赵惠杰｜山东师范大学｜学者主页

2026

RGS22 is a metazoa-specific radial spoke component required for coordinated ciliary beating

Ao Fang, Jiajun Luo, Haomang Xu, Ye-Jun Peng, Wei Xu, Huiwen Cao, Wei Li, Jialei Dai, Zhipeng Shi, Yong Wang, Xiaomeng Li, Huijie Zhao, Miao Gui, Chao Yuan Yu, Xueliang Zhu, Qianting Zhang

Nature Communications

DOI

2026

CCDC191 localizes to the sperm head-tail coupling apparatus and is essential for spermiogenesis and male fertility in mice

Shanshan Nai, Sijia Jia, Xunshuo Liu, Qingchao Li, Ting Song, Huijie Zhao

Biology of Reproduction

DOI

2026

PRMT1-mediated methylation controls OFIP ubiquitination and centrosome duplication to maintain epidermal homeostasis

Kai Liu, Ting Song, Junkui Zhao, Shaodong Yan, Weiwen Bu, Shenying Zhang, Die Hu, Dengwen Li, Huijie Zhao, Jun Zhou

Proceedings of the National Academy of Sciences

DOI

2026

Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia

Qian Lyu, Qingchao Li, Jingrui Li, Jiajun Luo, Chunyu Liu, Shanshan Nai, Hongbin Liu, Xueliang Zhu, Ting Song, Min Liu, Huijie Zhao

eLife

DOI

2026

Author response: Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia

Qian Lyu, Qingchao Li, J L Li, Jiajun Luo, C X Liu, Shanshan Nai, Liu H, Xueliang Zhu, Ting Song, Min Liu, Huijie Zhao

DOI

2026

Microtubule-associated CCDC112 is essential for spermiogenesis and male fertility in mice

Qingchao Li, Xirui Zi, Yue Lu, Hanxiao Yin, Qian Lyu, Junhao Han, Huixin Shen, Xiaoqian Meng, Shanshan Nai, Jun Zhou, Huijie Zhao, Ting Song

Journal of Molecular Cell Biology

DOI

2026

USP21-mediated deubiquitylation stimulates NuMA recruitment to the cell cortex to promote mitotic spindle orientation

Mingzheng Hu, Huixian Ma, Runa Wang, Zhenqi Yu, J. Z. Wang, Lin Li, Difei Wang, Hanxiao Yin, Mulin Yang, Feifei Qi, Ying Shan, Huijie Zhao, Jinmin Gao, Dengwen Li, Min Liu, Jun Zhou

Cell Death and Differentiation

DOI

2026

Reviewer #2 (Public review): Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia

Qian Lyu, Qingchao Li, Jingrui Li, Jiajun Luo, Chunyu Liu, Shanshan Nai, Hongbin Liu, Xueliang Zhu, Ting Song, Min Liu, Huijie Zhao

DOI

2025

USP21 deubiquitinates DPYSL2 and enhances its centrosomal abundance to promote cilium formation

Ting Song, Peng Zhou, Fengguo Zhang, Chunli Liu, Xueqing Han, Yiyang Yue, Mingzheng Hu, Shaodong Yan, Qingchao Li, Min Liu, Jun Yu Zhou, Huijie Zhao

Journal of genetics and genomics/Journal of Genetics and Genomics

DOI

2025

Characterization of membrane structures regulating primary ciliogenesis by quantitative isotropic ultrastructure imaging

Quan-Long Lu, Huijie Zhao, Ziam Khan, Adam Harned, Erina Kamiya, Valentin Magidson, A. Senthilkumar, Sumeth Perera, Kedar Narayan, Christopher J. Westlake

bioRxiv

DOI

2025

CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development

Shuang Sun, Zhaoying Wang, Zhaoyang Xu, Zhengfeng Wang, Jia Sun, Keke Li, Min Liu, Huijie Zhao, Peiwei Liu, Jun Yu Zhou

Nature Communications

DOI

2025

Coordination of IFT20 With Other IFT Components Is Required for Ciliogenesis

Weishu Wang, Ying Chun Shan, Ruming Liu, Dengwen Li, Jun Yu Zhou, Quanlong Lü, Huijie Zhao

Journal of Clinical Laboratory Analysis

DOI

2025

JHY enables the transition from switchable to fixed ciliary waveforms in metazoan evolution

Qingxia Chen, Shuxiang Ma, Hao Liu, Juyuan Liu, Qingchao Li, Qian Lyu, Hanxiao Yin, Junkui Zhao, Shanshan Nai, Ting Song, Hongbin Liu, Jun Yu Zhou, Xiumin Yan, Xueliang Zhu, Huijie Zhao

