黄德春｜中国药科大学｜学者主页

2026

Subcritical Regulation of Ethanol Polarity for Green, Efficient, and Integrated Extraction and Crystallization of Lycopene

Hao Chen, Huimin Gao, Tie Liu, Manxi Chen, Yu-Han Wang, Wei Liu, Dechun Huang, Hongliang Qian

ACS Sustainable Chemistry & Engineering

DOI

2026

Green Extraction of Rosmarinic Acid: Enhancing Bioactivity and Therapeutic Potential

Kun-Lun Dai, Fan-Xu Yang, Guo-Jian Zhu, Hong-Liang Qian, De-Chun Huang, Jing Shi

Revista Brasileira de Farmacognosia

DOI

2026

Uniform sub-10 nm crosslinked polymeric nanoparticles loaded with berberine for oral diabetes treatment

Xiang Zhou, Fuwei Han, Yu-Hong Ma, Yinan Zhong, De-Chun Huang, Hong-Liang Qian

Chemical Engineering Journal

DOI

2026

Green and Efficient Extraction of Puerarin‐Enriched Extracts From Pueraria lobata via Subcritical Ethanol‐Water for Multi‐Target Antidiabetic Effects

Xiang Zhou, Hao Chen, Chang-Jian Xue, Jia-Yao Sun, Yu-Kun Ma, Xiang Ma, Chen-Xi Wu, Jing Shi, Wei Chen, Hong-Liang Qian, De-Chun Huang

Molecular Nutrition & Food Research

DOI

2026

Ultrasmall zwitterion-micelles coupled with anti-checkpoint antibody for overcoming glioma barriers to eliminate stem cells and amplify immunotherapy.

Ke Wang, Yi Wang, Dongyu Zhang, Bing-Bing Zhao, Shineng Chen, Yinan Zhong, De-Chun Huang, Hong-Liang Qian, Hao Xie, Wei Chen

Journal of Controlled Release

DOI

2025

Small-sized twin-nanoparticles normalize tumor vasculature to enhance tumor accumulation and penetration for potent eradication of cancer stem-like cells

Changshun Zhao, Wei Wang, Zheng-Wei Huang, Yuqing Wan, Rui Xu, Jun-Mei Zhang, Bing-Bing Zhao, Ke Wang, Suchen Wen, Yinan Zhong, De-Chun Huang, Wei Chen

Acta Pharmaceutica Sinica B

DOI

2025

Targeted delivery of polymeric NO-donor micelles to hepatic stellate cells for restoration of liver function and inhibition of hepatic fibrosis.

Rui Yang, Lifen Yang, Ni Zhang, Yuqing Wan, Shineng Chen, Yiqing Xiao, Xiaoping Liang, Shangjie Yang, Yinan Zhong, De-Chun Huang, Wei Chen, Bing-Bing Zhao

Journal of Controlled Release

DOI

2025

On‐Demand ER Stress Modulation in Tumor Cells and TAMs via an Adaptively Transformable Nanoplatform Enhances Photodynamic Immunotherapy

Bing-Bing Zhao, Xiaoyu Chen, Shaohui Xu, Yanran Xing, Jiahan Shao, Yiqing Xiao, Junlong Qi, Hong-Liang Qian, De-Chun Huang, Wei Chen, Yinan Zhong

Advances in Materials

DOI

2025

Oral delivery of ultra-small zwitterionic nanoparticles to overcome mucus and epithelial barriers for macrophage modulation and colitis therapy.

Changshun Zhao, Suchen Wen, Rui Xu, Ke Wang, Yinan Zhong, De-Chun Huang, Bing-Bing Zhao, Wei Chen

Acta Biomaterialia

DOI

2025

Enterosoluble microcapsules embedded with tripeptide-modified zwitterionic nanosystems to overcome intestinal barriers for intact exocytosis and hepatic-targeted gradual insulin delivery

Yuhong Ma, Bing-Bing Zhao, Umm E. Hani, Yu-Kun Ma, Caihua Li, Li-Cheng Li, Jing-Xian Han, Yinan Zhong, De-Chun Huang, Wei Chen, Hong-Liang Qian

Chemical Engineering Journal

DOI

2025

Magnetic nano-crosslinked lipase aggregates: Preparation and catalytic synthesis of OPO.

Xiang Zhou, Jiahao Xu, Jia-Yao Sun, Hao Chen, De-Chun Huang, Wei Chen, Hong-Liang Qian

International Journal of Biological Macromolecules

DOI

2025

Sequentially unlockable prodrug nanoparticles enable spatiotemporal coordination of chemotherapy and tumor microenvironment regulation for metastasis prevention in breast cancer.

Zheng Wang, Rui Yang, William Lee Davis, Yanran Xing, Yiwen Fu, Bo Wang, Wanhong Li, Hong-Liang Qian, Li-Qing Gao, De-Chun Huang, Yinan Zhong, Wei Chen

Biomaterials Science

DOI

2025

Encapsulated hybrid deep eutectic solvents to overcome high viscosity barrier for NH3 capture and established mass transfer resistance model

Yuan Cheng, Sheng-Wen Zhou, Kun Zhao, Fa-Wen Wu, De-Chun Huang, Hong-Liang Qian

Separation and Purification Technology

DOI

2025

Solvent screening and extraction conditions prediction of subcritical extraction based on improved model: Extraction of lycopene as a case.

