted [18F]AlF-RESCA-RT4 ImmunoPET/CT in Guiding Clinical Surgeries of Thyroid Cancers: A Proof-of-Concept Study.

Xin-Lu Yin, Wen-Zhi Jia, Le Xu, Wen-Jie Zheng, Yi Gao, Linglin Tang, You Zhang, Qianyun Wu, Dongsheng Xu, Shu-Xian An, Wei-Jun Wei, Jian-Jun Liu, Qin-Yi Zhou, Jia-Lin Feng, Jun Chen

Molecular Pharmaceutics

DOI

2026

[18F]RCCB6 PET/CT in Diagnosing Clear Cell Renal Cell Carcinomas: A Prospective Comparison Study with [18F]FDG PET/CT and Conventional Imaging.

Qianyun Wu, Shu-Xian An, F. Gelardi, You Zhang, Liang-Hua Li, W. Kong, Min Cao, Wen-Zhi Jia, Dongsheng Xu, L. Wan, Gang Huang, Cheng Wang, Zhou-Mi Hu, Ji-Wei Huang, W. Zhai, Jin Zhang, A. Chiti, Gang Huang, Jian-Jun Liu, Wei-Jun Wei

Cancer Discovery

DOI

2026

Enhanced chemical stability of an immobilized artificial membrane stationary phase achieved via atom-transfer radical polymerization

Lixiao He, Hui Huang, Jacques Crommen, Minyi Li, Dongsheng Xu, Zhengjin Jiang

Journal of Chromatography A

DOI

2026

Impact of sulfonium versus ammonium groups in zwitterions on hydrophilic interaction chromatographic separation performance

Yuanyuan Wu, Liang Lai, Minyi Li, Kesara Ar-sanork, Zhengjin Jiang, Dongsheng Xu

Journal of Chromatography A

DOI

2025

CD70-Targeted [18F]RCCB6 Immuno-PET/CT for Diagnosing Clear Cell Renal Cell Carcinoma Metastases: A Prospective Study

Chen Ma, Min Cao, Liang-Hua Li, Qianyun Wu, You Zhang, Dongsheng Xu, Shu-Xian An, Yan-Fei Wu, Cheng Wang, Y. Guan, W. Kong, Jin Zhang, F. Xie, W. Zhai, Gang Huang, Jian-Jun Liu, Xiaojing Zhao, Wei-Jun Wei

Journal of Nuclear Medicine

DOI

2025

Trop2 immuno-PET/CT imaging of prostate cancer: a proof-of-concept translational study

Xing-Ru Long, Shu-Xian An, Xuanbingning Nian, Dongsheng Xu, Wei-Jun Wei, Xiao-Li Lan, Liang Dong, Da-Wei Jiang

BMC Medicine

DOI

2025

Development and Preclinical Evaluation of CDH17-Specific ImmunoPET Imaging in Colorectal Cancers.

Xinbing Pan, Qianyun Wu, You Zhang, Dongsheng Xu, Xinyuan Zhou, Liang-Hua Li, Cheng Wang, Wei-Jun Wei, Shu-Xian An, Gang Huang, Jian-Jun Liu

Molecular Pharmaceutics

DOI

2025

Total-body 18 F-AlF-RESCA-T4 immuno-PET/CT in patients with solid tumors: Initial experience and potential value in navigating clinical decision-making

Shu-Xian An, You Zhang, Liang-Hua Li, Qianyun Wu, Wen-Zhi Jia, Dongsheng Xu, Cheng Wang, Gang Huang, Jian-Jun Liu, Wei-Jun Wei

Journal of Nuclear Medicine and Molecular Imaging

DOI

2025

CD70-Targeted [18F]RCCB6 Immuno-PET/CT Imaging in Patients with Nasopharyngeal Carcinoma: A Proof-of-Concept Study

