王小虎｜清华大学｜学者主页

2026

Dynamic expression of IL-21 in effector CD8 T cells helps control chronic infections.

Zixuan Zhao, Han Feng, Xiaohong Zhao, Bowen Xie, Tian Xie, Qinli Sun, Yongzhen Chen, Kun Wei, Bi-Rui Pan, Peng Wei, Xuan Zhong, Lei Yuan, Xue Bai, Xiaohu Wang, Chen Dong

Science immunology

DOI

2026

The effector differentiation of TCRαβ+CD8αα+ intraepithelial lymphocytes is reciprocally regulated by BCL6 and BLIMP1.

Qi Xing, Shi-Yuan Xie, Jia-qi Ma, Hao Zhang, Jing Ge, Xiaohong Zhao, Yu-Jie Fu, Tian Xie, Qinli Sun, Xiaohu Wang, Yu-Ting Li, Chen Dong

Cell Reports

DOI

2026

Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection

Shiyuan Xie, Qi Xing, Qian Zhang, Hao Zhang, Qinli Sun, Qiuyan Lan, Zhiyu Gu, Birui Pan, Peng Wei, Yujie Fu, Xiaohu Wang, Chen Dong

Immunity

DOI

2026

The conserved noncoding sequence CNS11 is a master control region for Rorc transcription in type 17 immune cells

Hao Zhang, Dehui Chang, Shiyuan Xie, Ruifeng Li, Qian Zhang, Qi Xing, Tian Xie, Gongrui Zhang, Xinyi Lou, Shijie Li, Lin Yang, Vivian Dong, Jing Ge, Xiaohu Wang, Chen Dong

Science Advances

DOI

2025

Ciliated cell-derived IL-17D restrains allergic asthma through controlling monocyte recruitment.

Lei Yuan, Jin-Ling Huang, Jian-Hui Chen, Tian Xie, Genyu Wang, Bowen Xie, Lei Qin, Yongzhen Chen, Xuan Zhong, Zixuan Zhao, Z. Peng, Xiao-Shuang Wang, Miao Xu, Jing Ge, Xiaohu Wang, Chen Dong

Journal of Experimental Medicine

DOI

2025

The FoxO4/DKK3 axis represses IFN-γ expression by Th1 cells and limits antimicrobial immunity

Xiang Chen, Jia Hu, Yunfei Wang, Young-hee Lee, Xiaohong Zhao, Huiping Lu, Geng-Zheng Zhu, Hui Wang, Yu Jiang, F. Liu, Yongzhen Chen, Byung-Seok Kim, Qinghua Zhou, Xin-Dong Liu, Xiaohu Wang, S. Chang, C. Dong

Journal of Clinical Investigation

DOI

2025

VNUT-mediated ATP release suppresses T helper 1 (T H 1) cell differentiation via the P2X7R-JNK-FOXO3a-Eomes signaling cascade

Bolong Wu, Linlin Sheng, Ziyi Feng, Xiaohu Wang, Ligong Chen

Science Advances

DOI

2024

Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development

Xue Bai, Sijie Chen, Xinxin Chi, Bowen Xie, Xinyi Guo, Han Feng, Peng Wei, Di Zhang, Shan Xie, Tian Xie, Yongzhen Chen, Mengting Gou, Qin Qiao, Xin-Wei Liu, W. Jin, Wei Xu, Zixuan Zhao, Qi Xing, Xiaohu Wang, Xuegong Zhang, Chen Dong

Nature Immunology

DOI

2024

BCL6 is required for the thymic development of TCRαβ+CD8αα+ intraepithelial lymphocyte lineage

Qi Xing, Dehui Chang, Shi-Yuan Xie, Xiaohong Zhao, Hao Zhang, Xiaohu Wang, Xue Bai, Chen Dong

Science immunology

DOI

2023

Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6+ ILC3s

Yuling Li, Jing Ge, Xiaohong Zhao, Miao Xu, Mengting Gou, B. Xie, Jin-Ling Huang, Qinli Sun, Lin Sun, Xue Bai, Sangnee Tan, Xiaohu Wang, C. Dong

Journal of Experimental Medicine

DOI

2023

A cis-element at the Rorc locus regulates the development of type 3 innate lymphoid cells

Dehui Chang, H. Zhang, Jing Ge, Qi Xing, Xinyi Guo, Xiaohu Wang, C. Dong

Frontiers in Immunology

DOI

2023

A novel memory-like Tfh cell subset is precursor to effector Tfh cells in recall immune responses

Han Feng, Zixuan Zhao, Xiaohong Zhao, Xue Bai, Weiwei Fu, Liang-Tao Zheng, Bo-Xi Kang, Xiaohu Wang, Ze-Min Zhang, Chen Dong

