程克光｜广西师范大学｜学者主页

2026

Radical Fluoroalkoxylation of α-Mono/Trihalo Ketones

Qiyan Sun, Yinke Huang, Ruoyu Wang, Hongsen Xiu, Ning Chen, Yihan Tang, Keguang Cheng, Haichao Liu, Quande Wang

Organic Letters

DOI

2026

Maslinic acid derivative induces the death of transitional bladder cancer cells through apoptosis and autophagy via the PI3K–AKT signaling pathway

Jing-jing Liu, Li Sun, Dan-ting Guo, Yu-jie Liang, Li-qiong Zhang, Jun-ji Chen, Quande Wang, Keguang Cheng

RSC Medicinal Chemistry

DOI

2025

N-monofluoromethoxy benzoimidazole: a bench stable reagent for direct radical monofluoromethoxylation of alkenes

Ning Chen, Jingjing Ling, Keguang Cheng, Haitao Tang, Quande Wang

Science China Chemistry

DOI

2025

Photocatalytic C–H Trifluoroethoxylation of (Hetero)arenes

Mingxi Chen, Jingjing Ling, Keguang Cheng, Quande Wang

Organic Letters

DOI

2024

Research progress on GPX4 targeted compounds

Bingru Li, Keguang Cheng, Tzumei Wang, Xing Peng, Ping Xu, Guoquan Liu, Dong Xue, Ning Jiao, Chao Wang

European Journal of Medicinal Chemistry

DOI

2024

Radical Acylfluoroalkylation of 1,3-Enynes via N-Heterocyclic Carbene/Photoredox Cooperative Catalysis

Shichao Tian, Ning Chen, Keguang Cheng, Quande Wang

Organic Letters

DOI

2024

6-O-angeloylplenolin inhibits osteoclastogenesis in vitro via suppressing c-Src/NF-κB/NFATc1 pathways and ameliorates bone resorption in collagen-induced arthritis mouse model

Zhichao Li, Min Li, Ling-xiang Xiao, Xi Zheng, Rong Li, Shi-jia Dong, Yue Wang, Hong-yu Wen, Kun-lin Ruan, Keguang Cheng, Ming Chen, Yanhui Tan

Biochemical Pharmacology

DOI

2023

Design, synthesis and in vitro antitumor activity of 17β-estradiol-amino acid derivatives

Yuqing Zhou, Shi-chao Tian, Lixin Sheng, Liqiong Zhang, Jingjing Liu, Wei-bin Mo, Quande Wang, Keguang Cheng

Arabian Journal of Chemistry

DOI

2023

N-Heterocyclic Carbene and Manganese Synergistic Catalysis: A Three-Component Radical Acylmonofluoroalkylation of Alkenes

Feng Liang, Ning Chen, Keguang Cheng, Quande Wang

Organic Letters

DOI

2023

Synthesis of polycyclic fused oxazolidin-2-ones by catalytic Boron(III)-Promoted oxo-Michael addition reaction and evaluation on their cytotoxicity

Xiao You, Kai-Wen Hu, Haonan Zong, Xiaoan Wen, Haoliang Yuan, Keguang Cheng, Qing‐Long Xu, Zengwei Lai

Tetrahedron

DOI

2023

Rapid Formation of Intramolecular Disulfide Bridges using Light: An Efficient Method to Control the Conformation and Function of Bioactive Peptides

Feng He, Yu Chai, Zizhen Zeng, Fangling Lu, Huanwen Chen, Jinhua Zhu, Yuanying Fang, Keguang Cheng, Emeric Miclet, Valérie Alezra, Yang Wan

Journal of the American Chemical Society

DOI

2023

Pentacyclic triterpene-amino acid derivatives induced apoptosis and autophagy in tumor cells, affected the JNK and PI3K/AKT/mTOR pathway

Liqiong Zhang, Li Sun, Yuqing Zhou, Jing-jing Liu, Quande Wang, Wei-bin Mo, Keguang Cheng

Bioorganic & Medicinal Chemistry

DOI

2023

Acylmonofluoromethylation of alkenes via dual NHC/photoredox catalysis

Shichao Tian, Mingxi Chen, Yihan Tang, Keguang Cheng, Gavin Chit Tsui, Quande Wang

