百晓学者学者目录

陈建新

博士生导师、博导、教授、硕导，福建师范大学

精选作品

期刊论文

2026

多光子显微成像量化乳腺癌周围神经侵犯预后

李芷君，韩忠华，易雨，陶璇，韩侠辉，陈建新，康德勇

《中国激光》

2026

Label-free, multiphoton microscopy-based strategy for intraoperative grading of lung adenocarcinoma via quantitative extracellular matrix analysis

Houqiang Li, Shouzhi Wang, Qiming He, Qianshun Chen, Jianping Huang, Zhan Zhuang, Kangmei Tong, Xunbin Yu, Lan Lin, Xiyao Yan, Jianxin Chen, Shu Wang, Xu Li, Xin Chen

Biomedical Optics Express

DOI

2026

Denoising‐Assisted Rapid Multiphoton Imaging for Analysing Traumatic Penumbra Microenvironment in Rat Brain

Pan Guo, Le Chen, Shanghai Jiang, Li Ai, Shenghui Shi, Duan Yang, Jian Xu, Jianxin Chen, Hong Lu

Journal of Biophotonics

DOI

2026

From Label‐Free Multiphoton Imaging to Pathological Reports: A Vision‐Language Breast Cancer Margin Pathological Diagnosis System

Shu Wang, Jingze Su, Xiahui Han, Deyong Kang, Xiao Zhang, Fei Xu, Changzu Liu, Junlin Pan, Xingfu Wang, Qiaohui Zhan, Aimin Wang, Feng Huang, H-Y Cheng, Wenxi Liu, Ruolan Lin, Jianxin Chen

Advanced Science

DOI

2025

基于多光子显微技术的脑膜瘤微环境可视化研究（特邀）

方娜，吴赞艺，王行富，胡力文，蔡清远，陈建新

《中国激光》

2025

Label-free visualization of microvessels in breast cancer based on multiphoton microscopy

Jianping Huang, Junkang Li, Deyong Kang, Xi Chen, Zhen Zhong Lu, Jianxin Chen, Liqin Zheng, Juhong Jiang, Zhonghua Han

International Photonics and Optoelectronics Meetings

DOI

2025

Multiphoton microscopy for label-free imaging and quantitative characterization of tumor heterogeneity in hepatocellular carcinoma

Xingxin Huang, Lianhuang Li, Xunbin Yu, Jianxin Chen, haibo zheng, Yannan Bai

International Photonics and Optoelectronics Meetings

DOI

2025

Monitoring nasopharyngeal squamous metaplasia using multiphoton microscopy combined with spectroscopic imaging

Zhen Lu, Jianping Huang, Ying Linda Lin, Xi Chen, Hao Zheng, Jianxin Chen, Qing Ye, Liqin Zheng, Xiaoyan Wang

International Photonics and Optoelectronics Meetings

DOI

2025

Collagen reorganization at the bladder cancer tumor-stromal interface facilitates local invasion

Kaixiang Xiao, Xuan Tao, Tao Liu, Ling Long, Yihui Zheng, Jianhua Chen, Xiahui Han, Jianxin Chen

International Photonics and Optoelectronics Meetings

DOI

2025

Identifying the tumor margins of skin basal cell carcinoma using multiphoton microscopy

Long Li, Jianping Huang, Kaixiang Xiao, Jingyi Zhang, Yihui Zheng, Liqin Zheng, Jianxin Chen, Wenwen Zhong

International Photonics and Optoelectronics Meetings

DOI

2025

Gentle Label‐Free Nonlinear Optical Imaging Relaxes Linear‐Absorption‐Mediated Triplet

Geng Wang, Lianhuang Li, Janet Elise Sorrells, Jianxin Chen, Haohua Tu

Advanced Science

DOI

2025

Multiphoton imaging-based quantifiable collagen signatures for predicting outcomes in patients with pancreatic ductal adenocarcinoma

Xiwen Chen, Jikui Miao, Xingxin Huang, Xiahui Han, Liqin Zheng, Jianxin Chen, Linying Chen, Lianhuang Li

Scientific Reports

DOI

2025

Multiphoton microscopy for the visualization of collagen fiber alignment and extracellular matrix remodeling in fibrous meningioma

Linjing Shi, Liwen Hu, Rong Chen, Xingfu Wang, Jianxin Chen, Na Fang

DOI

2024

Automatic extraction of asymmetric collagen for T staging of esophageal cancer in multiphoton microscopy

Jian Xu, Chi Zhang, Shanghai Jiang, Ge‐Liang Xu, Yuan-Hua Wu, Deyong Kang, Jiangbo Lin, Jianxin Chen

International Conference on Optics and Image Processing (ICOIP)

DOI

2024

Tumor-associated collagen signatures and their clinical stage correlations in breast cancer as revealed by multiphoton microscopy

Tao Zhong, Yihui Zheng, Zhijun Li, Xi Chen, Liqin Zheng, Jianhua Chen, Xiahui Han, Jianxin Chen

DOI

2024

Label-free characterization of pathological changes in the portal area of liver fibrosis tissue using multiphoton imaging and quantitative image analysis

Xiong Zhang, Yuane Lian, Xunbin Yu, Xingxin Huang, Zheng Zhang, Jingyi Zhang, Jianxin Chen, Lianhuang Li, Yannan Bai

Journal of Physics D Applied Physics

DOI

2024

Prognostic significance of collagen signatures in pancreatic ductal adenocarcinoma obtained from second-harmonic generation imaging

Xiwen Chen, Linying Chen, Jikui Miao, Xingxin Huang, Xiahui Han, Liqin Zheng, Shuoyu Xu, Jianxin Chen, Lianhuang Li

BMC Cancer

DOI

2024

Exploration of the relationship between tumor-infiltrating lymphocyte score and histological grade in breast cancer

