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期刊论文

2026

Dietary intake and BCAA metabolism regulate pulmonary fibrosis through KDM4A-mediated epigenetic remodeling in male mice

Jie Yao, Su Fang, Miao Lei, Zexian Ou, Chuanfei Zeng, Wanli Peng, Na He, Lian Yang, Bingpeng Guo, Mingmeng Fang, Cuihua Wang, Jie Lv, Shuang Wu, Wei Kevin Zhang, Huimin Huang, Yang Peng, Wei Rao, Zhili Rong, Penghui Yang, Chaoqun Wang, Qian Han, Wenxiang Hu

Nature Communications

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期刊论文

Dietary intake and BCAA metabolism regulate pulmonary fibrosis through KDM4A-mediated epigenetic remodeling in male mice

ALKBH5 acts as a regulator of hair follicle telogen-to-anagen transition in mice

Loss of Alkbh5 enhances AT2 cell differentiation and alveolar repair across diverse injury models via m 6 A-dependent Areg signaling

BMP2-induced Adam12 + Fibroblasts Dictate Wound-associated Skin Scarring and Fibrosis

Osmotic pressure regulates DNA labelling and transcription with dCas9-SunTag system in live cells

METTL3/ALKBH5‐Mediated N6‐Methyladenosine Modification Drives Macrophage M1 Polarization via the SLC15A3‐TASL‐IRF5 Signaling Axis in Psoriasis

Lactate Promotes Collagen Expression, Proliferation, and Migration through H3K18 Lactylation–Dependent Stimulation of LTBP3/TGF-β1 Axis in Keloid Fibroblasts

hpCasMINI: An engineered hypercompact CRISPR-Cas12f system with boosted gene editing activity

Engineered circular guide RNAs enhance miniature CRISPR/Cas12f-based gene activation and adenine base editing

Human Pluripotent Stem Cell-Derived Alveolar Organoids for Gene-editing and Lung Adenocarcinomas Modeling

Short cell-penetration peptide conjugated bioreducible polymer enhances gene editing of CRISPR system

Dynamic pathological analysis reveals a protective role against skin fibrosis for TREM2-dependent macrophages

Engineered circular guide RNAs boost CRISPR/Cas12a- and CRISPR/Cas13d-based DNA and RNA editing

Phase-separated DropCRISPRa platform for efficient gene activation in mammalian cells and mice

Relief of Extracellular Matrix Deposition Repression by Downregulation of IRF1-Mediated TWEAK/Fn14 Signaling in Keloids

SLC35E1 promotes keratinocyte proliferation in psoriasis by regulating zinc homeostasis

Generation of Human Embryonic Stem Cell-Derived Lung Organoids for Modeling Infection and Replication Differences between Human Adenovirus Types 3 and 55 and Evaluating Potential Antiviral Drugs

Risk single-nucleotide polymorphism-mediated enhancer–promoter interaction drives keloids through long noncoding RNA down expressed in keloids

Live‐cell imaging of genomic loci with Cas9 variants

Engineered Cas12a-Plus nuclease enables gene editing with enhanced activity and specificity

Lung adeno-squamous carcinoma modeling using oncogenic KRAS activation in human embryonic stem cell-derived alveolar organoids

Generation of human embryonic stem cell-derived lung organoids

OSMRβ mutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients

Single-cell transcriptome analysis reveals the dynamics of human immune cells during early fetal skin development

Get ready for the CRISPR/Cas system: A beginner's guide to the engineering and design of guide RNAs

Tag-seq: a convenient and scalable method for genome-wide specificity assessment of CRISPR/Cas nucleases

Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases

Erratum for article ‘MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo’

MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo

SOX9 inactivation affects the proliferation and differentiation of human lung organoids

Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection

Cell-cell contact-induced gene editing/activation in mammalian cells using a synNotch-CRISPR/Cas9 system

Enhancing site-specific DNA integration by a Cas9 nuclease fused with a DNA donor-binding domain

Inhibition of the Extracellular Signal–Regulated Kinase/Ribosomal S6 Kinase Cascade Limits Chlamydia trachomatis Infection

MicroRNA-101-3p Downregulates TLR2 Expression, Leading to Reduction in Cytokine Production by Treponema pallidum–Stimulated Macrophages

TRAF4 Promotes Fibroblast Proliferation in Keloids by Destabilizing p53 via Interacting with the Deubiquitinase USP10

Sex differences of Chinese patients with primary localized cutaneous amyloidosis

Clinical and genetic features of Chinese patients with lichen and macular primary localized cutaneous amyloidosis

Correction to: Gene activation in human cells using CRISPR/Cpf1-p300 and CRISPR/Cpf1-SunTag systems

Long-Term Engraftment Promotes Differentiation of Alveolar Epithelial Cells from Human Embryonic Stem Cell Derived Lung Organoids

iKA‐CRISPR hESCs for inducible and multiplex orthogonal gene knockout and activation

1473 TRAF4 represses p53 signaling in keloid pathogenesis

768 Clinical and genetic features of Chinese patients with primary localized cutaneous amyloidosis

Gene activation in human cells using CRISPR/Cpf1-p300 and CRISPR/Cpf1-SunTag systems

Live cell imaging of genomic loci using dCas9-SunTag system and a bright fluorescent protein

Humanized mouse model for assessing the human immune response to xenogeneic and allogeneic decellularized biomaterials

A Safety Checkpoint to Eliminate Cancer Risk of the Immune Evasive Cells Derived from Human Embryonic Stem Cells

Gene Targeting Through Homologous Recombination in Monkey Embryonic Stem Cells Using CRISPR/Cas9 System

Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells

Genetic approach to track neural cell fate decisions using human embryonic stem cells

Homologous recombination in human embryonic stem cells using CRISPR/Cas9 nickase and a long DNA donor template

IL-17RD (Sef or IL-17RLM) interacts with IL-17 receptor and mediates IL-17 signaling

Transmembrane helix of novel oncogene with kinase-domain (NOK) influences its oligomerization and limits the activation of RAS/MAPK signaling

[Construction and characterization of hSef recombinant adenoviral vectors].

hSef potentiates EGF-mediated MAPK signaling through affecting EGFR trafficking and degradation.

The carboxyl terminal tyrosine 417 residue of NOK has an autoinhibitory effect on NOK-mediated signaling transductions.

Sef-S, an alternative splice isoform of sef gene, inhibits NIH3T3 cell proliferation via a mitogen-activated protein kinases p42 and p44 (ERK1/2)-independent mechanism.

Tyrosine 330 in hSef is critical for the localization and the inhibitory effect on FGF signaling.

Interleukin-17F signaling requires ubiquitination of interleukin-17 receptor via TRAF6.

hSef co-localizes and interacts with Ras in the inhibition of Ras/MAPK signaling pathway.

hSef Inhibits PC-12 Cell Differentiation by Interfering with Ras-Mitogen-activated Protein Kinase MAPK Signaling*

预印本

Single-cell analysis reveals shared and stage-specific features of the human skin response in primary and secondary syphilis lesions

Human Embryonic Stem Cell-derived Lung Organoids: a Model for SARS-CoV-2 Infection and Drug Test

Long-term Reconstruction of Human Airway Epithelium-like Structure in Vivo with hESCs-derived organoid cells

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