EMBO Reports

DOI

2025

Filippi syndrome-associated CKAP2L modulates microtubule dynamics essential for mitosis and ciliary length regulation

Qian Lyu, Yinghao Wang, Jun Yu Zhou, Huijie Zhao, Tao Zhong, Qingchao Li

Journal of Molecular Cell Biology

DOI

2025

The Cilia‐Associated Protein CCDC89 Is Dispensable for Male Fertility in Mice

Dehao Song, Qingchao Li, Yuqing Sun, Huijie Zhao, Ting Song

Cytoskeleton

DOI

2025

The New Nexin‐Dynein Regulatory Complex Component CCDC153 Is Dispensable for Ciliary Motility and Fertility in Mice

Shanshan Nai, Yanjie Zheng, Xunshuo Liu, Huijie Zhao

Cytoskeleton

DOI

2025

EFCAB10 anchors AK8 to the radial spoke for proper ciliary motility

Ting Song, Qingchao Li, Qian Lyu, Junkui Zhao, Xirui Zi, Shuo Ma, Jiajun Luo, Shushen Li, Shanshan Nai, Hongbin Liu, Xueliang Zhu, Te Li, Jun Zhou, Huijie Zhao

Proceedings of the National Academy of Sciences

DOI

2025

FUT8-mediated core fucosylation stabilizes TMEM67 to promote ciliogenesis

Difei Wang, Qingchao Li, Zhenqi Yu, Junkui Zhao, Mingzheng Hu, Xiaoshan Geng, Xinzhe Liu, Siyang Zhao, Ting Song, Min Liu, Dengwen Li, Huijie Zhao, Jun Zhou

The Journal of Cell Biology

DOI

2025

Dynamic SAS-6 phosphorylation aids centrosome duplication and elimination in C. elegans oogenesis

Feifei Qi, Shanshan Yin, Xiangrui Yang, Ning Ju, Bohan Liu, Xing Zhang, Zixuan Zhu, Li Ji, Fuxin Zhang, Li Zhao, Ruoxi Wang, Min Liu, Liangran Zhang, Huijie Zhao, Jun Yu Zhou, Jinmin Gao

EMBO Reports

DOI

2025

Intraflagellar transport-associated CCDC92 is required for spermiogenesis and male fertility in mice

Yue Lu, Xirui Zi, Qian Lyu, Qingchao Li, Hanxiao Yin, Yinghao Wang, Qijun Chen, Bingkun Kang, Shanshan Nai, Jun Yu Zhou, Huijie Zhao, Ting Song

Journal of Molecular Cell Biology

DOI

2025

HDAC6 deacetylates ENKD1 to regulate mitotic spindle behavior and corneal epithelial homeostasis

Ting Song, Xueqing Han, Hanxiao Yin, Junkui Zhao, Mingming Ma, Xiaonuan Wen, Chunli Liu, Yiyang Yue, Huijie Zhao, Jun Yu Zhou, Yang Yang, Jie Ran, Min Liu

EMBO Reports

DOI

2025

TBC1D20 coordinates vesicle transport and actin remodeling to regulate ciliogenesis

Denghui Zhai, Lamei Li, Difei Wang, Weishu Wang, Siyang Zhao, Xue Wang, Cheng Chen, Zixuan Zhu, Weiwen Bu, Mulin Yang, Hanxiao Yin, Ying Shan, Huijie Zhao, Christopher J. Westlake, Quanlong Lü, Jun Zhou

The Journal of Cell Biology

DOI

2024

CCDC181 is required for proper spermiogenesis in mice.

Xirui Zi, Qing-Chao Li, Yue Lu, Qian Lyu, Heng Guo, Xiaoqian Meng, Jun Zhou, Huijie Zhao

Journal of genetics and genomics = Yi chuan xue bao

DOI

2024

KIF11 UFMylation Maintains Photoreceptor Cilium Integrity and Retinal Homeostasis

Jie Ran, Gui-Zhi Guo, Sai Zhang, Yu-Fei Zhang, Liang Zhang, Deng-Wen Li, Shian Wu, Yu-Sheng Cong, Xiaohong Wang, Songbo Xie, Huijie Zhao, Hong-Bin Liu, Guang-Shuo Ou, Xue-Liang Zhu, Jun Zhou, Min Liu

Advancement of science

DOI

2024

A polarized multicomponent foundation upholds ciliary central microtubules

Qing-Xia Chen, Huijie Zhao, Xinwen Pan, Chuyu Fang, Benhua Qiu, Jingting Guo, Xiumin Yan, Xue-Liang Zhu