Deyong Kang, Chuan Wang, Zhonghua Han, Liqin Zheng, Wenhui Guo, Fangmeng Fu, Lida Qiu, Xiahui Han, Jiajia He, Lianhuang Li, Jianxin Chen

BMC Cancer

DOI

2024

Improving the diagnosis of ductal carcinoma in situ with microinvasion without immunohistochemistry: An innovative method with H&E‐stained and multiphoton microscopy images

Xiahui Han, Yulan Liu, Shichao Zhang, Lianhuang Li, Liqin Zheng, Lida Qiu, Jianhua Chen, Jianhua Chen, Zhenlin Zhan, Shu Wang, Jianli Ma, Deyong Kang, Jianxin Chen, Jianxin Chen

International Journal of Cancer

DOI

2023

Monitoring changes of collagen fibers surrounding breast ductal carcinoma in situ using multiphoton microscopy

Xi Chen, Zhijun Li, Zheng Zhang, Xiong Zhang, Tao Zhong, Shuoyu Xu, Biying Yu, Jianxin Chen, Deyong Kang, Liqin Zheng

DOI

2023

Spatial differential distribution of connective cells in two different tumor-associated collagen signatures at the breast cancer boundary

Zhijun Li, Xi Chen, Shuoyu Xu, Wenhui Guo, Lianhuang Li, Xiahui Han, Liqin Zheng, Deyong Kang, Jianxin Chen, Shunwu Xu, Jianhua Chen

DOI

2023

Application of multiphoton microscopy for studying liver fibrosis

Xiong Zhang, Xunbin Yu, Zheng Zhang, Jianxin Chen, Yannan Bai, Lianhuang Li

DOI

2023

Automatic recognition of tumor region in multiphoton images of hepatocellular carcinoma using a convolutional neural network

Zheng Zhang, Xunbin Yu, Xiong Zhang, Jianxin Chen, Yannan Bai, Lianhuang Li

DOI

2023

Rapid label‐free detection of early‐stage lung adenocarcinoma and tumor boundary via multiphoton microscopy

Gangqin Xi, Chen Huang, Jie Lin, Tianyi Luo, Bingzi Kang, Mingyu Xu, Huizhen Xu, Xiaolu Li, Jianxin Chen, Lida Qiu, Shuangmu Zhuo

Journal of Biophotonics

DOI

2023

Automatic and label-free detection of meningioma in dura mater using the combination of multiphoton microscopy and image analysis

Na Fang, Zanyi Wu, Rong Chen, Zhongjiang Chen, Limei Zheng, Tingqi Yang, Ling Wang, Xingfu Wang, Dezhi Kang, Jianxin Chen

Neurophotonics

DOI

2023

Prognostic value of tumor necrosis based on the evaluation of frequency in invasive breast cancer

Jianhua Chen, Jianhua Chen, Zhijun Li, Zhonghua Han, Deyong Kang, Jianli Ma, Yu Yi, Fangmeng Fu, Wenhui Guo, Liqin Zheng, Gangqin Xi, Jiajia He, Lida Qiu, Lianhuang Li, Qingyuan Zhang, Chuan Wang, Jianxin Chen, Jianxin Chen

BMC Cancer

DOI

2022

多光子技术可视化血管型脑膜瘤

方娜，吴赞艺，王行富，林元相，陈建新

《激光与光电子学进展》

2022

多光子显微技术在乳腺肿瘤微环境预后预测研究中的应用进展

徐顺武，何佳佳，席刚琴，李连煌，韩侠辉，郑莉琴，陈建新

《激光与光电子学进展》

2022

Differences in the spatial distribution of tumor cells at breast cancer borders based on multiphoton imaging

Shichao Zhang, Ying Feng, Jikui Miao, Liqin Zheng, Xiahui Han, Lianhuang Li, Deyong Kang, Jianxin Chen

DOI

2022

Identification of perineural invasion in pancreatic cancer using multiphoton microscopy

Jikui Miao, Shichao Zhang, Ying Feng, Jianxin Chen, Linying Chen, Lianhuang Li

DOI

2022

Monitoring adipose tissue invasion in breast cancer by multiphoton microscopy

Ying Feng, Jikui Miao, Shichao Zhang, Liqin Zheng, Xiahui Han, Lianhuang Li, Deyong Kang, Jianxin Chen

DOI

2022

Automated classification of breast cancer histologic grade using multiphoton microscopy and generative adversarial networks

Gangqin Xi, Qing Wang, Huiling Zhan, Deyong Kang, Yulan Liu, Tianyi Luo, Mingyu Xu, Qinglin Kong, Liqin Zheng, Guannan Chen, Jianxin Chen, Shuangmu Zhuo

Journal of Physics D Applied Physics

DOI

2022

Mapping Organizational Changes of Fiber‐Like Structures in Disease Progression by Multiparametric, Quantitative Imaging

Shuhao Qian, Jia Meng, Zhe Feng, Lingxi Zhou, Shenyi Jiang, Yalun Wang, Zitong Ye, Shuangmu Zhuo, Jianxin Chen, Xinjian Li, Lixia Gao, Zhihua Ding, Jun Qian, Zhiyi Liu

Laser & Photonics Review

DOI

2022

Collagen signature as a novel biomarker to predict axillary lymph node metastasis in breast cancer using multiphoton microscopy

Fang Ye, Deyong Kang, Wenhui Guo, Qingyuan Zhang, Shuoyu Xu, Xingxin Huang, Gangqin Xi, Jiajia He, Shulian Wu, Lianhuang Li, Xiahui Han, Jianhua Chen, Jianhua Chen, Liqin Zheng, Chuan Wang, Jianxin Chen, Jianxin Chen