Binyu Shi, You Zhang, Shuo Wu, Dongsheng Xu, Qianyun Wu, Wen-Zhi Jia, Shu-Xian An, Cheng Wang, Yong-Rui Bai, Jian-Jun Liu, Junjun Zhou, Wei-Jun Wei

Journal of Nuclear Medicine

DOI

2025

Head-to-head comparison of peptide-based and nanobody-based radiotracers in detecting PD-L1 expression in non-small cell lung cancer

Yan-Fei Wu, Hao Wang, Yue Gu, You Zhang, Guanglei Li, Yuan Huang, Min Cao, Xiaofeng Chen, Y. Guan, Dongsheng Xu, Wei-Jun Wei, F. Xie

European Journal of Nuclear Medicine and Molecular Imaging

DOI

2025

[68Ga]Ga-NOTA-T4 ImmunoPET imaging for evaluating TROP2 expression in patients with solid tumors

Dong-Lang Jiang, Zhaohui Chu, Yan-Fei Wu, You Zhang, Yao Liu, Qi-Yue Ge, Yue Gu, Zun-Guo Du, Yuan-Yuan Cheng, Xi-Wen Xu, Yuan Huang, Dongsheng Xu, Y. Guan, Wei-Jun Wei, F. Xie

European Journal of Nuclear Medicine and Molecular Imaging

DOI

2025

Recent progress in the application of hydrophilic interaction liquid chromatography for the separation and analysis of traditional Chinese medicine

Yuanyuan Wu, Hui Huang, Xianglong Zhao, Junhao Lin, Jialiang Guo, Zhengjin Jiang, Kesara Ar-sanork, Tao Deng, Dongsheng Xu

Frontiers in Chemistry

DOI

2025

Fabrication and evaluation of a dual-zwitterionic functionalized hydrophilic monolith for chromatographic separation

Liang Lai, Hongying Lan, Hui Huang, Tong Li, Kesara Ar-sanork, Jia-Huan Qu, Dongsheng Xu, Zhengjin Jiang

Journal of Chromatography A

DOI

2024

Preclinical evaluation and pilot clinical study of [68Ga]Ga-NOTA-H006 for non-invasive PET imaging of 5T4 oncofetal antigen

Ying-Fang He, Ruhua Tian, Dongsheng Xu, Yan-Fei Wu, Sa Rina, Tengxiang Chen, Y. Guan, Tianwu Xie, Tianlei Ying, F. Xie, Jun-Bin Han

European Journal of Nuclear Medicine and Molecular Imaging

DOI

2024

ImmunoPET imaging of EpCAM in solid tumours with nanobody tracers: a preclinical study

Dongsheng Xu, You Zhang, Wei Huang, Xinbing Pan, Shu-Xian An, Cheng Wang, Gang Huang, Jian-Jun Liu, Wei-Jun Wei

European Journal of Nuclear Medicine and Molecular Imaging

DOI

2024

Preclinical development of novel PD-L1 tracers and first-in-human study of [68Ga]Ga-NOTA-RW102 in patients with lung cancers

You Zhang, Min Cao, Yan-Fei Wu, Sara Malih, Dongsheng Xu, Er-Peng Yang, Muhsin H Younis, Wilson Lin, Haitao Zhao, Cheng Wang, Qiufang Liu, J. Engle, M. J. Rasaee, Y. Guan, Gang Huang, Jian-Jun Liu, Wei-Bo Cai, F. Xie, Wei-Jun Wei

Journal for ImmunoTherapy of Cancer

DOI

2024

Assessment of PD‐L1 Expression in Non‐Small Cell Lung Cancers Using [68Ga]Ga‐DOTA‐WL12 PET/CT

Yan-Fei Wu, Dongsheng Xu, Yue Gu, Guanglei Li, Hao Wang, Min Cao, Wei-Jun Wei, Posum Wan, Y. Guan, Xiaofeng Chen, F. Xie