Hao Chen, Xiang Zhou, Jingwei Du, Yu-Kun Ma, Yinan Zhong, Wei Chen, Hong-Liang Qian, De-Chun Huang

Food Chemistry

DOI

2025

Hepatic‐Targeted Liposomes‐Ginger‐Derived Exosomes Hybrid Nanocarrier for Synergistic Alleviation of Obesity‐Induced Nonalcoholic Steatohepatitis

Yuhong Ma, Yu-Kun Ma, Zhen Yuan, Jing-Xian Han, De-Chun Huang, Hong-Liang Qian

Advanced Healthcare Materials

DOI

2025

Macrophage-camouflaged nano-gasholder mediates a differentiated delivery of nitric oxide for blocking cancer-bone crosstalk and bone metastases

Jun-Mei Zhang, Bing-Bing Zhao, Jing-qi Li, Yiqing Xiao, Yanran Xing, Yecheng Tang, Xin Liu, Xuan Zhang, De-Chun Huang, Wei Chen, Yinan Zhong

Chemical Engineering Journal

DOI

2025

Non-insulin ultra-simple nanogels stimulate GLP-1 secretion through TGR5 for oral diabetes treatment

Yuhong Ma, Mujiao He, Zhen Yuan, De-Chun Huang, Hong-Liang Qian

Chemical Engineering Journal

DOI

2025

Mechanochemical biomimetic mineralization of UiO-66-NH 2 -immobilized cellulase for enhanced catalytic stability and efficiency

Xiaoyang Sun, Linyu Nian, Huimin Qi, Mengjun Wang, Dechun Huang, Chongjiang Cao

Green Chemistry

DOI

2024

基于核心素养形成的制药工程制图课程思政设计

林文，黄德春，武法文，陈维，王志祥

《药学教育》

2024

Dually crosslinked degradable polyionic micelles for sustained glucose-responsive insulin release.

Yuhong Ma, Yujie Xing, Fuwei Han, Jia-Hao Xu, Hong-Liang Qian, Wei Chen, De-Chun Huang

Biomaterials Science

DOI

2024

ROS-responsive core-shell nano-inhibitor impedes pyruvate metabolism for reinforced photodynamic therapy and interrupted pre-metastatic niche formation.

Mengtong Lv, Bing-Bing Zhao, Jun-Mei Zhang, Guizhi Miao, Siming Wei, Yecheng Tang, Xin Liu, Hong-Liang Qian, De-Chun Huang, Wei Chen, Yinan Zhong

Acta Biomaterialia

DOI

2024

Photothermal-controlled no-releasing Nanogels reverse epithelial-mesenchymal transition and restore immune surveillance against cancer metastasis.

Jun-Mei Zhang, Guizhi Miao, My Hanh Ta, Bing-Bing Zhao, Wei Wang, Yanran Xing, Hong-Liang Qian, De-Chun Huang, Wei Chen, Yinan Zhong

Journal of Controlled Release

DOI

2024

Cascade-Catalyzed Nanogel for Amplifying Starvation Therapy by Nitric Oxide-Mediated Hypoxia Alleviation.

Wei Wang, Yafan Niu, Ni Zhang, Yuqing Wan, Yiqing Xiao, Ling-Zhi Zhao, Bing-Bing Zhao, Wei Chen, De-Chun Huang

ACS Applied Materials and Interfaces

DOI

2024

Size-tailored and acid-degradable polyvinyl alcohol microgels for inhalation therapy of bacterial pneumonia.

Xiang Zhou, Jingjing Zhou, Lanlan Wang, Bing-Bing Zhao, Yu-Kun Ma, Ni Zhang, Wei Chen, De-Chun Huang

Journal of materials chemistry. B

DOI

2024

Bioresponsive Nanoparticles Boost Starvation Therapy and Prevent Premetastatic Niche Formation for Pulmonary Metastasis Treatment.

Yanran Xing, Yuanyuan Zhang, Jing-qi Li, Yecheng Tang, Jun-Mei Zhang, Rui Yang, Hui Tang, Hong-Liang Qian, De-Chun Huang, Wei Chen, Yinan Zhong

ACS Applied Materials and Interfaces

DOI

2024

Glucose Oxidase‐Immobilized Dually‐Crosslinked Nanogels for Rapid‐Responsive Insulin Delivery

Yuhong Ma, Jingru Yang, Yu-Kun Ma, Rui Yang, Fuwei Han, Mujiao He, Wei Liu, Hong-Liang Qian, Wei Chen, De-Chun Huang

Advanced Healthcare Materials

DOI

2024

Oral delivery of berberine by liver-targeted zwitterionic nanoparticles to overcome multi-intestinal barriers and extend insulin treatment duration

Yuhong Ma, Caihua Li, Fuwei Han, Yunzhu Liu, Umm E. Hani, Yinan Zhong, De-Chun Huang, Wei Chen, Hong-Liang Qian

Chemical Engineering Journal

DOI

2024

Ursodeoxycholic Acid‐Decorated Zwitterionic Nanoparticles for Orally Liver‐Targeted Close‐Looped Insulin Delivery