Journal of Biophotonics

DOI

2021

Label-free multiphoton imaging to detect hepatic steatosis in chronic liver disease

Xingxin Huang, Jiajia He, Xunbin Yu, Liqin Zheng, Jianxin Chen, Yannan Bai, Lianhuang Li

DOI

2021

Visualization of the important components in tumor microenvironment of breast cancer using multiphoton microscopy

Jiajia He, Xingxin Huang, Deyong Kang, Liqin Zheng, Gangqin Xi, Lianhuang Li, Jianxin Chen

DOI

2021

Computer-assisted quantification of tumor-associated collagen signatures to improve the prognosis prediction of breast cancer

Gangqin Xi, Lida Qiu, Shuoyu Xu, Wenhui Guo, Fangmeng Fu, Deyong Kang, Liqin Zheng, Jiajia He, Qingyuan Zhang, Lianhuang Li, Chuan Wang, Jianxin Chen

BMC Medicine

DOI

2021

Visualization of collagen morphological changes in transition from tumor to normal tissue in breast cancer by multiphoton microscopy

Yulan Liu, Yu Yi, Zhen Li, Zhenlin Zhan, Lianhuang Li, Liqin Zheng, Jianxin Chen, Deyong Kang, Xiahui Han

DOI

2021

Label-free multiphoton imaging to rapidly classify the early and late-stage tumor necrosis in invasive breast cancer

Yu Yi, Zhen Li, Yulan Liu, Zhijun Li, Zhonghua Han, Deyong Kang, Gangqin Xi, Jiajia He, Lianhuang Li, Liqin Zheng, Jianxin Chen, Jianhua Chen

DOI

2021

Label-free imaging of spinal cords injured tissues with multiphoton microscopy

Xiwen Chen, Shuang Wang, Jianxin Chen

DOI

2021

Using multiphoton microscopy to image the skin of mouse psoriasis model

Zhen Li, Yulan Liu, Yu Yi, Xiahui Han, Lianhuang Li, Shulian Wu, Jianxin Chen, Yelin Wu, Liqin Zheng

DOI

2021

Nomogram model combining macro and micro tumor-associated collagen signatures obtained from multiphoton images to predict the histologic grade in breast cancer

Gangqin Xi, Jiajia He, Deyong Kang, Shuoyu Xu, Wenhui Guo, Fangmeng Fu, Yulan Liu, Liqin Zheng, Lida Qiu, Lianhuang Li, Chuan Wang, Jianxin Chen

Biomedical Optics Express

DOI

2021

Multiphoton microscopy for monitoring the occurrence, metastasis and therapy of breast cancer

Yulan Liu, Yu Yi, Zhen Li, Lianhuang Li, Zhenlin Zhan, Jianxin Chen, Liqin Zheng

Microwave and Optical Technology Letters

DOI

2020

Identification of blood vessel invasion in breast tumor microenvironment by multiphoton microscopy

Fang Ye, Zhijun Li, Wenhui Guo, Xiahui Han, Gangqin Xi, Jiajia He, Lianghuang Li, Deyong Kang, Jianxin Chen, Liqin Zheng

DOI

2020

Monitoring collagen changes in tumor microenvironment using multiphoton microscopy

Xingxin Huang, Wei Wang, Fangmeng Fu, Deyong Kang, Wenhui Guo, Chuan Wang, Jianxin Chen, Lianhuang Li

DOI

2020

Label-free multiphoton imaging to identify two types of tumor-infiltrating lymphocytes in breast tumor microenvironment

Wei Wang, Xingxin Huang, Wenhui Guo, Airong Liu, Xiahui Han, Jianhua Chen, Jianxin Chen, Deyong Kang, Liqin Zheng

DOI

2020

Rapid identification of two types of tissue necrosis in breast tumor using multiphoton microscopy

Zhijun Li, Fang Ye, Wenhui Guo, Airong Liu, Jianhua Chen, Lianhuang Li, Jianxin Chen, Deyong Kang, Liqin Zheng

DOI

2020

Rapid prediction of drug inhibition under heat stress: single-photon imaging combined with a convolutional neural network

Hongxin Lin, Jianlei Xie, Taojian Fan, Youwu He, Jianxin Chen, Han Zhang, Shuangmu Zhuo

Nanoscale

DOI

2019

Label-free imaging of collagen as a potential diagnostic marker for detection of gliomas

Na Fang, Zanyi Wu, Xingfu Wang, Dezhi Kang, Yuanxiang Lin, Jianxin Chen

Tenth International Conference on Information Optics and Photonics

DOI

2019

Identifying three different grades of human breast ductal carcinoma in situ using multiphoton microscopy

Zhong Chen, Tingfeng Shen, Liqin Zheng, Deyong Kang, Jianxin Chen

Tenth International Conference on Information Optics and Photonics

DOI

2019

Imaging cancer-associated fibroblasts in human breast tumor tissue using multiphoton microscopy

Liqin Zheng, Wenhui Guo, Gangqin Xi, Jiajia He, Wenjiao Ren, Deyong Kang, Biying Yu, Chuan Wang, Jianxin Chen

Tenth International Conference on Information Optics and Photonics

DOI

2019

Identifying classic and florid lobular carcinoma in situ using multiphoton microscopy

Tingfeng Shen, Jiajia He, Deyong Kang, Gangqin Xi, Zhong Chen, Wenjiao Ren, Jianxin Chen

Tenth International Conference on Information Optics and Photonics

DOI

2019

Multiphoton imaging of normal breast lobules, pleomorphic invasive lobular carcinoma, and classic invasive lobular carcinoma

Jiajia He, Tingfeng Shen, Deyong Kang, Shu Wang, Wenhui Guo, Lianhuang Li, Liqin Zheng, Chuan Wang, Jianxin Chen