Organic Chemistry Frontiers

DOI

2022

1,3-二溴丙烷与醇羧酸和胺一锅法生成烯丙基化合物

阴玉栋，柯善喆，黄家艳，邓梦湘，刘观艳，程克光

《广西师范大学学报(自然科学版)》

2022

Pyrazolone derivatives as potent and selective small-molecule SIRT5 inhibitors

Jian Hua Yao, Yudong Yin, Hong Han, Shaoting Chen, Yuxiang Zheng, Benji Liang, Mengyue Wu, Kangqi Shu, Bikash Debnath, David B. Lombard, Quande Wang, Keguang Cheng, Nouri Neamati, Yanghan Liu

European Journal of Medicinal Chemistry

DOI

2022

(4-Picolylamino)-17β-Estradiol derivative and analogues induce apoptosis with death receptor trail R2/DR5 in MCF-7

Yudong Yin, Li Sun, Lixin Sheng, Liqiong Zhang, Jingjing Liu, Xiaoan Wen, Weibin Mo, Quande Wang, Keguang Cheng

Chemico-Biological Interactions

DOI

2022

Synthesis and in vitro/in vivo anticancer evaluation of pentacyclic triterpenoid derivatives linked with -phenylalanine or -proline

Yudong Yin, Lixin Sheng, Juzheng Zhang, Liqiong Zhang, Jingjing Liu, Xiaoan Wen, Yanghan Liu, Yang Si, Keguang Cheng

Bioorganic Chemistry

DOI

2022

Spectrum-Effect Relationship Analysis of Bioactive Compounds in Zanthoxylum nitidum (Roxb.) DC. by Ultra-High Performance Liquid Chromatography Mass Spectrometry Coupled With Comprehensive Filtering Approaches

Si-wei Rao, Yuanyuan Duan, Han‐Qing Pang, Shao-hua Xu, Shou-qian Hu, Keguang Cheng, Dong Liang, Wei Shi

Frontiers in Pharmacology

DOI

2021

齐墩果酸-对羟基苯甲腈及其类似物的合成与抗肿瘤活性评价

刘晶晶，陈转欣，尤佳航，黄家艳，程克光

《广西师范大学学报(自然科学版)》

DOI

2021

Discovery of Novel Small Molecule Inhibitors Disrupting the PCSK9-LDLR Interaction

Hengzhi Sun, Hengzhi Sun, Jin‐Zheng Wang, Shengjie Liu, Xinyu Zhou, Liang Xiang Dai, Caiping Chen, Qing‐Long Xu, Xiaoan Wen, Keguang Cheng, Hongbin Sun, Hongbin Sun, Haoliang Yuan

Journal of Chemical Information and Modeling

DOI

2021

Study on synthesis and anticancer activity of 17beta-estradiol-phenol/aniline nitrogen mustard derivatives

Yudong Yin, Jing-jing Liu, Wen-fei Liao, Xian-kun Guo, Li-shan Zhang, Wei-bin Mo, Keguang Cheng

Medicinal Chemistry Research

DOI

2020

熊果酸/甘草次酸-尿嘧啶核苷缀合物的合成与抗肿瘤活性评价

孙立，初相伍，刘春梅，张琚政，程克光

《广西师范大学学报(自然科学版)》

DOI

2020

New possible silver lining for pancreatic cancer therapy: Hydrogen sulfide and its donors

Xu Hu, Yan Xiao, Jianan Sun, Bao Ji, Shanshan Luo, Bo Wu, Chao Zheng, Peng Wang, Fanxing Xu, Keguang Cheng, Huiming Hua, Dahong Li

Acta Pharmaceutica Sinica B

DOI

2020

Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification

Yuxi Fang, Haonan Li, Bao Ji, Keguang Cheng, Bo Wu, Zhan‐Lin Li, Chao Zheng, Huiming Hua, Dahong Li

European Journal of Medicinal Chemistry

DOI

2020

Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid

Liu Liu, Haobin Li, Kaiwen Hu, Qing‐Long Xu, Xiaoan Wen, Keguang Cheng, Caiping Chen, Haoliang Yuan, Liang Xiang Dai, Hongbin Sun