Yuhong Ma, Wei Wang, Caihua Li, Fuwei Han, Mujiao He, Yinan Zhong, De-Chun Huang, Wei Chen, Hong-Liang Qian

Advanced Healthcare Materials

DOI

2024

Application of Life Cycle Assessment in the Pharmaceutical Industry: A Critical Review

Zhengyun Chen, Justin Z. Lian, Hengyi Zhu, Jiawei Zhang, Yu-Long Zhang, Xinyu Xiang, De-Chun Huang, Kristie J. Tjokro, V. Barbarossa, Stefano Cucurachi, Bin Dong

Journal of Cleaner Production

DOI

2024

Polysaccharide NAP-3 Synergistically Enhances the Efficiency of Metformin in Type 2 Diabetes via Bile Acid/GLP-1 Axis through Gut Microbiota Remodeling

Lu Sun, Jiang Jiang, Yan Zeng, Jie Zhu, Suilou Wang, Dechun Huang, Chongjiang Cao

Journal of Agricultural and Food Chemistry

DOI

2023

PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy.

Yuhong Ma, Wei Wang, Mujiao He, Yunzhu Liu, Caihua Li, Yinan Zhong, Quan-Min Bu, De-Chun Huang, Hong-Liang Qian, Wei Chen

Biomaterials Science

DOI

2023

Super-small zwitterionic micelles enable the improvement of blood-brain barrier crossing for efficient orthotopic glioblastoma combinational therapy.

Ke Wang, Bing-Bing Zhao, Yuli Ao, Jinyu Zhu, Changshun Zhao, Wei Wang, Yan Zou, De-Chun Huang, Yinan Zhong, Wei Chen, Hong-Liang Qian

Journal of Controlled Release

DOI

2023

Turbulence induced shear controllable synthesis of nano FePO4 irregularly-shaped particles in a counter impinging jet flow T-junction reactor assisted by ultrasound irradiation

B. Dong, Yanqing Guo, Jie Yang, Xiaogang Yang, Lulu Wang, De-Chun Huang

Ultrasonics sonochemistry

DOI

2023

Machine Learning Prediction of the Yield and BET Area of Activated Carbon Quantitatively Relating to Biomass Compositions and Operating Conditions

Cong Wang, Wenbo Jiang, Guancong Jiang, Tong-Huan Zhang, Kui He, Liwen Mu, Jiahua Zhu, De-Chun Huang, Hong-Liang Qian, Xiao-Hua Lu

Industrial & Engineering Chemistry Research

DOI

2023

Encapsulated Deep Eutectic Solvent and Carbonic Anhydrase Jointly by Microfluidics for High Capture Performance of Carbon Dioxide

Bing-Bing Zhao, Kun-Feng Zhao, Yuan Cheng, Simin Huang, Jia-Hao Xu, Yun Xu, Kui He, De-Chun Huang, Hong-Liang Qian, Wei Chen

Separation and Purification Technology

DOI

2023

Robust Construction of Supersmall Zwitterionic Micelles Based on Hyperbranched Polycarbonates Mediates High Tumor Accumulation.

Changshun Zhao, Suchen Wen, Jingfang Pan, Ke Wang, Yicheng Ji, De-Chun Huang, Bing-Bing Zhao, Wei Chen

ACS Applied Materials and Interfaces

DOI

2023

Reversibly "Double Locked" Hydroxycamptothecin Prodrug Nanoparticles for Targeted Chemotherapy of Lung Cancer.

Jun-Mei Zhang, Bo Wang, Hui Wang, Zheng Wang, Pan Zhang, Xin Huang, Hong-Liang Qian, De-Chun Huang, Wei Chen, Yi-Nan Zhong

Acta Biomaterialia

DOI

2023

Prediction of enhanced drug solubility related to clathrate compositions and operating conditions: machine learning study.

Cong Wang, Yuan Cheng, Yuhong Ma, Yuanhui Ji, De-Chun Huang, Hong-Liang Qian

International journal of pharmaceutics

DOI

2023

A polysaccharide NAP-3 from Naematelia aurantialba: Structural characterization and adjunctive hypoglycemic activity

Lu Sun, Jiang Jiang, Tao Jing, Dejun Hu, Jie Zhu, Yan Zeng, Yalun Pang, Dechun Huang, Shujie Cheng, Chongjiang Cao

Carbohydrate Polymers

DOI

2022

Up-converted nano-gasholder with precise nitric oxide release remodels immunosuppressive microenvironment and potentiates tumor immunotherapy

Yan-Fei Li, Hong-Liang Qian, Xin Huang, Xiang Zhou, Bing-Bing Zhao, Lifen Yang, Jiaxing Chen, Hai-Shi Qiao, De-Chun Huang, Yi-Nan Zhong, Wei Chen

Nano Today

DOI

2022

Macromolecular NO‐Donor Micelles for Targeted and Augmented Chemotherapy against Prostate Cancer

Jiaxing Chen, Bing-Bing Zhao, Junhui Zou, Jiachen Yang, Lifen Yang, Jun-Mei Zhang, Wei Chen, De-Chun Huang, Yi-Nan Zhong

Advanced Healthcare Materials

DOI

2022

Black Phosphorus-Synergic Nitric Oxide Nanogasholder Spatiotemporally Regulates Tumor Microenvironments for Self-Amplifying Immunotherapy.