DOI

2019

Identification of macrophages in breast tumor microenvironment using label-free multiphoton microscopy

Gangqin Xi, Wenhui Guo, Deyong Kang, Shu Wang, Lianhuang Li, Liqin Zheng, Chuan Wang, Jianxin Chen

DOI

2019

Label-free multiphoton imaging of β-amyloid plaques in Alzheimer’s disease mouse models

Shu Wang, Bingbing Lin, Guimin Lin, Caihong Sun, Ruolan Lin, Jia Huang, Jing Tao, Xingfu Wang, Yunkun Wu, Lidian Chen, Jianxin Chen

Neurophotonics

DOI

2019

Rapid, label‐free detection of intracranial germinoma using multiphoton microscopy

Na Fang, Zanyi Wu, Xingfu Wang, Ning Cao, Yuanxiang Lin, Lianhuang Li, Yupeng Chen, Shanshan Cai, Haohua Tu, Dezhi Kang, Jianxin Chen

Neurophotonics

DOI

2019

Monitoring the progression of lobular breast carcinoma using multiphoton microscopy

Tingfeng Shen, Ning Cao, Jiajia He, Deyong Kang, Gangqin Xi, Zhong Chen, Wenjiao Ren, Jianxin Chen

Laser Physics Letters

DOI

2019

Automated classification of hepatocellular carcinoma differentiation using multiphoton microscopy and deep learning

Hongxin Lin, Chao Wei, Guangxing Wang, Hu Chen, Lisheng Lin, Ming Ni, Jianxin Chen, Shuangmu Zhuo

Journal of Biophotonics

DOI

2019

Recent advances in multiphoton microscopy combined with nanomaterials in the field of disease evolution and clinical applications to liver cancer

Hongxin Lin, Taojian Fan, Jian Hua Sui, Guangxing Wang, Jianxin Chen, Shuangmu Zhuo, Han Zhang

Nanoscale

DOI

2018

多光子显微技术在医学诊断中的应用

林宏心，左宁，卓双木，陈建新

《中国激光》

2018

Identification of specific histological characteristics of glioblastoma based on multiphoton microscopy

Xiaomin Huang, Xingfu Wang, Deyong Kang, Yuanxiang Lin, Zanyi Wu, Shu Wang, Na Fang, Jianxin Chen, Zhida Chen

Tenth International Conference on Information Optics and Photonics

DOI

2018

Using multiphoton microscopy to assess pulmonary emphysema in mouse models

Liqin Zheng, Yina H. Huang, Zhida Chen, Xiaomin Huang, Yixuan Chen, Jianxin Chen

Tenth International Conference on Information Optics and Photonics

DOI

2018

Multiphoton imaging of gastric intestinal metaplasia

Lianhuang Li, Jianxin Chen, Deyong Kang, Changyin Feng, Shuangmu Zhuo, Yongjian Zhou, Zhenlin Zhan

DOI

2018

Diagnosis of lichen sclerosus based on multiphoton microscopy

Xiaomin Huang, Ying Huang, Liqin zhen, Shu Wang, Lihang Lin, Xiaoqin Zhu, Jianxin Chen

Tenth International Conference on Information Optics and Photonics

DOI

2018

Label-free multiphoton microscopy for ex vivo brain imaging: toward assisting pathologic diagnosis

Zhong Chen, Ruolan Lin, Yuanxiang Lin, Xingfu Wang, Shu Wang, Feng Wang, Yunkun Ma, Bingbing Lin, Yue Chen, Xiaoqin Zhu, Jianxin Chen, Airong Liu

DOI

2018

Intraoperative assisting diagnosis of esophageal submucosal cancer using multiphoton microscopy

Yaping Zeng, Jian Xu, Qun Zhou, Deyong Kang, Shuangmu Zhuo, Xiaoqin Zhu, Jiangbo Lin, Jianxin Chen

Laser Physics Letters

DOI

2018

Applications of multiphoton microscopy in the field of colorectal cancer

Shu Wang, Lianhuang Li, Xiaoqin Zhu, Liqin Zheng, Shuangmu Zhuo, Jianxin Chen

Laser Physics

DOI

2018

Spatial and temporal identification of cerebral infarctions based on multiphoton microscopic imaging

Shu Wang, Huiping Du, Bingbing Lin, Chenxi Liao, Xiaoqin Zhu, Xingfu Wang, Hong Chen, Shuangmu Zhuo, Liwei Jiang, Lianhuang Li, Haohua Tu, Jianxin Chen

Biomedical Optics Express

DOI

2018

Second‐harmonic imaging microscopy for identifying colorectal intraepithelial neoplasia

Lianhuang Li, Weizhong Jiang, Deyong Kang, Xuan Eric Liu, H.S. LI, Guoxian Guan, Shuangmu Zhuo, Zhifen Chen, Jianxin Chen

Journal of Microscopy

DOI

2017

Label-free imaging of brain and brain tumor specimens with combined two-photon excited fluorescence and second harmonic generation microscopy

Liwei Jiang, Xingfu Wang, Zanyi Wu, Huiping Du, Shu Wang, Lianhuang Li, Na Fang, Peihua Lin, Jianxin Chen, Dezhi Kang, Shuangmu Zhuo

Laser Physics Letters

DOI

2017

Multiphoton imaging of low grade, high grade intraepithelial neoplasia and intramucosal invasive cancer of esophagus

Jian Xu, Liwei Jiang, Deyong Kang, Xuejing Wu, Meifang Xu, Shuangmu Zhuo, Xiaoqin Zhu, Jiangbo Lin, Jianxin Chen

Laser Physics Letters

DOI

2017

Label-free imaging of cortical structures with multiphoton microscopy

Shu Wang, Xiuqiang Chen, Weilin Wu, Zhida Chen, Ruolan Lin, Peihua Lin, Xingfu Wang, Yu Vincent Fu, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2017

