江伟凡｜南华大学｜学者主页

期刊论文

2026

Discovery of Potent o-Aminobenzoamide-Based NAMPT Inhibitors for Targeting NAPRT-Deficient Gastric Cancer.

Heng Yang, Zhi-Yi Li, Huiqian Peng, Lixian Shen, Zhen Li, Lejing Zhu, Rifan Ding, Yiting Shi, Yuting Liu, Miao Zhang, Linsheng Zhuo, Meiling Yang, Zhen Wang, Weifan Jiang

Journal of Medicinal Chemistry

DOI

2026

NAMPT-targeted para-ureidobenzylamine derivatives: Design, synthesis, and antitumor evaluation in gastrointestinal cancers.

Huiqian Peng, Lejing Zhu, Lixian Shen, Zhen Li, Yiting Shi, Rifan Ding, Tao Zhang, Cheng-Hao Hu, Jie He, Zhen Wang, Weifan Jiang

European journal of medicinal chemistry

DOI

2025

Novel Carbamate-Based o-aminobenzamide Derivatives as Potent Antigastric Carcinoma Agents via Disrupting NAD+ Salvage Synthesis.

Siyi Zhang, Zhen Li, Bo Li, Zhi-Yi Li, Huiqian Peng, Lixian Shen, Lejing Zhu, Tong Mo, Jialiang Peng, Linsheng Zhuo, Zhen Wang, Weifan Jiang

Journal of Medicinal Chemistry

DOI

2024

Identification of a novel 10-hydroxyevodiamine prodrug as a potent topoisomerase inhibitor with improved aqueous solubility for treatment of hepatocellular carcinoma.

Xiuzhen Wei, Xi Zhang, Yan Peng, Jun-Bo Wu, Hanxuan Mo, Zhigang An, Xinyu Deng, Ying Peng, Linyi Liu, Weifan Jiang, Jinjin Chen, Zecheng Hu, Zhen Wang, Linsheng Zhuo

European journal of medicinal chemistry

DOI

2024

Novel N-phenyl-2-(aniline) benzamide hydrochloride salt development for colon cancer therapy

Yan Peng, Ying Peng, Wei Zhang, Siyi Zhang, Huiqian Peng, Zhen Li, Bo Li, Linyi Liu, Linsheng Zhuo, Zhen Wang, Jun-Bo Wu, Weifan Jiang

Frontiers in Pharmacology

DOI

2024

Discovery of novel small molecules targeting the USP21/JAK2/STAT3 axis for the treatment of triple-negative breast cancer.

Lin Long, Jiachi Xu, Xiaowen Qi, Pen Yan, Chengkun Wang, Weifan Jiang, Xue Peng, Zecheng Hu, Wenjun Yi, Liming Xie, Xiaoyong Lei, Zhen Wang, Linsheng Zhuo

European journal of medicinal chemistry

DOI

2024

Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future

Junfang Li, Xiaodong Wang, Honghua Zhang, Xiao-ling Hu, Xue Peng, Weifan Jiang, Linsheng Zhuo, Yan Peng, Guo-Li Zeng, Zhen Wang

Medicinal research reviews (Print)

DOI

2024

Structure-activity relationship study of novel evodiamine amino acid conjugates with potent anti-colorectal cancer efficacy

Shuting Chen, Xi Zhang, Hanxuan Mo, Ying Peng, Zhigang An, Junbo Wu, Xiuzhen Wei, Siyi Zhang, Yongxia Xiong, Weifan Jiang, Xue Peng, Linsheng Zhuo, Zhengwen Lei, Zhen Wang, Zecheng Hu

European Journal of Medicinal Chemistry

DOI

2023

Development of o-aminobenzamide salt derivatives for improving water solubility and anti-undifferentiated gastric cancer

Shuang Li, Yan-Li He, Xuelin Li, Yongxia Xiong, Yan Peng, Chengkun Wang, Lin-Sheng Zhuo, Weifan Jiang, Xian-Zhou Lu, Zhen Wang

Frontiers in Pharmacology

DOI

2023

N(14)-substituted evodiamine derivatives as dual topoisomerase 1/tubulin-Inhibiting anti-gastrointestinal tumor agents.

Jiedan Deng, Lin Long, Xue Peng, Weifan Jiang, Ying Peng, Xi Zhang, Yu-Ting Zhao, Ying Tian, Zhen Wang, Lin-Sheng Zhuo

European journal of medicinal chemistry

DOI

2023

Structure-activity relationship study of 1,6-naphthyridinone derivatives as selective type II AXL inhibitors with potent antitumor efficacy

Linsheng Zhuo, Mengqin Guo, Siyi Zhang, Junbo Wu, Mingshu Wang, Yang Shen, Xue Peng, Zhen Wang, Weifan Jiang, Wei Huang

European Journal of Medicinal Chemistry

DOI

2022

Natural product evodiamine-inspired medicinal chemistry: Anticancer activity, structural optimization and structure-activity relationship.

Zhen Wang, Yongxia Xiong, Ying Peng, Xi Zhang, Shuang Li, Yan Peng, Xue Peng, Lin-Sheng Zhuo, Weifan Jiang

European journal of medicinal chemistry

DOI

2022

Design, synthesis and biological evaluation of 3-arylisoquinoline derivatives as topoisomerase I and II dual inhibitors for the therapy of liver cancer.

