陈金铃｜南通大学｜学者主页

百晓学者学者目录

精选作品

期刊论文

2026

Trem2 negatively regulates the MTOR-PKCα axis to protect against Toxoplasma gondii-induced adverse pregnancy outcomes

Xiaoyu Geng, Yangchenxi Lu, Xin-Yi Zhou, Xiao-Yao Xu, Yahan Liu, Junfang Zhang, Jinling Chen

Frontiers in Cellular and Infection Microbiology

DOI

2026

Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss

Shuang Wu, C. Bu, Qinzheng Xu, Xi Cheng, Jun-Rong Zhang, Jinling Chen, Yun-Zhao Xu

iMetaMed

DOI

2025

ATF3-mediated inhibition of Trem2 by Toxoplasma gondii contributes to adverse pregnancy outcomes

Xiaoyu Geng, Tiankun Yao, Xinyue Wang, Jianan Wang, Tongrui Zhang, Tianmei Qian, Chun Liu, Jinling Chen

Parasites & Vectors

DOI

2025

Dynamics and Regulation of Maternal–Fetal Interface Macrophages: From Immune Tolerance to Pregnancy Outcomes

Xinyue Wang, Hao-Chen Yang, Yun-Zhao Xu, Jinling Chen

iMetaMed

DOI

2025

Trem2-MICAL1-P-ERK Axis in Macrophages Confers Protection Against Toxoplasma gondii-Induced Adverse Pregnancy Outcomes

Xiaoyu Geng, Haochen Yang, Zihan Wang, Ziqian Chen, Jinling Chen, Mei Yang

Pathogens

DOI

2024

Trem2/Syk/PI3K axis contributes to the host protection against Toxoplasma gondii-induced adverse pregnancy outcomes via modulating decidual macrophages

Qing Wang, Yining Cao, Songyi Ye, Maoyuan Ding, Wen-Liang Ge, Yuejin Liang, Jinling Chen

PLoS Pathogens

DOI

2024

ATF3 is involved in rSjP40‐mediated inhibition of HSCs activation in Schistosoma japonicum‐infected mice

Jing Li, Jiali Zhang, Bei Zhang, Guo Chen, Min Huang, Bo-Yin Xu, Dan-Dan Zhu, Jinling Chen, Yi-Nong Duan, Wenxi Gao

Journal of Cellular and Molecular Medicine

DOI

2024

Inhibition of Foxp3 expression in the placenta of mice infected intraperitoneally by toxoplasma gondii tachyzoites: insights into the PPARγ/miR-7b-5p/Sp1 signaling pathway

Yue Zhong, Cheng Qin, Qing Wang, Maoyuan Ding, Chong Qiu, Yun-Zhao Xu, Jinling Chen

Parasites & Vectors

DOI

2024

The role of microRNA-142a in Toxoplasma gondii infection-induced downregulation of Foxp3: implications for adverse pregnancy outcomes

Yue Zhong, Yining Cao, Xiaoyu Geng, Shujin Yang, Tianmei Qian, Chun Liu, Jinling Chen

BMC Infectious Diseases

DOI

2023

TREM2 expression promotes liver and peritoneal M2 macrophage polarization in mice infected with Schistosoma japonicum

Dan-Dan Zhu, Min Huang, Pei Shen, Bei Zhang, Guo Chen, Jinling Chen, Li-li Duan, Yi-Nong Duan

Journal of Cellular and Molecular Medicine

DOI

2023

From the immune system to mood disorders especially induced by Toxoplasma gondii: CD4+ T cell as a bridge

Qing Wang, Yue Zhong, Nan-Nan Chen, Jinling Chen

Frontiers in Cellular and Infection Microbiology

DOI

2022

Recombinant P40 protein of Schistosoma japonicum inhibits TREM-1 expression in RAW264.7 cells via FOXO3a.

Pei Shen, Tianyu Zhang, Guo Chen, Bei Zhang, Ai-Long Huang, Li-li Duan, Dan-Dan Zhu, Jinling Chen, Jian-Xin Wang, Yi-Nong Duan

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

DOI

2022

Toxoplasma gondii promotes microRNA-34a to inhibit Foxp3 expression in adverse outcomes of pregnancy in mice.

