梁坚家｜三峡大学｜学者主页

期刊论文

2026

脱氢弯孢霉素肉桂酰类ACLY抑制剂的设计、合成及抗肿瘤活性研究

王程，陈贤飞，周向锋，常煦，邓张双，梁坚家

《药学学报》

2025

ACLY抑制剂脱氢弯孢霉菌素的结构改造及抗肿瘤活性研究

王丹津，郜秋果，王淑琴，邓张双，梁坚家

《药学学报》

DOI

2025

Chemical proteomics reveals hesperidin and hesperetin as AKR1C1/2 inhibitors with chemosensitization effect.

Lijun Chen, Yuan-Yuan Zhou, Yiyun Geng, Jianjia Liang, Hongyue Ma, Lu Ran, Jingyuan Xu, Zhangshuang Deng, Yi-Qing Zhou

Chemical Communications

DOI

2024

Chemoproteomic Profiling Reveals Chlorogenic Acid as a Covalent Inhibitor of Arabidopsis Dehydroascorbate Reductase 1.

Jingyuan Xu, Lijun Chen, Shanshan Wang, Wen Zhang, Jianjia Liang, Lu Ran, Zhangshuang Deng, Yi-Qing Zhou

Journal of Agricultural and Food Chemistry

DOI

2024

Citrus polymethoxyflavones degrade estrogen receptor-alpha (ERα) and combine with tamoxifen for the treatment of estrogen receptor-positive breast cancer

Yiyu Wang, Meng Sun, Zhong He, Ying Han, Yin-Hong Song, Jianjia Liang, Huimin Wang, Ye Qin, Zhangshuang Deng

Heliyon

DOI

2024

Dehydrocurvularin-loaded mPEG-PLGA nanoparticles for targeted breast cancer drug delivery: preparation, characterization, in vitro, and in vivo evaluation

Xuewei Cui, Zhong He, Jianjia Liang, Mu-Lan Wei, Zhi-Qiang Guo, Yi-Qing Zhou, Ye Qin, Zhangshuang Deng

Journal of drug targeting (Print)

DOI

2024

Enrichment of polymethoxyflavones from citrus fruits using an optimized enzyme/acid-catalyzed hybrid hydrolysis process and its influence on mice gut microbiota.

Meng Sun, Jianjia Liang, Yan Peng, Leilei Qin, Dong-Xu Ma, Xiaorong Cai, Lu Ran, Yue-Ying Wang, Huimin Wang, Changying Yang, Xiao-Wen Liu, Zhangshuang Deng

Food & Function

DOI

会议论文

2018

A "Click Chemistry Platform" for the rapid synthesis of small-molecule-mediated degradation of the androgen receptor

Jianjia Liang, Hang Xie, Ruihua Yang, Longfei Zhao, Ying Liu, Yu Ke, Hongmin Liu

《第11届世界华人药物化学研讨会（ISCMC 2018）论文摘要集》

2018

Design,synthesis and in vitro activity of novel triazine-based LSD1 inhibitors

Ying Liu, Longfei Zhao, Jianjia Liang, Zhusong Cao, Xiaojing Li, Le Yang, Bo Wang, Fengzhi Suo, Jinyi Wang, Ruihua Yang, Yu Ke, Liying Ma, Hongmin Liu

《第11届世界华人药物化学研讨会（ISCMC 2018）论文摘要集》

梁坚家

精选作品

期刊论文

脱氢弯孢霉素肉桂酰类ACLY抑制剂的设计、合成及抗肿瘤活性研究

ACLY抑制剂脱氢弯孢霉菌素的结构改造及抗肿瘤活性研究

Chemical proteomics reveals hesperidin and hesperetin as AKR1C1/2 inhibitors with chemosensitization effect.

Chemoproteomic Profiling Reveals Chlorogenic Acid as a Covalent Inhibitor of Arabidopsis Dehydroascorbate Reductase 1.

Citrus polymethoxyflavones degrade estrogen receptor-alpha (ERα) and combine with tamoxifen for the treatment of estrogen receptor-positive breast cancer

Dehydrocurvularin-loaded mPEG-PLGA nanoparticles for targeted breast cancer drug delivery: preparation, characterization, in vitro, and in vivo evaluation

Enrichment of polymethoxyflavones from citrus fruits using an optimized enzyme/acid-catalyzed hybrid hydrolysis process and its influence on mice gut microbiota.

会议论文

A "Click Chemistry Platform" for the rapid synthesis of small-molecule-mediated degradation of the androgen receptor

Design,synthesis and in vitro activity of novel triazine-based LSD1 inhibitors

研究方向