Journal of Molecular Cell Biology

DOI

2024

Melanocortin 1 receptor mediates melanin production by interacting with the BBSome in primary cilia

Xiaoyu Tian, Hanyu Wang, Song Liu, Wei Liu, Kaiyue Zhang, Xiaohan Gao, Qingchao Li, Huijie Zhao, Liangran Zhang, Peiwei Liu, Min Liu, Youjun Wang, Xueliang Zhu, Rutao Cui, Jun Yu Zhou

PLoS Biology

DOI

2023

纤毛外体:细胞信号塔发送的重要微囊泡包裹（英文）

赵惠杰，李庆超，周军

Science Bulletin

2023

Pathologically relevant aldoses and environmental aldehydes cause cilium disassembly via formyl group-mediated mechanisms

Te Li, Min Liu, Fan Yu, Song Yang, Wei-Wen Bu, Kai Liu, Jia Yang, Hua Ni, Mulin Yang, H. Yin, Renjie Hong, Deng-Wen Li, Huijie Zhao, Jun Zhou

Journal of Molecular Cell Biology

DOI

2023

Ciliary ectosomes: critical microvesicle packets transmitted from the cell tower.

Huijie Zhao, Qing-Chao Li, Jun Zhou

Science Bulletin

DOI

2023

Formation and function of multiciliated cells

Qian Lyu, Qing-Chao Li, Jun Zhou, Huijie Zhao

Journal of Cell Biology

DOI

2023

Organization, functions, and mechanisms of the BBSome in development, ciliopathies, and beyond

Xiaoyu Tian, Huijie Zhao, Jun Zhou

eLife

DOI

2022

Ciliogenesis membrane dynamics and organization

Huijie Zhao, Ziam Khan, Christopher J. Westlake

Seminars in Cell and Developmental Biology

DOI

2022

ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis

Ting Song, Yun-Fan Yang, Peng Zhou, J. Ran, Liang Zhang, Xiaofan Wu, Wei Xie, Tao Zhong, Hong-Bin Liu, Min Liu, Deng-Wen Li, Huijie Zhao, Jun Zhou

EMBO Reports

DOI

2021

多纤毛细胞纤毛精确组装的调控机制

赵惠杰

《中国细胞生物学学报》

2021

Fibrogranular materials function as organizers to ensure the fidelity of multiciliary assembly

Huijie Zhao, Qing-Xia Chen, Fan Li, Li-Hong Cui, Lele Xie, Qiongping Huang, Xin Liang, Jun Zhou, Xiumin Yan, Xue-Liang Zhu

Nature Communications

DOI

2020

Cep57 and Cep57l1 function redundantly to recruit the Cep63-Cep152 complex for centriole biogenesis.

Huijie Zhao, Sen Yang, Qing-Xia Chen, Xiao-Meng Duan, Guoqing Li, Qiongping Huang, Xue-Liang Zhu, Xiumin Yan

Journal of Cell Science

DOI

2020

Parental centrioles are dispensable for deuterosome formation and function during basal body amplification (vol 20, e46735, 2019)

Huijie Zhao, Qing-Xia Chen, Chuyu Fang, Qiongping Huang, Jun Zhou, Xiumin Yan, Xue-Liang Zhu

2019

The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis

Adrian A. Cuenca, Christine Insinna, Huijie Zhao, P. John, Matthew A. Weiss, Quanlong Lu, Vijay Walia, Suzanne I. Specht, Selvambigai Manivannan, Jimmy K. Stauffer, Andrew A. Peden, Christopher J. Westlake

Journal of Biological Chemistry

DOI

2019

Microtubule-bundling protein Spef1 enables mammalian ciliary central apparatus formation

Jianqun Zheng, Hao Liu, Lei Zhu, Ya-Wen Chen, Huijie Zhao, Wei Zhang, Fan Li, Lele Xie, Xiumin Yan, Xue-Liang Zhu

Journal of Molecular Cell Biology

DOI

2019

Parental centrioles are dispensable for deuterosome formation and function during basal body amplification

Huijie Zhao, Qing-Xia Chen, Chuyu Fang, Qiongping Huang, Jun Zhou, Xiumin Yan, Xue-Liang Zhu