Identification of intramural metastasis in esophageal cancer using multiphoton microscopy

Jian Xu, Deyong Kang, Shuangmu Zhuo, Xiaoqin Zhu, Jiangbo Lin, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2016

Quantification of collagen distributions in rat hyaline and fibro cartilages based on second harmonic generation imaging

Xiaoqin Zhu, Chenxi Liao, Zhenyu Wang, Shuangmu Zhuo, Wenge Liu, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2016

Quantitative optical biomarkers of lung cancer based intrinsic two-photon excited fluorescence signal

Jingwen Li, Zhenlin Zhan, Hongxin Lin, Ning Zuo, Xiaoqin Zhu, Shusen Xie, Jianxin Chen, Shuangmu Zhuo

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2016

Identification of tumor cells infiltrating into connective tissue in esophageal cancer by multiphoton microscopy

Jian Xu, Liwei Jiang, Deyong Kang, Xuejing Wu, Meifang Xu, Shuangmu Zhuo, Xiaoqin Zhu, Jiangbo Lin, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2016

Label-free imaging of rat spinal cords based on multiphoton microscopy

Chenxi Liao, Zhenyu Wang, Linquan Zhou, Xiaoqin Zhu, Wenge Liu, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2016

Detection of the multiphoton signals in stained tissue using nonlinear optical microscopy

Yaping Zeng, Jian Xu, Deyong Kang, Jiangbo Lin, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2016

Identification of calcifications in intracranial neoplasms using two photon excitation fluorescence microscopy

Peihua Lin, Xingfu Wang, Zanyi Wu, Na Fang, Lianhuang Li, Dezhi Kang, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2016

Identification of the boundary between normal brain tissue and ischemia region using two-photon excitation fluorescence microscopy

Huiping Du, Shu Wang, Xingfu Wang, Xiaoqin Zhu, Shuangmu Zhuo, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2016

Label-free distinguishing between neurons and glial cells based on two-photon excited fluorescence signal of neuron perinuclear granules

Huiping Du, Liwei Jiang, Xingfu Wang, Gao‐Qiang Liu, Shu Wang, Liqin Zheng, Lianhuang Li, Shuangmu Zhuo, Xiaoqin Zhu, Jianxin Chen

Laser Physics Letters

DOI

2016

A new method of assessing the surgical margin in rectal carcinoma—using nonlinear optical microscopy

Lianhuang Li, Zhifen Chen, Deyong Kang, Tongxin Deng, Liwei Jiang, Yi Zhou, Xing Liu, Weizhong Jiang, Shuangmu Zhuo, Guoxian Guan, Pan Chi, Jianxin Chen

Laser Physics Letters

DOI

2016

Label-free identification of the hippocampus and surrounding structures by multiphoton microscopy

Shu Wang, Liwei Jiang, Huiping Du, Xingfu Wang, Liqin Zheng, Lianhuang Li, Shuangmu Zhuo, Xiaoqin Zhu, Jianxin Chen

Laser Physics Letters

DOI

2015

Identification of normal and cancerous human colorectal muscularis propria by multiphoton microscopy in different sections

Yi Zhou, Zhifen Chen, Deyong Kang, Lian-Huang Li, Shuangmu Zhuo, Xiaoqin Zhu, Guoxian Guan, Jianxin Chen

Laser Physics

DOI

2015

Monitoring the progression from intraductal carcinoma to invasive ductal carcinoma based on multiphoton microscopy

Yan Wu, Fangmeng Fu, Yuane Lian, Yuting Nie, Shuangmu Zhuo, Chuan Wang, Jianxin Chen

Journal of Biomedical Optics

DOI

2015

Identifying three different architectural subtypes of mammary ductal carcinoma in situ using multiphoton microscopy

Yan Wu, Fangmeng Fu, Yuane Lian, Yuting Nie, Shuangmu Zhuo, Chuan Wang, Jianxin Chen

Journal of Physics D Applied Physics

DOI

2015

Visualization of Tumor Response to Neoadjuvant Therapy for Rectal Carcinoma by Nonlinear Optical Imaging

Lianhuang Li, Zhifen Chen, Xingfu Wang, Xing Liu, Weizhong Jiang, Shuangmu Zhuo, Guoxian Guan, Jianxin Chen

IEEE Journal of Selected Topics in Quantum Electronics

DOI

2015

Layer-resolved colorectal tissues using nonlinear microscopy

Lianhuang Li, Hongsheng Li, Zhifen Chen, Shuangmu Zhuo, Changyin Feng, Yinghong Yang, Guoxian Guan, Jianxin Chen

Lasers in Medical Science

DOI

2015

Assessment of Tumor Invasion Depth in Colorectal Carcinoma Using Multiphoton Microscopy

Shu Wang, Jianxin Chen, Yinghong Yang, Weizhong Jiang, Changyin Feng, Guoxian Guan, Shuangmu Zhuo, Zhifen Chen

IEEE photonics journal

DOI

2015

Real-time monitoring of tumor response to preoperative radiochemotherapy for rectal carcinoma by nonlinear optical microscopy

Lianhuang Li, Zhifen Chen, Xingfu Wang, Weizhong Jiang, Guoxian Guan, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2015

Optical diagnosis of mammary ductal carcinoma using advanced optical technology

Yan Wu, Fangmeng Fu, Yuane Lian, Yuting Nie, Shuangmu Zhuo, Chuan Xi Wang, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2015

Monitoring morphological alterations during invasive ductal breast carcinoma progression using multiphoton microscopy

Yan Wu, Fangmeng Fu, Yuane Lian, Jianxin Chen, Chuan Wang, Yuting Nie, Liqin Zheng, Shuangmu Zhuo

