毛新良｜广州医科大学｜学者主页

精选作品

期刊论文

2026

FOXO3 upregulates and activates GSDME to trigger myeloma cell pyroptosis

Yan-Er Wang, Ya-Li Wang, Yao-Li Cui, Yuan-ming He, Ye Yang, Wen Zhou, Long-Long Liu, Hua Wang, Mo Liu, Yong-Qiang Wei, Zhenqian Huang, Xiaolei Wei, Xinliang Mao

International Journal on Biological Sciences

DOI

2026

HERC4 synergizes with USP16 to promote lung adenocarcinoma growth by augmenting protein translation via stabilizing RPS15

Qiuyun Jiang, Yi-Yang-Yan-Fu Liu, Wen-Shuang Sun, Ziyang Liu, Na Tao, Yun-Shu Zhao, Ping Li, Yu Ou, Yuening Sun, Hong-Biao Huang, Jia Yu, Wen-Hua Liang, Xinliang Mao

Oncogene

DOI

2026

IFI27 and BAX are Essential for GSDME‐Mediated Myeloma Cell Pyroptosis

Yao-Li Cui, Yuening Sun, Ziyang Liu, Xuntao Lai, Yun-Shu Zhao, Yan-Er Wang, Yuan-ming He, Fang Xu, Du Feng, Long-Long Liu, Zhenqian Huang, Li-Jie Xing, Xinliang Mao

Advancement of science

DOI

2026

RNF6 activates the AKT/mTOR signaling pathway by inhibiting PTEN via K27-linked polyubiquitination in myeloma

Yue-ya Zhong, Li-huan Zhang, Zi-Yang Liu, Na Tao, Zi-fu Fan, Ke Li, Hongxia Zhang, Yao‐Li Cui, Ya-li Wang, Xinliang Mao

Acta Pharmacologica Sinica

DOI

2025

UBE2O：兼具E2/E3活性的多功能泛素结合酶在多种生物学与病理生理过程中的独特作用（英文）

毛晨宇，汪亚丽，毛新良

《中国生物化学与分子生物学报》

DOI

2025

SNAI2 orchestrates a hypo-oxidative mitochondrial phenotype with elevated FAO dependence in acute myeloid leukemia

Xuntao Lai, Donghua Zhang, Long-Long Liu, Xinliang Mao, Jia Wei, Zhen-Qian Huang

Blood

DOI

2025

Acevaltrate Overcomes Myeloma Resistance to Bortezomib via Pyroptosis by Promoting BAX Translocalization to Mitochondria.

Yan-Er Wang, Yao-Li Cui, Ziyang Liu, Long-Long Liu, Zhenqian Huang, Qi Wang, Xinliang Mao

European Journal of Pharmacology

DOI

2025

RNF6 inhibits lung adenocarcinoma cell proliferation by promoting cyclin D2 degradation.

Yuening Sun, Liyang Jiang, Zubin Zhang, Rongrong Zhu, Jingpei Liang, Ziyang Liu, Yuan-ming He, Zhenqian Huang, Chunhua Ling, Xiu-Min Zhou, Xinliang Mao

Molecular Cancer Research

DOI

2025

Bardoxolone displays potent activity against triple negative breast cancer by inhibiting the TRIP13/STAT3 circuit

Jun-hao Deng, Hongyue Li, Ziyang Liu, Jingpei Liang, Ying Ren, Yuanying Zeng, Yali Wang, Xinliang Mao

Acta Pharmacologica Sinica

DOI

2024

Induction of IFIT1/IFIT3 and inhibition of Bcl-2 orchestrate the treatment of myeloma and leukemia via pyroptosis.

