胡文慧｜信阳师范大学｜学者主页

2026

IL10RB基因变异致极早发炎症性肠病临床表型及遗传学分析3例病例系列报告

汪谚秋，郑翠芳，胡文慧，黄志恒，黄瑛

《中国循证儿科杂志》

2026

MEF2D as a key regulator of osteoarthritis with exploratory therapeutic potential.

Jingjin Dai, Xiaoshan Gong, Hao Tang, Zhao-Yang Hu, Sha Yang, Yuwei He, Jie-Zhong Deng, Lan-Yi Liu, Wenhui Hu, Qi-Jie Dai, Jun-Yu Xiang, Shiwu Dong

Osteoarthritis and Cartilage

DOI

2026

Ferric ion-crosslinked hydrogel patch loaded with IGF-1R inhibitor for the treatment of heterotopic ossification through microenvironment multifaceted regulation.

Xuan Yao, Yuheng Li, Yixiang Xu, Jie Liao, Jianmei Li, Fei Kang, Haibin Ding, Wei Chen, Wenhui Hu, Shiwu Dong

Biomaterials

DOI

2025

HIV-TAT dysregulates microglial lipid metabolism through SREBP2/ miR-124 axis: Implication of lipid droplet accumulation microglia in NeuroHIV

Yan Cheng, Jaekeun Jung, Liyang Guo, Dorela D. Shuboni-Mulligan, Jian-Fu Chen, Wenhui Hu, Ming-Lei Guo

Brain Behavior And Immunity，Vol. 123

DOI

2025

An Attack and Defense Strategy for Osteoarthritis Repair: Constructing a Trace Element Modulated Hydrogel to Mitigate Ferroptosis and Promote Cartilage Matrix Reconstruction

Wenhui Hu, Fei Kang, Yuheng Li, Yixiang Xu, Xiaoming Li, Jing Zhang, Jie Liao, Jingjin Dai, Xiaoshan Gong, Jianmei Li, Xuan Yao, Shiwu Dong

Research

DOI

2025

T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration

Haixing Wang, Yashi Li, Hao-Xin Li, Xu Yan, Zhao-Wei Jiang, Lu Feng, Wenhui Hu, Yinuo Fan, Si-En Lin, Gang Li

Journal of Orthopaedic Translation

DOI

2025

MAGI1 attenuates osteoarthritis by regulating osteoclast fusion in subchondral bone through the RhoA-ROCK1 signaling pathway

Jing Zhang, Wenhui Hu, Yuheng Li, Fei Kang, Xuan Yao, Jianmei Li, Shiwu Dong

Journal of Orthopaedic Translation

DOI

2025

Design Considerations, Formulation Approaches, and Strategic Advances of Hydrogel Platforms for Tendinopathy Management

Junhao Lin, Xuan Yao, Hong-Yan Zhou, Yuheng Li, Jie Liao, Shiwu Dong, Wenhui Hu

Biomaterials Research

DOI

2025

Reverse biogradient biomimetic periosteum with osteogenic and angiogenic characteristics for bone regeneration

Xiaoming Li, Shuang Yang, Shidan Li, Peng-fei Wu, Wenhui Hu, Wei Dai, Jing-Ru Xie, Jinlong Qiu, Liang Zhang, Hui Zhao, Shiwu Dong

Materials Today Bio

DOI

2025

Polyetheretherketone biomaterials and their current progress, modification-based biomedical applications and future challenges

Zuge Yang, Weiwei Guo, Wenhao Yang, Jianye Song, Wenhui Hu, Kun Wang

Materials & Design

DOI

2025

Promising strategy of piezoelectric biomaterials for traumatic brain injury therapies from electrophysiological aspect.

Jingru Lv, Xuan Yao, Shuhang Liu, Yuheng Li, Wenhui Hu, Xiaoming Li

Biomaterials Advances

DOI

2025

Multiscale Hierarchical Micro- and Nano-Surface Induced by High-Repetition-Rate Femtosecond Laser Promote Peri-Implant Osseointegration.