Journal of Experimental Medicine

DOI

2023

Correction: Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6+ ILC3s

Yu-Ling Li, Jing Ge, Xiaohong Zhao, Miao Xu, Mengting Gou, B. Xie, Jin-Ling Huang, Qinli Sun, Lin Sun, Xue Bai, Sangnee Tan, Xiaohu Wang, Chen Dong

Journal of Experimental Medicine

DOI

2022

Pathogen-associated T follicular helper cell plasticity is critical in anti-viral immunity

Han Feng, Xiaohong Zhao, Jenny X. Xie, Xueyuan Bai, Weiwei Fu, Hairong Chen, Hong Tang, Xiaohu Wang, C. Dong

Science China Life Sciences

DOI

2022

RORγt expression in mature TH17 cells safeguards their lineage specification by inhibiting conversion to TH2 cells

Xinxin Chi, W. Jin, Xiaohong Zhao, T. Xie, Jing Shao, Xue Bai, Yu Jiang, Xiaohu Wang, C. Dong

Science Advances

DOI

2022

The FoxO4/DKK3 axis represses IFN-γ expression by Th1 cells and limits antimicrobial immunity

Xiang Chen, Jia Hu, Yunfei Wang, Young-hee Lee, Xiaohong Zhao, Huiping Lu, Geng-Zheng Zhu, Hui Wang, Yu Jiang, Fan Liu, Yongzhen Chen, Byung-Seok Kim, Qinghua Zhou, Xin-Dong Liu, Xiaohu Wang, S. Chang, Chen Dong

Journal of Clinical Investigation

DOI

2021

Costimulation molecules differentially regulate the ERK-Zfp831 axis to shape T follicular helper cell differentiation.

Siyuan Wan, L. Ni, Xiaohong Zhao, Xin-Dong Liu, Wei Xu, Wei Jin, Xiaohu Wang, C. Dong

Immunity

DOI

2021

RORα is critical for mTORC1 activity in T cell-mediated colitis.

Xinxin Chi, W. Jin, Xue Bai, Xiaohong Zhao, Jing Shao, Jiaqi Li, Qinli Sun, Bing Su, Xiaohu Wang, Xue-Xian O. Yang, C. Dong

Cell Reports

DOI

2021

Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93.

Jin-Ling Huang, Hae-Youn Lee, Xiaohong Zhao, Jin-Yi Han, Yang Su, Qinli Sun, Jing Shao, J. Ge, Yuxi Zhao, Xue Bai, Yi He, Xin-Quan Wang, Xiaohu Wang, C. Dong

Immunity

DOI

2020

The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation.

Dehui Chang, Qi Xing, Yang Su, Xiaohong Zhao, W. Xu, Xiaohu Wang, C. Dong

Immunity

DOI

2020

Corrigendum to ‘Cyclic AMP-Responsive element-binding protein (CREB) is critical in autoimmunity by promoting Th17 but inhibiting treg cell differentiation’

Xiaohu Wang, L. Ni, Dehui Chang, Huiping Lu, Yu Jiang, Byung-Seok Kim, Ai-Bo Wang, Xin-Dong Liu, Bo Zhong, Xue-Xian O. Yang, C. Dong

EBioMedicine

DOI

2020

Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells.

Xiaohu Wang, L. Ni, Siyuan Wan, Xiaohong Zhao, Xiao-Lan Ding, A. Dejean, C. Dong

Immunity

DOI

2019

Molecular mechanisms of T helper 17 cell differentiation: Emerging roles for transcription cofactors.

Yu Jiang, Xiaohu Wang, C. Dong

Advances in Immunology

DOI

2019

The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility.

Wei Xu, Xiaohong Zhao, Xiao-Shuang Wang, Han Feng, Mengting Gou, W. Jin, Xiaohu Wang, Xin-Dong Liu, C. Dong

Immunity

DOI

2019

Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction

Xin-Dong Liu, Yun E. Wang, Huiping Lu, Jing Li, Xiaowei Yan, Minglu Xiao, J. Hao, A. Alekseev, H. Khong, Teng-Hui Chen, Rui Huang, Jin Wu, Qiwen Zhao, Qi Wu, Senlin Xu, Xiaohu Wang, W. Jin, Shicang Yu, Yan Wang, Lai Wei, Ai-Bo Wang, Bo Zhong, L. Ni, Xiao-Long Liu, R. Nurieva, L. Ye, Qiang Tian, X. Bian, C. Dong

Nature

DOI

2019

Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation

Yang Su, Jin-Ling Huang, Xiaohong Zhao, Huiping Lu, Wang Wang, Xue-Xian O. Yang, Yu-Ling Shi, Xiaohu Wang, Y. Lai, C. Dong

Science immunology

DOI

2018

Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3.