Yuan-ming He, Shuo-yi Jiang, Yao-Li Cui, Jingpei Liang, Yue-Ya Zhong, Yuening Sun, Michael F Moran, Zhen-Qian Huang, Guisong He, Xinliang Mao

Cancer Letters

DOI

2024

P-274 Activation of the FOXO3/GSDME Axis to Overcome Bortezomib Resistance for the Treatment of Myeloma via Pyroptosis

Yan-Er Wang, Ye Yang, Wen Zhou, Long-Long Liu, Zhenqian Huang, Xinliang Mao

Clinical Lymphoma, Myeloma & Leukemia

DOI

2024

A new gene signature associated with pyroptosis for identifying high-risk myeloma patients

Yan-Er Wang, Qi Wang, Zhenqian Huang, Xinliang Mao

Gene & Protein in Disease

DOI

2024

Inhibiting the Otub1/phosphorylated STAT3 axis for the treatment of non-small cell lung cancer

Zi-yang Liu, Ya-wen Zhang, Hai-xia Zhuang, Yu-jie Ou, Qiu-yun Jiang, Ping-fei Li, Yuanming He, Ying Ren, Xinliang Mao

Acta Pharmacologica Sinica

DOI

2023

P-201 Induction of pyroptosis for the treatment of multiple myeloma

Xinliang Mao, Yuan-ming He, Shuo-yi Jiang, Zhenqian Huang

Clinical Lymphoma, Myeloma & Leukemia

DOI

2023

USP7 promotes non‐small‐cell lung cancer cell glycolysis and survival by stabilizing and activating c‐Abl

Yuan-ming He, Shuo-yi Jiang, Yue-Ya Zhong, Xiao-Ge Wang, Yao-Li Cui, Jingpei Liang, Yuening Sun, Zhi-Gang Zhu, Zhenqian Huang, Xinliang Mao

Clinical and Translational Medicine

DOI

2023

Bruceine B Displays Potent Antimyeloma Activity by Inducing the Degradation of the Transcription Factor c-Maf.

Hongyu Li, Xiao-ting Zhu, Zi-ying Sun, Qi Wang, Shao-Jiang Song, Yu-jia Xu, Guisong He, Xinliang Mao

ACS Pharmacology & Translational Science

DOI

2023

Ubiquitination is a major modulator for the activation of inflammasomes and pyroptosis

Qiuyun Jiang, Zhigang Zhu, Xinliang Mao

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

DOI

2023

RNF6 promotes chronic myelogenous leukemia cell proliferation and migration by stabilizing vimentin via multiple atypical ubiquitinations

Hongxia Zhang, Yueya Zhong, Yuanming He, Yujia Xu, Ying Ren, Haixia Zhuang, Tong Sun, Zhigang Zhu, Xinliang Mao

Genes & Diseases

DOI

2023

Inhibition of USP10 induces myeloma cell apoptosis by promoting cyclin D3 degradation

Yujia Xu, Kun Zeng, Ying Ren, Chen-yu Mao, Ying Ye, Xiao-ting Zhu, Ziying Sun, Biyin Cao, Zu-bin Zhang, Guoqiang Xu, Zhenqian Huang, Xinliang Mao

Acta Pharmacologica Sinica

DOI

2023

The ubiquitin ligase HERC4 suppresses MafA transcriptional activity triggered by GSK3β in myeloma by atypical K63-linked polyubiquitination

Zubin Zhang, Mei Li, Peng Lin, Ying Ren, Yuanming He, Siyu Wang, Yujia Xu, Biyin Cao, Guanghui Wang, Michael F. Moran, Xinliang Mao

Journal of Biological Chemistry

DOI

2023

Proteasomal inhibitors induce myeloma cell pyroptosis via the BAX/GSDME pathway

Jingpei Liang, Yuanming He, Yao‐Li Cui, Yuening Sun, Guisong He, Zhi-gang Zhu, Xinliang Mao

Acta Pharmacologica Sinica

DOI

2023

TRIM26 promotes non-small cell lung cancer survival by inducing PBX1 degradation

Yuening Sun, Peng Lin, Xiumin Zhou, Ying Ren, Yuanming He, Jingpei Liang, Zhigang Zhu, Xiaofeng Xu, Xinliang Mao

International Journal of Biological Sciences

DOI

2022

Induction of zinc finger protein RNF6 auto-ubiquitination for the treatment of myeloma and chronic myeloid leukemia

Haixia Zhuang, Ying Ren, Chenyu Mao, Yueya Zhong, Zubin Zhang, Biyin Cao, Yuming Zhang, Jinqi Huang, Guoqiang Xu, Zhenqian Huang, Yujia Xu, Xinliang Mao

