贾怡昌｜清华大学｜学者主页

精选作品

期刊论文

2026

The accessory protein ORF3a hijacks the CLCC1 chloride channel to disrupt ER homeostasis in betacoronavirus pathogenesis

Liang Guo, Baoying Huang, Hanzhi Yu, Yi Xu, Lei Wei, Jijie Zheng, Yuanzhe Li, Di Wu, Peng Zhao, Changcheng Wu, Wenjie Tan, Yichang Jia

Cell Discovery

DOI

2026

Optimized optogenetic anti-CRISPR for endogenous gene regulation in Drosophila

Clarissien Ramongolalaina, José Carlos Pastor-Pareja, Emily Zhang, Yichang Jia

Nucleic Acids Research

DOI

2026

BDNF insufficiency exacerbates ALS progression

Yihua Xu, Ji He, Shudan Wang, Yijun Ge, Yichang Jia, Wei Guo, Lv Chen, Xinmeng Yao, Yingying Mao, Fan Mei, Dongsheng Fan, Peng Yuan, Bai Lu

Cell Reports Medicine

DOI

2025

Slc22a17 governs postnatal neurogenesis by maintaining the iron homeostasis in hippocampus

Lei Tao, Long Teng, Mengmeng Ge, Yaqi Wang, Chengliang Hu, Jianan Chen, Jingyu Zhao, Lili Cheng, Zijuan Zhang, Wei Qin, Yichang Jia, Da Mi, Zengqiang Yuan, Ligong Chen

Nature Communications

DOI

2025

VIVIT: Resolving trans-scale volumetric biological architectures via ionic glassy tissue

Yixiao Gao, Fengyuan Xin, Tao Wang, Chengjun Shao, Ying Hu, Zhuoya Chen, Yiwei Wang, Fenghua Xie, Tianyu Li, Sijie Li, Liqun Ren, Caiqin Li, Xian Zi Yang, Zhongjun Yang, Meijie Li, KaMun Tan, Tao Bai, Changwei Wei, Hanchuan Peng, Kun Li, Yichang Jia, Kexin Yuan

Cell

DOI

2025

Cortisol regulates neonatal lung development via Smoothened

Shanshan Lu, Yifei Chen, Jiawen Song, Liangliang Ren, Jun Du, Donglai Shen, Jiayin Peng, Yin Yao, Xia Li, Yuqing Wang, Yuqing Wang, Yan Gao, 韩四满, Yichang Jia, Yun Zhao, Yizheng Wang, Yizheng Wang

Respiratory Research

DOI

2023

Three-dimensional surface motion capture of multiple freely moving pigs using MAMMAL

Liang An, Jilong Ren, Tao Yu, Tang Hai, Yichang Jia, Yebin Liu

Nature Communications

DOI

2023

Disruption of ER ion homeostasis maintained by an ER anion channel CLCC1 contributes to ALS-like pathologies

Liang Guo, Qionglei Mao, Ji He, Xiaoling Liu, Xuejiao Piao, Li Luo, Xiaoxu Hao, Hanzhi Yu, Qiang Song, Bailong Xiao, Dongsheng Fan, Zhaobing Gao, Yichang Jia

Cell Research

DOI

2023

Expression of TCF7L2 in midbrain Vglut2-positive neurons

Huihui Qi, Li Luo, Caijing Lu, Runze Chen, Xiaohui Zhang, Yichang Jia

Molecular Psychiatry

DOI

2023

Correction to: TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through its DNA binding domain but not transcription activation domain

Huihui Qi, Li Luo, Caijing Lu, Runze Chen, Xianyao Zhou, Xiaohui Zhang, Yichang Jia

Molecular Psychiatry

DOI

2023

TCF7L2 acts as a molecular switch in midbrain to control mammal vocalization through its DNA binding domain but not transcription activation domain

Huihui Qi, Li Luo, Caijing Lu, Runze Chen, Xianyao Zhou, Xiaohui Zhang, Yichang Jia

Molecular Psychiatry

DOI

2022

A molecular brake that modulates spliceosome pausing at detained introns contributes to neurodegeneration

Dawei Meng, Qian Sheng Zheng, Xue Zhang, Xuejiao Piao, Li Luo, Yichang Jia

Protein & Cell

DOI

2022

Dual-gRNA approach with limited off-target effect corrects C9ORF72 repeat expansion in vivo

Xuejiao Piao, Dawei Meng, Xue Zhang, Qiang Song, Hailong Lv, Yichang Jia

Scientific Reports

DOI

2021

An L1 retrotransposon insertion–induced deafness mouse model for studying the development and function of the cochlear stria vascularis