Xin Huang, Yi-Nan Zhong, Yan-Fei Li, Xiang Zhou, Lifen Yang, Bing-Bing Zhao, Jingjing Zhou, Hai-Shi Qiao, De-Chun Huang, Hong-Liang Qian, Wei Chen

ACS Applied Materials and Interfaces

DOI

2022

Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy.

Jing Liu, You-Qi Xu, Haojie Lu, Rongtang Wang, Zhuolu Xia, Changshun Zhao, De-Chun Huang, Feng Jiang, Wei Chen

Langmuir

DOI

2022

Liposomes and liposome-like nanoparticles: From anti-fungal infection to the COVID-19 pandemic treatment

Yonglong He, Wanting Zhang, Qingqing Xiao, Li-Fang Fan, De-Chun Huang, Wei Chen, Wei He

Asian Journal of Pharmaceutical Sciences

DOI

2022

Crosslinked zwitterionic microcapsules to overcome gastrointestinal barriers for oral insulin delivery.

Yuhong Ma, Qi-Hang Li, Jingru Yang, Yuan Cheng, Caihua Li, Changshun Zhao, Wei Chen, De-Chun Huang, Hong-Liang Qian

Biomaterials Science

DOI

2022

Recent advances on next generation of polyzwitterion-based nano-vectors for targeted drug delivery.

Hong-Liang Qian, Ke Wang, Mengtong Lv, Changshun Zhao, Hui Wang, Suchen Wen, De-Chun Huang, Wei Chen, Yi-Nan Zhong

Journal of Controlled Release

DOI

2022

Ginger polysaccharides enhance intestinal immunity by modulating gut microbiota in cyclophosphamide-induced immunosuppressed mice

Junping Liu, Jie Wang, Si-xuan Zhou, Dechun Huang, Guo-hong Qi, Guitang Chen

International Journal of Biological Macromolecules

DOI

2021

新工科背景下制药类《制药工程制图》的改革与探索

季菲，黄德春

《广东化工》

2021

工程认证背景下制药工程专业工程制图教学改革

林文，黄德春，江峰，王志祥

《药学教育》

DOI

2021

新工科背景下针对生物制药专业《化工原理》教学的探索与研究

钟伊南，钱红亮，黄德春

《云南化工》

2021

Preparing anti-SARS-CoV-2 agent EIDD-2801 by a practical and scalable approach, and quick evaluation via machine learning

Zhen Qin, Bin Dong, Renbing Wang, De-Chun Huang, Ju-Bo Wang, Xi Feng, Jin-Lei Bian, Zhi-Yu Li

Acta Pharmaceutica Sinica B

DOI

2021

Multi-functional polymeric micelles for chemotherapy-based combined cancer therapy.

Raut Bholakant, Bin Dong, Xiang Zhou, Xin Huang, Changshun Zhao, De-Chun Huang, Yi-Nan Zhong, Hong-Liang Qian, Wei Chen, J. Feijen

Journal of materials chemistry. B

DOI

2021

Inherently nitric oxide containing polymersomes remotely regulated by NIR for improving multi-modal therapy on drug resistant cancer.

Zhihong Liu, Yi-Nan Zhong, Xiang Zhou, Xin Huang, Jingjing Zhou, De-Chun Huang, Yan-Fei Li, Zhixiang Wang, Bin Dong, Hai-Shi Qiao, Wei Chen

Biomaterials

DOI

2021

Multifunctional Nanoaggregates Composed of Active CPUL1 and a Triphenylphosphine Derivative for Mitochondria‐Targeted Drug Delivery and Cell Imaging

Jing Liu, Fei Ji, Zhuolu Xia, Chunhua Zhang, Chang-Hao Zhao, Yan-Fei Li, Xiang Zhou, De-Chun Huang, Wei Chen, Feng Jiang

ChemMedChem

DOI

2021

Black phosphorus assisted polyionic micelles with efficient PTX loading for remotely controlled release and synergistic treatment of drug-resistant tumors.

Xin Huang, Yan-Fei Li, Dengyu Li, Xiang Zhou, Hai-Shi Qiao, Lifen Yang, Yicheng Ji, Xue-Jiao Zhang, De-Chun Huang, Wei Chen

Biomaterials Science

DOI

2021

Cascade-Responsive Hierarchical Nanosystems for Multisite Specific Drug Exposure and Boosted Chemoimmunotherapy.

Jun-Mei Zhang, Yuanyuan Zhang, Bing-Bing Zhao, Mengtong Lv, E. Chen, Chang-Hao Zhao, Lin-Yang Jiang, Hong-Liang Qian, De-Chun Huang, Yi-Nan Zhong, Wei Chen

ACS Applied Materials and Interfaces

DOI

2021

Synthesis of monodisperse spherical AgNPs by ultrasound-intensified Lee-Meisel method, and quick evaluation via machine learning

Bin Dong, Ning Xue, Guohao Mu, Mengjun Wang, Zonghu Xiao, Lin Dai, Zhixiang Wang, De-Chun Huang, Hong-Liang Qian, Wei Chen

Ultrasonics sonochemistry

DOI

2021

Glucose Oxidase and L-Arginine Functionalized Black Phosphorus Nanosheets for Multimodal Targeted Therapy of Glioblastoma

