王月桐｜复旦大学｜学者主页

2026

靶向肿瘤干细胞阿喀琉斯之踵

黄梦林，肖冰燕，王燕苗，唐晓宇，王月桐，侯宪玉

《中国科学:生命科学》

2026

Themis orchestrates T-cell development through coordinated regulation of mitochondrial metabolism and Jun family transcription factors.

Jiali Zhang, Gong Wang, Minfang Song, Yuetong Wang, Yuanyuan Zhang, Er-Wei Zuo, Haopeng Wang, Yu Wang, Liye Zhang, Gao-Feng Fan

Chinese Medical Journal

DOI

2026

Ablation of the adhesion G protein-coupled receptor ADGRL1 activates anti-tumor immune response via cDC1-T cell hub formation

Guangqian Cheng, Junning Wu, Yanmiao Wang, Yanmiao Wang, Qiaoming Li, Jun Yang, Ling V. Sun, Yang Wang, Yang Wang, Wei Zhang, Yiwei Li, Yuetong Wang, Yuetong Wang, Xianyu Steven Hou

Cell Reports

DOI

2026

Inhibition of the cancer stem cell immune checkpoint SOAT1 suppresses regulatory T cell functions through a trans-cellular 20(S)-Hydroxycholesterol-GPR132 pathway in mice

Yahui Ding, Wanqi Fang, Ruiqing Xiang, Haitao Liu, Menglin Huang, Yingran Shen, Ying Chen, Guohao Wang, Zhaocai Zhou, Yun Ling, Ling V. Sun, Yuetong Wang, Xianyu Steven Hou

Nature Communications

DOI

2025

Recharging Aged-CAR with NAD+ to Boost Immunotherapy

Gao-Feng Fan, Yuetong Wang, Ruo-Ning Wang

Trends in Cancer

DOI

2025

Design, synthesis and biological evaluation of (E)-4-(2-((1H-indol-5-yl) methylene) hydrazineyl)-5,6,7,8-tetrahydropyrido [4′,3′:4,5] thieno[2,3-d] pyrimidine derivatives as Arf1-GEFs inhibitors for the treatment of colon cancer

Ning Li, Ning Li, Chenfei Luo, Yu‐Fan Liu, Shaoliang Duan, Xuan Wang, Xuan Wang, Hua Cheng, Deng‐Qi Xue, Yuetong Wang, Wei Li, Xianyu Steven Hou, Liming Shao

European Journal of Medicinal Chemistry

DOI

2024

THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development

Jiali Zhang, Zhenzhou Jiang, Xue-Yuan Zhang, Zi-Qun Yang, Jinjiao Wang, Jialing Chen, Li Chen, Minfang Song, Yanchun Zhang, Mei Huang, Shengmiao Chen, Xuexue Xiong, Yuetong Wang, Piliang Hao, Tiffany Horng, M. Zhuang, Liye Zhang, Er-Wei Zuo, Fang Bai, Jie Zheng, Hao-Peng Wang, Gao-Feng Fan

Nature Structural & Molecular Biology

DOI

2024

NAMPT-targeting PROTAC and nicotinic acid co-administration elicit safe and robust anti-tumor efficacy in NAPRT-deficient pan-cancers.

Xiaotong Zhu, Yen-Cheng Li, Haixia Liu, Yuetong Wang, Ren-Hong Sun, Zhen-Zhou Jiang, Chun Hou, X. Hou, Suming Huang, Huijuan Zhang, Haopeng Wang, Biao Jiang, Xiaobao Yang, Bin Xu, Gao-Feng Fan

Cell Chemical Biology

DOI

2024

Novel Arf1 Inhibitors Drive Cancer Stem Cell Aging and Potentiate Anti‐Tumor Immunity

Yuetong Wang, Qiaoming Li, Yahui Ding, Chenfei Luo, Jun Yang, Na Wang, Ning Jiang, Tiange Yao, Guohao Wang, Guo‐Ming Shi, Xianyu Steven Hou

Advanced Science

DOI

2023

Blockade of Arf1-mediated lipid metabolism in cancers promotes tumor infiltration of cytotoxic T cells via the LPE-PPARγ-NF-κB-CCL5 pathway

Na Wang, Tiange Yao, Chenfei Luo, Ling V. Sun, Yuetong Wang, Xianyu Steven Hou

Life Metabolism

DOI

2023

A neuron-immune circuit regulates neurodegeneration in the hindbrain and spinal cord of Arf1-ablated mice

Guohao Wang, Shuhan Jin, Jiaqi Liu, Xu Li, Peng Dai, Yuetong Wang, Xianyu Steven Hou

National Science Review

DOI

2023

Allosterically inhibited PFKL via prostaglandin E2 withholds glucose metabolism and ovarian cancer invasiveness.