European Journal of Medicinal Chemistry

DOI

2020

Discovery of AdipoRon analogues as novel AMPK activators without inhibiting mitochondrial complex I

Geng Sun, Yanping You, Haobin Li, Yalong Cheng, Ming D. Qian, Xinyu Zhou, Haoliang Yuan, Qing‐Long Xu, Liang Xiang Dai, Pengfei Wang, Keguang Cheng, Xiaoan Wen, Caiping Chen

European Journal of Medicinal Chemistry

DOI

2020

N-benzylpiperidinol derivatives as novel USP7 inhibitors: Structure–activity relationships and X-ray crystallographic studies

Minglei Li, Shengjie Liu, Hui Chen, Xinyu Zhou, Jin Zhou, Shuxi Zhou, Haoliang Yuan, Qing‐Long Xu, Jun Liu, Keguang Cheng, Hongbin Sun, Yue Wang, Caiping Chen, Xiaoan Wen

European Journal of Medicinal Chemistry

DOI

2020

Discovery of Ubiquitin-Specific Protease 7 (USP7) Inhibitors with Novel Scaffold Structures by Virtual Screening, Molecular Dynamics Simulation, and Biological Evaluation

Shengjie Liu, Xinyu Zhou, Minglei Li, Wenfeng Zhao, Shuxi Zhou, Keguang Cheng, Qing‐Long Xu, Caiping Chen, Xiaoan Wen, Hongbin Sun, Haoliang Yuan

Journal of Chemical Information and Modeling

DOI

2020

Discovery of Novel Peroxisome Proliferator-Activated Receptor α (PPARα) Agonists by Virtual Screening and Biological Evaluation

Liang Xiang Dai, Zhiqi Feng, Rili Zha, Keguang Cheng, Xiaoan Wen, Hongbin Sun, Haoliang Yuan

Journal of Chemical Information and Modeling

DOI

2020

Design, Synthesis, and Evaluation of Novel 2-Methoxyestradiol Derivatives as Apoptotic Inducers through an Intrinsic Apoptosis Pathway

Lixin Sheng, Jiangyu Zhang, Li Li, Xiao Xie, Xiaoan Wen, Keguang Cheng

Biomolecules

DOI

2019

Design, synthesis and apoptosis-related antiproliferative activities of chelidonine derivatives

Xueyan Huang, Keguang Cheng, Lilin Liu, Xu Hu, Xiang Gao, Haonan Li, Fanxing Xu, Zhan‐Lin Li, Huiming Hua, Dahong Li

Bioorganic & Medicinal Chemistry Letters

DOI

2019

Synthesis and cytotoxicity of pentacyclic triterpenes‐aniline nitrogen mustard derivatives

Chunmei Liu, Xiao‐Yan Tian, Chunhua Su, Jiayan Huang, Chu Xiang-wu, Shengping Deng, Keguang Cheng

Journal of the Chinese Chemical Society

DOI

2019

Synthesis of oleanolic acid/ursolic acid/glycyrrhetinic acid-hydrogen sulfide donor hybrids and their antitumor activity

Lixin Sheng, Jiayan Huang, Chunmei Liu, Ju-zheng Zhang, Keguang Cheng

Medicinal Chemistry Research

DOI

2019

Antiproliferative activity of ursolic acid/glycyrrhetinic acid-uracil/thymine hybrids

Li Sun, Chu Xiang-wu, Chunmei Liu, Lixin Sheng, Zhuan-Xin Chen, Keguang Cheng

Medicinal Chemistry Research

DOI

2019

Synthesis and antitumor activity of fluorouracil – oleanolic acid/ursolic acid/glycyrrhetinic acid conjugates

Chunmei Liu, Jiayan Huang, Lixin Sheng, Xiaoan Wen, Keguang Cheng

MedChemComm

DOI

2018

Discovery of novel quinazolines as potential anti-tubulin agents occupying three zones of colchicine domain

Wenlong Li, Ying Yin, Shuai Wen, Feijie Xu, Hong Yao, Jie Liu, Keguang Cheng, Jinyi Xu, Zheying Zhu, Shengtao Xu

Bioorganic Chemistry

DOI

2018

Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway

Tong Han, Yan Wang, Mingying Wang, Xu Li, Keguang Cheng, Xiang Gao, Zhan‐Lin Li, Jiao Bai, Huiming Hua, Dahong Li