Lasers in Medical Science

DOI

2014

In-vivo monitoring rat skin wound healing using nonlinear optical microscopy

Jing Chen, Chungen Guo, Fan Zhang, Yahao Xu, Xiaoqin Zhu, Shuyuan Xiong, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2014

Quantitative changes of collagen in human normal breast tissue and invasive ductal carcinoma using nonlinear optical microscopy

Weiqiang Li, Yan Wu, Yuane Lian, Fangmeng Fu, Chuan Wang, Shuangmu Zhuo, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2014

Multiphoton microscopic imaging of fibrotic focus in invasive ductal carcinoma of the breast

Sijia Chen, Yuting Nie, Yuane Lian, Yan Wu, Fangmeng Fu, Chuan Wang, Shuangmu Zhuo, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2014

Identification of the boundary between normal breast tissue and invasive ductal carcinoma during breast-conserving surgery using multiphoton microscopy

Tongxin Deng, Yuting Nie, Yuane Lian, Yan Wu, Fangmeng Fu, Chuan Wang, Shuangmu Zhuo, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2014

Differentiating fibroadenoma and ductal carcinoma in situ from normal breast tissue by multiphoton microscopy

Yuting Nie, Yan Wu, Yuane Lian, Fangmeng Fu, Chuan Wang, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2014

Imaging of surgical margin in pancreatic metastasis using two-photon excited fluorescence microscopy

Jing Chen, Zhipeng Hong, Hong Chen, Youting Chen, Yahao Xu, Xiaoqin Zhu, Shuangmu Zhuo, Zheng Shi, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2014

Label-free visualization of collagen in submucosa as a potential diagnostic marker for early detection of colorectal cancer

Jingting Qiu, Yinghong Yang, Weizhong Jiang, Changyin Feng, Zhifen Chen, Guoxian Guan, Xiaoqin Zhu, Shuangmu Zhuo, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2014

Multiphoton microscopy as a diagnostic imaging modality for pancreatic neoplasms without hematoxylin and eosin stains

Youting Chen, Jing Chen, Hong Chen, Zhipeng Hong, Xiaoqin Zhu, Shuangmu Zhuo, Yanling Chen, Jianxin Chen

Journal of Biomedical Optics

DOI

2014

Optical diagnosis of gallbladder cancers via two-photon excited fluorescence imaging of unstained histological sections

Zhipeng Hong, Youting Chen, Jing Chen, Hong Chen, Yahao Xu, Xiaoqin Zhu, Shuangmu Zhuo, Zheng Shi, Jianxin Chen

Lasers in Medical Science

DOI

2014

Stereoscopic visualization and quantification of auricular cartilage regeneration in rabbits using multiphoton microscopy

Jing Chen, Xiaoqin Zhu, Yahao Xu, Yiyan Tang, Shuyuan Xiong, Shuangmu Zhuo, Jianxin Chen

Scanning

DOI

2014

Identification of dirty necrosis in colorectal carcinoma based on multiphoton microscopy

Lianhuang Li, Weizhong Jiang, Yinghong Yang, Zhifen Chen, Changyin Feng, Hongsheng Li, Guoxian Guan, Jianxin Chen

Journal of Biomedical Optics

DOI

2013

Real-time optical diagnosis for surgical margin in low rectal cancer using multiphoton microscopy

Jun Yan, Shuangmu Zhuo, Gang Chen, Jeffrey W. Milsom, Hui Zhang, Jianping Lu, Weifeng Zhu, Shusen Xie, Jianxin Chen, Mingang Ying

Surgical Endoscopy

DOI

2013

Label-Free Detection of Breast Masses Using Multiphoton Microscopy

Xiufeng Wu, Gang Chen, Jianping Lu, Weifeng Zhu, Jingting Qiu, Jianxin Chen, Shusen Xie, Shuangmu Zhuo, Jun Yan

PLoS ONE

DOI

2012

Imaging the morphological change of tissue structure during the early phase of esophageal tumor progression using multiphoton microscopy

Jian Xu, Deyong Kang, Meifang Xu, Xiaoqin Zhu, Shuangmu Zhuo, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2012

Second harmonic generation imaging of skin wound healing and scarring in a rabbit ear model

Yiyan Tang, Xiaoqin Zhu, Shuyuan Xiong, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2012

Identification of non-neoplastic and neoplastic gastric polyps using multiphoton microscopy

Shanghai Jiang, Deyong Kang, Meifang Xu, Xiaoqin Zhu, Shuangmu Zhuo, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2012

Nonlinear optical imaging characteristics of colonic adenocarcinoma using multiphoton microscopy

Nenrong Liu, Rong Chen, Hongsheng Li, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2012

Label‐free imaging characteristics of colonic mucinous adenocarcinoma using multiphoton microscopy

Nenrong Liu, Jianxin Chen, Renan Xu, Shanghai Jiang, Jian Xu, Rong Chen

Scanning

DOI

2012

Visualization of Epidermal and Dermal Alteration in Papulonodular Mucinosis by Multiphoton Microscopy

Xiaoqin Zhu, Lihang Lin, Haibo Yu, Shuangmu Zhuo, Jianxin Chen, Jingjing Liu, Yuying Wang

Scanning

DOI

2012

Quantitative analysis of collagen change between normal and cancerous thyroid tissues based on SHG method

Xiwen Chen, Zufang Huang, Gangqin Xi, Yongjian Chen, Duo Lin, Jing Wang, Zuanfang Li, Liqing Sun, Jianxin Chen, Rong Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2012

Preclinical study of using multiphoton microscopy to diagnose liver cancer and differentiate benign and malignant liver lesions

Jun Yan, Shuangmu Zhuo, Gang Chen, Xiufeng Wu, Dong Zhou, Shusen Xie, Jiahao Jiang, Mingang Ying, Fan Jia, Jianxin Chen, Jian Zhou