Shengmiao Chen, Yi-Ran Wu, Yang Gao, Chenxu Wu, Yuetong Wang, Chun Hou, Miao Ren, Shu-Yuan Zhang, Qi Zhu, Jiali Zhang, Yufeng Yao, Mei Huang, Yingchuan B. Qi, Xue-Song Liu, Tiffany Horng, Haopeng Wang, Dan Ye, Zheng-Jiang Zhu, Suwen Zhao, Gao-Feng Fan

Cell Reports

DOI

2023

Arf1 Ablation in Colorectal Cancer Cells Activates a Super Signal Complex in DC to Enhance Anti‐Tumor Immunity

Handong Ma, Wanqi Fang, Qiaoming Li, Yuetong Wang, Xianyu Steven Hou

Advanced Science

DOI

2022

FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells

Yanchun Zhang, Xuexue Xiong, Qi Zhu, Jiali Zhang, Shengmiao Chen, Yuetong Wang, Jian Cao, Li Chen, Linjun Hou, Xi Zhao, P. Hao, Jian Chen, M. Zhuang, Da-Ke Li, G. Fan

eLife

DOI

2021

Targeting HSPA1A in ARID2-deficient lung adenocarcinoma

Xue Wang, Yuetong Wang, Z. Fang, Hua Wang, Jian Zhang, Long-Fu Zhang, Hsinyi Huang, Zhonglin Jiang, Yujuan Jin, Xiang-Kun Han, Shenda Hou, Bin Zhou, F. Meng, Luo-Nan Chen, Kwok-Kin Wong, Jinfeng Liu, Zhiqi Zhang, Xin Zhang, Hai-Quan Chen, Yi-Hua Sun, Liang-Liang Hu, H. Ji

National Science Review

DOI

2021

THEMIS is a priming substrate of non-receptor tyrosine phosphatase PTPN6/SHP1 and plays dual roles during T cell development

Jiali Zhang, Erwei Zuo, Min-Fang Song, Li Chen, Zhenzhou Jiang, Shengmiao Chen, Xuexue Xiong, Yuetong Wang, P. Hao, Tiffany Horng, M. Zhuang, Li-Ye Zhang, Haopeng Wang, G. Fan

bioRxiv

DOI

2021

NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells.

Yuetong Wang, Fei Wang, Lihua Wang, Shi-Zhen Qiu, Yu-Feng Yao, Chen-Xu Yan, Xuexue Xiong, Xuyong Chen, Quanquan Ji, Jian Cao, G. Gao, Da-Ke Li, Li-Ye Zhang, Zhi-yi Guo, Ruoning Wang, Haopeng Wang, G. Fan

Cell Reports

DOI

2020

Potentiating the anti-tumor response of tumor infiltrated T cells by NAD+ supplementation

Yuetong Wang, Fei Wang, Lihua Wang, Shi-Zhen Qiu, Yu-Feng Yao, Xuexue Xiong, Xuyong Chen, Quanquan Ji, Jian Cao, Da-Ke Li, Li-Ye Zhang, Ruoning Wang, Haopeng Wang, G. Fan

bioRxiv

DOI

2019

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

Yuetong Wang, Jian Zhang, S. Ren, Dan Sun, Hsinyi Huang, Hua Wang, Yujuan Jin, Fu-Ming Li, Chao-Gu Zheng, Liu Yang, L. Deng, Zhonglin Jiang, T. Jiang, Xiang-Kun Han, Shenda Hou, Chen-Chen Guo, Fei Li, Dong Gao, J. Qin, Da-Ming Gao, Luo-Nan Chen, Shu-Hai Lin, Kwok-Kin Wong, Cheng Li, Liang-Liang Hu, Cai-Cun Zhou, H. Ji

bioRxiv

DOI

2019

Protein tyrosine phosphatase receptor type R (PTPRR) antagonizes the Wnt signaling pathway in ovarian cancer by dephosphorylating and inactivating β-catenin

Yuetong Wang, Jian Cao, Wei-Wei Liu, Jiali Zhang, Zuo Wang, Yi-Qun Zhang, Linjun Hou, Shengmiao Chen, P. Hao, Li-Ye Zhang, M. Zhuang, Yang Yu, Da-Ke Li, G. Fan

Journal of Biological Chemistry

DOI

2017

Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis

Chao-Gu Zheng, Yuetong Wang, Liu Yang, Shu-Ling Zhou, Yijun Gao, Fu-Ming Li, Yan Feng, Zuo-Yun Wang, Li-Xing Zhan, Qin Yan, Xueliang Zhu, Kwok-Kin Wong, Zheng-Jun Chen, H. Ji

Scientific Reports

DOI

2016

LKB1失活引起氧化应激水平的失衡从而导致非小细胞肺癌可塑性及耐药

Fuming Li, Xiangkun Han, Fei Li, Rui Wang, Hui Wang, Yijun Gao, Xujun Wang, Zhaoyuan Fang, Wenjing Zhang, Shun Yao, Xinyuan Tong, Yuetong Wang, Yan Feng, Yihua Sun, Yuan Li, Kwok-Kin Wong, Qiwei Zhai, 陈海泉, 季红斌