Xu-Yang Gao, Yue-Yuan Zhong, Ke-Qin Li, Amin Miao, Nan-Nan Chen, Runmin Ding, Yunzhao Xu, Jinling Chen

International Immunopharmacology

DOI

2021

The Role and Function of Regulatory T Cells in Toxoplasma gondii-Induced Adverse Pregnancy Outcomes

Xu-Yang Gao, Yue-Yuan Zhong, Yifan Liu, Runmin Ding, Jinling Chen

Journal of Immunological Research

DOI

2021

rSjP40 Inhibited the Activity of Collagen Type I Promoter via Ets-1 in HSCs

Jing Li, Jiali Zhang, Bei Zhang, Liuting Chen, Guo Chen, Dan-Dan Zhu, Jinling Chen, Lianxiang Duan, Yi-Nong Duan

Frontiers in Cell and Developmental Biology

DOI

2020

Toxoplasma gondii excreted‐secreted antigens suppress Foxp3 promoter activity via a SP1‐dependent mechanism

Jinling Chen, Jingjing Wang, Xu-Yang Gao, Dan-Dan Zhu, Liuting Chen, Yi-Nong Duan

Journal of Cellular and Molecular Medicine

DOI

2020

Expression of recombinant Schistosoma japonicum protein rSjE16 and its effects on LX-2 cells in vitro

Wen-Xi Gao, Wenxia Peng, X. Ji, Dan-Dan Zhu, Jinling Chen, Jin-Rong Feng, Yang Yu, L. Duan, Yi-Nong Duan

Journal of International Medical Research

DOI

2019

Ⅲ型干扰素抵抗寨卡病毒感染导致不良妊娠的机制

王晶晶，曹阳青，陈金铃

《中国人兽共患病学报》

2019

Stat3对Foxp3表达的影响

曹阳青，陈金铃

《中国病原生物学杂志》

2019

蜕膜中免疫调节细胞参与妊娠的研究进展

胡亮，陈金铃

《南通大学学报(医学版)》

2019

Toxoplasma gondii excreted‐secreted antigens suppress Foxp3 via PI3K‐AKT‐mTOR signaling pathway

Jinling Chen, Liang Hu, Jingjing Wang, Y. Cao, Dan-Dan Zhu, Liuting Chen, Yi-Nong Duan

Journal of Cellular Biochemistry

DOI

2019

rSJYB1 inhibits collagen type I protein expression in hepatic stellate cells via down‐regulating activity of collagen α1 (I) promoter

Liuting Chen, Zhaodong Ji, L. Duan, Dan-Dan Zhu, Jinling Chen, Xiao-Lei Sun, Yang Yu, Yi-Nong Duan

Journal of Cellular and Molecular Medicine

DOI

2019

rSjp40 inhibits activated hepatic stellate cells by promoting nuclear translocation of YB1 and inducing BMP-7/Smad1/5/8 pathway

Liuting Chen, Qi Zhou, Er-Tao Liu, Jiali Zhang, L. Duan, Dan-Dan Zhu, Jinling Chen, Yi-Nong Duan

Parasites & Vectors

DOI

2018

rSjP40 suppresses hepatic stellate cell activation by promoting microRNA‐155 expression and inhibiting STAT5 and FOXO3a expression

Dan-Dan Zhu, Chunzhao Yang, Pei Shen, Liuting Chen, Jinling Chen, Xiao-Lei Sun, L. Duan, Li Zhang, Jinhua Zhu, Yi-Nong Duan

Journal of Cellular and Molecular Medicine

DOI

2018

rSjP40 protein promotes PPARγ expression in LX‐2 cells through microRNA‐27b

Dan-Dan Zhu, Lei Lyu, Pei Shen, Jian-Xin Wang, Jinling Chen, Xiao-Lei Sun, Liuting Chen, Li Zhang, Qi Zhou, Yi-Nong Duan

The FASEB Journal

DOI

2018

microRNA‐146a is involved in rSjP40‐inhibited activation of LX‐2 cells by targeting Smad4 expression

Dan-Dan Zhu, Bin Hu, Yong-Hua Zhou, Xiao-Lei Sun, Jinling Chen, Liuting Chen, Zhaodong Ji, Jinhua Zhu, Yi-Nong Duan

Journal of Cellular Biochemistry

DOI

2018

Schistosoma japonicum soluble egg antigen inhibits TNF-α-induced IL-34 expression in hepatic stellate cells