Journal of Biomedical Optics

DOI

2012

Use of Multiphoton Microscopy to Diagnose Liver Cancer and Lung Metastasis in an Orthotopic Rat Model

Jun Yan, Shuangmu Zhuo, Gang Chen, Chang‐Jun Tan, Weifeng Zhu, Jianping Lu, Jia Fan, Jianxin Chen, Jian Zhou

Scanning

DOI

2011

Detecting the imaging characteristics of colorectal carcinoma invading the muscularis propria with multiphoton microscopy

Na Liu, Jianxin Chen, G. Chen, Jun Yan, Shuangmu Zhuo, Xiujuan Jiang

Laser Physics Letters

DOI

2011

Real‐time in vivo imaging collagen in lymphedematous skin using multiphoton microscopy

Xiufeng Wu, Shuangmu Zhuo, Jianxin Chen, Ningfei Liu

Scanning

DOI

2011

Multiphoton microscopy study of the morphological and quantity changes of collagen and elastic fiber components in keloid disease

Jianxin Chen, Shuangmu Zhuo, Xingshan Jiang, Xiaoqin Zhu, Liqin Zheng, Shusen Xie, Bifang Lin, Haishan Zeng

Journal of Biomedical Optics

DOI

2011

Establishing diagnostic features for identifying the mucosa and submucosa of normal and cancerous gastric tissues by multiphoton microscopy

Jianxin Chen, Shuangmu Zhuo, Gang Chen, Jun Yan, Hongquan Yang, Nenrong Liu, Liqin Zheng, Xingshan Jiang, Shusen Xie

Gastrointestinal Endoscopy

DOI

2011

Label-free monitoring of colonic cancer progression using multiphoton microscopy

Shuangmu Zhuo, Jun Yan, Gang Chen, Jianxin Chen, Yuchun Liu, Jianping Lu, Xiaoqin Zhu, Xingshan Jiang, Shusen Xie

Biomedical Optics Express

DOI

2010

Characteristics of scar margin dynamic with time based on multiphoton microscopy

Xiaoqin Zhu, Shuangmu Zhuo, Liqin Zheng, Xingshan Jiang, Jianxin Chen, Bifang Lin

Lasers in Medical Science

DOI

2010

Collagen alteration as quantitative optical biomarker of epithelial tumor progression

Shuangmu Zhuo, Jianxin Chen, Shusen Xie

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2010

Marginal characteristics of skin scarred dermis quantitatively extracted from multiphoton microscopic imaging

Xiaoqin Zhu, Shuangmu Zhuo, Liqin Zheng, Xingshan Jiang, Jianxin Chen, Bifang Lin

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2010

Stromal optical properties: differentiating normal and cancerous stroma

Shuangmu Zhuo, Jianxin Chen, Shusen Xie, Liqin Zheng, Xiaoqin Zhu, Xingshan Jiang

Lasers in Medical Science

DOI

2010

Nonlinear Spectral Imaging of Esophageal Tissue Based on Two-Photon Excited Fluorescence and Second-Harmonic Generation

Hongquan Yang, Shuangmu Zhuo, Liqin Zheng, Xingshan Jiang, Jianxin Chen

Symposium on Photonics and Optoelectronics

DOI

2010

Monitoring Dermal Wound Healing After Mesenchymal Stem Cell Transplantation Using Nonlinear Optical Microscopy

Shuangmu Zhuo, Jianxin Chen, Shusen Xie, Lin Fan, Liqin Zheng, Xiaoqin Zhu, Xingshan Jiang

Tissue Engineering Part C Methods

DOI

2009

皮肤增生性疤痕组织的双光子显微图像纹理分析

谢志明，陈冠楠，陈建新，杨坤涛，陈荣

《中国图象图形学报》

2009

Imaging of matrix-disorder in normal and pathological human dermis using nonlinear optical microscopy

Shuangmu Zhuo, Jianxin Chen, Shusen Xie, Liqin Zheng, Xingshan Jiang

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2009

Quantified characterization of dermal collagen structure in human cutaneous scars from second harmonic generation imaging

Xiaoqin Zhu, Youting Chen, Shuangmu Zhuo, Biying Yu, Liqin Zheng, Kecheng Lu, Jianxin Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2009

Pathological process investigation of Jadassohn-Pellizzari anetoderma based on multiphoton microscopy

Jianxin Chen, Jingjun Zhao, Yinghong Yang, Shuangmu Zhuo, Xingshan Jiang, Wei Tian, Xiaoyin Ye, Lihang Lin

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2009

Differentiating normal and cancerous stroma by nonlinear spectral imaging

Shuangmu Zhuo, Jianxin Chen, Shusen Xie, Liqin Zheng, Xiaoqin Zhu, Xingshan Jiang

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2009

Multiphoton microscopy for monitoring collagen remodeling and sensing transplanted autologous fibroblasts metabolism

Shuangmu Zhuo, Jianxin Chen, Shusen Xie, Xingshan Jiang

DOI

2009

Investigation of collagen changes in sclerodermatous skin using second harmonic generation microscopy

Kecheng Lu, Jianxin Chen, Shuangmu Zhuo, Liqin Zheng, Xingshan Jiang, Xiaoqin Zhu, Jingjun Zhao

DOI

2009

Nonlinear optical microscopy for visualizing dermal structural assembly in normal and pathological human dermis

Shuangmu Zhuo, Jianxin Chen, S Xie, Liqiang Zheng, Zhen-Sheng Hong, X.S. Jiang

Laser Physics Letters

DOI

2009

Theoretical simulation study of linearly polarized light on microscopic second-harmonic generation in collagen type I