Xin Huang, Ke Ren, Zhiyong Chang, You-Qing Ye, De-Chun Huang, Wei Zhao, Lixin Yang, Yu Dong, Zhiting Cao, Hai-Shi Qiao

Chemical Engineering Journal

DOI

2021

Mitochondrial Targeting and pH-Responsive Nanogels for Co-Delivery of Lonidamine and Paclitaxel to Conquer Drug Resistance

E. Chen, Ting Wang, Jun-Mei Zhang, Xiang Zhou, Yafan Niu, Fu-Lei Liu, Yi-Nan Zhong, De-Chun Huang, Wei Chen

Frontiers in Bioengineering and Biotechnology

DOI

2021

Synthesis of zwitterionic chimeric polymersomes for efficient protein loading and intracellular delivery

Bing-Bing Zhao, Yu-Ting Yan, Jun-Mei Zhang, E. Chen, Ke Wang, Changshun Zhao, Yi-Nan Zhong, De-Chun Huang, Zhiqin Cui, Da-Wei Deng, Cong-Ying Gu, Wei Chen

Polymer Chemistry

DOI

2021

Synthesis of biogas-residue-based mesoporous carbons via one-step template-free method for organic and inorganic pollutants removal

Hong-Liang Qian, Dong-Hang Yin, Beichen Qin, Li-Cheng Li, Jiahua Zhu, Liwen Mu, Cao-Long Li, Bin Dong, De-Chun Huang, Xiao-Hua Lu

Fuel

DOI

2021

FeSe2 nanosheets as a bifunctional platform for synergistic tumor therapy reinforced by NIR-II light.

Lan Fang, Jie Wang, Xueliang Ouyang, Binbin Liang, Li-Ying Zhao, De-Chun Huang, Da-Wei Deng

Biomaterials Science

DOI

2020

Recent Advances of Polycationic siRNA Vectors for Cancer Therapy.

Raut Bholakant, Hong-Liang Qian, Jun-Mei Zhang, Xin Huang, De-Chun Huang, J. Feijen, Yi-Nan Zhong, Wei Chen

Biomacromolecules

DOI

2020

Tumor localization of oncolytic adenovirus assisted by pH-degradable microgels with JQ1-mediated boosting replication and PD-L1 suppression for enhanced cancer therapy.

Hai-Shi Qiao, Xingmei Chen, Qiming Wang, Jun-Mei Zhang, De-Chun Huang, E. Chen, Hong-Liang Qian, Yi-Nan Zhong, Qi Tang, Wei Chen

Biomaterials Science

DOI

2020

Prediction model, experimental optimization, and verification for yield of high-pressure crystallization: a case study of citric acid

De-Chun Huang, Zhong-Lin Zhu, Qiming Wang, Beichen Qin, Lin Dai, Feng Jiang, W. Liu, Hong-Liang Qian

Separation Science and Technology

DOI

2020

Tumor Microenvironment‐Activatable Nanoenzymes for Mechanical Remodeling of Extracellular Matrix and Enhanced Tumor Chemotherapy

Yi-Nan Zhong, Jian-Guang Zhang, Jun-Mei Zhang, Yong Hou, E. Chen, De-Chun Huang, Wei Chen, R. Haag

Advanced Functional Materials

DOI

2020

Tumor-Adhesive and pH-Degradable Microgels by Microfluidics and Photo-Crosslinking for Efficient Anti-Angiogenesis and Enhanced Cancer Chemotherapy.

Xingmei Chen, Hong-Liang Qian, Hai-Shi Qiao, Bin Dong, E. Chen, De-Chun Huang, Ting Wang, Wei Chen

Biomacromolecules

DOI

2019

Functional Biodegradable Nitric Oxide Donor-Containing Polycarbonate-Based Micelles for Reduction-Triggered Drug Release and Overcoming Multidrug Resistance.

Lei-Lei Gao, Bin Dong, Jun-Mei Zhang, Ying Chen, Hai-Shi Qiao, Zhi-Hong Liu, E. Chen, Yuqin Dong, Chong-Jiang Cao, De-Chun Huang, Wei Chen

ACS Macro Letters

DOI

2019

Folated pH-degradable nanogels for the simultaneous delivery of docetaxel and an IDO1-inhibitor in enhancing cancer chemo-immunotherapy.

Hai-Shi Qiao, Xingmei Chen, E. Chen, Jun-Mei Zhang, De-Chun Huang, Dan-bo Yang, You-Chao Ding, Hong-Liang Qian, J. Feijen, Wei Chen

Biomaterials Science

DOI

2019

Simulation and evaluation of utilization pathways of biomasses based on thermodynamic data prediction

Hong-Liang Qian, Wei Chen, Weiwei Zhu, Chang Liu, Xiao-Hua Lu, Xiao-Jing Guo, De-Chun Huang, Xiaodong Liang, G. Kontogeorgis

Energy

DOI

2019

Purification, characterization and anti-tumor activities of polysaccharides from Ecklonia kurome obtained by three different extraction methods

Ying Li, Gaoyixin Qin, Cheng Chen, Biao Yuan, Dechun Huang, Shujie Cheng, Chongjiang Cao, Guitang Chen