Liuting Chen, Yang Yu, Er-Tao Liu, L. Duan, Dan-Dan Zhu, Jinling Chen, J. Dai, Yi-Nong Duan

Parasitology Research

DOI

2018

Excreted‐secreted antigens of Toxoplasma gondii inhibit Foxp3 via IL‐2Rγ/JAK3/Stats pathway

Jinling Chen, Cai-Qun Huang, Dan-Dan Zhu, Liuting Chen, Jian-Xin Wang, Xiao-Lei Sun, Liang Hu, Yi-Nong Duan

Journal of Cellular Biochemistry

DOI

2018

Differentiation and Function of T Cell Subsets in Infectious Diseases

Yuejin Liang, Xiao-Jun Chen, Jinling Chen, Feng-Liang Liu

Journal of Immunological Research

DOI

2017

STAT与肝纤维化

王婧帆，陈金铃

《南通大学学报(医学版)》

2017

Egg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells via SKP2/P27 signaling pathway

Tianhua Xu, Jinling Chen, Dan-Dan Zhu, Liuting Chen, Jian-Xin Wang, Xiao-Lei Sun, Bin Hu, Yi-Nong Duan

Scientific Reports

DOI

2017

Chinese 1 strain of Toxoplasma gondii excreted–secreted antigens negatively modulate Foxp3 via inhibition of the TGFßRII/Smad2/Smad3/Smad4 pathway

Jinling Chen, Cai-Qun Huang, Dan-Dan Zhu, Pei Shen, Yi-Nong Duan, Jian-Xin Wang, Chunzhao Yang, Li-Ting Wu

Journal of Cellular and Molecular Medicine

DOI

2017

Outcomes of congenital Zika disease depend on timing of infection and maternal-fetal interferon action

Jinling Chen, Yuejin Liang, Panpan Yi, Lan-Man Xu, H. Hawkins, S. Rossi, L. Soong, Ji-Yang Cai, R. Menon, Jia-Ren Sun

Cell Reports

DOI

2017

Recombinant SjP40 protein enhances p27 promoter expression in hepatic stellate cells via an E2F1-dependent mechanism

Yi-Nong Duan, Lei Lyu, Dan-Dan Zhu, Jian-Xin Wang, Jinling Chen, Liuting Chen, Chunzhao Yang, Xiao-Lei Sun

OncoTarget

DOI

2016

Foxp3转录调控的研究进展

黄彩群，陈金铃，朱丹丹，段义农

《中国病原生物学杂志》

2016

Recombinant T2 RNase protein of Schistosoma japonicum inhibits expression of α-SMA in LX-2 cells

Jian-Xin Wang, Wenxia Peng, Jin-Rong Feng, Dan-Dan Zhu, Jinling Chen, Xiao-Lei Sun, Lei Lyu, S. Ju, Yi-Nong Duan

Parasitology Research

DOI

2016

Soluble egg antigens of Schistosoma japonicum induce senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway

Jinling Chen, Jing-Kun Pan, Jian-Xin Wang, Ke Song, Dan-Dan Zhu, Cai-Qun Huang, Yi-Nong Duan

Scientific Reports

DOI

2016

Soluble Egg Antigens of Schistosoma japonicum Induce Senescence of Activated Hepatic Stellate Cells by Activation of the FoxO3a/SKP2/P27 Pathway

Yi-Nong Duan, Jing-Kun Pan, Jinling Chen, Dan-Dan Zhu, Jian-Xin Wang, Xiao-Lei Sun, Liuting Chen, Li-Ting Wu

PLoS Neglected Tropical Diseases

DOI

2016

Egg antigen p40 of Schistosoma japonicum promotes senescence in activated hepatic stellate cells by activation of the STAT3/p53/p21 pathway

Jinling Chen, Tianhua Xu, Dan-Dan Zhu, Jian-Xin Wang, Cai-Qun Huang, Lei Lyu, Bin Hu, Wei Sun, Yi-Nong Duan

Cell Death and Disease

DOI

2015

肝星状细胞在逆转肝纤维化中的作用

徐天华，陈金铃，朱丹丹，吕蕾，段义农

《中国人兽共患病学报》

2015

Schistosoma japonicum protein SjP40 inhibits TGF-β1-induced activation of hepatic stellate cells