European Journal of Medicinal Chemistry

DOI

2018

Synthesis, Cytotoxicity and Antimicrobial Activity of New Enmein-type Kauranoid Diterpenoid Derivatives

Dahong Li, Tong Han, Xu Hu, Kangtao Tian, Shengtao Xu, Tingting Zhou, Keguang Cheng, Zhan‐Lin Li, Huiming Hua, Jinyi Xu

Anti-Cancer Agents in Medicinal Chemistry

DOI

2018

Synthesis and Cytotoxicity Evaluation of Pentacyclic Triterpene–Phenol Nitrogen Mustard Conjugates

Jiayan Huang, Lindong Yang, Chunhua Su, Chu Xiang-wu, Jiangyu Zhang, Shengping Deng, Keguang Cheng

Chemistry of Natural Compounds

DOI

2017

Scutellarin derivatives as apoptosis inducers: Design, synthesis and biological evaluation

Tong Han, Jia Li, Jingjing Xue, He Li, Fanxing Xu, Keguang Cheng, Dahong Li, Zhan‐Lin Li, Ming Gao, Huiming Hua

European Journal of Medicinal Chemistry

DOI

2017

In Silico Prediction of Chemical Toxicity Profile Using Local Lazy Learning

Jing Lu, Pin Zhang, Xiao-Wen Zou, Xiaoqiang Zhao, Keguang Cheng, Yi‐Lei Zhao, Yi Bi, Ming-Yue Zheng, Xiaomin Luo

Combinatorial Chemistry & High Throughput Screening

DOI

2016

O-炔丙基-N,N-二(2-氯乙基)-4-氨基苯酚的合成

黄家艳，黎淑宁，廖雯菲，邓胜平，程克光

《合成化学》

2016

Synthesis of acyl oleanolic acid-uracil conjugates and their anti-tumor activity

Wei-bin Mo, Chunhua Su, Jiayan Huang, Jun Hong Liu, Zhen‐Feng Chen, Keguang Cheng

Chemistry Central Journal

DOI

2016

Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound

Dahong Li, Tong Han, Jie Liao, Xu Hu, Shengtao Xu, Kangtao Tian, Xiaoke Gu, Keguang Cheng, Zhan‐Lin Li, Huiming Hua, Jinyi Xu

International Journal of Molecular Sciences

DOI

2016

Synthesis, Biological Activity, and Apoptotic Properties of NO-Donor/Enmein-Type ent-Kauranoid Hybrids

Dahong Li, Xu Hu, Tong Han, Shengtao Xu, Tingting Zhou, Zhenzhong Wang, Keguang Cheng, Zhan‐Lin Li, Huiming Hua, Wei Xiao, Jinyi Xu

International Journal of Molecular Sciences

DOI

2016

Estimation of elimination half-lives of organic chemicals in humans using gradient boosting machine

Jing Lu, Dong Lu, Xiaochen Zhang, Yi Bi, Keguang Cheng, Mingyue Zheng, Xiaomin Luo

Biochimica et Biophysica Acta (BBA) - General Subjects

DOI

2016

Antiproliferative activity and apoptosis inducing effects of nitric oxide donating derivatives of evodiamine

Nan Zhao, Kangtao Tian, Keguang Cheng, Tong Han, Xu Hu, Dahong Li, Zhan‐Lin Li, Huiming Hua

Bioorganic & Medicinal Chemistry

DOI

2016

Antitumor and Antibacterial Derivatives of Oridonin: A Main Composition of Dong-Ling-Cao

Dahong Li, Tong Han, Shengtao Xu, Tingting Zhou, Kangtao Tian, Xu Hu, Keguang Cheng, Zhan‐Lin Li, Huiming Hua, Jinyi Xu

Molecules

DOI

2016

Conjugation of Uridine with Oleanolic Acid Derivatives as Potential Antitumor Agents

Keguang Cheng, Chunhua Su, Jiayan Huang, Jun Hong Liu, Yuan‐Ting Zheng, Zhen‐Feng Chen

Chemical Biology & Drug Design

DOI

2016

Synthesis and cytotoxic evaluation of several oleanolic acid–uracil/thymine conjugates