International Journal of Biological Macromolecules

DOI

2019

A peptide-Fe(II) complex from Grifola frondosa protein hydrolysates and its immunomodulatory activity

Biao Yuan, Cong Zhao, Chen Cheng, Dechun Huang, Shujie Cheng, Chongjiang Cao, Guitang Chen

Food Bioscience

DOI

2019

Triterpenes from Poria cocos are revealed as potential retinoid X receptor selective agonists based on cell and in silico evidence

Hui Xu, Yuchen Wang, Junnan Zhao, Peter W. Jurutka, Dechun Huang, Liangyun Liu, Lange Zhang, Suilou Wang, Yadong Chen, Shujie Cheng

Chemical Biology & Drug Design

DOI

2019

Immunomodulatory activities of proteins from Astragalus membranaceus waste

Hao Huang, Shuanghui Luo, Dechun Huang, Shujie Cheng, Chongjiang Cao, Guitang Chen

Journal of the Science of Food and Agriculture

DOI

2018

Determining Key Factor of Synthetic Conditions of the Solid Sintering Preparation of Sodium Titanates by Thermo-Chemical Equilibrium Calculation

Hong-Liang Qian, Fa-Wen Wu, Yi-Qiang Shi, Lin Dai, Zhiqin Cui, De-Chun Huang

Journal of Chemical Engineering of Japan

DOI

2018

Polymeric crown ethers: LCST behavior in water and stimuli-responsiveness

De-Chun Huang, Qiao Zhang, Yan Deng, Zheng Luo, Bo Li, Xin Shen, Zhen-Hui Qi, Shengyi Dong, Yan Ge, Wei Chen

DOI

2018

Bioresponsive functional nanogels as an emerging platform for cancer therapy

De-Chun Huang, Hong-Liang Qian, Hai-Shi Qiao, Wei Chen, J. Feijen, Z. Zhong

Expert Opinion on Drug Delivery

DOI

2018

Micronization of Gefitinib Using Solution-Enhanced Dispersion by Supercritical CO2

Jing Zhang, Qiming Wang, Zhong-Lin Zhu, Hong-Liang Qian, Feng Jiang, Zhixiang Wang, W. Liu, De-Chun Huang

Chemical Engineering & Technology

DOI

2018

Quantitative Design of Seed Load Based on model identification of nucleation and crystal growth stages without transmittance data

Hong-Liang Qian, Lin Dai, Feng Jiang, Yi-Qiang Shi, Zhixiang Wang, W. Liu, De-Chun Huang, Wei Chen

Powder Technology

DOI

2018

Self-Decomposable Mesoporous Doxorubicin@Silica Nanocomposites for Nuclear Targeted Chemo-Photodynamic Combination Therapy

Jie Wang, Dajun Xu, T. Deng, Yun-Yan Li, Le Xue, Tong Yan, De-Chun Huang, Da-Wei Deng

DOI

2018

Promoted Chondrogenesis of Cocultured Chondrocytes and Mesenchymal Stem Cells under Hypoxia Using In-situ Forming Degradable Hydrogel Scaffolds.

Xiao-Bin Huang, Yong Hou, L. Zhong, De-Chun Huang, Hong-Liang Qian, M. Karperien, Wei Chen

Biomacromolecules

DOI

2017

Water-Solubilizing Hydrophobic ZnAgInSe/ZnS QDs with Tumor-Targeted cRGD-Sulfobetaine-PIMA-Histamine Ligands via a Self-Assembly Strategy for Bioimaging.

T. Deng, Yanan Peng, Rong Zhang, Jie Wang, Jie Zhang, Yueqing Gu, De-Chun Huang, Da-Wei Deng

ACS Applied Materials and Interfaces

DOI

2017

Prediction models for chemical exergy of biomass on dry basis from ultimate analysis using available electron concepts

Hong-Liang Qian, Weiwei Zhu, Sudong Fan, Chang Liu, Xiao-Hua Lu, Zhixiang Wang, De-Chun Huang, Wei Chen

DOI

2016

A Simple Prediction Model for Higher Heat Value of Biomass

Hong-Liang Qian, Xiao-Jing Guo, Sudong Fan, K. Hagos, Xiao-Hua Lu, Chang Liu, De-Chun Huang

DOI

2016

Effect of ultrasonication on the dilution crystallization of naproxen

Hua-Ming Zhang, Zhixiang Wang, Hui-Dan Huang, Zhiqin Cui, De-Chun Huang

DOI

2016

Micronization of etoposide using solution-enhanced dispersion by supercritical CO2

Yue Cheng, Wen-Bo Xu, Zhen Chen, Zhixiang Wang, De-Chun Huang

DOI

2015

Preparation and characterization of baicalein powder micronized by the SEDS process

Ting-Xuan Yan, Yue Cheng, Zhixiang Wang, De-Chun Huang, H. Miao, Yi Zhang

DOI

2014

超临界抗溶剂法研制卡马西平微粒

潘丁丁，颜庭轩，王志祥，黄德春，党蓓蕾

《中国医药工业杂志》

2012

超临界CO2抗溶剂法制备布洛芬/EC-PVP缓释复合微粒

蔡锦源，黄德春，王志祥，党蓓蕾，王秋玲，苏鑫光

《药学学报》

2012

超临界抗溶剂制粒装置的现状及其展望

巫先坤，王志祥，黄德春，蔡锦源，颜庭轩

《化工进展》

2010

多功能中药提取与分离中试实验装置

戴琳，王志祥，史益强，黄德春，巫先坤

《机电信息》

2007

超临界流体抗溶剂结晶技术在药物制粒领域中的应用

乐龙，黄德春，刘巍，王志祥

《药学进展》

2006

Application of Cartoons in Teaching Principles of Pharmaceutical and Chemical Engineering