Small Methods

DOI

2024

ImmunoPET imaging of Trop2 in patients with solid tumours

Wei Huang, You Zhang, Min Cao, Yan-Fei Wu, Feng Jiao, Zhaohui Chu, Xinyuan Zhou, Liang-Hua Li, Dongsheng Xu, Xinbing Pan, Y. Guan, Gang Huang, Jian-Jun Liu, F. Xie, Wei-Jun Wei

EMBO Molecular Medicine

DOI

2024

Effect of anionic groups in zwitterionic hydrophilic stationary phases on their chromatographic characteristics

Liang Lai, Mengyao Zhang, Yuexiang Chang, Minyi Li, Jacques Crommen, Jia-Huan Qu, Dongsheng Xu, Zhengjin Jiang

Journal of Chromatography A

DOI

2024

A systematic review and meta-analysis on sodium tanshinone IIA sulfonate injection for the adjunctive therapy of pulmonary heart disease

Huikai Shao, Fei Yu, Dongsheng Xu, Chunyan Fang, Rongsheng Tong, Lingguo Zhao

BMC Complementary Medicine and Therapies

DOI

2024

Preparation and evaluation of a piperidinium-sulfonate based zwitterionic monolith for HILIC separation

Liang Lai, Mengyao Zhang, Tong Li, Jia-Huan Qu, Dongsheng Xu, Pei Yu, Zhengjin Jiang

Journal of Chromatography A

DOI

2023

Development of biomimetic phospholipid membrane chromatography for drug discovery: A comprehensive review

Jincai Wang, Jialiang Guo, Dongsheng Xu, Lixiao He, Jia-Huan Qu, Qiqin Wang, Jacques Crommen, Zhengjin Jiang

TrAC Trends in Analytical Chemistry

DOI

2023

A comprehensive evaluation of a polymeric zwitterionic hydrophilic monolith for nucleotide separation

Liang Lai, Mengyun Zhang, Chusheng Liu, Jia-Huan Qu, Dongsheng Xu, Zhengjin Jiang

Analytical Sciences

DOI

2023

Inside-Out Oriented Choline Phosphate-Based Biomimetic Magnetic Nanomaterials for Precise Recognition and Analysis of C-Reactive Protein

Zhiwei Chen, Chendi Zhu, Jiawen Yang, Mengyun Zhang, Jiaming Yuan, Yuan Shen, Jingwei Zhou, Hao Huang, Dongsheng Xu, Jacques Crommen, Zhengjin Jiang, Qiqin Wang

Analytical Chemistry

DOI

2022

A Systematic Review and Meta-Analysis on the Efficacy of Puerarin Injection as Adjunctive Therapy for Unstable Angina Pectoris

Huikai Shao, Yang Huang, Dongsheng Xu, Shengfeng Huang, Rongsheng Tong

Frontiers in Cardiovascular Medicine

DOI

2021

UPLC-QQQ-MS/MS在中药分析中的应用研究进展

徐东升，何云娇，钟灵佼

《中医药临床杂志》

2021

Photo-assisted generation of versatile zwitterionic carboxybetaine-based hypercrosslinked polymers for separation science

Lingjue Sun, Dongsheng Xu, Y. R. Shen, Jacques Crommen, Qiqin Wang, Zhengjin Jiang

Chemical Engineering Journal

DOI

2021

Single-step fabrication of a teicoplanin functionalized organic-silica hybrid monolith for enantioseparation by nano-liquid chromatography

Dongsheng Xu, Huikai Shao, Liang Lai, Elena Sánchez‐López, Marı́a Luisa Marina, Zhengjin Jiang

Journal of Chromatography Open

DOI

2021

A systematic investigation of the effect of sample solvent on peak shape in nano- and microflow hydrophilic interaction liquid chromatography columns

Haibin Li, Chusheng Liu, Li Zhao, Dongsheng Xu, Tingting Zhang, Qiqin Wang, Deirdre Cabooter, Zhengjin Jiang