Xuemei Deng, Tian Luo, Xi Zhang, Yue-Hua Li, Li-Ming Xie, Weifan Jiang, Linyi Liu, Zhen Wang

European journal of medicinal chemistry

DOI

2022

N-2-(Phenylamino) Benzamide Derivatives as Dual Inhibitors of COX-2 and Topo I Deter Gastrointestinal Cancers via Targeting Inflammation and Tumor Progression.

Junfang Li, Xiao-ling Hu, Honghua Zhang, Yan Peng, Shuang Li, Yongxia Xiong, Weifan Jiang, Zhen Wang

Journal of Medicinal Chemistry

DOI

2022

Design, synthesis and anti-gastric carcinoma activity of 1-styryl isoquinoline derivatives

Zhao Li, Xi Zhang, Yiyue Feng, Ying-mei Lu, Yue-Hua Li, Weifan Jiang, Yu-Qing Wang, Li-Ming Xie, Zhen Wang

Journal of Molecular Structure

DOI

2022

Discovery of dual inhibitors of topoisomerase I and Cyclooxygenase-2 for colon cancer therapy.

Xiao-ling Hu, Junfang Li, Honghua Zhang, Quanwei Yu, Yu-Ying Wang, Xuelin Li, Lin Long, Weifan Jiang, Zhen Wang

European journal of medicinal chemistry

DOI

2021

Design, synthesis and biological evaluation of novel o-aminobenzamide derivatives as potential anti-gastric cancer agents in vitro and in vivo.

Yiyue Feng, Ying-mei Lu, Junfang Li, Honghua Zhang, Z. Li, Han-Zhong Feng, Xuemei Deng, Dan Liu, Tao Shi, Weifan Jiang, Yongxing He, Jian Zhang, Zhen Wang

European journal of medicinal chemistry

DOI

2021

Novel piperazine based benzamide derivatives as potential anti-glioblastoma agents inhibiting cell proliferation and cell cycle progression.

Ying-mei Lu, Yiyue Feng, Z. Li, Junfang Li, Honghua Zhang, Xiao-ling Hu, Weifan Jiang, Tao Shi, Zhen Wang

European journal of medicinal chemistry

DOI

2020

双氯芬酸及其代谢物诱导的急性肝毒性和免疫活化研究

江伟凡

《华南理工大学》

会议论文

2019

High-efficient in vitro screening for drug efflux transporters with antiHIV drugs by CRISPR/Cas9 mediated gene knockout Caco-2 cells

Guorui Zhong, Mingping Huang, Shuxiang Zou, Tianming Dai, Ergang Jiang, Jing Bai, Shihui Pang, Weifan Jiang, Haojian Li, Yang Zhou, Shuilin Xie, Zhaozhi Zeng, Nan Zhao, Renke Dai, Lizhen Huang

《中国毒理学会第九次全国毒理学大会论文集》

江伟凡

精选作品

期刊论文

Discovery of Potent o-Aminobenzoamide-Based NAMPT Inhibitors for Targeting NAPRT-Deficient Gastric Cancer.

NAMPT-targeted para-ureidobenzylamine derivatives: Design, synthesis, and antitumor evaluation in gastrointestinal cancers.

Novel Carbamate-Based o-aminobenzamide Derivatives as Potent Antigastric Carcinoma Agents via Disrupting NAD+ Salvage Synthesis.

Identification of a novel 10-hydroxyevodiamine prodrug as a potent topoisomerase inhibitor with improved aqueous solubility for treatment of hepatocellular carcinoma.

Novel N-phenyl-2-(aniline) benzamide hydrochloride salt development for colon cancer therapy

Discovery of novel small molecules targeting the USP21/JAK2/STAT3 axis for the treatment of triple-negative breast cancer.

Fenamates: Forgotten treasure for cancer treatment and prevention: Mechanisms of action, structural modification, and bright future

Structure-activity relationship study of novel evodiamine amino acid conjugates with potent anti-colorectal cancer efficacy

Development of o-aminobenzamide salt derivatives for improving water solubility and anti-undifferentiated gastric cancer

N(14)-substituted evodiamine derivatives as dual topoisomerase 1/tubulin-Inhibiting anti-gastrointestinal tumor agents.

Structure-activity relationship study of 1,6-naphthyridinone derivatives as selective type II AXL inhibitors with potent antitumor efficacy

Natural product evodiamine-inspired medicinal chemistry: Anticancer activity, structural optimization and structure-activity relationship.

Design, synthesis and biological evaluation of 3-arylisoquinoline derivatives as topoisomerase I and II dual inhibitors for the therapy of liver cancer.

N-2-(Phenylamino) Benzamide Derivatives as Dual Inhibitors of COX-2 and Topo I Deter Gastrointestinal Cancers via Targeting Inflammation and Tumor Progression.

Design, synthesis and anti-gastric carcinoma activity of 1-styryl isoquinoline derivatives

Discovery of dual inhibitors of topoisomerase I and Cyclooxygenase-2 for colon cancer therapy.

Design, synthesis and biological evaluation of novel o-aminobenzamide derivatives as potential anti-gastric cancer agents in vitro and in vivo.

Novel piperazine based benzamide derivatives as potential anti-glioblastoma agents inhibiting cell proliferation and cell cycle progression.

双氯芬酸及其代谢物诱导的急性肝毒性和免疫活化研究

会议论文

High-efficient in vitro screening for drug efflux transporters with antiHIV drugs by CRISPR/Cas9 mediated gene knockout Caco-2 cells

研究方向