Dechun Huang

Pharmaceutical Education

2005

Content and Characteristics of the Textbook of Principles of Pharmaceutical and Chemical Engineering

Dechun Huang

Pharmaceutical Education

精选作品

期刊论文

Subcritical Regulation of Ethanol Polarity for Green, Efficient, and Integrated Extraction and Crystallization of Lycopene

Green Extraction of Rosmarinic Acid: Enhancing Bioactivity and Therapeutic Potential

Uniform sub-10 nm crosslinked polymeric nanoparticles loaded with berberine for oral diabetes treatment

Green and Efficient Extraction of Puerarin‐Enriched Extracts From Pueraria lobata via Subcritical Ethanol‐Water for Multi‐Target Antidiabetic Effects

Ultrasmall zwitterion-micelles coupled with anti-checkpoint antibody for overcoming glioma barriers to eliminate stem cells and amplify immunotherapy.

Small-sized twin-nanoparticles normalize tumor vasculature to enhance tumor accumulation and penetration for potent eradication of cancer stem-like cells

Targeted delivery of polymeric NO-donor micelles to hepatic stellate cells for restoration of liver function and inhibition of hepatic fibrosis.

On‐Demand ER Stress Modulation in Tumor Cells and TAMs via an Adaptively Transformable Nanoplatform Enhances Photodynamic Immunotherapy

Oral delivery of ultra-small zwitterionic nanoparticles to overcome mucus and epithelial barriers for macrophage modulation and colitis therapy.

Enterosoluble microcapsules embedded with tripeptide-modified zwitterionic nanosystems to overcome intestinal barriers for intact exocytosis and hepatic-targeted gradual insulin delivery

Magnetic nano-crosslinked lipase aggregates: Preparation and catalytic synthesis of OPO.

Sequentially unlockable prodrug nanoparticles enable spatiotemporal coordination of chemotherapy and tumor microenvironment regulation for metastasis prevention in breast cancer.

Encapsulated hybrid deep eutectic solvents to overcome high viscosity barrier for NH3 capture and established mass transfer resistance model

Solvent screening and extraction conditions prediction of subcritical extraction based on improved model: Extraction of lycopene as a case.

Hepatic‐Targeted Liposomes‐Ginger‐Derived Exosomes Hybrid Nanocarrier for Synergistic Alleviation of Obesity‐Induced Nonalcoholic Steatohepatitis

Macrophage-camouflaged nano-gasholder mediates a differentiated delivery of nitric oxide for blocking cancer-bone crosstalk and bone metastases

Non-insulin ultra-simple nanogels stimulate GLP-1 secretion through TGR5 for oral diabetes treatment

Mechanochemical biomimetic mineralization of UiO-66-NH 2 -immobilized cellulase for enhanced catalytic stability and efficiency

基于核心素养形成的制药工程制图课程思政设计

Dually crosslinked degradable polyionic micelles for sustained glucose-responsive insulin release.

ROS-responsive core-shell nano-inhibitor impedes pyruvate metabolism for reinforced photodynamic therapy and interrupted pre-metastatic niche formation.

Photothermal-controlled no-releasing Nanogels reverse epithelial-mesenchymal transition and restore immune surveillance against cancer metastasis.

Cascade-Catalyzed Nanogel for Amplifying Starvation Therapy by Nitric Oxide-Mediated Hypoxia Alleviation.

Size-tailored and acid-degradable polyvinyl alcohol microgels for inhalation therapy of bacterial pneumonia.

Bioresponsive Nanoparticles Boost Starvation Therapy and Prevent Premetastatic Niche Formation for Pulmonary Metastasis Treatment.

Glucose Oxidase‐Immobilized Dually‐Crosslinked Nanogels for Rapid‐Responsive Insulin Delivery

Oral delivery of berberine by liver-targeted zwitterionic nanoparticles to overcome multi-intestinal barriers and extend insulin treatment duration

Ursodeoxycholic Acid‐Decorated Zwitterionic Nanoparticles for Orally Liver‐Targeted Close‐Looped Insulin Delivery

Application of Life Cycle Assessment in the Pharmaceutical Industry: A Critical Review

Polysaccharide NAP-3 Synergistically Enhances the Efficiency of Metformin in Type 2 Diabetes via Bile Acid/GLP-1 Axis through Gut Microbiota Remodeling

PVA-based bulk microneedles capable of high insulin loading and pH-triggered degradation for multi-responsive and sustained hypoglycemic therapy.

Super-small zwitterionic micelles enable the improvement of blood-brain barrier crossing for efficient orthotopic glioblastoma combinational therapy.