Keguang Cheng, Chunhua Su, Jiayan Huang, Heng‐Shan Wang, Jun Hong Liu, Yuanting Zheng, Zhen‐Feng Chen

MedChemComm

DOI

2015

Design, synthesis, nitric oxide release and antibacterial evaluation of novel nitrated ocotillol-type derivatives

Yi Bi, Xiao Yang, Tingting Zhang, Zeyun Liu, Xiaochen Zhang, Jing Lu, Keguang Cheng, Jinyi Xu, Hongbo Wang, Guangyao Lv, Peter John Lewis, Qingguo Meng, Cong Ma

European Journal of Medicinal Chemistry

DOI

2014

17-取代雌二醇-嘧啶类衍生物的合成与体外抗肿瘤活性研究

程克光，张江玉，刘观艳，初相伍，凌丹，姚国义

《中国新药杂志》

2014

3-取代雌二醇-嘧啶类衍生物的合成与抗肿瘤活性

程克光，初相伍，刘观艳，苏春华，邓胜平，潘红梅

《中国药科大学学报》

2014

Synthesis of oleanolic acid dimers linked at C-28 and evaluation of anti-tumor activity

Keguang Cheng, Chunhua Su, Lin-Dong Yang, Jun Liu, Zhen‐Feng Chen

European Journal of Medicinal Chemistry

DOI

2014

Simultaneous reduction of aldehyde group to hydroxymethyl group in palladium-catalyzed Suzuki cross-coupling reaction

Ying‐Chun Wang, Xiu-Ying Li, Yajun Li, Ying‐Ming Pan, Keguang Cheng, Heng‐Shan Wang

Chemical Research in Chinese Universities

DOI

2013

雌二醇酯类衍生物的合成与抗肿瘤活性研究

刘观艳，程克光，邓胜平，刘延成，初相伍，陈健辉，马璐

《广西师范大学学报(自然科学版)》

精选作品

期刊论文

Radical Fluoroalkoxylation of α-Mono/Trihalo Ketones

Maslinic acid derivative induces the death of transitional bladder cancer cells through apoptosis and autophagy via the PI3K–AKT signaling pathway

N-monofluoromethoxy benzoimidazole: a bench stable reagent for direct radical monofluoromethoxylation of alkenes

Photocatalytic C–H Trifluoroethoxylation of (Hetero)arenes

Research progress on GPX4 targeted compounds

Radical Acylfluoroalkylation of 1,3-Enynes via N-Heterocyclic Carbene/Photoredox Cooperative Catalysis

6-O-angeloylplenolin inhibits osteoclastogenesis in vitro via suppressing c-Src/NF-κB/NFATc1 pathways and ameliorates bone resorption in collagen-induced arthritis mouse model

Design, synthesis and in vitro antitumor activity of 17β-estradiol-amino acid derivatives

N-Heterocyclic Carbene and Manganese Synergistic Catalysis: A Three-Component Radical Acylmonofluoroalkylation of Alkenes

Synthesis of polycyclic fused oxazolidin-2-ones by catalytic Boron(III)-Promoted oxo-Michael addition reaction and evaluation on their cytotoxicity

Rapid Formation of Intramolecular Disulfide Bridges using Light: An Efficient Method to Control the Conformation and Function of Bioactive Peptides

Pentacyclic triterpene-amino acid derivatives induced apoptosis and autophagy in tumor cells, affected the JNK and PI3K/AKT/mTOR pathway

Acylmonofluoromethylation of alkenes via dual NHC/photoredox catalysis

1,3-二溴丙烷与醇羧酸和胺一锅法生成烯丙基化合物

Pyrazolone derivatives as potent and selective small-molecule SIRT5 inhibitors

(4-Picolylamino)-17β-Estradiol derivative and analogues induce apoptosis with death receptor trail R2/DR5 in MCF-7

Synthesis and in vitro/in vivo anticancer evaluation of pentacyclic triterpenoid derivatives linked with -phenylalanine or -proline

Spectrum-Effect Relationship Analysis of Bioactive Compounds in Zanthoxylum nitidum (Roxb.) DC. by Ultra-High Performance Liquid Chromatography Mass Spectrometry Coupled With Comprehensive Filtering Approaches