Ying Chang, Changshui Chen, Jianxin Chen, Ying Jin, Xiaoyuan Deng

Journal of Biomedical Optics

DOI

2009

Extracting diagnostic stromal organization features based on intrinsic two-photon excited fluorescence and second-harmonic generation signals

Shuangmu Zhuo, Jianxin Chen, Shusen Xie, Zhibin Hong, Xingshan Jiang

Journal of Biomedical Optics

DOI

2008

Imaging collagen remodeling and sensing transplanted autologous fibroblast metabolism in mouse dermis using multimode nonlinear optical imaging

Shuangmu Zhuo, Jianxin Chen, Ning Cao, Xingshan Jiang, Shusen Xie, Shuyuan Xiong

Physics in Medicine and Biology

DOI

2008

Imaging rat esophagus using combination of reflectance confocal and multiphoton microscopy

Shuangmu Zhuo, Jianxin Chen, X.S. Jiang, Kecheng Lu, S Xie

Laser Physics Letters

DOI

2008

Multiphoton microscopy of unstained bladder mucosa based on two-photon excited autofluorescence and second harmonic generation

Shuangmu Zhuo, Jianxin Chen, T. Luo, X.S. Jiang, S Xie

Laser Physics Letters

DOI

2008

Nonlinear optical microscopy of the bronchus

Shuangmu Zhuo, Jianxin Chen, Biying Yu, Xingshan Jiang, Teng Luo, Quangang Liu, Rong Chen, Shusen Xie

Journal of Biomedical Optics

DOI

2008

Spectral imaging technology of epithelial tissue based on two-photon excited fluorescence and second-harmonic generation

Tianshu Luo, Jianxin Chen, Shuangmu Zhuo, Xingshan Jiang, Huanglin Chen, Teng Luo, Qilian Zou

Frontiers of Optoelectronics in China

DOI

2008

Two-layered multiphoton microscopic imaging of cervical tissue

Shuangmu Zhuo, Jianxin Chen, Tianshu Luo, Xingshan Jiang, Shusen Xie, Rong Chen

Lasers in Medical Science

DOI

2007

Nonlinear optical microscopy of bronchus

Shuangmu Zhuo, Jianxin Chen, Xingshan Jiang, Shusen Xie, Huanglin Chen, Rong Chen

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2007

Sequential Multitrack Nonlinear Ex vivo Imaging of Esophageal Stroma Based on Backscattered Second‐harmonic Generation and Two‐photon Autofluorescence

Shuangmu Zhuo, Jianxin Chen, Xingshan Jiang, Tianshu Luo, Rong Chen, Shusen Xie, Qilian Zou

Scanning

DOI

2007

Depth-resolved spectral imaging of rabbit oesophageal tissue based on two-photon excited fluorescence and second-harmonic generation

Jianxin Chen, Shuangmu Zhuo, Rong Chen, Xingshan Jiang, Shusen Xie, Qilian Zou

New Journal of Physics

DOI

2007

Simultaneous observation of collagen and elastin based on the combined nonlinear optical imaging technique coupled with two-channel synchronized detection method

Jianxin Chen, Shuangmu Zhuo, Tianshu Luo, Liu Dingzhong, Jingjun Zhao

Optik

DOI

2007

Spectral resolved imaging of biological samples

Jianxin Chen, Shuangmu Zhuo, Qilian Zou, Tianshu Luo, Xingshan Jiang

Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE

DOI

2006

Spectral characteristics of autofluorescence and second harmonic generation from ex vivo human skin induced by femtosecond laser and visible lasers

Jianxin Chen, Shuangmu Zhuo, Tianshu Luo, Xingshan Jiang, Jingjun Zhao

Scanning

DOI

2006

Multimode nonlinear optical imaging of the dermis in ex vivo human skin based on the combination of multichannel mode and Lambda mode

Shuangmu Zhuo, Jianxin Chen, Tianshu Luo, Dingsong Zou, Jingjun Zhao

Optics Express

DOI

会议论文

2018

无标记非线性光学显微成像在合并癫痫的人局灶性皮质发育不良快速术中诊断中的应用

林元相，陈越，王丰，陈建新，王行富，康德智

《第十三届中国医师协会神经外科医师年会摘要集》

DOI

2012

乳腺纤维腺瘤的非线性光学显微成像研究

吴燕，傅芳萌，徐健，许仁安，卓双木，王川，陈建新

《中国遗传学会“第十一届全国激光生物学学术会议”暨《激光生物学报》创刊廿周年庆祝会、第十届粤港生物物理研讨会暨2012年广东生物物理学术年会》

2011

消化道肿瘤的内源性非线性光学信号研究

陈建新

《中国光学学会2011年学术大会》

2006

细胞间质的非线性光学复合成像

卓双木，陈建新，罗天舒

《中国光学学会2006年学术大会论文摘要集》

预印本

2026

A Portable Multiphoton Microscopy Platform With Integrated Deep Learning Enables Rapid, Label-Free Intraoperative Diagnosis Of Visceral Pleural Invasion

Suyi Chen, Changzu Liu, Jianing Ouchen, Kexin Feng, Shouzhi Wang, Dawei Li, Jingxiang Lu, Jianxin Chen, Feng Huang, Kunkun Sun, Huimin Zhao, Liqi Liu, Ruinan Zhao, Ronggan Gao, Jintao Hu, Yun Li, Fan Yang, Aimin Wang, Shu Wang, Runlong Wu, Jian Hua Zhou, Kezhong Chen

SSRN Electronic Journal

DOI

2022

Label-Free Second Harmonic Generation Imaging of Cerebral Vascular Wall in Local Ischemia Mouse Model In Vivo

Hengfei Sun, Shu Wang, Jianxin Chen, Hongbo Yu

SSRN Electronic Journal

DOI

研究方向

生物医学光子学多光子显微肿瘤诊疗光学成像与深度学习医学诊断

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