Journal of Chromatography A

DOI

2021

Development of acidic phospholipid containing immobilized artificial membrane column to predict drug-induced phospholipidosis potency

Jincai Wang, Xianglong Zhao, Dongsheng Xu, Liang Lai, Jacques Crommen, Jialiang Guo, Zhengjin Jiang

Journal of Chromatography A

DOI

2021

Development of zirconium modified adenosine triphosphate functionalized monolith for specific enrichment of N-glycans

Huikai Shao, Liang Lai, Dongsheng Xu, Jacques Crommen, Qiqin Wang, Zhengjin Jiang

Journal of Chromatography A

DOI

2020

Preparation and application of teicoplanin functionalized polymeric monolith for enantioseparation of chiral drugs

Rongying Luo, Hai Han, Jia Liu, Dongsheng Xu, Qiqin Wang, Salvatore Fanali, Zhengjin Jiang

Journal of Pharmaceutical and Biomedical Analysis

DOI

2019

Recent advances in preparation and applications of monolithic chiral stationary phases

Jialiang Guo, Qiqin Wang, Dongsheng Xu, Jacques Crommen, Zhengjin Jiang

TrAC Trends in Analytical Chemistry

DOI

2019

Determination of l-norvaline and l-tryptophan in dietary supplements by nano-LC using an O-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine-silica hybrid monolithic column

Dongsheng Xu, Elena Sánchez‐López, Qiqin Wang, Zhengjin Jiang, Marı́a Luisa Marina

Journal of Pharmaceutical Analysis

DOI

2019

Preparation of an O-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine-silica hybrid monolithic column for the enantioseparation of amino acids by nano-liquid chromatography

Dongsheng Xu, Qiqin Wang, Elena Sánchez‐López, Zhengjin Jiang, Marı́a Luisa Marina

Journal of Chromatography A

DOI

2018

A facile and efficient single-step approach for the fabrication of vancomycin functionalized polymer-based monolith as chiral stationary phase for nano-liquid chromatography

Dongsheng Xu, Huikai Shao, Rongying Luo, Qiqin Wang, Elena Sánchez‐López, Salvatore Fanali, Marı́a Luisa Marina, Zhengjin Jiang

Journal of Chromatography A

DOI

2014

不同采收期钩藤中绿原酸含量的高效液相色谱法测定

唐才林，高言明，杨春，叶世芸，林昌虎，付志明，吴明花，徐东升

《时珍国医国药》

2014

高效毛细管电泳内标法测定山银花中绿原酸含量

徐东升，高言明，杨春，林昌虎，吴明花，唐才林

《江西中医药》

精选作品

期刊论文

[18F]AlF-RESCA-R8B4 and [68Ga]Ga-NOTA-R8B4: A Pair of Novel CD70-Targeted ImmunoPET/CT Imaging Agents for Clinical Use

Trop2 immunoPET/CT in annotating differential Trop2 expression in lung cancers: a prospective clinical study

Immuno-PET/CT Imaging of Trop2 Expression with [18F]AlF-RESCA-RT4 Enhances Diagnosis of Breast Cancers and the Metastases

Trop2-Targeted [18F]AlF-RESCA-RT4 ImmunoPET/CT in Guiding Clinical Surgeries of Thyroid Cancers: A Proof-of-Concept Study.

[18F]RCCB6 PET/CT in Diagnosing Clear Cell Renal Cell Carcinomas: A Prospective Comparison Study with [18F]FDG PET/CT and Conventional Imaging.

Enhanced chemical stability of an immobilized artificial membrane stationary phase achieved via atom-transfer radical polymerization

Impact of sulfonium versus ammonium groups in zwitterions on hydrophilic interaction chromatographic separation performance

CD70-Targeted [18F]RCCB6 Immuno-PET/CT for Diagnosing Clear Cell Renal Cell Carcinoma Metastases: A Prospective Study

Trop2 immuno-PET/CT imaging of prostate cancer: a proof-of-concept translational study

Development and Preclinical Evaluation of CDH17-Specific ImmunoPET Imaging in Colorectal Cancers.