《科学新闻》

2016

ヒト肺扁平上皮癌における新規発癌ドライバーとしてのTRA2B DNAH5融合の同定【Powered by NICT】

Fei Li, Z. Fang, Jian Zhang, Chen Li, Hong-Yang Liu, Jufeng Xia, Hong-Wen Zhu, Chen-Chen Guo, Zhen Qin, Fu-Ming Li, Xiang-Kun Han, Yuetong Wang, Yan Feng, Ye Wang, Wen-Jing Zhang, Zuo-Yun Wang, Yujuan Jin, Yi-Hua Sun, Wenyi Wei, R. Zeng, Hai-Quan Chen, H. Ji

2016

Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma

Fei Li, Z. Fang, Jian Zhang, Chen Li, Hong-Yan Liu, Jufeng Xia, Hongwen Zhu, Chen-Chen Guo, Zhen Qin, Fu-Ming Li, Xiang-Kun Han, Yuetong Wang, Yan Feng, Ye Wang, Wen-Jing Zhang, Zuo-Yun Wang, Yujuan Jin, Yi-Hua Sun, Wenyi Wei, R. Zeng, Hai-Quan Chen, H. Ji

Cell Research

DOI

2015

LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response

Fu-Ming Li, Xiang-Kun Han, Fei Li, Rui Wang, Hui Wang, Yijun Gao, Xu-Jun Wang, Z. Fang, Wen-Jing Zhang, S. Yao, Xinyuan Tong, Yuetong Wang, Yan Feng, Yi-Hua Sun, Yuan Li, Kwok-Kin Wong, Q. Zhai, Hai-Quan Chen, H. Ji

Cancer Cell

DOI

王月桐

精选作品

期刊论文

靶向肿瘤干细胞阿喀琉斯之踵

Themis orchestrates T-cell development through coordinated regulation of mitochondrial metabolism and Jun family transcription factors.

Ablation of the adhesion G protein-coupled receptor ADGRL1 activates anti-tumor immune response via cDC1-T cell hub formation

Inhibition of the cancer stem cell immune checkpoint SOAT1 suppresses regulatory T cell functions through a trans-cellular 20(S)-Hydroxycholesterol-GPR132 pathway in mice

Recharging Aged-CAR with NAD+ to Boost Immunotherapy

Design, synthesis and biological evaluation of (E)-4-(2-((1H-indol-5-yl) methylene) hydrazineyl)-5,6,7,8-tetrahydropyrido [4′,3′:4,5] thieno[2,3-d] pyrimidine derivatives as Arf1-GEFs inhibitors for the treatment of colon cancer

THEMIS is a substrate and allosteric activator of SHP1, playing dual roles during T cell development

NAMPT-targeting PROTAC and nicotinic acid co-administration elicit safe and robust anti-tumor efficacy in NAPRT-deficient pan-cancers.

Novel Arf1 Inhibitors Drive Cancer Stem Cell Aging and Potentiate Anti‐Tumor Immunity

Blockade of Arf1-mediated lipid metabolism in cancers promotes tumor infiltration of cytotoxic T cells via the LPE-PPARγ-NF-κB-CCL5 pathway

A neuron-immune circuit regulates neurodegeneration in the hindbrain and spinal cord of Arf1-ablated mice

Allosterically inhibited PFKL via prostaglandin E2 withholds glucose metabolism and ovarian cancer invasiveness.

Arf1 Ablation in Colorectal Cancer Cells Activates a Super Signal Complex in DC to Enhance Anti‐Tumor Immunity

FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells

Targeting HSPA1A in ARID2-deficient lung adenocarcinoma

THEMIS is a priming substrate of non-receptor tyrosine phosphatase PTPN6/SHP1 and plays dual roles during T cell development

NAD+ supplement potentiates tumor-killing function by rescuing defective TUB-mediated NAMPT transcription in tumor-infiltrated T cells.

Potentiating the anti-tumor response of tumor infiltrated T cells by NAD+ supplementation

Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors

Protein tyrosine phosphatase receptor type R (PTPRR) antagonizes the Wnt signaling pathway in ovarian cancer by dephosphorylating and inactivating β-catenin

Cell Division Cycle 42 plays a Cell type-Specific role in Lung Tumorigenesis

LKB1失活引起氧化应激水平的失衡从而导致非小细胞肺癌可塑性及耐药

ヒト肺扁平上皮癌における新規発癌ドライバーとしてのTRA2B DNAH5融合の同定【Powered by NICT】

Identification of TRA2B-DNAH5 fusion as a novel oncogenic driver in human lung squamous cell carcinoma

LKB1 Inactivation Elicits a Redox Imbalance to Modulate Non-small Cell Lung Cancer Plasticity and Therapeutic Response

会议论文

The function of NAD+ metabolism in T cell activation

研究方向