Kentaro Tanaka, G. Martinez, Xiaowei Yan, Weiwen Long, K. Ichiyama, Xinxin Chi, Byung-Seok Kim, J. Reynolds, Yeonseok Chung, Shinya Tanaka, L. Liao, Y. Nakanishi, A. Yoshimura, P. Zheng, Xiaohu Wang, Qiang Tian, Jian-Ming Xu, B. O'Malley, C. Dong

Cell Reports

DOI

2018

Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28

Yu Jiang, Ying Liu, Huiping Lu, Shao-Cong Sun, W. Jin, Xiaohu Wang, C. Dong

Nature Communications

DOI

2018

Trim33 mediates the proinflammatory function of Th17 cells

Shinya Tanaka, Yu Jiang, G. Martinez, Kentaro Tanaka, Xiaowei Yan, T. Kurosaki, V. Kaartinen, Xin-Hua Feng, Qiang Tian, Xiaohu Wang, C. Dong

Journal of Experimental Medicine

DOI

2018

An Interleukin‐25‐Mediated Autoregulatory Circuit in Keratinocytes Plays a Pivotal Role in Psoriatic Skin Inflammation

Miao Xu, Huiping Lu, Young-hee Lee, Ye-Lin Wu, Kewei Liu, Yu-Ling Shi, Haoran An, Jingren Zhang, Xiaohu Wang, Y. Lai, C. Dong

Immunity

DOI

2017

Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation

Xiaohu Wang, L. Ni, Dehui Chang, Huiping Lu, Yu Jiang, Byung-Seok Kim, Ai-Bo Wang, Xin-Dong Liu, Bo Zhong, Xue-Xian O. Yang, C. Dong

EBioMedicine

DOI

2017

Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes

Ai-Bo Wang, Xiao-Lan Ding, Maud D. Demarque, Xin-Dong Liu, D. Pan, Huawei Xin, Bo Zhong, Xiaohu Wang, A. Dejean, W. Jin, C. Dong

Journal of Immunology

DOI

2017

Metabolic control of TH17/iTreg balance by an epigenetic mechanism

Tao Xu, Kelly M. Stewart, Xiaohu Wang, Kai Liu, M. Xie, J. Ryu, Ke Li, Tian-Hua Ma, Haixia Wang, L. Ni, Sai-Yong Zhu, N. Cao, Donwei Zhu, Yu Zhang, K. Akassoglou, C. Dong, E. Driggers, Sheng Ding

Nature

DOI

2015

The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells

K. Ichiyama, Tingting Chen, Xiaohu Wang, Xiaowei Yan, Byung-Seok Kim, Shinya Tanaka, Delphine Ndiaye-Lobry, Yuhua Deng, Yan-Li Zou, Pan Zheng, Qiang Tian, I. Aifantis, Lai Wei, C. Dong

Immunity

DOI

2015

Interleukin-17B antagonizes interleukin-25-mediated mucosal inflammation

J. Reynolds, Young-hee Lee, Yun-Jie Shi, Xiaohu Wang, P. Angkasekwinai, Kalyan C. Nallaparaju, S. Flaherty, S. Chang, H. Watarai, C. Dong

Immunity

DOI

2014

Transcription factor Achaete-Scute homologue 2 initiates T follicular helper cell development

Xin-Dong Liu, Xin Chen, Bo Zhong, Ai-Bo Wang, Xiaohu Wang, F. Chu, R. Nurieva, Xiaowei Yan, Ping Chen, L. G. van der Flier, Hiroko Nakatsukasa, S. Neelapu, Wan-Jun Chen, H. Clevers, Qiang Tian, Hai Qi, Lai Wei, C. Dong

Nature

DOI

2013

The CD70-CD27 Axis, a New Brake in the T Helper 17 Cell Response

Xiaohu Wang, C. Dong

Immunity

DOI

2013

Ubiquitin-Specific Protease 25 Regulates TLR4-Dependent Innate Immune Responses Through Deubiquitination of the Adaptor Protein TRAF3

Bo Zhong, Xi-Kui Liu, Xiaohu Wang, Xin-Dong Liu, Hongxiu Li, B. Darnay, Xin Lin, Shao-Cong Sun, C. Dong

Science Signaling

DOI

2012

Negative regulation of IL-17-mediated signaling and inflammation by ubiquitin-specific protease 25

Bo Zhong, Xi-Kui Liu, Xiaohu Wang, S. Chang, Xin-Dong Liu, Ai-Bo Wang, J. Reynolds, C. Dong

Nature Immunology

DOI

2012

Bcl6 expression specifies the T follicular helper cell program in vivo

Xin-Dong Liu, Xiao Yan, Bo Zhong, R. Nurieva, Ai-Bo Wang, Xiaohu Wang, N. Martín-Orozco, Yihong Wang, S. Chang, E. Esplugues, R. Flavell, Qiang Tian, C. Dong

Journal of Experimental Medicine

DOI

2012

Regulation of TLR-triggered innate immune response by ubiquitin-specific protease 25 (180.8)