Journal of Biological Chemistry

DOI

2022

Targeting the oncogenic transcription factor c-Maf for the treatment of multiple myeloma

Qiuyun Jiang, Hongwu Mao, Guisong He, Xinliang Mao

Cancer Letters

DOI

2021

Deubiquitinase USP5 promotes non-small cell lung cancer cell proliferation by stabilizing cyclin D1

Zhiwei Zhang, Zihan Cui, Zhuolin Xie, Chang Li, Chun Xu, Xia Nan Guo, Jie Zhong Yu, Tengfei Chen, Francesco Facchinetti, Hanibal Bohnenberger, Tracy L. Leong, Yufeng Xie, Xinliang Mao, Jun Zhao

Translational Lung Cancer Research

DOI

2021

The deubiquitinase USP10 restores PTEN activity and inhibits non–small cell lung cancer cell proliferation

Yuanming He, Shuoyi Jiang, Chenyu Mao, Hui Zheng, Biyin Cao, Zubin Zhang, Jun Zhao, Yuanying Zeng, Xinliang Mao

Journal of Biological Chemistry

DOI

2021

Suppression of USP7 induces BCR-ABL degradation and chronic myelogenous leukemia cell apoptosis

Shuoyi Jiang, Xiaoge Wang, Yuanming He, Hongbiao Huang, Biyin Cao, Zubin Zhang, Jinbao Liu, Qi Wang, Zhenqian Huang, Xinliang Mao

Cell Death and Disease

DOI

2021

TRIM25 activates AKT/mTOR by inhibiting PTEN via K63-linked polyubiquitination in non-small cell lung cancer

Yuanming He, Xiumin Zhou, Shuoyi Jiang, Zu-bin Zhang, Biyin Cao, Jin-bao Liu, Yuanying Zeng, Jun Zhao, Xinliang Mao

Acta Pharmacologica Sinica

DOI

2021

Inhibition of the Otub1/c-Maf axis by the herbal acevaltrate induces myeloma cell apoptosis

Tong Sun, Yujia Xu, Zhuan Xu, Biyin Cao, Zubin Zhang, Qi Wang, Yan Kong, Xinliang Mao

Cell Communication and Signaling

DOI

2020

Suppression of the USP10/CCND1 axis induces glioblastoma cell apoptosis

Tong Sun, Yujia Xu, Shuoyi Jiang, Zhuan Xu, Biyin Cao, Gautam Sethi, Yuanying Zeng, Yan Kong, Xinliang Mao

Acta Pharmacologica Sinica

DOI

2020

Anti-bacterial and anti-viral nanchangmycin displays anti-myeloma activity by targeting Otub1 and c-Maf

Yujia Xu, Tong Sun, Kun Zeng, Min Xu, Jinhao Chen, Xiaofeng Xu, Zubin Zhang, Biyin Cao, Xiaowen Tang, Depei Wu, Yan Kong, Yuanying Zeng, Xinliang Mao

Cell Death and Disease

DOI

2020

Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma

Yujia Xu, Min Xu, Jiefei Tong, Xiaowen Tang, Jinhao Chen, Xuehan Chen, Zubin Zhang, Biyin Cao, A. Keith Stewart, Michael F. Moran, Depei Wu, Xinliang Mao

Blood

DOI

2020

Novel conjugates of endoperoxide and 4-anilinoquinazoline induce myeloma cell apoptosis by inhibiting the IGF1-R/AKT/mTOR signaling pathway

Yujia Xu, Kun Zeng, Xiaoge Wang, Jieyu Zhang, Biyin Cao, Zubin Zhang, Chunhua Qiao, Xiaofeng Xu, Qi Wang, Yuanying Zeng, Xinliang Mao

BioScience Trends

DOI

2019

长柱重楼皂苷抑制急性髓系白血病细胞增殖的机制研究

陆芹，郑云菁，胡昳歆，王跃虎，毛新良，胡绍燕

《中国实验血液学杂志》

2019

The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival

Yuanming He, Siyu Wang, Jiefei Tong, Shuoyi Jiang, Ye Yang, Zubin Zhang, Yujia Xu, Yuanying Zeng, Biyin Cao, Michael F. Moran, Xinliang Mao