Weiwei Guo, Xu He, Jianye Song, Zheng Cao, Wenhui Hu, Ying-Hui Tan, Shiwu Dong, Yun-Can Ma, Kun Wang

ACS Applied Bio Materials

DOI

2025

Topography-based implants for bone regeneration: Design, biological mechanism, and therapeutics

Weiwei Guo, Zuge Yang, Fuwei Liu, Jianye Song, Wenhao Yang, Yun-Peng Li, Wenhui Hu, Kun Wang

Materials Today Bio

DOI

2024

T细胞免疫在骨重建和骨再生中的研究进展

胡文慧，邓金霞，苏展鹏，王海兴，林思恩

《浙江大学学报(医学版)》

2024

Dual Dynamic Crosslinked Hydrogel Patch Embodied with Anti‐Bacterial and Macrophage Regulatory Properties for Synergistic Prevention of Peritendinous Adhesion

Xuan Yao, Wenhui Hu, Yuheng Li, Jianmei Li, Fei Kang, Jing Zhang, Shiwu Dong

Advanced Functional Materials

DOI

2024

Interplay between lipid dysregulation and ferroptosis in chondrocytes and the targeted therapy effect of metformin on osteoarthritis

Z. Zou, Wenhui Hu, Fei Kang, Zhonghua Xu, Yuheng Li, Jing Zhang, Jianmei Li, Yuan Zhang, Shiwu Dong

Journal of Advanced Research

DOI

2024

Mechanotransduction in subchondral bone microenvironment and targeted interventions for osteoarthritis

Rui Feng, Wenhui Hu, Yuheng Li, Xuan Yao, Jianmei Li, Xiaoming Li, Jing Zhang, Yu Wu, Fei Kang, Shiwu Dong

Mechanobiology in medicine

DOI

2023

Injectable hydrogel with selenium nanoparticles delivery for sustained glutathione peroxidase activation and enhanced osteoarthritis therapeutics

Wenhui Hu, Xuan Yao, Yuheng Li, Jianmei Li, Jing Zhang, Z. Zou, Fei Kang, Shiwu Dong

Materials Today Bio

DOI

2023

The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism

Jing Zhang, Wenhui Hu, Z. Zou, Yuheng Li, Fei Kang, Jianmei Li, Shiwu Dong

Genes and Diseases

DOI

2023

Biosynthesized Silver Nanoparticles Inhibit Osteoclastogenesis by Suppressing NF‐κB Signaling Pathways

Yu Wu, Zhongjun Cheng, Wenhui Hu, Shanwen Tang, Xue Zhou, Shiwu Dong

Advances in Biology

DOI

2022

Anemoside B4 Inhibits Vascular Smooth Muscle Cell Proliferation, Migration, and Neointimal Hyperplasia

Shan Dan, Ping Qu, Chao Zhong, Lu-Ling He, Qingshan Zhang, Guo-Yue Zhong, Wenhui Hu, Yu-hui Feng, Shi-Ling Yang, Xiao-feng Yang, Jun Yu

Frontiers in Cardiovascular Medicine

DOI

2022

Interplay Between Iron Overload and Osteoarthritis: Clinical Significance and Cellular Mechanisms

Chen-Hui Cai, Wenhui Hu, T. Chu

Frontiers in Cell and Developmental Biology

DOI

2022

A hierarchical biomimetic periosteum combined immunomodulatory and osteogenic functions for bone regeneration

Xiao-Ming Li, Shuang Yang, Shao-Chuan Wang, Shidan Li, Hao Jiang, Wenhui Hu, Ping Liu, Qi-Jie Dai, Bo Zhang, Yan-Feng Luo, Shiwu Dong

Composites Part B: Engineering

DOI

2022

Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment

Mi Zhang, Wenhui Hu, Chen-Hui Cai, Yu Wu, Jianmei Li, Shiwu Dong

Materials Today Bio

DOI

2022

Farnesoid X receptor agonist attenuates subchondral bone osteoclast fusion and osteochondral pathologies of osteoarthritis via suppressing JNK1/2/NFATc1 pathway

Wenhui Hu, Chen-Hui Cai, Yuheng Li, Fei Kang, T. Chu, Shiwu Dong

The FASEB Journal

DOI

2021

CARD11基因变异所致原发性免疫缺陷病研究进展

胡文慧，黄瑛

《临床儿科杂志》

2021

BCI Suppresses RANKL-Mediated Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss

Chen-Hui Cai, Wenhui Hu, Ying Zhang, Xu Hu, Si-Zhen Yang, Hao Qiu, Ru-Jie Wang, Min Ma, Yiyun Qiu, T. Chu

Frontiers in Pharmacology

DOI

2021

Corrigendum: CDT1 is a Novel Prognostic and Predictive Biomarkers for Hepatocellular Carcinoma

Chen-Hui Cai, Ying Zhang, Xu Hu, Wenhui Hu, Si-Zhen Yang, Hao Qiu, T. Chu

Frontiers in Oncology

DOI

2021

CDT1 Is a Novel Prognostic and Predictive Biomarkers for Hepatocellular Carcinoma

Chen-Hui Cai, Ying Zhang, Xu Hu, Wenhui Hu, Si-Zhen Yang, Hao Qiu, T. Chu

Frontiers in Oncology

DOI

2020

The dramatic role of IFN family in aberrant inflammatory osteolysis.

Zihan Deng, Wenhui Hu, Hong-Bo Ai, Yue-Qi Chen, Shiwu Dong

Current Gene Therapy

DOI

2020

Tumour dormancy in inflammatory microenvironment: A promising therapeutic strategy for cancer-related bone metastasis

Wenhui Hu, Lincheng Zhang, Yutong Dong, Zhansong Tian, Yue-Qi Chen, Shiwu Dong

Cellular and Molecular Life Sciences

DOI

2020

Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis

Wenhui Hu, Yue-Qi Chen, Ce Dou, Shiwu Dong

Annals of the Rheumatic Diseases

DOI

2020

A selected small molecule prevents inflammatory osteolysis through restraining osteoclastogenesis by modulating PTEN activity

Yue-Qi Chen, Wenhui Hu, Yiran Wang, Yuheng Li, Xiaoming Li, Haibo Li, Yong Tang, Lincheng Zhang, Yutong Dong, Xiao-Chao Yang, Ye Wei, Shiwu Dong

Clinical and Translational Medicine

DOI

2020

Sphingosine‐1‐phosphate (S1P) receptors: Promising drug targets for treating bone‐related diseases

Lincheng Zhang, Yutong Dong, Yiran Wang, Wenhui Hu, Shiwu Dong, Yue-Qi Chen

Journal of Cellular and Molecular Medicine

DOI

2020

Epothilone B prevents lipopolysaccharide-induced inflammatory osteolysis through suppressing osteoclastogenesis via STAT3 signaling pathway

Yue-Qi Chen, Yiran Wang, Junxian Hu, Yong Tang, Zhansong Tian, Wenhui Hu, Fan-Chun Zeng, Jiu-Lin Tan, Qi-Jie Dai, Z. Hou, F. Luo, Jian-Zhong Xu, Shiwu Dong

Aging

DOI

2019

巨噬细胞与单核细胞的细胞骨架调控相关的差异基因表达

宋咏刚，胡文慧，余鹏，石玉玲，赵雪，胡祖权，王赟，曾柱

《贵州医科大学学报》

DOI

2017

不同分化阶段树突状细胞的弹性模量的研究

黄文竹，胡文慧，曾柱

《贵州医科大学学报》

2017

Ⅰ型鼠尾胶原三维培养模型对树突状细胞形态及分泌能力的影响

黄文竹，胡文慧，曾柱

《贵州医科大学学报》

精选作品

期刊论文

IL10RB基因变异致极早发炎症性肠病临床表型及遗传学分析3例病例系列报告

MEF2D as a key regulator of osteoarthritis with exploratory therapeutic potential.

Ferric ion-crosslinked hydrogel patch loaded with IGF-1R inhibitor for the treatment of heterotopic ossification through microenvironment multifaceted regulation.