Chenmeng Song, Jie Li, Shuang Liu, Hanqing Hou, Tong Zhu, Jiaofeng Chen, Lian Liu, Yichang Jia, Wei Xiong

Proceedings of the National Academy of Sciences

DOI

2020

In vivo stress granule misprocessing evidenced in a FUS knock-in ALS mouse model

Xue Zhang, Fengchao Wang, Yi Hu, Runze Chen, Dawei Meng, Liang Guo, Hailong Lv, Ji‐Song Guan, Yichang Jia

Brain

DOI

2020

An ENU-induced mutation in Twist1 transactivation domain causes hindlimb polydactyly with complete penetrance and dominant-negatively impairs E2A-dependent transcription

Run-Ze Chen, Xuebo Cheng, Yuexi Tan, Tien-Chien Chang, Hailong Lv, Yichang Jia

Scientific Reports

DOI

2017

小鼠大脑抑制性神经元特异性多聚核糖体结合型mRNA的提取

陈访访，贾怡昌

《现代生物医学进展》

2017

记忆形成时海马区两个转录翻译关键期的差异表达及调控

谭月茜，贾怡昌

《基因组学与应用生物学》

2017

Activity-induced histone modifications govern Neurexin-1 mRNA splicing and memory preservation

Xinlu Ding, Sanxiong Liu, Miaomiao Tian, Wenhao Zhang, Tao Zhu, Dongdong Li, Jiawei Wu, Haiteng Deng, Yichang Jia, Wei Xie, Hong Bo Xie, Ji‐Song Guan

Nature Neuroscience

DOI

2016

Identification of a Novel ENU-Induced Mutation in MouseTbx1Linked to Human DiGeorge Syndrome

Jiaofeng Chen, Xue Zhang, Jie Li, Chenmeng Song, Yichang Jia, Wei Xiong

Neural Plasticity

DOI

2015

Loss of Clcc1 Results in ER Stress, Misfolded Protein Accumulation, and Neurodegeneration

Yichang Jia, Thomas J. Jucius, S. Cook, S. Ackerman

Journal of Neuroscience

DOI

2012

Global Disruption of Alternative Splicing and Neurodegeneration Is Caused by Mutation of a U2 snRNA Gene

Yichang Jia, J. Mu, S. Ackerman

Cell

DOI

2007

TRPC channels promote cerebellar granule neuron survival

Yichang Jia, Jian Zhou, Yi-Lin Tai, Yi-Zheng Wang

Nature Neuroscience

DOI

2002

铝中毒痴呆模型大鼠海马脂质过氧化和谷氨酰胺合成酶活性变化

贾怡昌，钟才云，王颖明

《中华老年医学杂志》

2001

铝对大鼠海马氨基酸类神经递质含量的影响

贾怡昌，钟才云，王颖明，何执静，王心如

《中华预防医学杂志》

2001

氧化应激、谷氨酸神经递质、NMDA受体在铝所致大鼠神经毒性中的作用

贾怡昌

《南京医科大学》

会议论文

2021

Link ER ion homeostasis maintained by an ER anion channel to ALS

Liang Guo, Qionglei Mao, Ji He, Xiaoling Liu, Xuejiao Piao, LiLuo, Xiaoxu Hao, Bailong Xiao, Dongsheng Fan, Zhaobing Gao, Yichang Jia

《第十九次中国暨国际生物物理大会论文集》

DOI

2017

Discovery and Gene Repair for Neurodegenerative Diseases

Yichang Jia

《全球华人生物学家大会暨第十六届美洲华人生物科学学会学术研讨会》

2015

Disease mechanisms underlying neurodegeneration caused by RNA abnormalities

Yichang Jia

《第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议论文集》

2015

Identification of novel genes involved in learning and memory by mouse forward genetic

Xuebo Cheng, Yichang Jia

《第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议》

2005

BDNF-mediated neuronal protection requires TRPC channels

贾怡昌，周健，杜婉璐，王以政

《中国神经科学学会第六届学术会议暨学会成立十周年庆祝大会论文摘要汇编》

预印本

2025

Cell-autonomous and non-cell-autonomous effect of TRIM72 on ALS disease progression

Xue Zhang, Ji He, Ning Song, Xipeng Li, Weizhe Wang, Yueting Hu, Qing Li, Yiqing Hu, Chunmu Yin, Peng Zhao, Xinyi Jiang, Xuejiao Piao, Dawei Meng, Hongmei Cheng, Zhaohui Chen, Xusheng Huang, Yu Pan, Xinming Qi, Jin Ren, Li Luo, Lin Peng, Wei Peng Guo, Tong Wang, Haipeng Gong, Dongsheng Fan, Yichang Jia

bioRxiv (Cold Spring Harbor Laboratory)

DOI

2022