EMBO Reports

DOI

2016

Production of Basal Bodies in bulk for dense multicilia formation

Xiumin Yan, Huijie Zhao, Xue-Liang Zhu

F1000Research

DOI

2014

多纤毛细胞中心粒扩增的分子机制

赵惠杰，鄢秀敏

《中国细胞生物学学报》

2013

The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis

Huijie Zhao, Lei Zhu, Yunlu Zhu, Jingli Cao, Shanshan Li, Qiongping Huang, Tao Xu, Xiao Huang, Xiumin Yan, Xue-Liang Zhu

Nature Cell Biology

DOI

The Regulatory Mechanism for Accurate Construction of Motile Cilia in Multiciliated Cells

Huijie Zhao

精选作品

期刊论文

RGS22 is a metazoa-specific radial spoke component required for coordinated ciliary beating

CCDC191 localizes to the sperm head-tail coupling apparatus and is essential for spermiogenesis and male fertility in mice

PRMT1-mediated methylation controls OFIP ubiquitination and centrosome duplication to maintain epidermal homeostasis

Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia

Author response: Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia

Microtubule-associated CCDC112 is essential for spermiogenesis and male fertility in mice

USP21-mediated deubiquitylation stimulates NuMA recruitment to the cell cortex to promote mitotic spindle orientation

Reviewer #2 (Public review): Proteomic composition and mutual assembly of the C2a projection in vertebrate motile cilia

USP21 deubiquitinates DPYSL2 and enhances its centrosomal abundance to promote cilium formation

Characterization of membrane structures regulating primary ciliogenesis by quantitative isotropic ultrastructure imaging

CFAP100 couples microtubule glutamylation to spindle pole integrity in keratinocytes to promote epidermal development

Coordination of IFT20 With Other IFT Components Is Required for Ciliogenesis

JHY enables the transition from switchable to fixed ciliary waveforms in metazoan evolution

Filippi syndrome-associated CKAP2L modulates microtubule dynamics essential for mitosis and ciliary length regulation

The Cilia‐Associated Protein CCDC89 Is Dispensable for Male Fertility in Mice

The New Nexin‐Dynein Regulatory Complex Component CCDC153 Is Dispensable for Ciliary Motility and Fertility in Mice

EFCAB10 anchors AK8 to the radial spoke for proper ciliary motility

FUT8-mediated core fucosylation stabilizes TMEM67 to promote ciliogenesis

Dynamic SAS-6 phosphorylation aids centrosome duplication and elimination in C. elegans oogenesis

Intraflagellar transport-associated CCDC92 is required for spermiogenesis and male fertility in mice

HDAC6 deacetylates ENKD1 to regulate mitotic spindle behavior and corneal epithelial homeostasis

TBC1D20 coordinates vesicle transport and actin remodeling to regulate ciliogenesis

CCDC181 is required for proper spermiogenesis in mice.

KIF11 UFMylation Maintains Photoreceptor Cilium Integrity and Retinal Homeostasis

A polarized multicomponent foundation upholds ciliary central microtubules

Melanocortin 1 receptor mediates melanin production by interacting with the BBSome in primary cilia

纤毛外体:细胞信号塔发送的重要微囊泡包裹（英文）

Pathologically relevant aldoses and environmental aldehydes cause cilium disassembly via formyl group-mediated mechanisms

Ciliary ectosomes: critical microvesicle packets transmitted from the cell tower.

Formation and function of multiciliated cells

Organization, functions, and mechanisms of the BBSome in development, ciliopathies, and beyond

Ciliogenesis membrane dynamics and organization

ENKD1 promotes CP110 removal through competing with CEP97 to initiate ciliogenesis

多纤毛细胞纤毛精确组装的调控机制

Fibrogranular materials function as organizers to ensure the fidelity of multiciliary assembly

Cep57 and Cep57l1 function redundantly to recruit the Cep63-Cep152 complex for centriole biogenesis.

Parental centrioles are dispensable for deuterosome formation and function during basal body amplification (vol 20, e46735, 2019)

The C7orf43/TRAPPC14 component links the TRAPPII complex to Rabin8 for preciliary vesicle tethering at the mother centriole during ciliogenesis

Microtubule-bundling protein Spef1 enables mammalian ciliary central apparatus formation

Parental centrioles are dispensable for deuterosome formation and function during basal body amplification

Production of Basal Bodies in bulk for dense multicilia formation

多纤毛细胞中心粒扩增的分子机制

The Cep63 paralogue Deup1 enables massive de novo centriole biogenesis for vertebrate multiciliogenesis

The Regulatory Mechanism for Accurate Construction of Motile Cilia in Multiciliated Cells

预印本

CCDC180 functions as a C1 projection scaffold essential for ciliary motility and male fertility

研究方向