Journal of Biological Chemistry

DOI

2019

RNF6 promotes myeloma cell proliferation and survival by inducing glucocorticoid receptor polyubiquitination

Ying Ren, Xin Xu, Chen-yu Mao, Kunkun Han, Yujia Xu, Biyin Cao, Zu-bin Zhang, Gautam Sethi, Xiaowen Tang, Xinliang Mao

Acta Pharmacologica Sinica

DOI

2019

RNF6 promotes myeloma cell proliferation and survival by stabilizing and activating glucocorticoid receptor

Xinliang Mao, Ying Ren, Xin Xu, Kunkun Han

Clinical Lymphoma Myeloma & Leukemia

DOI

2019

Inhibition of the deubiquitinase USP9x induces pre-B cell homeobox 1 (PBX1) degradation and thereby stimulates prostate cancer cell apoptosis

Yan Liu, Xiaofeng Xu, Peng Lin, Yuanming He, Yawen Zhang, Biyin Cao, Zubin Zhang, Gautam Sethi, Jinbao Liu, Xiumin Zhou, Xinliang Mao

Journal of Biological Chemistry

DOI

2018

米非司酮衍生物FZU-00,033通过负调控KLF5表达抑制三阴性乳腺癌的生长

鲍敏，陈海军，毛新良，陈策实，刘蓉

《医学研究与战创伤救治》

2017

Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis

Siyu Wang, Jiaxiang Juan, Zubin Zhang, Yanyun Du, Yujia Xu, Jiefei Tong, Biyin Cao, Michael F. Moran, Yuanying Zeng, Xinliang Mao

Cell Death and Disease

DOI

2017

The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis

Yujia Xu, Zubin Zhang, Jie Li, Jiefei Tong, Biyin Cao, Paul P. Taylor, Xiaowen Tang, Depei Wu, Michael F. Moran, Yuanying Zeng, Xinliang Mao

Journal of Hematology & Oncology

DOI

2017

Ring finger protein 6 promotes breast cancer cell proliferation by stabilizing estrogen receptor alpha

Yuanying Zeng, Xin Xu, Siyu Wang, Zubin Zhang, Yan Liu, Kunkun Han, Biyin Cao, Xinliang Mao

Oncotarget

DOI

2016

抗多发性骨髓瘤的STAT3抑制剂及其研究策略

毛新良

《中国生化药物杂志》

2013

山楂核中具有抗肿瘤活性化合物的分离(英文)

李玲芝，彭缨，牛超，高品一，黄肖霄，毛新良，宋少江

Chinese Journal of Natural Medicines

会议论文

2018

靶向c-Maf泛素化降解的多发性骨髓瘤精准治疗策略

毛新良

《中国药理学会化疗药理专业委员会第十五届学术大会暨2018重庆化疗药物基础与前沿国际论坛会议手册》

DOI

2018

克服多发性骨髓瘤对硼替佐米天然耐药的治疗策略研究

徐宇嘉，张祖斌，刘燕，曹碧茵，毛新良

《中国药理学会化疗药理专业委员会第十五届学术大会暨2018重庆化疗药物基础与前沿国际论坛会议手册》

DOI

2010

一种对白血病和多发性骨髓瘤表现出显著治疗活性的新型细胞周期素D反向激活抑制剂

曹碧茵，王文洁，Hurren Rose，王晓鸣，Aaron Schimmer，毛新良

《转化医学研讨会》

预印本

2023

The Interferon-Inducible Genes IFIT1 and IFIT3 are Essential for Clioquinol-Induced Pyroptosis in Myeloma and Leukemia Cells by Promoting N-Terminal GSDME Translocalization to Mitochondria

Yuanming He, Shuoyi Jiang, Yao‐Li Cui, Jingpei Liang, Yueya Zhong, Yuening Sun, Michael F. Moran, Zhenqian Huang, Guisong He, Xinliang Mao

SSRN Electronic Journal

DOI

研究方向

肿瘤发生和靶向治疗所

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