Xiao-Lei Sun, Lingbo Zhang, Jian-Xin Wang, Jinling Chen, Dan-Dan Zhu, Pei Shen, Xue-Kun He, Jing-Kun Pan, Wenxia Peng, Yi-Nong Duan

Parasitology Research

DOI

2015

Septin4_i1 Regulates Apoptosis in Hepatic Stellate Cells through Peroxisome Proliferator-Activated Receptor-γ/Akt/B-Cell Lymphoma 2 Pathway

Dan-Dan Zhu, Jian-Xin Wang, Xiao-Lei Sun, Jinling Chen, Yi-Nong Duan, Jing-Kun Pan, Tianhua Xu, Yong-Wei Qin, Xingxin He, Cai-Qun Huang

Journal of Histochemistry and Cytochemistry

DOI

2015

Expression of Septin4 in Schistosoma japonicum-infected mouse livers after praziquantel treatment

Dan-Dan Zhu, Ke Song, Jinling Chen, Jian-Xin Wang, Xiao-Lei Sun, Hong-Yan Qian, X. Gu, Lingbo Zhang, Yong-Wei Qin, Yi-Nong Duan

Parasites & Vectors

DOI

2015

Adenovirus-mediated over-expression of Septin4 ameliorates hepatic fibrosis in mouse livers infected with Schistosoma japonicum.

Xue-Kun He, J. Bao, Jinling Chen, Xiao-Lei Sun, Jian-Xin Wang, Dan-Dan Zhu, Ke Song, Wenxia Peng, Tianhua Xu, Yi-Nong Duan

Parasitology international

DOI

2014

Schistosoma japonicum Soluble Egg Antigens Facilitate Hepatic Stellate Cell Apoptosis by Downregulating Akt Expression and Upregulating p53 and DR5 Expression

Jian-Xin Wang, Fei-Fan Xu, Dan-Dan Zhu, Yi-Nong Duan, Jinling Chen, Xiao-Lei Sun, Xue-Kun He, Pan Li, Wei Sun, Jin-Rong Feng

PLoS Neglected Tropical Diseases

DOI

2014

Expression of microRNA-454 in TGF-β1-stimulated hepatic stellate cells and in mouse livers infected with Schistosoma japonicum

Dan-Dan Zhu, Xue-Kun He, Yi-Nong Duan, Jinling Chen, Jian-Xin Wang, Xiao-Lei Sun, Hong-Yan Qian, Jin-Rong Feng, Wei Sun, Fei-Fan Xu, Lingbo Zhang

Parasites & Vectors

DOI

2014

Schistosoma japonicum soluble egg antigens induce apoptosis and inhibit activation of hepatic stellate cells: a possible molecular mechanism.

Yi-Nong Duan, X. Gu, Dan-Dan Zhu, Wei Sun, Jinling Chen, Jin-Rong Feng, Ke Song, Fei-Fan Xu, Xue-Kun He, Xingxin He

International Journal of Parasitology

DOI

2014

Natural killer cell intrinsic toll-like receptor MyD88 signaling contributes to IL-12-dependent IFN-γ production by mice during infection with Toxoplasma gondii

Yiyue Ge, Jinling Chen, Xiaoyan Qiu, Jie Zhang, Lunbiao Cui, Yuhua Qi, Xinjian Liu, Jingfan Qiu, Zhiyang Shi, Zhao‐Rong Lun, Jilong Shen, Yong Wang

International Journal for Parasitology

DOI

2013

The Dysfunction of CD4+CD25+ Regulatory T Cells Contributes to the Abortion of Mice Caused by Toxoplasma gondii Excreted-Secreted Antigens in Early Pregnancy

Jinling Chen, Yiyue Ge, Jie Zhang, Xiaoyan Qiu, Jingfan Qiu, Jiang-ping Wu, Yong Wang

PLoS ONE

DOI

2012

刚地弓形虫微线体蛋白3的研究进展

陈金铃

《中国畜牧兽医》

2011

卡氏肺孢子虫kexin蛋白抗原表位预测

朱丹丹，段义农，陈金铃

《现代预防医学》

2011

纤毛虫抑动抗原及其诱导的免疫反应的研究进展

原丽平，徐阳，陈金铃，黄晓红

《生物技术通报》

2011

Dynamics of Sept4 expression in fibrotic livers of mice infected with Schistosoma japonicum