Turbulence induced shear controllable synthesis of nano FePO4 irregularly-shaped particles in a counter impinging jet flow T-junction reactor assisted by ultrasound irradiation

Machine Learning Prediction of the Yield and BET Area of Activated Carbon Quantitatively Relating to Biomass Compositions and Operating Conditions

Encapsulated Deep Eutectic Solvent and Carbonic Anhydrase Jointly by Microfluidics for High Capture Performance of Carbon Dioxide

Robust Construction of Supersmall Zwitterionic Micelles Based on Hyperbranched Polycarbonates Mediates High Tumor Accumulation.

Reversibly "Double Locked" Hydroxycamptothecin Prodrug Nanoparticles for Targeted Chemotherapy of Lung Cancer.

Prediction of enhanced drug solubility related to clathrate compositions and operating conditions: machine learning study.

A polysaccharide NAP-3 from Naematelia aurantialba: Structural characterization and adjunctive hypoglycemic activity

Up-converted nano-gasholder with precise nitric oxide release remodels immunosuppressive microenvironment and potentiates tumor immunotherapy

Macromolecular NO‐Donor Micelles for Targeted and Augmented Chemotherapy against Prostate Cancer

Black Phosphorus-Synergic Nitric Oxide Nanogasholder Spatiotemporally Regulates Tumor Microenvironments for Self-Amplifying Immunotherapy.

Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy.

Liposomes and liposome-like nanoparticles: From anti-fungal infection to the COVID-19 pandemic treatment

Crosslinked zwitterionic microcapsules to overcome gastrointestinal barriers for oral insulin delivery.

Recent advances on next generation of polyzwitterion-based nano-vectors for targeted drug delivery.

Ginger polysaccharides enhance intestinal immunity by modulating gut microbiota in cyclophosphamide-induced immunosuppressed mice

新工科背景下制药类《制药工程制图》的改革与探索

工程认证背景下制药工程专业工程制图教学改革

新工科背景下针对生物制药专业《化工原理》教学的探索与研究

Preparing anti-SARS-CoV-2 agent EIDD-2801 by a practical and scalable approach, and quick evaluation via machine learning

Multi-functional polymeric micelles for chemotherapy-based combined cancer therapy.

Inherently nitric oxide containing polymersomes remotely regulated by NIR for improving multi-modal therapy on drug resistant cancer.

Multifunctional Nanoaggregates Composed of Active CPUL1 and a Triphenylphosphine Derivative for Mitochondria‐Targeted Drug Delivery and Cell Imaging

Black phosphorus assisted polyionic micelles with efficient PTX loading for remotely controlled release and synergistic treatment of drug-resistant tumors.

Cascade-Responsive Hierarchical Nanosystems for Multisite Specific Drug Exposure and Boosted Chemoimmunotherapy.

Synthesis of monodisperse spherical AgNPs by ultrasound-intensified Lee-Meisel method, and quick evaluation via machine learning

Glucose Oxidase and L-Arginine Functionalized Black Phosphorus Nanosheets for Multimodal Targeted Therapy of Glioblastoma

Mitochondrial Targeting and pH-Responsive Nanogels for Co-Delivery of Lonidamine and Paclitaxel to Conquer Drug Resistance

Synthesis of zwitterionic chimeric polymersomes for efficient protein loading and intracellular delivery

Synthesis of biogas-residue-based mesoporous carbons via one-step template-free method for organic and inorganic pollutants removal

FeSe2 nanosheets as a bifunctional platform for synergistic tumor therapy reinforced by NIR-II light.

Recent Advances of Polycationic siRNA Vectors for Cancer Therapy.

Tumor localization of oncolytic adenovirus assisted by pH-degradable microgels with JQ1-mediated boosting replication and PD-L1 suppression for enhanced cancer therapy.

Prediction model, experimental optimization, and verification for yield of high-pressure crystallization: a case study of citric acid

Tumor Microenvironment‐Activatable Nanoenzymes for Mechanical Remodeling of Extracellular Matrix and Enhanced Tumor Chemotherapy

Tumor-Adhesive and pH-Degradable Microgels by Microfluidics and Photo-Crosslinking for Efficient Anti-Angiogenesis and Enhanced Cancer Chemotherapy.

Functional Biodegradable Nitric Oxide Donor-Containing Polycarbonate-Based Micelles for Reduction-Triggered Drug Release and Overcoming Multidrug Resistance.

Folated pH-degradable nanogels for the simultaneous delivery of docetaxel and an IDO1-inhibitor in enhancing cancer chemo-immunotherapy.

Simulation and evaluation of utilization pathways of biomasses based on thermodynamic data prediction

Purification, characterization and anti-tumor activities of polysaccharides from Ecklonia kurome obtained by three different extraction methods

A peptide-Fe(II) complex from Grifola frondosa protein hydrolysates and its immunomodulatory activity

Triterpenes from Poria cocos are revealed as potential retinoid X receptor selective agonists based on cell and in silico evidence

Immunomodulatory activities of proteins from Astragalus membranaceus waste

Determining Key Factor of Synthetic Conditions of the Solid Sintering Preparation of Sodium Titanates by Thermo-Chemical Equilibrium Calculation

Polymeric crown ethers: LCST behavior in water and stimuli-responsiveness

Bioresponsive functional nanogels as an emerging platform for cancer therapy

Micronization of Gefitinib Using Solution-Enhanced Dispersion by Supercritical CO2