Total-body 18 F-AlF-RESCA-T4 immuno-PET/CT in patients with solid tumors: Initial experience and potential value in navigating clinical decision-making

CD70-Targeted [18F]RCCB6 Immuno-PET/CT Imaging in Patients with Nasopharyngeal Carcinoma: A Proof-of-Concept Study

Head-to-head comparison of peptide-based and nanobody-based radiotracers in detecting PD-L1 expression in non-small cell lung cancer

[68Ga]Ga-NOTA-T4 ImmunoPET imaging for evaluating TROP2 expression in patients with solid tumors

Recent progress in the application of hydrophilic interaction liquid chromatography for the separation and analysis of traditional Chinese medicine

Fabrication and evaluation of a dual-zwitterionic functionalized hydrophilic monolith for chromatographic separation

Preclinical evaluation and pilot clinical study of [68Ga]Ga-NOTA-H006 for non-invasive PET imaging of 5T4 oncofetal antigen

ImmunoPET imaging of EpCAM in solid tumours with nanobody tracers: a preclinical study

Preclinical development of novel PD-L1 tracers and first-in-human study of [68Ga]Ga-NOTA-RW102 in patients with lung cancers

Assessment of PD‐L1 Expression in Non‐Small Cell Lung Cancers Using [68Ga]Ga‐DOTA‐WL12 PET/CT

ImmunoPET imaging of Trop2 in patients with solid tumours

Effect of anionic groups in zwitterionic hydrophilic stationary phases on their chromatographic characteristics

A systematic review and meta-analysis on sodium tanshinone IIA sulfonate injection for the adjunctive therapy of pulmonary heart disease

Preparation and evaluation of a piperidinium-sulfonate based zwitterionic monolith for HILIC separation

Development of biomimetic phospholipid membrane chromatography for drug discovery: A comprehensive review

A comprehensive evaluation of a polymeric zwitterionic hydrophilic monolith for nucleotide separation

Inside-Out Oriented Choline Phosphate-Based Biomimetic Magnetic Nanomaterials for Precise Recognition and Analysis of C-Reactive Protein

A Systematic Review and Meta-Analysis on the Efficacy of Puerarin Injection as Adjunctive Therapy for Unstable Angina Pectoris

UPLC-QQQ-MS/MS在中药分析中的应用研究进展

Photo-assisted generation of versatile zwitterionic carboxybetaine-based hypercrosslinked polymers for separation science

Single-step fabrication of a teicoplanin functionalized organic-silica hybrid monolith for enantioseparation by nano-liquid chromatography

A systematic investigation of the effect of sample solvent on peak shape in nano- and microflow hydrophilic interaction liquid chromatography columns

Development of acidic phospholipid containing immobilized artificial membrane column to predict drug-induced phospholipidosis potency

Development of zirconium modified adenosine triphosphate functionalized monolith for specific enrichment of N-glycans

Preparation and application of teicoplanin functionalized polymeric monolith for enantioseparation of chiral drugs

Recent advances in preparation and applications of monolithic chiral stationary phases

Determination of l-norvaline and l-tryptophan in dietary supplements by nano-LC using an O-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine-silica hybrid monolithic column

Preparation of an O-[2-(methacryloyloxy)-ethylcarbamoyl]-10,11-dihydroquinidine-silica hybrid monolithic column for the enantioseparation of amino acids by nano-liquid chromatography

A facile and efficient single-step approach for the fabrication of vancomycin functionalized polymer-based monolith as chiral stationary phase for nano-liquid chromatography

不同采收期钩藤中绿原酸含量的高效液相色谱法测定

高效毛细管电泳内标法测定山银花中绿原酸含量

研究方向