齐墩果酸-对羟基苯甲腈及其类似物的合成与抗肿瘤活性评价

Discovery of Novel Small Molecule Inhibitors Disrupting the PCSK9-LDLR Interaction

Study on synthesis and anticancer activity of 17beta-estradiol-phenol/aniline nitrogen mustard derivatives

熊果酸/甘草次酸-尿嘧啶核苷缀合物的合成与抗肿瘤活性评价

New possible silver lining for pancreatic cancer therapy: Hydrogen sulfide and its donors

Renieramycin-type alkaloids from marine-derived organisms: Synthetic chemistry, biological activity and structural modification

Synthesis and anti-inflammatory activity of saponin derivatives of δ-oleanolic acid

Discovery of AdipoRon analogues as novel AMPK activators without inhibiting mitochondrial complex I

N-benzylpiperidinol derivatives as novel USP7 inhibitors: Structure–activity relationships and X-ray crystallographic studies

Discovery of Ubiquitin-Specific Protease 7 (USP7) Inhibitors with Novel Scaffold Structures by Virtual Screening, Molecular Dynamics Simulation, and Biological Evaluation

Discovery of Novel Peroxisome Proliferator-Activated Receptor α (PPARα) Agonists by Virtual Screening and Biological Evaluation

Design, Synthesis, and Evaluation of Novel 2-Methoxyestradiol Derivatives as Apoptotic Inducers through an Intrinsic Apoptosis Pathway

Design, synthesis and apoptosis-related antiproliferative activities of chelidonine derivatives

Synthesis and cytotoxicity of pentacyclic triterpenes‐aniline nitrogen mustard derivatives

Synthesis of oleanolic acid/ursolic acid/glycyrrhetinic acid-hydrogen sulfide donor hybrids and their antitumor activity

Antiproliferative activity of ursolic acid/glycyrrhetinic acid-uracil/thymine hybrids

Synthesis and antitumor activity of fluorouracil – oleanolic acid/ursolic acid/glycyrrhetinic acid conjugates

Discovery of novel quinazolines as potential anti-tubulin agents occupying three zones of colchicine domain

Synthesis of scutellarein derivatives with antiproliferative activity and selectivity through the intrinsic pathway

Synthesis, Cytotoxicity and Antimicrobial Activity of New Enmein-type Kauranoid Diterpenoid Derivatives

Synthesis and Cytotoxicity Evaluation of Pentacyclic Triterpene–Phenol Nitrogen Mustard Conjugates

Scutellarin derivatives as apoptosis inducers: Design, synthesis and biological evaluation

In Silico Prediction of Chemical Toxicity Profile Using Local Lazy Learning

O-炔丙基-N,N-二(2-氯乙基)-4-氨基苯酚的合成

Synthesis of acyl oleanolic acid-uracil conjugates and their anti-tumor activity

Oridonin, a Promising ent-Kaurane Diterpenoid Lead Compound

Synthesis, Biological Activity, and Apoptotic Properties of NO-Donor/Enmein-Type ent-Kauranoid Hybrids

Estimation of elimination half-lives of organic chemicals in humans using gradient boosting machine

Antiproliferative activity and apoptosis inducing effects of nitric oxide donating derivatives of evodiamine

Antitumor and Antibacterial Derivatives of Oridonin: A Main Composition of Dong-Ling-Cao

Conjugation of Uridine with Oleanolic Acid Derivatives as Potential Antitumor Agents

Synthesis and cytotoxic evaluation of several oleanolic acid–uracil/thymine conjugates

Design, synthesis, nitric oxide release and antibacterial evaluation of novel nitrated ocotillol-type derivatives

17-取代雌二醇-嘧啶类衍生物的合成与体外抗肿瘤活性研究

3-取代雌二醇-嘧啶类衍生物的合成与抗肿瘤活性

Synthesis of oleanolic acid dimers linked at C-28 and evaluation of anti-tumor activity

Simultaneous reduction of aldehyde group to hydroxymethyl group in palladium-catalyzed Suzuki cross-coupling reaction

雌二醇酯类衍生物的合成与抗肿瘤活性研究

会议论文

5-氟尿嘧啶-五环三萜衍生物的合成

天然五环三萜类糖原磷酸化酶抑制剂的构效关系研究

研究方向