Yinong Duan, Hongyan Qian, Yongwei Qin, Dandan Zhu, Xuesen He, Qianyun Zhou, Y. N. YANG, J. BAO, Jinrong Feng, Wei Sun, Jinling Chen

Parasitology

DOI

2011

Protective effect of DNA vaccine with the gene encoding 55kDa antigen fragment against Pneumocystis carinii in mice

Yinong Duan, Yi LiangHeng, Jinling Chen, Dandan Zhu, Jianxin Wang, Jinrong Feng, Yongwei Qin, Ying Zhu

Asian Pacific Journal of Tropical Medicine

DOI

2010

大鼠源肺孢子菌p55基因片段真核表达质粒的构建及表达

易亮衡，秦永伟，陈金铃，朱丹丹，何兴新，段义农

《中国人兽共患病学报》

2010

卡氏肺孢子虫p55基因片段DNA疫苗的免疫原性研究

易亮衡，陈金铃，秦永伟，朱丹丹，何兴新，段义农

《现代预防医学》

2009

卡氏肺孢子菌55kDa抗原的原核表达与纯化

陈金铃，段义农，朱丹丹，王建新，秦永伟

《中国人兽共患病学报》

2009

卡氏肺孢子虫p55抗原片段免疫原性的研究

陈金铃，段义农，王建新，朱丹丹，秦永伟

《中国寄生虫学与寄生虫病杂志》

2009

[Immunogenicity of p55 gene fragment from Pneumocystis carinii].

Jinling Chen, Yinong Duan, Jianxin Wang, Dandan Zhu, Yongwei Qin

PubMed

2008

卡氏肺孢子虫MSG抗原基因片段真核表达质粒构建与表达

段义农，董永生，朱丹丹，王建新，陈金铃，秦永伟

《现代预防医学》

2008

卡氏肺孢子虫MSG抗原片段细胞表位的预测

董永生，段义农，王建新，陈金铃，秦永伟

《现代预防医学》

2007

大鼠源卡氏肺孢子菌p55抗原基因克隆和序列分析

段义农，王建新，陈金铃，董永生

《中国人兽共患病学报》

2007

卡氏肺孢子虫p55抗原基因片段原核表达质粒的构建与表达

王建新，段义农，陈金铃，董永生

《中国寄生虫学与寄生虫病杂志》

2007

卡氏肺孢子虫MSG抗原基因片段的克隆与分析

陈金铃，董永生，王建新，段义农

《热带病与寄生虫学》

2006

替硝唑对大鼠卡氏肺孢子虫肺炎作用的初步观察

王建新，段义农，陈金铃，董永生，周全，蔡云平

《中国人兽共患病学报》

2006

卡氏肺孢子虫P55抗原表位与蛋白特性的分析

段义农，王建新，陈金铃

《中国人兽共患病学报》

会议论文

2016

日本血吸虫可溶性虫卵抗原SEA诱导HSC凋亡的分子机制研究

朱丹丹，陈金铃，王建新，段义农

《中国动物学会寄生虫学专业委员会第十届全国寄生虫学青年工作者学术研讨会》

2013

Schistosoma japomicum SEA ameliorates hepatic fibrosis in mice by inhibition of activation and induction of apoptosis on hepatic stellate cells

Yinong Duan, Dandan Zhu, Xijuan Gu, Ke Song, Jinrong Feng, Jinling Chen

《中国动物学会寄生虫学专业委员会第十四次全国学术会议暨第五次国际寄生虫学学术研讨会》

2013

NK cell-intrinsic TLR-My D88 signaling is required for IL-12-dependent early IFN-γ production and innate resistance to Toxoplasma gondii

Yiyue Ge, Jinling Chen, Jie Zhang, Lunbiao Cui, Yuhua Qi, Xinjian Liu, Xiaoyan Qiu, Jingfan Qiu, Zhiyang Shi, Zhaorong Lun, Jilong Shen, Yong Wang

《中国动物学会寄生虫学专业委员会第十四次全国学术会议暨第五次国际寄生虫学学术研讨会论文摘要集》

2009

大鼠卡氏肺孢子菌kexin基因克隆、表达及融合蛋白的免疫特性研究

段义农，朱丹丹，陈金铃，秦永伟，王建新

《中国动物学会寄生虫学专业委员会第十二次全国学术会议暨第三次国际寄生虫学学术研讨会论文摘要集》

研究方向

病原体感染导致不良妊娠的机制研究

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