HIV-TAT dysregulates microglial lipid metabolism through SREBP2/ miR-124 axis: Implication of lipid droplet accumulation microglia in NeuroHIV

An Attack and Defense Strategy for Osteoarthritis Repair: Constructing a Trace Element Modulated Hydrogel to Mitigate Ferroptosis and Promote Cartilage Matrix Reconstruction

T cell related osteoimmunology in fracture healing: Potential targets for augmenting bone regeneration

MAGI1 attenuates osteoarthritis by regulating osteoclast fusion in subchondral bone through the RhoA-ROCK1 signaling pathway

Design Considerations, Formulation Approaches, and Strategic Advances of Hydrogel Platforms for Tendinopathy Management

Reverse biogradient biomimetic periosteum with osteogenic and angiogenic characteristics for bone regeneration

Polyetheretherketone biomaterials and their current progress, modification-based biomedical applications and future challenges

Promising strategy of piezoelectric biomaterials for traumatic brain injury therapies from electrophysiological aspect.

Multiscale Hierarchical Micro- and Nano-Surface Induced by High-Repetition-Rate Femtosecond Laser Promote Peri-Implant Osseointegration.

Topography-based implants for bone regeneration: Design, biological mechanism, and therapeutics

T细胞免疫在骨重建和骨再生中的研究进展

Dual Dynamic Crosslinked Hydrogel Patch Embodied with Anti‐Bacterial and Macrophage Regulatory Properties for Synergistic Prevention of Peritendinous Adhesion

Interplay between lipid dysregulation and ferroptosis in chondrocytes and the targeted therapy effect of metformin on osteoarthritis

Mechanotransduction in subchondral bone microenvironment and targeted interventions for osteoarthritis

Injectable hydrogel with selenium nanoparticles delivery for sustained glutathione peroxidase activation and enhanced osteoarthritis therapeutics

The role of lipid metabolism in osteoporosis: Clinical implication and cellular mechanism

Biosynthesized Silver Nanoparticles Inhibit Osteoclastogenesis by Suppressing NF‐κB Signaling Pathways

Anemoside B4 Inhibits Vascular Smooth Muscle Cell Proliferation, Migration, and Neointimal Hyperplasia

Interplay Between Iron Overload and Osteoarthritis: Clinical Significance and Cellular Mechanisms

A hierarchical biomimetic periosteum combined immunomodulatory and osteogenic functions for bone regeneration

Advanced application of stimuli-responsive drug delivery system for inflammatory arthritis treatment

Farnesoid X receptor agonist attenuates subchondral bone osteoclast fusion and osteochondral pathologies of osteoarthritis via suppressing JNK1/2/NFATc1 pathway

CARD11基因变异所致原发性免疫缺陷病研究进展

BCI Suppresses RANKL-Mediated Osteoclastogenesis and Alleviates Ovariectomy-Induced Bone Loss

Corrigendum: CDT1 is a Novel Prognostic and Predictive Biomarkers for Hepatocellular Carcinoma

CDT1 Is a Novel Prognostic and Predictive Biomarkers for Hepatocellular Carcinoma

The dramatic role of IFN family in aberrant inflammatory osteolysis.

Tumour dormancy in inflammatory microenvironment: A promising therapeutic strategy for cancer-related bone metastasis

Microenvironment in subchondral bone: predominant regulator for the treatment of osteoarthritis

A selected small molecule prevents inflammatory osteolysis through restraining osteoclastogenesis by modulating PTEN activity

Sphingosine‐1‐phosphate (S1P) receptors: Promising drug targets for treating bone‐related diseases

Epothilone B prevents lipopolysaccharide-induced inflammatory osteolysis through suppressing osteoclastogenesis via STAT3 signaling pathway

巨噬细胞与单核细胞的细胞骨架调控相关的差异基因表达

不同分化阶段树突状细胞的弹性模量的研究

Ⅰ型鼠尾胶原三维培养模型对树突状细胞形态及分泌能力的影响

会议论文

2D和3D细胞外基质力学刺激对树突状细胞生物力学特性和免疫功能的调控

Fibrin细胞外基质维度对树突状细胞形态的影响

树突状细胞诱导T细胞免疫应答的数学模型

不同维度的Fibrin细胞外基质对树突状细胞形态的影响

Physiological fluid flow-derived shear stress:a negative regulator for dendritic cells-induced immune response?

研究方向