Bo Zhong, Xi-Kui Liu, Xiaohu Wang, Xin-Dong Liu, S. Chang, Hongxiu Li, B. Darnay, Xin Lin, Shao-Cong Sun, C. Dong

Journal of Immunology

DOI

2012

Transcription of Il17 and Il17f is controlled by conserved non-coding sequence (CNS) 2

Xiaohu Wang, Yi-Bin Zhang, Xue-Xian O. Yang, R. Nurieva, S. Chang, Sandra S. Ojeda, H. Kang, K. Schluns, Jian-Fang Gui, A. Jetten, C. Dong

Immunity

DOI

2011

Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORγt Protein*

Tao Xu, Xiaohu Wang, Bo Zhong, R. Nurieva, Sheng Ding, C. Dong

Journal of Biological Chemistry

DOI

精选作品

期刊论文

Dynamic expression of IL-21 in effector CD8 T cells helps control chronic infections.

The effector differentiation of TCRαβ+CD8αα+ intraepithelial lymphocytes is reciprocally regulated by BCL6 and BLIMP1.

Effector differentiation by stem-like intraepithelial γδ T cells is required for host defense against infection

The conserved noncoding sequence CNS11 is a master control region for Rorc transcription in type 17 immune cells

Ciliated cell-derived IL-17D restrains allergic asthma through controlling monocyte recruitment.

The FoxO4/DKK3 axis represses IFN-γ expression by Th1 cells and limits antimicrobial immunity

VNUT-mediated ATP release suppresses T helper 1 (T H 1) cell differentiation via the P2X7R-JNK-FOXO3a-Eomes signaling cascade

Reciprocal regulation of T follicular helper cells and dendritic cells drives colitis development

BCL6 is required for the thymic development of TCRαβ+CD8αα+ intraepithelial lymphocyte lineage

Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6+ ILC3s

A cis-element at the Rorc locus regulates the development of type 3 innate lymphoid cells

A novel memory-like Tfh cell subset is precursor to effector Tfh cells in recall immune responses

Correction: Cell autonomous expression of BCL6 is required to maintain lineage identity of mouse CCR6+ ILC3s

Pathogen-associated T follicular helper cell plasticity is critical in anti-viral immunity

RORγt expression in mature TH17 cells safeguards their lineage specification by inhibiting conversion to TH2 cells

The FoxO4/DKK3 axis represses IFN-γ expression by Th1 cells and limits antimicrobial immunity

Costimulation molecules differentially regulate the ERK-Zfp831 axis to shape T follicular helper cell differentiation.

RORα is critical for mTORC1 activity in T cell-mediated colitis.

Interleukin-17D regulates group 3 innate lymphoid cell function through its receptor CD93.

The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation.

Corrigendum to ‘Cyclic AMP-Responsive element-binding protein (CREB) is critical in autoimmunity by promoting Th17 but inhibiting treg cell differentiation’

Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells.

Molecular mechanisms of T helper 17 cell differentiation: Emerging roles for transcription cofactors.

The Transcription Factor Tox2 Drives T Follicular Helper Cell Development via Regulating Chromatin Accessibility.

Genome-wide analysis identifies NR4A1 as a key mediator of T cell dysfunction

Interleukin-17 receptor D constitutes an alternative receptor for interleukin-17A important in psoriasis-like skin inflammation

Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3.

Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28

Trim33 mediates the proinflammatory function of Th17 cells

An Interleukin‐25‐Mediated Autoregulatory Circuit in Keratinocytes Plays a Pivotal Role in Psoriatic Skin Inflammation

Cyclic AMP-Responsive Element-Binding Protein (CREB) is Critical in Autoimmunity by Promoting Th17 but Inhibiting Treg Cell Differentiation

Ubc9 Is Required for Positive Selection and Late-Stage Maturation of Thymocytes

Metabolic control of TH17/iTreg balance by an epigenetic mechanism

The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells

Interleukin-17B antagonizes interleukin-25-mediated mucosal inflammation

Transcription factor Achaete-Scute homologue 2 initiates T follicular helper cell development

The CD70-CD27 Axis, a New Brake in the T Helper 17 Cell Response

Ubiquitin-Specific Protease 25 Regulates TLR4-Dependent Innate Immune Responses Through Deubiquitination of the Adaptor Protein TRAF3

Negative regulation of IL-17-mediated signaling and inflammation by ubiquitin-specific protease 25

Bcl6 expression specifies the T follicular helper cell program in vivo

Regulation of TLR-triggered innate immune response by ubiquitin-specific protease 25 (180.8)

Transcription of Il17 and Il17f is controlled by conserved non-coding sequence (CNS) 2

Ursolic Acid Suppresses Interleukin-17 (IL-17) Production by Selectively Antagonizing the Function of RORγt Protein*

研究方向